Baker Bros. Advisors Lp Top Holdings and 13F Report (2025) About Baker Bros. Advisors LpInvestment ActivityBaker Bros. Advisors Lp has $9.36 billion in total holdings as of December 31, 2024.Baker Bros. Advisors Lp owns shares of 95 different stocks, but just 13 companies or ETFs make up 80% of its holdings.Approximately 3.11% of the portfolio was purchased this quarter.About 2.55% of the portfolio was sold this quarter.This quarter, Baker Bros. Advisors Lp has purchased 93 new stocks and bought additional shares in 20 stocks.Baker Bros. Advisors Lp sold shares of 4 stocks and completely divested from 8 stocks this quarter.Largest Holdings Incyte $2,123,174,917BeiGene $1,760,633,555ACADIA Pharmaceuticals $786,809,759Madrigal Pharmaceuticals $609,299,236Summit Therapeutics $435,861,716 Largest New Holdings this Quarter Ionis Pharmaceuticals, Inc. $29,543,640 HoldingGRAIL, Inc. $29,097,731 HoldingCandel Therapeutics $25,883,612 HoldingVir Biotechnology $7,960,516 HoldingIntellia Therapeutics $7,510,393 Holding Largest Purchases this Quarter Insmed 590,945 shares (about $40.80M)Ionis Pharmaceuticals, Inc. 30,000,000 shares (about $29.54M)GRAIL, Inc. 1,630,125 shares (about $29.10M)Candel Therapeutics 2,981,983 shares (about $25.88M)Bicycle Therapeutics 1,485,397 shares (about $20.80M) Largest Sales this Quarter BeiGene 1,037,017 shares (about $191.55M)Rhythm Pharmaceuticals 314,117 shares (about $17.58M)Biomea Fusion 656,959 shares (about $2.55M)Sagimet Biosciences Inc. 428,902 shares (about $1.93M) Sector Allocation Over TimeMap of 500 Largest Holdings ofBaker Bros. Advisors Lp Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorINCYIncyte$2,123,174,917$30,805 ▲0.0%30,739,46622.7%MedicalBGNEBeiGene$1,760,633,555$191,547,410 ▼-9.8%9,531,88018.8%MedicalACADACADIA Pharmaceuticals$786,809,7590.0%42,877,9168.4%MedicalMDGLMadrigal Pharmaceuticals$609,299,2360.0%1,974,5906.5%MedicalSMMTSummit Therapeutics$435,861,7160.0%24,424,8654.7%MedicalRVMDRevolution Medicines$347,163,155$16,091,159 ▲4.9%7,936,9723.7%MedicalINSMInsmed$345,673,822$40,798,843 ▲13.4%5,006,8633.7%MedicalRYTMRhythm Pharmaceuticals$340,596,259$17,584,270 ▼-4.9%6,084,2493.6%MedicalKYMRKymera Therapeutics$241,216,2240.0%5,995,9292.6%MedicalKODKodiak Sciences$172,239,3760.0%17,310,4901.8%MedicalEWTXEdgewise Therapeutics$164,363,598$8,434,023 ▲5.4%6,155,9401.8%MedicalBCYCBicycle Therapeutics$152,394,998$20,795,558 ▲15.8%10,885,3571.6%MedicalREPLReplimune Group$133,759,0190.0%11,045,3361.4%MedicalALKSAlkermes$120,267,1590.0%4,181,7511.3%MedicalInsmed Incorporated$92,928,7090.0%42,850,0001.0%Note 0.75% 6/1/2028TRDAEntrada Therapeutics$84,130,0110.0%4,865,8190.9%MedicalABCLAbCellera Biologics$80,650,1250.0%27,525,6400.9%MedicalDNLIDenali Therapeutics$76,051,9440.0%3,731,6950.8%MedicalNRIXNurix Therapeutics$73,139,2350.0%3,882,1250.8%MedicalARGXargenx$68,820,9600.0%111,9040.7%MedicalRAREUltragenyx Pharmaceutical$66,307,1160.0%1,576,1140.7%MedicalKiniksa Pharmaceuticals International, plc$55,746,4290.0%2,818,3230.6%ORD SHS CL AIMTXImmatics$51,731,151$5,918,591 ▲12.9%7,275,8300.6%MedicalCRSPCRISPR Therapeutics$51,483,313$18,299,881 ▲55.1%1,308,0110.5%MedicalSTOKStoke Therapeutics$51,111,233$2,927,307 ▲6.1%4,633,8380.5%MedicalIMCRImmunocore$44,701,8810.0%1,515,3180.5%MedicalROIVRoivant Sciences$44,572,755$11,463,944 ▲34.6%3,767,7730.5%MedicalSERASera Prognostics$44,236,0080.0%5,434,3990.5%MedicalIMVTImmunovant$42,304,212$11,950,807 ▲39.4%1,707,8810.5%MedicalXENEXenon Pharmaceuticals$38,952,2170.0%993,6790.4%MedicalCELCCelcuity$35,062,259$10,518,797 ▲42.9%2,678,5530.4%MedicalGLUEMonte Rosa Therapeutics$34,117,6990.0%4,916,0950.4%MedicalAKROAkero Therapeutics$30,520,8210.0%1,097,0820.3%MedicalCERSCerus$29,995,1020.0%19,477,3390.3%MedicalIonis Pharmaceuticals, Inc.$29,543,640$29,543,640 ▲New Holding30,000,0000.3%Note 1.75% 6/15/2028GRAIL, Inc.