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Samsara Biocapital, LLC Top Holdings and 13F Report (2025)

About Samsara Biocapital, LLC

Investment Activity

  • Samsara Biocapital, LLC has $728.58 million in total holdings as of December 31, 2024.
  • Samsara Biocapital, LLC owns shares of 43 different stocks, but just 10 companies or ETFs make up 80% of its holdings.
  • Approximately 17.86% of the portfolio was purchased this quarter.
  • About 11.00% of the portfolio was sold this quarter.
  • This quarter, Samsara Biocapital, LLC has purchased 42 new stocks and bought additional shares in 2 stocks.
  • Samsara Biocapital, LLC sold shares of 8 stocks and completely divested from 4 stocks this quarter.

Largest Holdings

Scholar Rock
$242,589,365
CARGO THERAPEUTICS INC
$63,674,235
SEPTERNA INC
$63,399,108
Mineralys Therapeutics
$62,472,216
NEUROGENE INC
$39,253,523

Largest New Holdings this Quarter

SEPTERNA INC
$63,399,108 Holding
UPSTREAM BIO INC
$36,449,880 Holding
PALVELLA THERAPEUTICS INC NE
$8,153,832 Holding
ONKURE THERAPEUTICS INC
$7,087,733 Holding
CURIS INC
$606,541 Holding

Largest Purchases this Quarter

SEPTERNA INC
2,768,520 shares (about $63.40M)
UPSTREAM BIO INC
2,217,146 shares (about $36.45M)
NEUROGENE INC
449,337 shares (about $10.27M)
PALVELLA THERAPEUTICS INC NE
679,486 shares (about $8.15M)
ONKURE THERAPEUTICS INC
824,155 shares (about $7.09M)

Largest Sales this Quarter

Scholar Rock
1,175,713 shares (about $50.81M)
Arcellx
100,000 shares (about $7.67M)
LENZ THERAPEUTICS INC
221,492 shares (about $6.39M)
Verona Pharma
97,600 shares (about $4.53M)
HilleVax
399,637 shares (about $827.25K)

Sector Allocation Over Time

Map of 500 Largest Holdings ofSamsara Biocapital, LLC

 
 
