Sio Capital Management, LLC Top Holdings and 13F Report (2025)

About Sio Capital Management, LLC

Investment Activity

Sio Capital Management, LLC has $355.41 million in total holdings as of December 31, 2024.
Sio Capital Management, LLC owns shares of 51 different stocks, but just 19 companies or ETFs make up 80% of its holdings.
Approximately 65.66% of the portfolio was purchased this quarter.
About 31.84% of the portfolio was sold this quarter.
This quarter, Sio Capital Management, LLC has purchased 39 new stocks and bought additional shares in 9 stocks.
Sio Capital Management, LLC sold shares of 5 stocks and completely divested from 10 stocks this quarter.

Largest Holdings

ICON Public: $40,998,305
Maximus: $28,473,227
The Cigna Group: $27,062,548
LABCORP HOLDINGS INC: $25,980,351
Sanofi: $18,665,010

Largest New Holdings this Quarter

ICON Public: $40,998,305 Holding
Sanofi: $18,665,010 Holding
BRIGHT MINDS BIOSCIENCES INC: $16,273,584 Holding
ANTERIS TECHNOLOGIES GLOBAL: $13,224,600 Holding
Viatris: $9,088,500 Holding

Largest Purchases this Quarter

ICON Public: 195,500 shares (about $41.00M)
The Cigna Group: 71,500 shares (about $19.74M)
Sanofi: 387,000 shares (about $18.67M)
Maximus: 226,281 shares (about $16.89M)
BRIGHT MINDS BIOSCIENCES INC: 451,793 shares (about $16.27M)

Largest Sales this Quarter

LABCORP HOLDINGS INC: 60,000 shares (about $13.76M)
Disc Medicine: 114,430 shares (about $7.25M)
Tyra Biosciences: 160,000 shares (about $2.22M)
Erasca: 863,000 shares (about $2.17M)
Vaxart: 2,092,929 shares (about $1.39M)

