Sofinnova Investments, Inc. Top Holdings and 13F Report (2025) About Sofinnova Investments, Inc.Investment ActivitySofinnova Investments, Inc. has $1.37 billion in total holdings as of December 31, 2024.Sofinnova Investments, Inc. owns shares of 60 different stocks, but just 21 companies or ETFs make up 80% of its holdings.Approximately 35.85% of the portfolio was purchased this quarter.About 22.69% of the portfolio was sold this quarter.This quarter, Sofinnova Investments, Inc. has purchased 58 new stocks and bought additional shares in 11 stocks.Sofinnova Investments, Inc. sold shares of 21 stocks and completely divested from 15 stocks this quarter.Largest Holdings Natera $245,409,324Vera Therapeutics $118,157,710Gilead Sciences $71,515,348AbbVie $63,864,136Jazz Pharmaceuticals $62,091,368 Largest New Holdings this Quarter Gilead Sciences $71,515,348 HoldingAbbVie $63,864,136 HoldingSarepta Therapeutics $52,134,266 HoldingStryker $41,767,600 HoldingAlnylam Pharmaceuticals $25,921,044 Holding Largest Purchases this Quarter Gilead Sciences 774,227 shares (about $71.52M)AbbVie 359,393 shares (about $63.86M)Sarepta Therapeutics 428,771 shares (about $52.13M)Stryker 116,005 shares (about $41.77M)Jazz Pharmaceuticals 315,631 shares (about $38.87M) Largest Sales this Quarter IDEAYA Biosciences 680,365 shares (about $17.49M)Incyte 189,909 shares (about $13.12M)Edwards Lifesciences 162,898 shares (about $12.06M)Cogent Biosciences 1,442,070 shares (about $11.25M)AstraZeneca 158,062 shares (about $10.36M) Sector Allocation Over TimeMap of 500 Largest Holdings ofSofinnova Investments, Inc. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorNTRANatera$245,409,3240.0%1,550,28017.9%MedicalVERAVera Therapeutics$118,157,7100.0%2,793,9878.6%MedicalGILDGilead Sciences$71,515,348$71,515,348 ▲New Holding774,2275.2%MedicalABBVAbbVie$63,864,136$63,864,136 ▲New Holding359,3934.7%MedicalJAZZJazz Pharmaceuticals$62,091,368$38,869,958 ▲167.4%504,1934.5%MedicalSRPTSarepta Therapeutics$52,134,266$52,134,266 ▲New Holding428,7713.8%MedicalAXSMAxsome Therapeutics$50,065,937$5,262,657 ▲11.7%591,7263.6%MedicalArrivent BioPharma Inc$45,201,4730.0%1,696,7523.3%COMAZNAstraZeneca$42,676,059$10,356,222 ▼-19.5%651,3443.1%MedicalSYKStryker$41,767,600$41,767,600 ▲New Holding116,0053.0%MedicalREPLReplimune Group$38,140,711$37,557,760 ▲6,442.7%3,149,5222.8%MedicalINCYIncyte$36,211,122$13,117,015 ▼-26.6%524,2672.6%MedicalRapport Therapeutics Inc$35,401,8380.0%1,995,5942.6%COMSLNOSoleno Therapeutics$34,038,298$5,802,865 ▼-14.6%757,2482.5%MedicalBSXBoston Scientific$30,955,722$18,824,369 ▲155.2%346,5712.3%MedicalIDYAIDEAYA Biosciences$27,475,613$17,485,381 ▼-38.9%1,069,0902.0%MedicalALNYAlnylam Pharmaceuticals$25,921,044$25,921,044 ▲New Holding110,1571.9%MedicalALKSAlkermes$25,719,090$25,719,090 ▲New Holding894,2661.9%MedicalDyne Therapeutics Inc$25,244,493$7,054,524 ▲38.8%1,071,4981.8%COMDXCMDexCom$22,569,632$22,569,632 ▲New Holding290,2101.6%MedicalRYTMRhythm Pharmaceuticals$22,248,019$6,759,585 ▲43.6%397,4281.6%MedicalGMEDGlobus Medical$20,239,137$20,239,137 ▲New Holding244,7001.5%MedicalISRGIntuitive Surgical$19,780,196$19,780,196 ▲New