Paradigm Biocapital Advisors Lp Top Holdings and 13F Report (2025) About Paradigm Biocapital Advisors LpInvestment ActivityParadigm Biocapital Advisors Lp has $2.87 billion in total holdings as of December 31, 2024.Paradigm Biocapital Advisors Lp owns shares of 28 different stocks, but just 12 companies or ETFs make up 80% of its holdings.Approximately 17.54% of the portfolio was purchased this quarter.About 13.45% of the portfolio was sold this quarter.This quarter, Paradigm Biocapital Advisors Lp has purchased 31 new stocks and bought additional shares in 19 stocks.Paradigm Biocapital Advisors Lp sold shares of 4 stocks and completely divested from 7 stocks this quarter.Largest Holdings Nuvalent $419,845,308Arcellx $335,258,081argenx $296,002,575Revolution Medicines $286,633,075Janux Therapeutics $188,245,890 Largest New Holdings this Quarter TECTONIC THERAPEUTIC INC $22,397,298 HoldingLENZ THERAPEUTICS INC $22,243,036 HoldingScholar Rock $17,288,000 HoldingAgios Pharmaceuticals $9,083,786 Holding Largest Purchases this Quarter BeiGene 415,688 shares (about $76.78M)Janux Therapeutics 1,115,412 shares (about $59.72M)Revolution Medicines 1,239,022 shares (about $54.19M)MoonLake Immunotherapeutics 840,731 shares (about $45.53M)Edgewise Therapeutics 1,704,757 shares (about $45.52M) Largest Sales this Quarter Arcellx 428,399 shares (about $32.85M)Merus 764,995 shares (about $32.17M)Crinetics Pharmaceuticals 605,925 shares (about $30.98M)Viridian Therapeutics 1,075,610 shares (about $20.62M) Sector Allocation Over TimeMap of 500 Largest Holdings ofParadigm Biocapital Advisors Lp Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorNUVLNuvalent$419,845,308$28,445,308 ▲7.3%5,363,37914.6%MedicalACLXArcellx$335,258,081$32,853,919 ▼-8.9%4,371,60111.7%MedicalARGXargenx$296,002,575$572,565 ▲0.2%481,30510.3%MedicalRVMDRevolution Medicines$286,633,075$54,194,822 ▲23.3%6,553,11110.0%MedicalJANXJanux Therapeutics$188,245,890$59,719,158 ▲46.5%3,515,9866.5%MedicalTARSTarsus Pharmaceuticals$140,191,082$5,063,642 ▲3.7%2,531,8964.9%MedicalEWTXEdgewise Therapeutics$119,987,904$45,517,012 ▲61.1%4,493,9294.2%MedicalPCVXVaxcyte$116,469,344$42,424,354 ▲57.3%1,422,7874.1%MedicalBGNEBeiGene$113,785,793$76,781,730 ▲207.5%616,0244.0%MedicalCRNXCrinetics Pharmaceuticals$97,697,210$30,980,945 ▼-24.1%1,910,7613.4%MedicalMLTXMoonLake Immunotherapeutics$95,965,226$45,525,584 ▲90.3%1,772,2113.3%MedicalIRONDisc Medicine$94,955,4480.0%1,497,7203.3%MedicalMRUSMerus$71,061,220$32,168,040 ▼-31.2%1,689,9222.5%MedicalVERAVera Therapeutics$60,785,066$14,399,237 ▲31.0%1,437,3392.1%MedicalAPOGEE THERAPEUTICS INC$58,154,600$26,362,290 ▲82.9%1,283,7662.0%COMOLMAOlema Pharmaceuticals$42,587,975$10,501,987 ▲32.7%7,304,9701.5%MedicalPLRXPliant Therapeutics$42,105,149$1,219,068 ▲3.0%3,197,0501.5%MedicalIMTXImmatics$38,496,448$10,732,879 ▲38.7%5,414,4091.3%MedicalCOGTCogent Biosciences$38,355,814$2,399,670 ▲6.7%4,917,4121.3%MedicalSPYRE THERAPEUTICS INC$35,553,332$6,044,047 ▲20.5%1,527,2051.2%COM NEWVRDNViridian Therapeutics$34,890,914$20,619,443 ▼-37.1%1,820,0791.2%MedicalYMABY-mAbs Therapeutics$33,170,589$1,174,500 ▲3.7%4,236,3461.2%MedicalERASErasca$26,988,409$211,375 ▲0.8%10,752,3540.9%MedicalTECTONIC THERAPEUTIC INC$22,397,298$22,397,298 ▲New Holding485,1050.8%COMLENZ THERAPEUTICS INC$22,243,036$22,243,036 ▲New Holding770,4550.8%COMSRRKScholar Rock$17,288,000$17,288,000 ▲New Holding400,0000.6%MedicalORUKA THERAPEUTICS INC$15,893,207$1,939,000 ▲13.9%819,6600.6%COMAGIOAgios Pharmaceuticals$9,083,786$9,083,786 ▲New Holding276,4390.3%MedicalKURAKura Oncology$0$84,634,012 ▼-100.0%00.0%MedicalARVNArvinas$0$57,633,239 ▼-100.0%00.0%MedicalIMVTImmunovant$0$38,854,198 ▼-100.0%00.0%MedicalCGEMCullinan Therapeutics$0$38,853,758 ▼-100.0%00.0%MedicalKROSKeros Therapeutics$0$30,488,899 ▼-100.0%00.0%MedicalPERSPECTIVE THERAPEUTICS INC$0$12,277,888 ▼-100.0%00.0%COM NEWCMPSCOMPASS Pathways$0$7,308,000 ▼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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