Ra Capital Management, L.P. Top Holdings and 13F Report (2025) About Ra Capital Management, L.P.Investment ActivityRa Capital Management, L.P. has $7.51 billion in total holdings as of December 31, 2024.Ra Capital Management, L.P. owns shares of 89 different stocks, but just 25 companies or ETFs make up 80% of its holdings.Approximately 10.82% of the portfolio was purchased this quarter.About 9.80% of the portfolio was sold this quarter.This quarter, Ra Capital Management, L.P. has purchased 81 new stocks and bought additional shares in 9 stocks.Ra Capital Management, L.P. sold shares of 16 stocks and completely divested from 9 stocks this quarter.Largest Holdings Ascendis Pharma A/S $1,392,221,466Vaxcyte $711,297,093Janux Therapeutics $554,977,008Rhythm Pharmaceuticals $340,605,384Legend Biotech $244,275,632 Largest New Holdings this Quarter SEPTERNA INC $160,205,148 HoldingSPDR S&P Biotech ETF $110,615,294 Holding10x Genomics $47,092,198 HoldingKura Oncology $38,768,567 HoldingZai Lab $33,917,098 Holding Largest Purchases this Quarter SEPTERNA INC 6,995,858 shares (about $160.21M)SPDR S&P Biotech ETF 1,228,240 shares (about $110.62M)Arcellx 935,848 shares (about $71.77M)Janux Therapeutics 1,200,000 shares (about $64.25M)Ascendis Pharma A/S 402,316 shares (about $55.39M) Largest Sales this Quarter Verona Pharma 3,242,823 shares (about $150.60M)Evolent Health 4,937,665 shares (about $55.55M)Recursion Pharmaceuticals 7,659,519 shares (about $51.78M)Day One Biopharmaceuticals 2,116,144 shares (about $26.81M)APOGEE THERAPEUTICS INC 392,372 shares (about $17.77M) Sector Allocation Over TimeMap of 500 Largest Holdings ofRa Capital Management, L.P. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorASNDAscendis Pharma A/S$1,392,221,466$55,386,844 ▲4.1%10,112,74418.5%MedicalPCVXVaxcyte$711,297,0930.0%8,689,1909.5%MedicalJANXJanux Therapeutics$554,977,008$64,248,000 ▲13.1%10,365,6527.4%MedicalRYTMRhythm Pharmaceuticals$340,605,3840.0%6,084,4124.5%MedicalLEGNLegend Biotech$244,275,6320.0%7,506,9343.3%MedicalEWTXEdgewise Therapeutics$237,872,7300.0%8,909,0913.2%MedicalNAMSNewAmsterdam Pharma$227,316,500$20,071,700 ▲9.7%8,845,0003.0%MedicalWVEWave Life Sciences$225,158,8510.0%18,202,0093.0%MedicalACLXArcellx$213,760,108$71,770,183 ▲50.5%2,787,3272.8%MedicalRNAAvidity Biosciences$183,215,8650.0%6,300,4082.4%MedicalSEPTERNA INC$160,205,148$160,205,148 ▲New Holding6,995,8582.1%SHDYNE THERAPEUTICS INC$150,339,7530.0%6,381,1442.0%SHTYRATyra Biosciences$147,858,331$3,067,466 ▲2.1%10,637,2902.0%MedicalRXSTRxSight$128,684,959$5,975,485 ▼-4.4%3,743,0181.7%MedicalBICARA THERAPEUTICS INC$121,173,3980.0%6,955,9931.6%SHLENZ THERAPEUTICS INC$120,642,6200.0%4,178,8231.6%SHSPRYARS Pharmaceuticals$114,583,3070.0%10,860,9771.5%MedicalETNB89bio$110,851,6120.0%14,175,3981.5%MedicalXBISPDR S&P