Sector Allocation Over Time

Selling

Neutral

Buying

Latest 13F Holdings and Changes Since Previous Quarterly Filing

Issuer Name	Holdings Value	Approximate Purchase/Sale	Change in Shares	Shares Held	% of Portfolio	Sector
ICLR ICON Public	$40,998,305	$40,998,305 ▲	New Holding	195,500	11.5%	Medical
MMS Maximus	$28,473,227	$16,891,877 ▲	145.9%	381,423	8.0%	Business Services
CI The Cigna Group	$27,062,548	$19,744,010 ▲	269.8%	98,003	7.6%	Medical
LABCORP HOLDINGS INC	$25,980,351	$13,759,200 ▼	-34.6%	113,293	7.3%	COM SHS
SNY Sanofi	$18,665,010	$18,665,010 ▲	New Holding	387,000	5.3%	Medical
ZBH Zimmer Biomet	$18,465,286	$4,996,299 ▲	37.1%	174,811	5.2%	Medical
BRIGHT MINDS BIOSCIENCES INC	$16,273,584	$16,273,584 ▲	New Holding	451,793	4.6%	COM NEW
ANTERIS TECHNOLOGIES GLOBAL	$13,224,600	$13,224,600 ▲	New Holding	2,370,000	3.7%	COM
ANNX Annexon	$12,142,746	$4,790,661 ▲	65.2%	2,367,007	3.4%	Medical
TFX Teleflex	$11,884,081	$4,894,450 ▲	70.0%	66,772	3.3%	Medical
VTRS Viatris	$9,088,500	$9,088,500 ▲	New Holding	730,000	2.6%	Medical
OGN Organon & Co.	$9,047,637	$9,047,637 ▲	New Holding	606,410	2.5%	Medical
VTYX Ventyx Biosciences	$8,862,485	$4,543,919 ▲	105.2%	4,046,797	2.5%	Medical
ANIP ANI Pharmaceuticals	$8,847,619	$8,847,619 ▲	New Holding	160,051	2.5%	Medical
EMBC Embecta	$8,788,103	$8,788,103 ▲	New Holding	425,574	2.5%	Medical
VIR Vir Biotechnology	$7,741,138	$7,741,138 ▲	New Holding	1,054,651	2.2%	Medical
VXRT Vaxart	$7,624,290	$1,385,728 ▼	-15.4%	11,515,315	2.1%	Medical
TARA Protara Therapeutics	$7,590,000	$7,590,000 ▲	New Holding	1,437,500	2.1%	Medical
CARGO THERAPEUTICS INC	$6,824,871	$4,317,810 ▲	172.2%	473,292	1.9%	COM
NEUMORA THERAPEUTICS INC.	$6,744,780	$6,744,780 ▲	New Holding	636,300	1.9%	COM
SEPTERNA INC	$6,221,632	$6,221,632 ▲	New Holding	271,687	1.8%	COM
PRQR ProQR Therapeutics	$5,444,671	$5,444,671 ▲	New Holding	2,054,593	1.5%	Medical
PMVP PMV Pharmaceuticals	$5,393,972	$540,471 ▲	11.1%	3,572,167	1.5%	Medical
IRON Disc Medicine	$4,660,597	$7,254,861 ▼	-60.9%	73,511	1.3%	Medical
ATXS Astria Therapeutics	$4,513,690		0.0%	504,887	1.3%	Medical
IRWD Ironwood Pharmaceuticals	$4,021,479	$4,021,479 ▲	New Holding	907,783	1.1%	Medical
AORT Artivion	$3,464,479		0.0%	121,178	1.0%	Medical
ERAS Erasca	$3,404,027	$2,166,130 ▼	-38.9%	1,356,186	1.0%	Medical
TYRA Tyra Biosciences	$3,348,093	$2,224,000 ▼	-39.9%	240,870	0.9%	Medical
IDYA IDEAYA Biosciences	$3,161,100		0.0%	123,000	0.9%	Medical
ALPHA COGNITION INC	$2,560,383	$2,560,383 ▲	New Holding	434,700	0.7%	COM NEW
Q32 BIO INC	$2,399,101	$2,399,101 ▲	New Holding	697,413	0.7%	COM
TELA TELA Bio	$1,902,600	$1,902,600 ▲	New Holding	630,000	0.5%	Medical
NUVB Nuvation Bio	$1,777,186		0.0%	668,115	0.5%	Medical
CNTX Context Therapeutics	$1,394,770		0.0%	1,328,352	0.4%	Medical
ALEC Alector	$1,163,537	$1,163,537 ▲	New Holding	615,628	0.3%	Medical
ENTA Enanta Pharmaceuticals	$1,017,773		0.0%	177,004	0.3%	Medical
OVID Ovid Therapeutics	$933,700	$933,700 ▲	New Holding	1,000,000	0.3%	Medical
APRE Aprea Therapeutics	$910,024		0.0%	276,603	0.3%	Medical
FHTX Foghorn Therapeutics	$574,292		0.0%	121,672	0.2%	Medical
CCCC C4 Therapeutics	$558,000	$558,000 ▲	New Holding	155,000	0.2%	Medical
AVALO THERAPEUTICS INC	$530,933		0.0%	71,458	0.1%	COM NEW
BOUNDLESS BIO INC	$469,968		0.0%	162,058	0.1%	COM
NYXH Nyxoah	$406,712		0.0%	50,839	0.1%	Medical
MODD Modular Medical	$345,226	$179,769 ▲	108.6%	251,990	0.1%	Medical
MESOBLAST LTD	$229,680	$229,680 ▲	New Holding	11,600	0.1%	SPONS ADR
NXTC NextCure	$100,230		0.0%	130,000	0.0%	Medical
HUMAW Humacyte	$91,746		0.0%	49,998	0.0%	Medical
TERN Terns Pharmaceuticals	$55,400		0.0%	10,000	0.0%	Medical
RCKTW Rocket Pharmaceuticals	$15,440		0.0%	400,000	0.0%	Medical
SVRA Savara	$11,503	$11,503 ▲	New Holding	3,747	0.0%	Medical
ISRG Intuitive Surgical	$0	$28,984,930 ▼	-100.0%	0	0.0%	Medical
TEVA Teva Pharmaceutical Industries	$0	$24,313,917 ▼	-100.0%	0	0.0%	Medical
KVUE Kenvue	$0	$10,980,759 ▼	-100.0%	0	0.0%	Consumer Staples
BDSX Biodesix	$0	$7,722,555 ▼	-100.0%	0	0.0%	Medical
RLAY Relay Therapeutics	$0	$6,696,540 ▼	-100.0%	0	0.0%	Medical
CMPS COMPASS Pathways	$0	$5,762,226 ▼	-100.0%	0	0.0%	Medical
XFOR X4 Pharmaceuticals	$0	$872,438 ▼	-100.0%	0	0.0%	Medical
RAPT RAPT Therapeutics	$0	$633,150 ▼	-100.0%	0	0.0%	Medical
VSTM Verastem	$0	$398,902 ▼	-100.0%	0	0.0%	Medical
CMAXW CareMax	$0	$108 ▼	-100.0%	0	0.0%	Medical

Showing largest 100 holdings. View all holdings.

More Institutional Buying and Selling Information

SEC Filings and Trading Data

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Sio Capital Management, LLC Top Holdings and 13F Report (2025)

About Sio Capital Management, LLC

Investment Activity

Largest Holdings

Largest New Holdings this Quarter

Largest Purchases this Quarter

Largest Sales this Quarter

Sector Allocation Over Time

Latest 13F Holdings and Changes Since Previous Quarterly Filing

More Institutional Buying and Selling Information

Best-in-Class Portfolio Monitoring

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Sio Capital Management, LLC Top Holdings and 13F Report (2025)

About Sio Capital Management, LLC

Investment Activity

Largest Holdings

Largest New Holdings this Quarter

Largest Purchases this Quarter

Largest Sales this Quarter

Sector Allocation Over Time

Map of 500 Largest Holdings ofSio Capital Management, LLC

Latest 13F Holdings and Changes Since Previous Quarterly Filing

More Institutional Buying and Selling Information

MarketBeat All Access Features

Best-in-Class Portfolio Monitoring

Stock Ideas and Recommendations

Advanced Stock Screeners and Research Tools