Ikarian Capital, LLC Top Holdings and 13F Report (2024) About Ikarian Capital, LLCInvestment ActivityIkarian Capital, LLC has $717.15 million in total holdings as of September 30, 2024.Ikarian Capital, LLC owns shares of 121 different stocks, but just 33 companies or ETFs make up 80% of its holdings.Approximately 67.55% of the portfolio was purchased this quarter.About 24.62% of the portfolio was sold this quarter.This quarter, Ikarian Capital, LLC has purchased 95 new stocks and bought additional shares in 17 stocks.Ikarian Capital, LLC sold shares of 28 stocks and completely divested from 14 stocks this quarter.Largest Holdings Vertex Pharmaceuticals $93,016,000Amgen $51,328,054SPDR S&P Biotech ETF $49,400,000Tarsus Pharmaceuticals $33,885,812AnaptysBio $25,269,050 Largest New Holdings this Quarter Vertex Pharmaceuticals $93,016,000 HoldingSPDR S&P Biotech ETF $49,400,000 HoldingAnaptysBio $25,269,050 HoldingCelldex Therapeutics $20,767,890 HoldingJanux Therapeutics $16,591,036 Holding Largest Purchases this Quarter Vertex Pharmaceuticals 200,000 shares (about $93.02M)SPDR S&P Biotech ETF 500,000 shares (about $49.40M)Amgen 120,400 shares (about $38.79M)AnaptysBio 754,300 shares (about $25.27M)Celldex Therapeutics 611,000 shares (about $20.77M) Largest Sales this Quarter Sarepta Therapeutics 150,436 shares (about $18.79M)Nuvalent 99,363 shares (about $10.16M)Crinetics Pharmaceuticals 161,905 shares (about $8.27M)Soleno Therapeutics 114,014 shares (about $5.76M)Nurix Therapeutics 180,500 shares (about $4.06M) Sector Allocation Over TimeMap of 500 Largest Holdings ofIkarian Capital, LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorVRTXVertex Pharmaceuticals$93,016,000$93,016,000 ▲New Holding200,00013.0%MedicalAMGNAmgen$51,328,054$38,794,085 ▲309.5%159,3007.2%MedicalXBISPDR S&P Biotech ETF$49,400,000$49,400,000 ▲New Holding500,0006.9%ETFTARSTarsus Pharmaceuticals$33,885,812$7,564,700 ▲28.7%1,030,2774.7%MedicalANABAnaptysBio$25,269,050$25,269,050 ▲New Holding754,3003.5%MedicalCRNXCrinetics Pharmaceuticals$21,815,255$8,273,346 ▼-27.5%426,9133.0%MedicalCLDXCelldex Therapeutics$20,767,890$20,767,890 ▲New Holding611,0002.9%MedicalSLNOSoleno Therapeutics$16,734,255$5,756,567 ▼-25.6%331,4372.3%MedicalJANXJanux Therapeutics$16,591,036$16,591,036 ▲New Holding365,2002.3%MedicalBHVNBiohaven$16,270,232$16,270,232 ▲New Holding325,6002.3%MedicalVRDNViridian Therapeutics$15,924,478$15,838,278 ▲18,373.9%699,9772.2%MedicalIMVTImmunovant$14,255,000$6,331,358 ▲79.9%500,0002.0%MedicalCAPRCapricor Therapeutics$13,689,000$13,689,000 ▲New Holding900,0001.9%MedicalRCUSArcus Biosciences$13,114,233$10,897,183 ▲491.5%857,7001.8%MedicalCRBPCorbus Pharmaceuticals$12,906,437$6,520,627 ▲102.1%625,6151.8%MedicalELVNEnliven Therapeutics$12,758,915$2,221,622 ▼-14.8%499,5661.8%MedicalCYTKCytokinetics$11,745,201$2,761,440 ▲30.7%222,4471.6%MedicalINSMInsmed$11,302,955$7,389,133 ▲188.8%154,8351.6%MedicalNEUMORA THERAPEUTICS INC.