Great Point Partners LLC Top Holdings and 13F Report (2025) About Great Point Partners LLCInvestment ActivityGreat Point Partners LLC has $212.20 million in total holdings as of December 31, 2024.Great Point Partners LLC owns shares of 26 different stocks, but just 16 companies or ETFs make up 80% of its holdings.Approximately 19.52% of the portfolio was purchased this quarter.About 52.46% of the portfolio was sold this quarter.This quarter, Great Point Partners LLC has purchased 29 new stocks and bought additional shares in 5 stocks.Great Point Partners LLC sold shares of 12 stocks and completely divested from 8 stocks this quarter.Largest Holdings Ionis Pharmaceuticals $17,655,045Cytokinetics $16,934,400KalVista Pharmaceuticals $15,135,915Viridian Therapeutics $14,377,500Pliant Therapeutics $13,894,350 Largest New Holdings this Quarter Xenon Pharmaceuticals $9,614,662 HoldingUPSTREAM BIO INC $4,932,000 HoldingMereo BioPharma Group $4,025,000 HoldingRezolute $3,047,281 HoldingOPTINOSE INC $2,473,397 Holding Largest Purchases this Quarter Xenon Pharmaceuticals 245,272 shares (about $9.61M)Ionis Pharmaceuticals 250,007 shares (about $8.74M)UPSTREAM BIO INC 300,000 shares (about $4.93M)KalVista Pharmaceuticals 487,500 shares (about $4.13M)Mereo BioPharma Group 1,150,000 shares (about $4.03M) Largest Sales this Quarter NEUROGENE INC 561,530 shares (about $12.84M)Pliant Therapeutics 855,121 shares (about $11.26M)UroGen Pharma 570,943 shares (about $6.08M)Dynavax Technologies 466,234 shares (about $5.95M)ORUKA THERAPEUTICS INC 285,856 shares (about $5.54M) Sector Allocation Over TimeMap of 500 Largest Holdings ofGreat Point Partners LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorIONSIonis Pharmaceuticals$17,655,045$8,740,245 ▲98.0%505,0078.3%MedicalCYTKCytokinetics$16,934,400$2,069,760 ▲13.9%360,0008.0%MedicalKALVKalVista Pharmaceuticals$15,135,915$4,129,125 ▲37.5%1,787,0037.1%MedicalVRDNViridian Therapeutics$14,377,5000.0%750,0006.8%MedicalPLRXPliant Therapeutics$13,894,350$11,261,944 ▼-44.8%1,055,0006.5%MedicalABIVAX SA$12,067,188$3,515,430 ▼-22.6%1,648,5235.7%SPONSORED ADSDVAXDynavax Technologies$10,982,200$5,953,808 ▼-35.2%860,0005.2%MedicalNEUROGENE INC$10,121,516$12,836,575 ▼-55.9%442,7614.8%COMEOLSEvolus$9,886,585$3,030,215 ▼-23.5%895,5244.7%MedicalXENEXenon Pharmaceuticals$9,614,662$9,614,662 ▲New Holding245,2724.5%MedicalUNCYUnicycive Therapeutics$8,720,316$1,922,758 ▲28.3%10,980,0004.1%MedicalZURAZura Bio$7,925,485$233,695 ▼-2.9%3,170,1943.7%MedicalAUTLAutolus Therapeutics$7,072,071$463,977 ▲7.0%3,009,3923.3%MedicalJASPER THERAPEUTICS INC$6,892,4840.0%322,3803.2%COM NEWMRUSMerus$6,647,769$3,864,732 ▼-36.8%158,0923.1%MedicalDIANTHUS THERAPEUTICS INC$5,995,0000.0%275,0002.8%COMHELIX ACQUISITION CORP II$5,250,0000.0%500,0002.5%CL A ORD SHSUPSTREAM BIO INC$4,932,000$4,932,000 ▲New Holding300,0002.3%COMCNTXContext Therapeutics$4,917,897$2,363,835 ▼-32.5%4,683,7112.3%MedicalVYGRVoyager Therapeutics$4,687,678$755,255 ▼-13.9%826,7512.2%MedicalORUKA THERAPEUTICS INC$4,436,490$5,542,748 ▼-55.5%228,8032.1%COMMREOMereo BioPharma Group$4,025,000$4,025,000 ▲New Holding1,150,0001.9%MedicalRZLTRezolute$3,047,281$3,047,281 ▲New Holding621,8941.4%MedicalPMNProMIS Neurosciences$2,507,052$137,971 ▼-5.2%2,645,1281.2%MedicalOPTINOSE INC$2,473,397$2,473,397 ▲New Holding370,2691.2%COM NEWURGNUroGen Pharma$2,000,528$6,080,543 ▼-75.2%187,8430.9%MedicalACLXArcellx$0$16,702,000 ▼-100.0%00.0%MedicalOLMAOlema Pharmaceuticals$0$11,940,000 ▼-100.0%00.0%MedicalOPTNOptiNose$0$8,616,961 ▼-100.0%00.0%MedicalOUTLOOK THERAPEUTICS INC$0$6,904,770 ▼-100.0%00.0%COMTCRXTScan Therapeutics$0$5,061,548 ▼-100.0%00.0%MedicalCARTESIAN THERAPEUTICS INC$0$3,224,000 ▼-100.0%00.0%COM NEWVTGNVistagen Therapeutics$0$2,028,966 ▼-100.0%00.0%MedicalELYMEliem Therapeutics$0$1,263,175 ▼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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