Avoro Capital Advisors LLC Top Holdings and 13F Report (2025) About Avoro Capital Advisors LLCInvestment ActivityAvoro Capital Advisors LLC has $7.07 billion in total holdings as of December 31, 2024.Avoro Capital Advisors LLC owns shares of 39 different stocks, but just 14 companies or ETFs make up 80% of its holdings.Approximately 7.61% of the portfolio was purchased this quarter.About 2.38% of the portfolio was sold this quarter.This quarter, Avoro Capital Advisors LLC has purchased 36 new stocks and bought additional shares in 10 stocks.Avoro Capital Advisors LLC sold shares of 7 stocks and completely divested from 4 stocks this quarter.Largest Holdings United Therapeutics $973,944,252argenx $761,657,205Ascendis Pharma A/S $702,537,582Madrigal Pharmaceuticals $626,088,530Krystal Biotech $411,831,255 Largest New Holdings this Quarter Blueprint Medicines $103,355,700 HoldingAlkermes $70,462,000 HoldinguniQure $38,410,500 Holding89bio $32,062,000 HoldingSEPTERNA INC $25,419,000 Holding Largest Purchases this Quarter Blueprint Medicines 1,185,000 shares (about $103.36M)Alkermes 2,450,000 shares (about $70.46M)Vera Therapeutics 1,300,410 shares (about $54.99M)Arrowhead Pharmaceuticals 2,222,223 shares (about $41.78M)uniQure 2,175,000 shares (about $38.41M) Largest Sales this Quarter BioMarin Pharmaceutical 575,515 shares (about $37.83M)United Therapeutics 98,588 shares (about $34.79M)Syndax Pharmaceuticals 1,613,437 shares (about $21.33M)Kura Oncology 1,291,505 shares (about $11.25M)Monte Rosa Therapeutics 1,445,236 shares (about $10.03M) Sector Allocation Over TimeMap of 500 Largest Holdings ofAvoro Capital Advisors LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorUTHRUnited Therapeutics$973,944,252$34,785,790 ▼-3.4%2,760,30013.8%MedicalARGXargenx$761,657,2050.0%1,238,46710.8%MedicalASNDAscendis Pharma A/S$702,537,582$15,717,371 ▲2.3%5,103,0559.9%MedicalMDGLMadrigal Pharmaceuticals$626,088,5300.0%2,029,0008.9%MedicalKRYSKrystal Biotech$411,831,255$1,033,956 ▲0.3%2,628,8225.8%MedicalAPLSApellis Pharmaceuticals$390,011,104$35,455,552 ▲10.0%12,222,2225.5%MedicalSRPTSarepta Therapeutics$310,729,9320.0%2,555,5554.4%MedicalITCIIntra-Cellular Therapies$254,736,0000.0%3,050,0003.6%MedicalVERAVera Therapeutics$237,246,900$54,994,339 ▲30.2%5,610,0003.4%MedicalXENEXenon Pharmaceuticals$222,133,3070.0%5,666,6663.1%MedicalFOLDAmicus Therapeutics$218,308,5000.0%23,175,0003.1%MedicalRNAAvidity Biosciences$218,100,000$18,175,000 ▲9.1%7,500,0003.1%MedicalARWRArrowhead Pharmaceuticals$208,888,887$41,777,792 ▲25.0%11,111,1113.0%MedicalKYMRKymera Therapeutics$207,184,500$26,149,500 ▲14.4%5,150,0002.9%MedicalMLTXMoonLake Immunotherapeutics$150,000,9150.0%2,770,1002.1%MedicalSLNOSoleno Therapeutics$113,498,750$15,462,800 ▲15.8%2,525,0001.6%MedicalBPMCBlueprint Medicines$103,355,700$103,355,700 ▲New Holding1,185,0001.5%MedicalPCVXVaxcyte$96,185,5000.0%1,175,0001.4%MedicalBMRNBioMarin Pharmaceutical$96,130,125$37,828,601 ▼-28.2%1,462,5001.4%MedicalMRUSMerus$89,356,250$32,378,500 ▲56.8%2,125,0001.3%MedicalBCRXBioCryst Pharmaceuticals$89,224,8000.0%11,865,0001.3%MedicalALKSAlkermes$70,462,000$70,462,000 ▲New Holding2,450,0001.0%MedicalOCULOcular Therapeutix$68,832,4000.0%8,060,0001.0%MedicalMNKDMannKind$56,262,5000.0%8,750,0000.8%MedicalTOURMALINE BIO INC$45,066,6620.0%2,222,2220.6%CommonQUREuniQure$38,410,500$38,410,500 ▲New Holding2,175,0000.5%MedicalRAREUltragenyx Pharmaceutical$34,918,1000.0%830,0000.5%MedicalTSHATaysha Gene Therapies$34,599,998$2,335,498 ▲7.2%19,999,9990.5%MedicalETNB89bio$32,062,000$32,062,000 ▲New Holding4,100,0000.5%MedicalGLUEMonte Rosa Therapeutics$30,154,300$10,029,938 ▼-25.0%4,345,0000.4%MedicalSNDXSyndax Pharmaceuticals$30,075,500$21,329,637 ▼-41.5%2,275,0000.4%MedicalIOVAIovance Biotherapeutics$25,900,000$5,476,000 ▼-17.5%3,500,0000.4%MedicalSEPTERNA INC$25,419,000$25,419,000 ▲New Holding1,110,0000.4%CommonAUTLAutolus Therapeutics$23,290,009$5,722,335 ▼-19.7%9,910,6420.3%MedicalCG ONCOLOGY INC$20,076,0000.0%700,0000.3%CommonKURAKura Oncology$19,597,500$11,249,009 ▼-36.5%2,250,0000.3%MedicalRCKTRocket Pharmaceuticals$15,084,000$15,084,000 ▲New Holding1,200,0000.2%MedicalOLMAOlema Pharmaceuticals$9,631,055$9,631,055 ▲New Holding1,651,9820.1%MedicalAADIAadi Bioscience$8,989,8630.0%2,849,4020.1%MedicalDYNE THERAPEUTICS INC.$0$23,348,000 ▼-100.0%00.0%CommonSPYRE THERAPEUTICS INC$0$17,604,826 ▼-100.0%00.0%CommonNEUROGENE INC$0$924,337 ▼-100.0%00.0%CommonINSMED INC$0$125,000 ▼-100.0%00.0%CommonShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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