Sofinnova Investments, Inc. Top Holdings and 13F Report (2024)

About Sofinnova Investments, Inc.

Investment Activity

Sofinnova Investments, Inc. has $1.92 billion in total holdings as of December 31, 2023.
Sofinnova Investments, Inc. owns shares of 75 different stocks, but just 25 companies or ETFs make up 80% of its holdings.
Approximately 38.58% of the portfolio was purchased this quarter.
About 24.22% of the portfolio was sold this quarter.
This quarter, Sofinnova Investments, Inc. has purchased 69 new stocks and bought additional shares in 32 stocks.
Sofinnova Investments, Inc. sold shares of 15 stocks and completely divested from 12 stocks this quarter.

Largest Holdings

Invesco QQQ: $191,644,000
Natera: $167,879,821
Edwards Lifesciences: $113,081,663
Vera Therapeutics: $101,086,450
Ascendis Pharma A/S: $100,141,652

Largest New Holdings this Quarter

Invesco QQQ: $191,644,000 Holding
Edwards Lifesciences: $113,081,663 Holding
Stryker: $65,696,831 Holding
Rapport Therapeutics Inc: $45,393,332 Holding
Abbott Laboratories: $40,545,682 Holding

Largest Purchases this Quarter

Invesco QQQ: 400,000 shares (about $191.64M)
Edwards Lifesciences: 1,224,225 shares (about $113.08M)
Stryker: 193,084 shares (about $65.70M)
Rapport Therapeutics Inc: 1,951,562 shares (about $45.39M)
Abbott Laboratories: 390,200 shares (about $40.55M)

Largest Sales this Quarter

SPDR S&P Biotech ETF: 600,000 shares (about $55.63M)
Insulet: 159,236 shares (about $32.13M)
Immatics: 1,366,942 shares (about $15.88M)
Boston Scientific: 182,771 shares (about $14.08M)
Dyne Therapeutics Inc: 310,947 shares (about $10.97M)

