Baker Bros. Advisors Lp Top Holdings and 13F Report (2024) About Baker Bros. Advisors LpInvestment ActivityBaker Bros. Advisors Lp has $9.65 billion in total holdings as of September 30, 2024.Baker Bros. Advisors Lp owns shares of 93 different stocks, but just 12 companies or ETFs make up 80% of its holdings.Approximately 2.48% of the portfolio was purchased this quarter.About 1.39% of the portfolio was sold this quarter.This quarter, Baker Bros. Advisors Lp has purchased 95 new stocks and bought additional shares in 16 stocks.Baker Bros. Advisors Lp sold shares of 2 stocks and completely divested from 8 stocks this quarter.Largest Holdings BeiGene $2,372,823,065Incyte $2,031,849,222ACADIA Pharmaceuticals $659,462,348Summit Therapeutics $534,904,544Madrigal Pharmaceuticals $419,047,490 Largest New Holdings this Quarter Bicara Therapeutics Inc. $21,224,992 HoldingArvinas $9,989,337 HoldingIonis Pharmaceuticals $8,952,208 HoldingStructure Therapeutics $3,752,595 HoldingWave Life Sciences $2,821,317 Holding Largest Purchases this Quarter Insmed 839,880 shares (about $61.31M)CRISPR Therapeutics 743,075 shares (about $34.91M)Summit Therapeutics 1,202,643 shares (about $26.34M)Immunovant 760,692 shares (about $21.69M)Bicara Therapeutics Inc. 833,333 shares (about $21.22M) Largest Sales this Quarter HOOKIPA Pharma Inc. 7,315,337 shares (about $31.46M)NewAmsterdam Pharma 116 shares (about $1.93K) Sector Allocation Over TimeMap of 500 Largest Holdings ofBaker Bros. Advisors Lp Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorBGNEBeiGene$2,372,823,0650.0%10,568,89724.6%MedicalINCYIncyte$2,031,849,222$32,786 ▲0.0%30,739,02021.1%MedicalACADACADIA Pharmaceuticals$659,462,3480.0%42,877,9166.8%MedicalSMMTSummit Therapeutics$534,904,544$26,337,882 ▲5.2%24,424,8655.5%MedicalMDGLMadrigal Pharmaceuticals$419,047,4900.0%1,974,5904.3%MedicalRVMDRevolution Medicines$343,258,2320.0%7,569,0903.6%MedicalRYTMRhythm Pharmaceuticals$335,210,395$52 ▲0.0%6,398,3663.5%MedicalINSMInsmed$322,362,014$61,311,240 ▲23.5%4,415,9183.3%MedicalKYMRKymera Therapeutics$283,787,320$47 ▲0.0%5,995,9292.9%MedicalBCYCBicycle Therapeutics$212,721,0950.0%9,399,9602.2%MedicalEWTXEdgewise Therapeutics$155,871,1750.0%5,840,0591.6%MedicalREPLReplimune Group$121,056,883$10,960,000 ▲10.0%11,045,3361.3%MedicalALKSAlkermes$117,047,2100.0%4,181,7511.2%MedicalDNLIDenali Therapeutics$108,704,2750.0%3,731,6951.1%MedicalInsmed Incorporated$98,325,4950.0%42,850,0001.0%Note 0.75% 6/1/2028RAREUltragenyx Pharmaceutical$87,553,133$6,086,447 ▲7.5%1,576,1140.9%MedicalNRIXNurix Therapeutics$87,231,3490.0%3,882,1250.9%MedicalTRDAEntrada Therapeutics$77,755,7880.0%4,865,8190.8%MedicalIMTXImmatics$73,519,1710.0%6,443,3980.8%MedicalABCLAbCellera Biologics$71,566,6640.0%27,525,6400.7%MedicalKiniksa Pharmaceuticals International, plc$70,429,8920.0%2,818,3230.7%ORD SHS CL AIGMSIGM Biosciences$67,686,807$32,981 ▲0.0%4,092,3100.7%MedicalARGXargenx$60,660,9200.0%111,9040.6%MedicalSTOKStoke Therapeutics$53,688,1640.0%4,368,4430.6%MedicalIMCRImmunocore$47,171,8490.0%1,515,3180.5%MedicalKODKodiak Sciences$45,180,3790.0%17,310,4900.5%MedicalSERASera Prognostics$42,388,3120.0%5,434,3990.4%MedicalCRSPCRISPR Therapeutics$39,607,664$34,909,664 ▲743.1%843,0750.4%MedicalXENEXenon Pharmaceuticals$39,121,1420.0%993,6790.4%MedicalIMVTImmunovant$34,936,439$21,687,329 ▲163.7%1,225,4100.4%MedicalCERSCerus$33,890,5700.0%19,477,3390.4%MedicalIDYAIDEAYA Biosciences$33,648,0570.0%1,062,1230.3%MedicalROIVRoivant Sciences$32,297,1830.0%2,798,7160.3%MedicalAKROAkero Therapeutics$31,475,2830.0%1,097,0820.3%MedicalKRYSKrystal Biotech$30,933,0860.0%169,9340.3%MedicalCELCCelcuity$27,955,9220.0%1,874,9780.3%MedicalGLUEMonte Rosa Therapeutics$26,055,3040.0%4,916,0950.3%MedicalDyne Therapeutics, Inc.