Selling
 
 
Neutral
 
 
Buying
Issuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSector
Scholar Rock Holding Co. stock logo
SRRK
Scholar Rock
$242,589,365$50,814,316 ▼-17.3%5,612,89633.3%Medical
CARGO THERAPEUTICS INC
$63,674,2350.0%4,415,6898.7%COM
SEPTERNA INC
$63,399,108$63,399,108 ▲New Holding2,768,5208.7%COM
Mineralys Therapeutics, Inc. stock logo
MLYS
Mineralys Therapeutics
$62,472,2160.0%5,074,9168.6%Medical
NEUROGENE INC
$39,253,523$10,271,844 ▲35.4%1,717,1275.4%COM
UPSTREAM BIO INC
$36,449,880$36,449,880 ▲New Holding2,217,1465.0%COM
LENZ THERAPEUTICS INC
$28,494,141$6,394,474 ▼-18.3%986,9813.9%COM
ALUMIS INC
$25,674,6740.0%3,266,4983.5%COM
Arcellx, Inc. stock logo
ACLX
Arcellx
$19,451,728$7,669,000 ▼-28.3%253,6412.7%Medical
Zymeworks Inc. stock logo
ZYME
Zymeworks
$14,640,0000.0%1,000,0002.0%Medical
JASPER THERAPEUTICS INC
$12,499,6460.0%584,6421.7%COM NEW
AVADEL PHARMACEUTICALS PLC
$10,168,7090.0%967,5271.4%COM SHS
Rhythm Pharmaceuticals, Inc. stock logo
RYTM
Rhythm Pharmaceuticals
$9,664,7790.0%172,6471.3%Medical
Nkarta, Inc. stock logo
NKTX
Nkarta
$9,382,4070.0%3,768,0351.3%Medical
CONTINEUM THERAPEUTICS INC
$8,626,1540.0%588,8161.2%CL A
PALVELLA THERAPEUTICS INC NE
$8,153,832$8,153,832 ▲New Holding679,4861.1%COM
Acelyrin, Inc. stock logo
SLRN
Acelyrin
$7,922,2890.0%2,523,0221.1%Medical
ONKURE THERAPEUTICS INC
$7,087,733$7,087,733 ▲New Holding824,1551.0%COM CL A
Leap Therapeutics, Inc. stock logo
LPTX
Leap Therapeutics
$7,021,7620.0%2,442,3521.0%Medical
ABIVAX SA
$6,222,0000.0%850,0000.9%SPONSORED ADS
Aclaris Therapeutics, Inc. stock logo
ACRS
Aclaris Therapeutics
$5,914,949$4,188,445 ▲242.6%2,385,0600.8%Medical
Gossamer Bio, Inc. stock logo
GOSS
Gossamer Bio
$5,545,4400.0%6,130,2680.8%Medical
Eliem Therapeutics, Inc. stock logo
ELYM
Eliem Therapeutics
$4,696,4050.0%2,609,1140.6%Medical
Verona Pharma plc stock logo
VRNA
Verona Pharma
$4,533,705$4,532,544 ▼-50.0%97,6250.6%Medical
Inozyme Pharma, Inc. stock logo
INZY
Inozyme Pharma
$4,328,1250.0%1,562,5000.6%Medical
Sutro Biopharma, Inc. stock logo
STRO
Sutro Biopharma
$4,042,1380.0%2,196,8140.6%Medical
ARTIVA BIOTHERAPEUTICS INC
$2,939,9930.0%291,6660.4%COM
VTV THERAPEUTICS INC
$2,855,4180.0%206,7840.4%CL A NEW
Tango Therapeutics, Inc. stock logo
TNGX
Tango Therapeutics
$1,946,7000.0%630,0000.3%Medical
Day One Biopharmaceuticals, Inc. stock logo
DAWN
Day One Biopharmaceuticals
$1,866,5320.0%147,3190.3%Medical
Immatics stock logo
IMTX
Immatics
$1,407,7800.0%198,0000.2%Medical
Prime Medicine, Inc. stock logo
PRME
Prime Medicine
$1,183,266$394,422 ▼-25.0%405,2280.2%Medical
Terns Pharmaceuticals, Inc. stock logo
TERN
Terns Pharmaceuticals
$1,121,0080.0%202,3480.2%Medical
HilleVax, Inc. stock logo
HLVX
HilleVax
$827,249$827,249 ▼-50.0%399,6370.1%Medical
CURIS INC
$606,541$606,541 ▲New Holding198,2160.1%COM
Janux Therapeutics, Inc. stock logo
JANX
Janux Therapeutics
$603,021$603,021 ▼-50.0%11,2630.1%Medical
Bolt Biotherapeutics, Inc. stock logo
BOLT
Bolt Biotherapeutics
$561,4020.0%1,049,1530.1%Medical
Lyra Therapeutics, Inc. stock logo
LYRA
Lyra Therapeutics
$405,718$168,128 ▼-29.3%1,965,6890.1%Medical
Allakos Inc. stock logo
ALLK
Allakos
$208,2280.0%172,0890.0%Medical
Kronos Bio, Inc. stock logo
KRON
Kronos Bio
$74,2240.0%78,1310.0%Medical
AlloVir, Inc. stock logo
ALVR
AlloVir
$34,5810.0%82,3360.0%Medical
NUVATION BIO INC
$30,6670.0%133,3330.0%*W EXP 02/10/202
SRZNW
Surrozen
$2,1400.0%99,9990.0%Medical
Syros Pharmaceuticals, Inc. stock logo
SYRS
Syros Pharmaceuticals
$0$3,840,818 ▼-100.0%00.0%Medical
IO Biotech, Inc. stock logo
IOBT
IO Biotech
$0$3,822,016 ▼-100.0%00.0%Medical
BICARA THERAPEUTICS INC
$0$891,450 ▼-100.0%00.0%COMMON STOCK
Viracta Therapeutics, Inc. stock logo
VIRX
Viracta Therapeutics
$0$159,599 ▼-100.0%00.0%Medical

Showing largest 100 holdings. View all holdings.
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