Frazier Life Sciences Management, L.P. Top Holdings and 13F Report (2024)

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About Frazier Life Sciences Management, L.P.

Investment Activity

Frazier Life Sciences Management, L.P. has $2.37 billion in total holdings as of March 31, 2024.
Frazier Life Sciences Management, L.P. owns shares of 50 different stocks, but just 21 companies or ETFs make up 80% of its holdings.
Approximately 9.70% of the portfolio was purchased this quarter.
About 4.50% of the portfolio was sold this quarter.
This quarter, Frazier Life Sciences Management, L.P. has purchased 49 new stocks and bought additional shares in 13 stocks.
Frazier Life Sciences Management, L.P. sold shares of 6 stocks and completely divested from 6 stocks this quarter.

Largest Holdings

NewAmsterdam Pharma: $289,167,202
Krystal Biotech: $175,876,688
Mirum Pharmaceuticals: $163,164,247
HilleVax: $162,665,879
Alpine Immune Sciences: $124,113,157

Largest New Holdings this Quarter

CG ONCOLOGY INC: $33,803,000 Holding
PepGen: $22,090,984 Holding
Adverum Biotechnologies: $15,119,110 Holding
Puma Biotechnology: $14,926,358 Holding
Applied Therapeutics: $13,279,428 Holding

Largest Purchases this Quarter

CG ONCOLOGY INC: 770,000 shares (about $33.80M)
ORIC Pharmaceuticals: 2,000,000 shares (about $27.50M)
PepGen: 1,502,788 shares (about $22.09M)
BridgeBio Pharma: 689,655 shares (about $21.32M)
Soleno Therapeutics: 410,730 shares (about $17.58M)

Largest Sales this Quarter

89bio: 1,000,000 shares (about $11.64M)
Rhythm Pharmaceuticals: 181,125 shares (about $7.85M)
Cogent Biosciences: 1,058,691 shares (about $7.11M)
ACADIA Pharmaceuticals: 260,579 shares (about $4.82M)
Tyra Biosciences: 194,200 shares (about $3.18M)