Holding37,8961.4%MedicalINSMInsmed$17,693,640$2,072,995 ▼-10.5%256,2811.3%MedicalYMABY-mAbs Therapeutics$17,181,1970.0%2,194,2781.3%MedicalSVRASavara$16,796,888$587,141 ▼-3.4%5,471,2991.2%MedicalJANXJanux Therapeutics$13,559,647$4,737,862 ▲53.7%253,2621.0%MedicalBioAge Labs Inc$13,345,3770.0%2,304,9011.0%COMINZYInozyme Pharma$11,856,4530.0%4,280,3080.9%MedicalLLYEli Lilly and Company$11,089,008$11,089,008 ▲New Holding14,3640.8%MedicalEWTXEdgewise Therapeutics$10,754,039$480,760 ▲4.7%402,7730.8%MedicalPHVSPharvaris$10,749,060$758,729 ▼-6.6%560,7230.8%MedicalAVTEAerovate Therapeutics$9,960,5180.0%3,758,6860.7%MedicalNARIInari Medical$9,212,279$4,601,086 ▲99.8%180,4560.7%MedicalSNDXSyndax Pharmaceuticals$8,707,049$1,697,078 ▼-16.3%658,6270.6%MedicalInhibrx Biosciences Inc$8,118,726$136,721 ▼-1.7%527,1900.6%COMIMNMImmunome$7,931,271$744,016 ▲10.4%746,8240.6%MedicalCOGTCogent Biosciences$6,420,648$11,248,146 ▼-63.7%823,1600.5%MedicalACHVAchieve Life Sciences$4,598,817$730,576 ▼-13.7%1,306,4820.3%MedicalERASErasca$4,507,659$117,438 ▼-2.5%1,795,8800.3%MedicalESTAEstablishment Labs$4,390,701$3,969,898 ▼-47.5%95,3050.3%MedicalAVTRAvantor$4,214,000$4,214,000 ▲New Holding200,0000.3%MedicalEWEdwards Lifesciences$2,961,200$12,059,339 ▼-80.3%40,0000.2%MedicalEXASExact Sciences$2,924,240$809,417 ▲38.3%52,0420.2%MedicalIMTXImmatics$2,440,195$304,976 ▼-11.1%343,2060.2%MedicalDHRDanaher$2,295,500$2,295,500 ▲New Holding10,0000.2%MedicalNXTCNextCure$2,060,0010.0%2,671,8560.2%MedicalANABAnaptysBio$1,759,953$1,759,953 ▲New Holding132,9270.1%MedicalKROSKeros Therapeutics$1,509,786$1,509,786 ▲New Holding95,3750.1%MedicalBOLTBolt Biotherapeutics$1,473,6240.0%2,754,4370.1%MedicalIRONDisc Medicine$1,442,477$1,179,240 ▼-45.0%22,7520.1%MedicalBDXBecton, Dickinson and Company$1,123,233$2,323,148 ▼-67.4%4,9510.1%MedicalVIRVir Biotechnology$837,722$110,944 ▼-11.7%114,1310.1%MedicalICUIICU Medical$775,850$775,850 ▲New Holding5,0000.1%MedicalELVNEnliven Therapeutics$765,563$765,563 ▲New Holding34,0250.1%MedicalIKNAIkena Oncology$627,4900.0%382,6160.0%MedicalTVTXTravere Therapeutics$568,171$568,171 ▲New Holding32,6160.0%MedicalGPCRStructure Therapeutics$566,591$485,448 ▼-46.1%20,8920.0%MedicalLUNGPulmonx$416,404$6,702 ▼-1.6%61,3260.0%MedicalRNAAvidity Biosciences$400,984$485,141 ▼-54.7%13,7890.0%MedicalNVONovo Nordisk A/S$0$86,483,994 ▼-100.0%00.0%MedicalELANElanco Animal Health$0$51,689,468 ▼-100.0%00.0%MedicalNVSNovartis$0$23,004,000 ▼-100.0%00.0%MedicalGHGuardant Health$0$9,328,436 ▼-100.0%00.0%MedicalRVMDRevolution Medicines$0$9,218,340 ▼-100.0%00.0%MedicalTGTXTG Therapeutics$0$8,388,683 ▼-100.0%00.0%MedicalMRNSMarinus Pharmaceuticals$0$7,719,672 ▼-100.0%00.0%MedicalCABACabaletta Bio$0$7,239,928 ▼-100.0%00.0%MedicalKURAKura Oncology$0$5,801,113 ▼-100.0%00.0%MedicalPAHCPhibro Animal Health$0$5,363,904 ▼-100.0%00.0%MedicalILMNIllumina$0$5,296,081 ▼-100.0%00.0%MedicalTMOThermo Fisher Scientific$0$3,569,149 ▼-100.0%00.0%MedicalPerspective Therapeutics Inc$0$1,610,437 ▼-100.0%00.0%COMATXSAstria Therapeutics$0$942,896 ▼-100.0%00.0%MedicalIMTXWImmatics$0$852,271 ▼-100.0%00.0%MedicalShowing largest 100 holdings. 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