Biotech ETF$110,615,294$110,615,294 ▲New Holding1,228,2401.5%ETFGERNGeron$106,233,757$8,057,815 ▼-7.1%30,009,5361.4%MedicalARTIVA BIOTHERAPEUTICS INC$99,321,2840.0%9,853,3021.3%SHAXSMAxsome Therapeutics$84,610,0000.0%1,000,0001.1%MedicalVRNAVerona Pharma$82,051,585$150,596,700 ▼-64.7%1,766,8301.1%MedicalDAWNDay One Biopharmaceuticals$72,923,161$26,811,545 ▼-26.9%5,755,5771.0%MedicalAPOGEE THERAPEUTICS INC$71,097,942$17,774,452 ▼-20.0%1,569,4910.9%SHMLYSMineralys Therapeutics$59,715,6130.0%4,850,9840.8%MedicalPRAXIS PRECISION MEDICINES I$58,640,0570.0%761,9550.8%SHELYMEliem Therapeutics$56,554,6810.0%31,419,2670.8%MedicalRXRXRecursion Pharmaceuticals$52,221,649$51,778,348 ▼-49.8%7,725,0960.7%MedicalTOURMALINE BIO INC$51,489,3990.0%2,538,9250.7%SHACRVAcrivon Therapeutics$50,209,8580.0%8,340,5080.7%MedicalFULCFulcrum Therapeutics$48,076,7650.0%10,229,0990.6%MedicalTXG10x Genomics$47,092,198$47,092,198 ▲New Holding3,279,4010.6%MedicalGHRSGH Research$46,806,8230.0%6,686,6890.6%MedicalATXSAstria Therapeutics$45,640,6040.0%5,105,2130.6%MedicalVORVor Biopharma$44,007,103$18,755,846 ▲74.3%39,646,0390.6%MedicalGPCRStructure Therapeutics$41,152,376$10,288,080 ▼-20.0%1,517,4180.5%MedicalDIANTHUS THERAPEUTICS INC$40,687,520$10,171,880 ▼-20.0%1,866,4000.5%SHPEPGPepGen$40,513,3760.0%10,689,5450.5%MedicalEVHEvolent Health$40,243,466$55,548,731 ▼-58.0%3,577,1970.5%Computer and TechnologyKURAKura Oncology$38,768,567$38,768,567 ▲New Holding4,451,0410.5%MedicalIDYAIDEAYA Biosciences$34,624,3760.0%1,347,2520.5%MedicalZLABZai Lab$33,917,098$33,917,098 ▲New Holding1,295,0400.5%MedicalCMRXChimerix$30,624,0000.0%8,800,0000.4%MedicalCIDARA THERAPEUTICS INC$29,374,356$10,475,566 ▲55.4%1,092,7960.4%SHMBX BIOSCIENCES INC$27,853,8860.0%1,511,3340.4%SHNKTXNkarta$26,904,7710.0%10,805,1290.4%MedicalABOSAcumen Pharmaceuticals$25,683,1480.0%14,932,0630.3%MedicalFDMT4D Molecular Therapeutics$25,417,085$2,979,950 ▼-10.5%4,563,2110.3%MedicalNRIXNurix Therapeutics$25,119,994$25,119,994 ▲New Holding1,333,3330.3%MedicalSERASera Prognostics$24,687,0570.0%3,032,8080.3%MedicalAVTEAerovate Therapeutics$24,359,0440.0%9,192,0920.3%MedicalEYPTEyePoint Pharmaceuticals$23,704,544$23,704,544 ▲New Holding3,181,8180.3%MedicalLRMRLarimar Therapeutics$23,395,5080.0%6,045,3510.3%MedicalCERIBELL INC$21,340,182$21,340,182 ▲New Holding824,5820.3%SHTVTXTravere Therapeutics$20,033,000$20,033,000 ▲New Holding1,150,0000.3%MedicalELVNEnliven Therapeutics$19,102,185$4,775,558 ▼-20.0%848,9860.3%MedicalTSHATaysha Gene Therapies$18,809,4300.0%10,872,5030.3%MedicalALECAlector$18,323,981$18,323,981 ▲New Holding9,695,2280.2%MedicalTARAProtara Therapeutics$17,952,000$7,920,000 ▲78.9%3,400,0000.2%MedicalCCCCC4 Therapeutics$17,560,8000.0%4,878,0000.2%MedicalSLDBSolid Biosciences$17,321,7840.0%4,330,4460.2%MedicalPLRXPliant