Frazier Life Sciences Management, L.P. Top Holdings and 13F Report (2025) About Frazier Life Sciences Management, L.P.Investment ActivityFrazier Life Sciences Management, L.P. has $2.41 billion in total holdings as of December 31, 2024.Frazier Life Sciences Management, L.P. owns shares of 50 different stocks, but just 17 companies or ETFs make up 80% of its holdings.Approximately 5.96% of the portfolio was purchased this quarter.About 7.73% of the portfolio was sold this quarter.This quarter, Frazier Life Sciences Management, L.P. has purchased 53 new stocks and bought additional shares in 12 stocks.Frazier Life Sciences Management, L.P. sold shares of 9 stocks and completely divested from 6 stocks this quarter.Largest Holdings NewAmsterdam Pharma $409,051,943Mirum Pharmaceuticals $271,685,709Verona Pharma $157,150,638Krystal Biotech $123,520,144Arcutis Biotherapeutics $122,379,006 Largest New Holdings this Quarter Pliant Therapeutics $14,760,976 HoldingPALVELLA THERAPEUTICS INC NE $7,846,704 HoldingEledon Pharmaceuticals $4,848,148 Holding Largest Purchases this Quarter NewAmsterdam Pharma 3,061,224 shares (about $78.67M)Pliant Therapeutics 1,120,803 shares (about $14.76M)Trevi Therapeutics 3,283,684 shares (about $13.53M)KalVista Pharmaceuticals 1,200,000 shares (about $10.16M)PALVELLA THERAPEUTICS INC NE 653,892 shares (about $7.85M) Largest Sales this Quarter Edgewise Therapeutics 1,561,622 shares (about $41.70M)Krystal Biotech 200,000 shares (about $31.33M)Rhythm Pharmaceuticals 547,144 shares (about $30.63M)Vaxcyte 340,000 shares (about $27.83M)AnaptysBio 635,470 shares (about $8.41M) Sector Allocation Over TimeMap of 500 Largest Holdings ofFrazier Life Sciences Management, L.P. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorNAMSNewAmsterdam Pharma$409,051,943$78,673,457 ▲23.8%15,916,41817.0%MedicalMIRMMirum Pharmaceuticals$271,685,7090.0%6,570,39211.3%MedicalVRNAVerona Pharma$157,150,6380.0%3,383,9506.5%MedicalKRYSKrystal Biotech$123,520,144$31,332,000 ▼-20.2%788,4605.1%MedicalARQTArcutis Biotherapeutics$122,379,0060.0%8,785,2845.1%MedicalIRONDisc Medicine$111,256,4760.0%1,754,8344.6%MedicalMBX BIOSCIENCES INC$110,309,9450.0%5,985,3474.6%COMRYTMRhythm Pharmaceuticals$104,671,852$30,629,121 ▼-22.6%1,869,8084.3%MedicalBBIOBridgeBio Pharma$104,284,540$1,097,600 ▲1.1%3,800,4574.3%MedicalTARSTarsus Pharmaceuticals$87,901,3700.0%1,587,5273.6%MedicalPHATPhathom Pharmaceuticals$82,087,3450.0%10,109,2793.4%MedicalERASErasca$48,673,1340.0%19,391,6872.0%MedicalPCVXVaxcyte$44,155,693$27,832,400 ▼-38.7%539,4051.8%MedicalTRVITrevi Therapeutics$43,938,869$13,528,778 ▲44.5%10,664,7741.8%MedicalRVMDRevolution Medicines$43,628,6820.0%997,4551.8%MedicalKALVKalVista Pharmaceuticals$41,400,233$10,164,000 ▲32.5%4,887,8671.7%MedicalAGIOAgios Pharmaceuticals$35,152,116$841,216 ▲2.5%1,069,7541.5%MedicalEWTXEdgewise Therapeutics$33,942,242$41,695,308 ▼-55.1%1,271,2451.4%MedicalSLNOSoleno Therapeutics$31,427,197$7,934,035 ▼-20.2%699,1591.3%MedicalORICORIC Pharmaceuticals$31,378,081$2,054,759 ▼-6.1%3,888,2381.3%MedicalRAREUltragenyx Pharmaceutical$27,712,140$1,051,750 ▲3.9%658,7151.2%MedicalSVRASavara$26,587,364$1,544,192 ▲6.2%8,660,3791.1%MedicalCG ONCOLOGY INC$22,083,6000.0%770,0000.9%COMHLVXHilleVax$21,977,3180.0%10,617,0620.9%MedicalANABAnaptysBio$20,836,040$8,413,623 ▼-28.8%1,573,7190.9%MedicalRCKTRocket Pharmaceuticals$18,591,344$83,025 ▼-0.4%1,479,0250.8%MedicalASNDAscendis Pharma A/S$18,355,9540.0%133,3330.8%MedicalMREOMereo BioPharma Group$17,842,2270.0%5,097,7790.7%MedicalALKSAlkermes$17,288,470$719,000 ▲4.3%601,1290.7%MedicalMRUSMerus$15,688,8550.0%373,1000.7%MedicalIMTXImmatics$15,271,647$5,639,652 ▲58.6%2,147,9110.6%MedicalPLRXPliant Therapeutics$14,760,976$14,760,976 ▲New Holding1,120,8030.6%MedicalDSGNDesign Therapeutics$12,053,385$376,370 ▲3.2%1,953,5470.5%MedicalORUKA THERAPEUTICS INC$11,310,711$2,055,340 ▲22.2%583,3270.5%COMAUTLAutolus Therapeutics$10,864,8110.0%4,623,3240.5%MedicalMGNXMacroGenics$10,320,911$536,048 ▲5.5%3,175,6650.4%MedicalDAWNDay One Biopharmaceuticals$8,737,9290.0%689,6550.4%MedicalACADACADIA Pharmaceuticals$8,630,7020.0%470,3380.4%MedicalSLNSilence Therapeutics$7,902,3060.0%1,148,5910.3%MedicalPALVELLA THERAPEUTICS INC NE$7,846,704$7,846,704 ▲New Holding653,8920.3%COMETNB89bio$7,820,0000.0%1,000,0000.3%MedicalCOGTCogent Biosciences$7,305,2930.0%936,5760.3%MedicalNAMSWNewAmsterdam Pharma$7,129,7450.0%500,3330.3%MedicalLEXEO THERAPEUTICS INC$6,287,289$1,942,883 ▼-23.6%955,5150.3%COMALLOAllogene Therapeutics$6,108,3080.0%2,867,7500.3%MedicalARVNArvinas$5,469,7950.0%285,3310.2%MedicalADVERUM BIOTECHNOLOGIES INC$4,993,3690.0%1,069,2440.2%COM NEWELDNEledon Pharmaceuticals$4,848,148$4,848,148 ▲New Holding1,176,7350.2%MedicalELEVElevation Oncology$3,371,9880.0%5,993,5790.1%MedicalIMCRImmunocore$3,208,4790.0%108,7620.1%MedicalTYRATyra Biosciences$0$17,186,280 ▼-100.0%00.0%MedicalPBYIPuma Biotechnology$0$7,809,523 ▼-100.0%00.0%MedicalPEPGPepGen$0$6,008,034 ▼-100.0%00.0%MedicalNUVBNuvation Bio$0$2,789,760 ▼-100.0%00.0%MedicalACRSAclaris Therapeutics$0$304,034 ▼-100.0%00.0%MedicalPIERIS PHARMACEUTICALS INC$0$266,869 ▼-100.0%00.0%COM NEWShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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