$24,141,6880.0%672,0960.3%COMBMEABiomea Fusion$21,300,3850.0%2,108,9490.2%MedicalBicara Therapeutics Inc.$21,224,992$21,224,992 ▲New Holding833,3330.2%COMPRLDPrelude Therapeutics$20,956,3160.0%10,123,8240.2%MedicalCNTACentessa Pharmaceuticals$19,622,576$10,840,676 ▲123.4%1,227,1780.2%MedicalNeurogene Inc.$19,134,3890.0%456,0150.2%COMPraxis Precision Medicines, Inc.$18,591,462$11,023,053 ▲145.6%323,1050.2%COMAlumis Inc.$16,687,5000.0%1,562,5000.2%COMMRUSMerus$14,988,0000.0%300,0000.2%MedicalTCRXTScan Therapeutics$13,868,2640.0%2,784,7920.1%MedicalNeumora Therapeutics, Inc.$13,667,0660.0%1,034,6000.1%COMXNCRXencor$13,482,367$2,513,750 ▲22.9%670,4310.1%MedicalTSVT2seventy bio$11,788,3230.0%2,497,5260.1%MedicalFATEFate Therapeutics$10,492,2020.0%2,997,7720.1%MedicalARVNArvinas$9,989,337$9,989,337 ▲New Holding405,5760.1%MedicalSANASana Biotechnology$9,904,7480.0%2,380,9490.1%MedicalDSGNDesign Therapeutics$9,381,241$260,559 ▲2.9%1,743,7250.1%MedicalIONSIonis Pharmaceuticals$8,952,208$8,952,208 ▲New Holding223,4700.1%MedicalOPTOpthea$8,846,6420.0%2,173,6220.1%MedicalCLDXCelldex Therapeutics$8,417,4200.0%247,6440.1%MedicalRLAYRelay Therapeutics$8,213,6280.0%1,160,1170.1%MedicalVERVVerve Therapeutics$8,187,0050.0%1,691,5300.1%MedicalTSHATaysha Gene Therapies$8,049,5600.0%4,004,7560.1%MedicalMIRMMirum Pharmaceuticals$7,428,5640.0%190,4760.1%MedicalContineum Therapeutics, Inc.$5,981,2500.0%312,5000.1%CL ATNGXTango Therapeutics$5,775,0000.0%750,0000.1%MedicalSkye Bioscience, Inc.$5,609,419$3,654,419 ▲186.9%1,434,6340.1%COMPCVXVaxcyte$5,586,0890.0%48,8850.1%MedicalCRNXCrinetics Pharmaceuticals$5,310,6700.0%103,9270.1%MedicalDBV Technologies S.A.$5,114,9920.0%7,307,1310.1%SPONSORED ADRKALAKALA BIO$5,080,6100.0%891,3350.1%MedicalGBIOGeneration Bio$4,804,014$1,822,830 ▲61.1%1,944,9450.0%MedicalALECAlector$4,321,0500.0%927,2640.0%MedicalPRMEPrime Medicine$3,980,1630.0%1,028,4660.0%MedicalSagimet Biosciences Inc.$3,827,8570.0%1,381,8980.0%COM SER AGPCRStructure Therapeutics$3,752,595$3,752,595 ▲New Holding85,5000.0%MedicalARCTArcturus Therapeutics$3,512,3460.0%151,3290.0%MedicalHOOKIPA Pharma Inc.$3,495,100$31,455,947 ▼-90.0%812,8140.0%COMLPTXLeap Therapeutics$3,012,4900.0%1,172,1750.0%MedicalELVNEnliven Therapeutics$2,932,8350.0%114,8330.0%MedicalCMPXCompass Therapeutics$2,866,0390.0%1,557,6300.0%MedicalWVEWave Life Sciences$2,821,317$2,821,317 ▲New Holding344,0630.0%MedicalMRSNMersana Therapeutics$2,052,7570.0%1,086,1150.0%MedicalNAMSNewAmsterdam Pharma$1,605,403$1,926 ▼-0.1%96,7110.0%MedicalIPSCCentury Therapeutics$1,363,6570.0%797,4600.0%MedicalvTv Therapeutics, Inc.$1,320,0640.0%97,3140.0%CL AAVTEAerovate Therapeutics$1,314,4830.0%628,9390.0%MedicalPFEPfizer$1,012,9000.0%35,0000.0%MedicalTARAProtara Therapeutics$982,4030.0%536,8320.0%MedicalAligos Therapeutics, Inc.$719,256$719,256 ▲New Holding83,0550.0%COMBCRXBioCryst Pharmaceuticals$575,9130.0%75,7780.0%MedicalPMVPPMV Pharmaceuticals$479,8160.0%322,0240.0%MedicalFHTXFoghorn Therapeutics$419,2010.0%45,0270.0%MedicalACRVAcrivon Therapeutics$370,1950.0%52,8850.0%MedicalTYRATyra Biosciences$249,3710.0%10,6070.0%MedicalSRZNWSurrozen$8,5830.0%833,3330.0%MedicalInsmed Incorporated$0$56,192,307 ▼-100.0%00.0%Note 1.75% 1/15/2025CERECerevel Therapeutics$0$27,951,913 ▼-100.0%00.0%MedicalATHAAthira Pharma$0$8,357,589 ▼-100.0%00.0%MedicalTLISTalis Biomedical$0$4,402,992 ▼-100.0%00.0%MedicalADAPAdaptimmune Therapeutics$0$2,284,868 ▼-100.0%00.0%MedicalSAGESage Therapeutics$0$1,857,342 ▼-100.0%00.0%MedicalACHLAchilles Therapeutics$0$903,645 ▼-100.0%00.0%MedicalShowing largest 100 holdings. 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