$10,568,000$10,568,000 ▲New Holding800,0001.5%COMAPLSApellis Pharmaceuticals$10,094,000$10,094,000 ▲New Holding350,0001.4%MedicalALTO NEUROSCIENCE INC$10,078,640$10,078,640 ▲New Holding881,0001.4%COM SHSRAREUltragenyx Pharmaceutical$9,943,450$9,943,450 ▲New Holding179,0001.4%MedicalAVALO THERAPEUTICS INC$9,218,411$8,698,476 ▲1,673.0%970,3591.3%COM NEWSPYRE THERAPEUTICS INC$8,889,085$8,889,085 ▲New Holding302,2471.2%COM NEWBGNEBeiGene$8,331,743$8,331,743 ▲New Holding117,9671.2%MedicalCPRXCatalyst Pharmaceuticals$8,306,858$1,998,656 ▼-19.4%417,8501.2%MedicalTECTONIC THERAPEUTIC INC$8,094,495$6,190,564 ▲325.1%267,1451.1%COMBPMCBlueprint Medicines$7,862,501$7,862,501 ▲New Holding85,0001.1%MedicalBBIOBridgeBio Pharma$7,271,706$1,334,104 ▼-15.5%285,6131.0%MedicalBDTXBlack Diamond Therapeutics$7,177,500$7,177,500 ▲New Holding1,650,0001.0%MedicalSRPTSarepta Therapeutics$6,766,041$18,787,953 ▼-73.5%54,1760.9%MedicalNRIXNurix Therapeutics$5,842,200$4,055,835 ▼-41.0%260,0000.8%MedicalAKROAkero Therapeutics$5,706,441$5,706,441 ▲New Holding198,9000.8%MedicalSANASana Biotechnology$5,408,000$5,374,720 ▲16,150.0%1,300,0000.8%MedicalNUVLNuvalent$5,343,947$10,164,834 ▼-65.5%52,2380.7%MedicalGPCRStructure Therapeutics$5,056,129$5,030,673 ▲19,762.1%115,2000.7%MedicalMDGLMadrigal Pharmaceuticals$4,987,170$4,987,170 ▲New Holding23,5000.7%MedicalRLAYRelay Therapeutics$4,908,918$4,908,918 ▲New Holding693,3500.7%MedicalLENZ THERAPEUTICS INC$4,855,1390.0%204,5130.7%COMPYXSPyxis Oncology$4,829,750$1,284,449 ▼-21.0%1,316,0080.7%MedicalDYNE THERAPEUTICS INC$4,777,360$4,777,360 ▲New Holding133,0000.7%COMWVEWave Life Sciences$4,462,973$252,749 ▼-5.4%544,2650.6%MedicalRZLTRezolute$4,303,066$80,093 ▼-1.8%887,2300.6%MedicalXENEXenon Pharmaceuticals$4,219,9530.0%107,1870.6%MedicalEOLSEvolus$4,184,120$4,184,120 ▲New Holding258,2790.6%MedicalABEOAbeona Therapeutics$3,688,308$1,170,281 ▼-24.1%583,5930.5%MedicalRCKTRocket Pharmaceuticals$3,640,3630.0%197,0960.5%MedicalSLNSilence Therapeutics$3,374,286$463,495 ▲15.9%587,3430.5%MedicalSLRNAcelyrin$3,337,975$3,934,140 ▼-54.1%677,0740.5%MedicalCYBIN INC$3,264,364$3,264,364 ▲New Holding367,1950.5%COM NEWSRRKScholar Rock$3,237,642$1,766,197 ▲120.0%404,2000.5%MedicalCERVOMED INC$2,954,237$511,000 ▼-14.7%202,3450.4%COMTOURMALINE BIO INC$2,789,0990.0%108,4830.4%COMGALTGalectin Therapeutics$2,750,000$2,750,000 ▲New Holding1,000,0000.4%MedicalTERNTerns Pharmaceuticals$2,572,865$1,251,000 ▼-32.7%308,4970.4%MedicalALNYAlnylam Pharmaceuticals$2,404,038$1,578,948 ▲191.4%8,7410.3%MedicalLEXEO THERAPEUTICS INC$2,325,233$2,325,233 ▲New Holding257,2160.3%COMMLYSMineralys Therapeutics$2,179,800$2,179,800 ▲New Holding180,0000.3%MedicalSLDBSolid Biosciences$2,091,000$2,091,000 ▲New Holding300,0000.3%MedicalFULCFulcrum Therapeutics$1,858,542$1,858,542 ▲New Holding520,6000.3%MedicalRPHMReneo Pharmaceuticals$1,743,635$1,743,635 ▲New Holding1,025,6680.2%MedicalNKTRNektar Therapeutics$1,706,1260.0%1,312,4050.2%MedicalGLUEMonte Rosa Therapeutics$1,651,443$1,651,443 ▲New Holding311,5930.2%MedicalACHLAchilles Therapeutics$1,472,0450.0%1,443,1810.2%MedicalSWTXSpringWorks Therapeutics$1,403,352$1,403,352 ▲New Holding43,8000.2%MedicalIBIO INC$1,332,0000.0%600,0000.2%CON NEWCMPSCOMPASS Pathways$1,278,320$630,000 ▼-33.0%202,9080.2%MedicalKODKodiak Sciences$1,243,8900.0%476,5860.2%MedicalMRNSMarinus Pharmaceuticals$1,242,8310.0%706,1540.2%MedicalROIVRoivant Sciences$1,161,0280.0%100,6090.2%MedicalCRVSCorvus Pharmaceuticals$1,152,624$1,152,624 ▲New Holding218,3000.2%MedicalOLMAOlema Pharmaceuticals$1,098,479$1,098,479 ▲New Holding92,0000.2%MedicalIFRXInflaRx$1,078,6300.0%704,9870.2%MedicalSAGIMET BIOSCIENCES INC$1,073,555$69,250 ▼-6.1%387,5650.1%COM SER AJASPER THERAPEUTICS INC$1,037,842$940,500 ▼-47.5%55,1750.1%COM NEWPERSPECTIVE THERAPEUTICS INC$1,029,285$1,029,285 ▲New Holding77,1000.1%COM NEWBIOMX INC$910,860$910,860 ▲New Holding893,0000.1%COM NEWDCTHDelcath Systems$906,3400.0%100,3700.1%MedicalELYMEliem Therapeutics$891,258$382,259 ▲75.1%175,1000.1%MedicalAMLXAmylyx Pharmaceuticals$889,5460.0%274,5510.1%MedicalPRQRProQR Therapeutics$880,1210.0%483,5830.1%MedicalCARTESIAN THERAPEUTICS INC$841,352$3,065,656 ▼-78.5%52,1930.1%COM NEWKZRKezar Life Sciences$826,544$154,640 ▲23.0%1,068,9920.1%MedicalVERVVerve Therapeutics$822,800$822,800 ▲New Holding170,0000.1%MedicalIMUXImmunic$814,2680.0%493,4960.1%MedicalITOSiTeos Therapeutics$802,2410.0%78,5740.1%MedicalAVTEAerovate Therapeutics$769,046$2,090 ▼-0.3%367,9650.1%MedicalVERUVeru$727,7670.0%946,3820.1%MedicalLYELLyell Immunopharma$725,9710.0%526,0660.1%MedicalMISTMilestone Pharmaceuticals$708,3490.0%466,0190.1%MedicalABOSAcumen Pharmaceuticals$660,7590.0%266,4350.1%MedicalINHIBRX BIOSCIENCES INC$659,646$2,942,153 ▼-81.7%42,1230.1%COMALLKAllakos$635,3520.0%972,6750.1%MedicalIMTXImmatics$563,8250.0%49,4150.1%MedicalBMEABiomea Fusion$535,300$535,300 ▲New Holding53,0000.1%MedicalNYXHNyxoah$484,1750.0%50,6990.1%MedicalNAMSNewAmsterdam Pharma$483,060$483,060 ▲New Holding29,1000.1%MedicalVTYXVentyx Biosciences$419,970$544,999 ▼-56.5%192,6470.1%MedicalELEVElevation Oncology$413,9840.0%690,0890.1%MedicalPRTAProthena$394,828$394,828 ▲New Holding23,6000.1%MedicalShowing largest 100 holdings. 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