$29,097,731$29,097,731 ▲New Holding1,630,1250.3%COMIDYAIDEAYA Biosciences$27,296,5610.0%1,062,1230.3%MedicalKRYSKrystal Biotech$26,621,8600.0%169,9340.3%MedicalCADLCandel Therapeutics$25,883,612$25,883,612 ▲New Holding2,981,9830.3%MedicalPraxis Precision Medicines, Inc.$25,514,780$648,619 ▲2.6%331,5330.3%COMIGMSIGM Biosciences$25,016,197$12,183 ▲0.0%4,094,3040.3%MedicalCNTACentessa Pharmaceuticals$20,555,2320.0%1,227,1780.2%MedicalMRUSMerus$18,922,500$6,307,500 ▲50.0%450,0000.2%MedicalDyne Therapeutics, Inc.$15,834,5820.0%672,0960.2%COMNeurogene Inc.$15,417,927$4,993,424 ▲47.9%674,4500.2%COMXNCRXencor$15,406,5040.0%670,4310.2%MedicalBicara Therapeutics Inc.$14,516,6610.0%833,3330.2%COMPRLDPrelude Therapeutics$12,907,8760.0%10,123,8240.1%MedicalIONSIonis Pharmaceuticals$12,512,708$4,700,197 ▲60.2%357,9150.1%MedicalAlumis Inc.$12,281,2500.0%1,562,5000.1%COMNeumora Therapeutics, Inc.$10,966,7600.0%1,034,6000.1%COMDSGNDesign Therapeutics$10,758,7830.0%1,743,7250.1%MedicalGPCRStructure Therapeutics$9,805,643$7,486,883 ▲322.9%361,5650.1%MedicalVERVVerve Therapeutics$9,540,2290.0%1,691,5300.1%MedicalOPTOpthea$8,536,9000.0%2,173,6220.1%MedicalTCRXTScan Therapeutics$8,465,7680.0%2,784,7920.1%MedicalKALAKALA BIO$8,341,144$2,155,279 ▲34.8%1,201,8940.1%MedicalVIRVir Biotechnology$7,960,516$7,960,516 ▲New Holding1,084,5390.1%MedicalMIRMMirum Pharmaceuticals$7,876,1830.0%190,4760.1%MedicalARVNArvinas$7,774,8920.0%405,5760.1%MedicalNTLAIntellia Therapeutics$7,510,393$7,510,393 ▲New Holding644,1160.1%MedicalTSVT2seventy bio$7,342,7260.0%2,497,5260.1%MedicalTSHATaysha Gene Therapies$6,928,2280.0%4,004,7560.1%MedicalCLDXCelldex Therapeutics$6,257,9640.0%247,6440.1%MedicalBMEABiomea Fusion$5,633,721$2,549,001 ▼-31.2%1,451,9900.1%MedicalFATEFate Therapeutics$5,376,363$430,039 ▲8.7%3,258,4020.1%MedicalBNTXBioNTech$5,131,282$5,131,282 ▲New Holding45,0310.1%MedicalIRONDisc Medicine$4,884,970$4,884,970 ▲New Holding77,0500.1%MedicalRLAYRelay Therapeutics$4,779,6820.0%1,160,1170.1%MedicalContineum Therapeutics, Inc.$4,578,1250.0%312,5000.0%CL ADBV Technologies S.A.$4,515,803$4,515,803 ▲New Holding1,461,4250.0%SPONSORED ADSSagimet Biosciences Inc.$4,288,482$1,930,059 ▼-31.0%952,9960.0%COM SER AWVEWave Life Sciences$4,256,0590.0%344,0630.0%MedicalSkye Bioscience, Inc.$4,105,306$45,291 ▲1.1%1,450,6380.0%COMPCVXVaxcyte$4,001,7260.0%48,8850.0%MedicalSANASana Biotechnology$3,880,9470.0%2,380,9490.0%MedicalLPTXLeap Therapeutics$3,370,0030.0%1,172,1750.0%MedicalAligos Therapeutics, Inc.$3,308,9110.0%83,0550.0%COMPRMEPrime Medicine$3,003,1210.0%1,028,4660.0%MedicalTARAProtara Therapeutics$2,834,4730.0%536,8320.0%MedicalELVNEnliven Therapeutics$2,583,7430.0%114,8330.0%MedicalARCTArcturus Therapeutics$2,568,0530.0%151,3290.0%MedicalCMPXCompass Therapeutics$2,258,5640.0%1,557,6300.0%MedicalGBIOGeneration Bio$2,061,6420.0%1,944,9450.0%MedicalHOOKIPA Pharma Inc.$1,633,7560.0%812,8140.0%COMMRSNMersana Therapeutics$1,553,1440.0%1,086,1150.0%MedicalvTv Therapeutics, Inc.$1,343,7800.0%97,3140.0%CL ARCKTRocket Pharmaceuticals$1,220,283$1,220,283 ▲New Holding97,0790.0%MedicalPTCTPTC Therapeutics$920,856$920,856 ▲New Holding20,4000.0%MedicalIPSCCentury Therapeutics$805,4350.0%797,4600.0%MedicalPMVPPMV Pharmaceuticals$486,2560.0%322,0240.0%MedicalACRVAcrivon Therapeutics$318,3680.0%52,8850.0%MedicalFHTXFoghorn Therapeutics$212,5270.0%45,0270.0%MedicalTYRATyra Biosciences$147,4370.0%10,6070.0%MedicalSRZNWSurrozen$17,8330.0%833,3330.0%MedicalTNGXTango Therapeutics$0$5,775,000 ▼-100.0%00.0%MedicalCRNXCrinetics Pharmaceuticals$0$5,310,670 ▼-100.0%00.0%MedicalDBV Technologies S.A.$0$5,114,992 ▼-100.0%00.0%SPONSORED ADRALECAlector$0$4,321,050 ▼-100.0%00.0%MedicalNAMSNewAmsterdam Pharma$0$1,605,403 ▼-100.0%00.0%MedicalShowing largest 100 holdings. 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