Opaleye Management Inc. Top Holdings and 13F Report (2025) About Opaleye Management Inc.Investment ActivityOpaleye Management Inc. has $571.42 million in total holdings as of December 31, 2024.Opaleye Management Inc. owns shares of 39 different stocks, but just 12 companies or ETFs make up 80% of its holdings.Approximately 7.01% of the portfolio was purchased this quarter.About 11.15% of the portfolio was sold this quarter.This quarter, Opaleye Management Inc. has purchased 44 new stocks and bought additional shares in 13 stocks.Opaleye Management Inc. sold shares of 12 stocks and completely divested from 11 stocks this quarter.Largest Holdings Harrow $133,864,500TG Therapeutics $68,026,000Codexis $42,166,800Eton Pharmaceuticals $37,989,572Ocular Therapeutix $37,084,950 Largest New Holdings this Quarter ESSA Pharma $3,955,896 HoldingImmatics $1,173,150 HoldingLEXEO THERAPEUTICS INC $855,400 HoldingREGENXBIO $618,400 HoldingVentyx Biosciences $613,200 Holding Largest Purchases this Quarter Immunome 802,500 shares (about $8.52M)Arvinas 370,000 shares (about $7.66M)ESSA Pharma 2,209,998 shares (about $3.96M)GINKGO BIOWORKS HOLDINGS 379,798 shares (about $3.73M)CARGO THERAPEUTICS INC 208,563 shares (about $3.01M) Largest Sales this Quarter Ocular Therapeutix 682,500 shares (about $5.83M)UroGen Pharma 184,100 shares (about $1.96M)Edgewise Therapeutics 42,500 shares (about $1.13M)Trevi Therapeutics 250,490 shares (about $1.03M)Vaxcyte 10,000 shares (about $818.60K) Sector Allocation Over TimeMap of 500 Largest Holdings ofOpaleye Management Inc. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorHROWHarrow$133,864,5000.0%3,990,00023.4%MedicalTGTXTG Therapeutics$68,026,000$602,000 ▼-0.9%2,260,00011.9%MedicalCDXSCodexis$42,166,800$333,900 ▲0.8%8,840,0007.4%MedicalETONEton Pharmaceuticals$37,989,572$959,972 ▲2.6%2,852,0706.6%MedicalOCULOcular Therapeutix$37,084,950$5,828,550 ▼-13.6%4,342,5006.5%MedicalARVNArvinas$33,643,350$7,660,332 ▲29.5%1,625,0005.9%MedicalRYTMRhythm Pharmaceuticals$27,990,0000.0%500,0004.9%MedicalIMNMImmunome$21,664,800$8,522,550 ▲64.8%2,040,0003.8%MedicalLQDALiquidia$19,970,1500.0%1,698,1423.5%MedicalEWTXEdgewise Therapeutics$12,816,000$1,134,750 ▼-8.1%480,0002.2%MedicalGINKGO BIOWORKS HOLDINGS$11,784,000$3,729,616 ▲46.3%1,200,0002.1%Class A NewCARGO THERAPEUTICS INC$10,815,000$3,007,478 ▲38.5%750,0001.9%COMTARAProtara Therapeutics$9,636,000$759,507 ▲8.6%1,825,0001.7%MedicalTRVITrevi Therapeutics$9,548,100$1,032,019 ▼-9.8%2,317,5001.7%MedicalJASPER THERAPEUTICS INC$8,552,000$994,170 ▲13.2%400,0001.5%COM NEWNAMSNewAmsterdam Pharma$8,352,500$257,000 ▼-3.0%325,0001.5%MedicalSLRNAcelyrin$7,174,900$1,095,785 ▲18.0%2,235,0001.3%MedicalNRIXNurix Therapeutics$7,130,940$781,860 ▼-9.9%378,5001.2%MedicalXOMAXOMA$6,570,0000.0%250,0001.1%MedicalPCVXVaxcyte$6,139,500$818,600 ▼-11.8%75,0001.1%MedicalGOSSAMER BIO INC$6,090,400$1,853,600 ▲43.8%11,500,0001.1%NOTE 5.000% 6/0ZNTLZentalis Pharmaceuticals$5,355,525$2,425,515 ▲82.8%1,767,5000.9%MedicalBDSXBiodesix$5,301,450$535,500 ▼-9.2%3,465,0000.9%MedicalKARYOPHARM THERAPEUTICS INC$4,669,5600.0%6,000,0000.8%NOTE 3.000%10/1NUVLNuvalent$4,579,380$430,540 ▼-8.6%58,5000.8%MedicalGOSSGossamer Bio$4,061,654$746,286 ▲22.5%4,490,0000.7%MedicalPTGXProtagonist Therapeutics$4,053,0000.0%105,0000.7%MedicalEPIXESSA Pharma$3,955,896$3,955,896 ▲New Holding2,209,9980.7%MedicalABCLAbCellera Biologics$2,827,450$483,450 ▲20.6%965,0000.5%MedicalURGNUroGen Pharma$2,343,000$1,960,665 ▼-45.6%220,0000.4%MedicalRZLTRezolute$2,278,500$7,659 ▼-0.3%465,0000.4%MedicalIMTXImmatics$1,173,150$1,173,150 ▲New Holding165,0000.2%MedicalIBIO INC$918,7500.0%375,0000.2%COM NEWLEXEO THERAPEUTICS INC$855,400$855,400 ▲New Holding130,0000.1%COMRGNXREGENXBIO$618,400$618,400 ▲New Holding80,0000.1%MedicalVTYXVentyx Biosciences$613,200$613,200 ▲New Holding280,0000.1%MedicalPEPGPepGen$416,900$262,268 ▼-38.6%110,0000.1%MedicalSTOKStoke Therapeutics$275,750$275,750 ▲New Holding25,0000.0%MedicalADAGIO MED HLDGS INC$116,1000.0%110,5710.0%COMKROSKeros Therapeutics$0$22,953,677 ▼-100.0%00.0%MedicalAPLTApplied Therapeutics$0$11,220,000 ▼-100.0%00.0%MedicalCYTKCytokinetics$0$3,975,840 ▼-100.0%00.0%MedicalCPRXCatalyst Pharmaceuticals$0$2,236,500 ▼-100.0%00.0%MedicalLYELLyell Immunopharma$0$1,925,100 ▼-100.0%00.0%MedicalALLKAllakos$0$1,572,644 ▼-100.0%00.0%MedicalRLMDRelmada Therapeutics$0$1,555,200 ▼-100.0%00.0%MedicalRVNCRevance Therapeutics$0$1,427,250 ▼-100.0%00.0%MedicalSYRSSyros Pharmaceuticals$0$1,408,127 ▼-100.0%00.0%MedicalAVTEAerovate Therapeutics$0$919,600 ▼-100.0%00.0%MedicalRGLSRegulus Therapeutics$0$839,950 ▼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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