Therapeutics$16,870,7700.0%1,281,0000.2%MedicalBright Minds Biosciences Inc$16,599,061$16,599,061 ▲New Holding460,8290.2%SHITOSiTeos Therapeutics$16,068,549$8,390,031 ▼-34.3%2,092,2590.2%MedicalBCYCBicycle Therapeutics$15,308,678$16,233,322 ▼-51.5%1,093,4770.2%MedicalELDNEledon Pharmaceuticals$14,693,313$14,693,313 ▲New Holding3,566,3380.2%MedicalINSMInsmed$13,808,0000.0%200,0000.2%MedicalXNCRXencor$13,213,5000.0%575,0000.2%MedicalIMTXImmatics$12,442,5000.0%1,750,0000.2%MedicalACRSAclaris Therapeutics$11,573,334$11,573,334 ▲New Holding4,666,6670.2%MedicalMONOPAR THERAPEUTICS INC$11,246,554$11,246,554 ▲New Holding511,2070.1%SHTHRDTF Financial$9,884,780$3,294,920 ▼-25.0%960,6200.1%MedicalHOWLWerewolf Therapeutics$9,094,4240.0%6,144,8810.1%MedicalARVNArvinas$8,077,2410.0%421,3480.1%MedicalZURAZura Bio$8,043,7580.0%3,217,5030.1%MedicalPERCEPTIVE CAPITAL SOLUTIONS$7,635,0000.0%750,0000.1%SHBIOAGE LABS INC$7,588,310$5,211,000 ▼-40.7%1,310,5890.1%SHACETAdicet Bio$7,254,4420.0%7,541,0000.1%MedicalAVALO THERAPEUTICS INC$7,184,8100.0%967,0000.1%SHBOUNDLESS BIO INC$6,323,8300.0%2,180,6310.1%SHENTAEnanta Pharmaceuticals$5,968,500$5,968,500 ▲New Holding1,038,0000.1%MedicalNAMSWNewAmsterdam Pharma$4,749,9950.0%333,3330.1%MedicalSURROZEN INC$4,055,0230.0%282,5800.1%SHLEXEO THERAPEUTICS INC$3,596,3250.0%546,5540.0%SHALLKAllakos$1,367,217$1,367,217 ▲New Holding1,129,9310.0%MedicalSRRKScholar Rock$761,364$761,364 ▲New Holding17,6160.0%MedicalRGLSRegulus Therapeutics$532,212$679,386 ▼-56.1%336,8430.0%MedicalSCLXScilex$441,843$330,476 ▲296.7%1,036,2180.0%MedicalBIIBBiogen$0$229,594,951 ▼-100.0%00.0%MedicalCG ONCOLOGY INC$0$52,725,147 ▼-100.0%00.0%SHALTO NEUROSCIENCE INC$0$23,739,762 ▼-100.0%00.0%SHNUVLNuvalent$0$18,033,546 ▼-100.0%00.0%MedicalTNYATenaya Therapeutics$0$13,476,393 ▼-100.0%00.0%MedicalCERVOMED INC$0$11,929,952 ▼-100.0%00.0%SHADAGIO MEDICAL HOLDINGS INC$0$3,441,529 ▼-100.0%00.0%SHMETAGENOMI INC$0$2,832,369 ▼-100.0%00.0%SHANTX(ANTX)$0$2,139,997 ▼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. Real-time analyst ratings, insider transactions, earnings data, and more. Our daily ratings and market update email newsletter. Sign in to your free account to enjoy all that MarketBeat has to offer. Sign In Create Account Your Email Address: Email Address Required Your Password: Password Required Log In or Sign in with Facebook Sign in with Google Forgot your password? Your Email Address: Please enter your email address. Please enter a valid email address Choose a Password: Please enter your password. Your password must be at least 8 characters long and contain at least 1 number, 1 letter, and 1 special character. Create My Account (Free) or Sign in with Facebook Sign in with Google By creating a free account, you agree to our terms of service. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