Sector Allocation Over Time

Selling

Neutral

Buying

Latest 13F Holdings and Changes Since Previous Quarterly Filing

Issuer Name	Holdings Value	Approximate Purchase/Sale	Change in Shares	Shares Held	% of Portfolio	Sector
NAMS NewAmsterdam Pharma	$289,167,202	$2,252,379 ▲	0.8%	12,226,943	12.2%	Medical
KRYS Krystal Biotech	$175,876,688		0.0%	988,460	7.4%	Medical
MIRM Mirum Pharmaceuticals	$163,164,247		0.0%	6,495,392	6.9%	Medical
HLVX HilleVax	$162,665,879		0.0%	9,781,472	6.9%	Medical
ALPN Alpine Immune Sciences	$124,113,157		0.0%	3,131,008	5.2%	Medical
PHAT Phathom Pharmaceuticals	$107,360,543		0.0%	10,109,279	4.5%	Medical
BBIO BridgeBio Pharma	$105,610,476	$21,324,133 ▲	25.3%	3,415,604	4.5%	Medical
RYTM Rhythm Pharmaceuticals	$94,900,456	$7,848,146 ▼	-7.6%	2,190,179	4.0%	Medical
ARQT Arcutis Biotherapeutics	$87,062,164	$208,625 ▲	0.2%	8,785,284	3.7%	Medical
PCVX Vaxcyte	$77,832,756	$1,707,750 ▼	-2.1%	1,139,405	3.3%	Medical
TARS Tarsus Pharmaceuticals	$64,976,606		0.0%	1,787,527	2.7%	Medical
EWTX Edgewise Therapeutics	$60,257,062	$11,607,279 ▲	23.9%	3,303,567	2.5%	Medical
ORIC ORIC Pharmaceuticals	$56,964,256	$27,500,000 ▲	93.3%	4,142,855	2.4%	Medical
APLS Apellis Pharmaceuticals	$52,029,999		0.0%	885,165	2.2%	Medical
IRON Disc Medicine	$48,874,100		0.0%	785,000	2.1%	Medical
VRNA Verona Pharma	$48,500,875		0.0%	3,014,349	2.0%	Medical
KALV KalVista Pharmaceuticals	$43,738,103	$777,696 ▲	1.8%	3,687,867	1.8%	Medical
RCKT Rocket Pharmaceuticals	$42,059,536	$1,029,566 ▲	2.5%	1,561,230	1.8%	Medical
SLNO Soleno Therapeutics	$37,478,548	$17,579,244 ▲	88.3%	875,667	1.6%	Medical
MGNX MacroGenics	$36,383,483	$1,030,400 ▲	2.9%	2,471,704	1.5%	Medical
AVTE Aerovate Therapeutics	$35,627,917		0.0%	1,204,867	1.5%	Medical
CG ONCOLOGY INC	$33,803,000	$33,803,000 ▲	New Holding	770,000	1.4%	COM
MRUS Merus	$33,613,949		0.0%	746,479	1.4%	Medical
RVMD Revolution Medicines	$32,147,975		0.0%	997,455	1.4%	Medical
AUTL Autolus Therapeutics	$29,496,807	$5,591,859 ▲	23.4%	4,623,324	1.2%	Medical
GPCR Structure Therapeutics	$26,967,255	$13,372,492 ▲	98.4%	629,194	1.1%	Medical
TRVI Trevi Therapeutics	$25,464,761		0.0%	7,381,090	1.1%	Medical
SLN Silence Therapeutics	$24,809,566	$5,776,229 ▲	30.3%	1,148,591	1.0%	Medical
DCPH Deciphera Pharmaceuticals	$22,900,316	$6,827,402 ▲	42.5%	1,455,837	1.0%	Medical
PEPG PepGen	$22,090,984	$22,090,984 ▲	New Holding	1,502,788	0.9%	Medical
ANAB AnaptysBio	$20,261,244		0.0%	899,700	0.9%	Medical
SVRA Savara	$19,920,000		0.0%	4,000,000	0.8%	Medical
CERE Cerevel Therapeutics	$16,612,110		0.0%	393,000	0.7%	Medical
AGIO Agios Pharmaceuticals	$15,297,374		0.0%	523,166	0.6%	Medical
ADVM Adverum Biotechnologies	$15,119,110	$15,119,110 ▲	New Holding	1,069,244	0.6%	Medical
PBYI Puma Biotechnology	$14,926,358	$14,926,358 ▲	New Holding	2,816,294	0.6%	Medical
TYRA Tyra Biosciences	$13,648,408	$3,184,880 ▼	-18.9%	832,220	0.6%	Medical
APLT Applied Therapeutics	$13,279,428	$13,279,428 ▲	New Holding	1,952,857	0.6%	Medical
ALLO Allogene Therapeutics	$12,818,843	$12,818,843 ▲	New Holding	2,867,750	0.5%	Medical
ARVN Arvinas	$11,778,464		0.0%	285,331	0.5%	Medical
ETNB 89bio	$11,640,000	$11,640,000 ▼	-50.0%	1,000,000	0.5%	Medical
ACAD ACADIA Pharmaceuticals	$8,696,550	$4,818,106 ▼	-35.7%	470,338	0.4%	Medical
COGT Cogent Biosciences	$6,293,791	$7,114,404 ▼	-53.1%	936,576	0.3%	Medical
NTLA Intellia Therapeutics	$5,603,347		0.0%	203,684	0.2%	Medical
NAMSW NewAmsterdam Pharma	$5,523,676		0.0%	500,333	0.2%	Medical
ANTX (ANTX)	$4,513,889		0.0%	1,388,889	0.2%	Medical
METAGENOMI INC	$2,943,714	$2,943,714 ▲	New Holding	279,025	0.1%	COM
GRTS Gritstone bio	$2,649,356		0.0%	1,030,878	0.1%	Medical
BLUE bluebird bio	$2,188,681		0.0%	1,709,907	0.1%	Medical
ACRS Aclaris Therapeutics	$327,827		0.0%	264,377	0.0%	Medical
MDGL Madrigal Pharmaceuticals	$0	$16,059,160 ▼	-100.0%	0	0.0%	Medical
DYNE THERAPEUTICS INC	$0	$15,758,372 ▼	-100.0%	0	0.0%	COM
CRNX Crinetics Pharmaceuticals	$0	$14,142,445 ▼	-100.0%	0	0.0%	Medical
APOGEE THERAPEUTICS INC	$0	$11,176,000 ▼	-100.0%	0	0.0%	COM
THRX Theseus Pharmaceuticals	$0	$8,578,107 ▼	-100.0%	0	0.0%	Medical
MRTX Mirati Therapeutics	$0	$4,700,000 ▼	-100.0%	0	0.0%	Medical

Showing largest 100 holdings. View all holdings.

More Institutional Buying and Selling Information

SEC Filings and Trading Data:

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Frazier Life Sciences Management, L.P. Top Holdings and 13F Report (2024)

About Frazier Life Sciences Management, L.P.

Investment Activity

Largest Holdings

Largest New Holdings this Quarter

Largest Purchases this Quarter

Largest Sales this Quarter

Sector Allocation Over Time

Latest 13F Holdings and Changes Since Previous Quarterly Filing

More Institutional Buying and Selling Information

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Frazier Life Sciences Management, L.P. Top Holdings and 13F Report (2024)

About Frazier Life Sciences Management, L.P.

Investment Activity

Largest Holdings

Largest New Holdings this Quarter

Largest Purchases this Quarter

Largest Sales this Quarter

Sector Allocation Over Time

Map of 500 Largest Holdings ofFrazier Life Sciences Management, L.P.

Latest 13F Holdings and Changes Since Previous Quarterly Filing

More Institutional Buying and Selling Information