Sector Allocation Over Time

Selling

Neutral

Buying

Latest 13F Holdings and Changes Since Previous Quarterly Filing

Issuer Name	Holdings Value	Approximate Purchase/Sale	Change in Shares	Shares Held	% of Portfolio	Sector
QQQ Invesco QQQ	$191,644,000	$191,644,000 ▲	New Holding	400,000	10.0%	Finance
NTRA Natera	$167,879,821		0.0%	1,550,280	8.7%	Medical
EW Edwards Lifesciences	$113,081,663	$113,081,663 ▲	New Holding	1,224,225	5.9%	Medical
VERA Vera Therapeutics	$101,086,450		0.0%	2,793,987	5.3%	Medical
ASND Ascendis Pharma A/S	$100,141,652	$2,693,232 ▼	-2.6%	734,284	5.2%	Medical
NVO Novo Nordisk A/S	$92,715,482	$5,375,160 ▲	6.2%	649,541	4.8%	Medical
SYK Stryker	$65,696,831	$65,696,831 ▲	New Holding	193,084	3.4%	Medical
AZN AstraZeneca	$62,502,512	$15,964,865 ▲	34.3%	801,417	3.2%	Medical
ISRG Intuitive Surgical	$61,040,982	$1,629,486 ▼	-2.6%	137,217	3.2%	Medical
Dyne Therapeutics Inc	$57,371,059	$10,973,320 ▼	-16.1%	1,625,703	3.0%	COM
ALGN Align Technology	$52,758,249	$29,706,996 ▲	128.9%	218,524	2.7%	Medical
ALNY Alnylam Pharmaceuticals	$48,096,747	$23,058,999 ▲	92.1%	197,929	2.5%	Medical
Rapport Therapeutics Inc	$45,393,332	$45,393,332 ▲	New Holding	1,951,562	2.4%	COM
SNDX Syndax Pharmaceuticals	$44,214,825	$11,191,498 ▲	33.9%	2,153,669	2.3%	Medical
ELAN Elanco Animal Health	$41,331,128	$4,454,584 ▲	12.1%	2,864,250	2.1%	Medical
ABT Abbott Laboratories	$40,545,682	$40,545,682 ▲	New Holding	390,200	2.1%	Medical
IDYA IDEAYA Biosciences	$40,430,148	$12,988,312 ▲	47.3%	1,151,528	2.1%	Medical
TGTX TG Therapeutics	$33,112,118	$2,200,356 ▼	-6.2%	1,861,277	1.7%	Medical
Arrivent BioPharma Inc	$31,474,750		0.0%	1,696,752	1.6%	COM
IDXX IDEXX Laboratories	$31,113,566	$5,535,566 ▼	-15.1%	63,862	1.6%	Medical
SRPT Sarepta Therapeutics	$30,944,616	$4,998,488 ▼	-13.9%	195,852	1.6%	Medical
YMAB Y-mAbs Therapeutics	$26,506,878		0.0%	2,194,278	1.4%	Medical
AXSM Axsome Therapeutics	$24,970,939	$24,970,939 ▲	New Holding	310,198	1.3%	Medical
COGT Cogent Biosciences	$23,378,801	$3,140,301 ▲	15.5%	2,773,286	1.2%	Medical
XBI SPDR S&P Biotech ETF	$23,177,500	$55,626,000 ▼	-70.6%	250,000	1.2%	ETF
SLNO Soleno Therapeutics	$22,617,847	$16,466,227 ▲	267.7%	554,359	1.2%	Medical
SVRA Savara	$22,200,940	$12,741,478 ▲	134.7%	5,508,918	1.2%	Medical
CLDX Celldex Therapeutics	$20,270,636	$9,403,131 ▼	-31.7%	547,707	1.1%	Medical
ROIV Roivant Sciences	$19,749,115	$9,161,104 ▲	86.5%	1,868,412	1.0%	Medical
ESTA Establishment Labs	$19,504,847	$13,090,446 ▲	204.1%	429,244	1.0%	Medical
INZY Inozyme Pharma	$19,090,174		0.0%	4,280,308	1.0%	Medical
RVMD Revolution Medicines	$17,662,392	$17,662,392 ▲	New Holding	455,099	0.9%	Medical
KURA Kura Oncology	$16,991,753	$6,656,809 ▲	64.4%	825,243	0.9%	Medical
INSM Insmed	$15,259,049	$8,559,049 ▲	127.7%	227,747	0.8%	Medical
BSX Boston Scientific	$13,174,871	$14,075,195 ▼	-51.7%	171,080	0.7%	Medical
MDGL Madrigal Pharmaceuticals	$12,443,867	$7,112,702 ▲	133.4%	44,417	0.6%	Medical
PODD Insulet	$12,303,141	$32,133,826 ▼	-72.3%	60,967	0.6%	Medical
PHVS Pharvaris	$11,308,839	$317,006 ▲	2.9%	601,534	0.6%	Medical
AXNX Axonics	$10,117,443	$74,289 ▲	0.7%	150,490	0.5%	Medical
IMTX Immatics	$9,257,700	$15,883,865 ▼	-63.2%	796,704	0.5%	Medical
CABA Cabaletta Bio	$9,128,592	$5,914,092 ▲	184.0%	1,220,400	0.5%	Medical
PEPG PepGen	$8,955,603	$917,764 ▲	11.4%	561,128	0.5%	Medical
EWTX Edgewise Therapeutics	$8,567,195	$8,567,195 ▲	New Holding	475,691	0.4%	Medical
IMNM Immunome	$7,933,728	$741,536 ▲	10.3%	655,680	0.4%	Medical
EXAS Exact Sciences	$7,682,233	$2,013,339 ▼	-20.8%	181,828	0.4%	Medical
NARI Inari Medical	$7,503,600	$7,011,700 ▲	1,425.4%	155,838	0.4%	Medical
DXCM DexCom	$6,972,190	$6,972,190 ▲	New Holding	61,494	0.4%	Medical
Inhibrx Biosciences Inc	$6,565,174	$6,565,174 ▲	New Holding	463,315	0.3%	COM
ACHV Achieve Life Sciences	$6,525,348	$610,333 ▼	-8.6%	1,388,372	0.3%	Medical
WAT Waters	$6,325,776	$6,325,776 ▲	New Holding	21,804	0.3%	Medical
AVTE Aerovate Therapeutics	$6,239,419		0.0%	3,758,686	0.3%	Medical
FDMT 4D Molecular Therapeutics	$5,691,543	$1,531,619 ▲	36.8%	271,155	0.3%	Medical
MRNS Marinus Pharmaceuticals	$4,979,843	$1,170,612 ▲	30.7%	4,256,276	0.3%	Medical
NXTC NextCure	$4,248,251		0.0%	2,671,856	0.2%	Medical
ERAS Erasca	$4,010,886	$4,010,886 ▲	New Holding	1,699,528	0.2%	Medical
PAHC Phibro Animal Health	$3,974,641	$3,974,641 ▲	New Holding	237,009	0.2%	Medical
BAX Baxter International	$3,939,373	$3,270,373 ▲	488.8%	117,769	0.2%	Medical
AVTR Avantor	$2,990,154	$1,937,701 ▼	-39.3%	141,045	0.2%	Medical
TFX Teleflex	$2,870,794	$316,967 ▲	12.4%	13,649	0.1%	Medical
MASI Masimo	$2,539,076	$20,276 ▲	0.8%	20,161	0.1%	Medical
BOLT Bolt Biotherapeutics	$2,065,828		0.0%	2,754,437	0.1%	Medical
INSP Inspire Medical Systems	$1,338,300	$254,411 ▲	23.5%	10,000	0.1%	Medical
IRON Disc Medicine	$1,318,568	$1,040,351 ▲	373.9%	29,256	0.1%	Medical
Perspective Therapeutics Inc	$1,316,927	$1,316,927 ▲	New Holding	132,089	0.1%	COM
ZBH Zimmer Biomet	$1,153,674	$1,153,674 ▲	New Holding	10,630	0.1%	Medical
AMLX Amylyx Pharmaceuticals	$1,139,413	$13,372 ▼	-1.2%	599,691	0.1%	Medical
LIVN LivaNova	$1,129,402	$8,004 ▲	0.7%	20,602	0.1%	Medical
IMTXW Immatics	$932,855	$86,622 ▲	10.2%	348,731	0.0%	Medical
RNA Avidity Biosciences	$875,211	$875,211 ▲	New Holding	21,425	0.0%	Medical
IKNA Ikena Oncology	$631,316		0.0%	382,616	0.0%	Medical
ATXS Astria Therapeutics	$552,297	$552,297 ▲	New Holding	60,692	0.0%	Medical
PDSB PDS Biotechnology	$417,921		0.0%	142,635	0.0%	Medical
LUNG Pulmonx	$381,960	$381,960 ▲	New Holding	60,246	0.0%	Medical
Kyverna Therapeutics Inc	$358,875	$283,875 ▲	378.5%	47,850	0.0%	COM
GPCR Structure Therapeutics	$350,092	$7,147 ▲	2.1%	8,915	0.0%	Medical
MRK Merck & Co., Inc.	$0	$85,938,903 ▼	-100.0%	0	0.0%	Medical
INCY Incyte	$0	$75,609,331 ▼	-100.0%	0	0.0%	Medical
ARGX argenx	$0	$58,782,396 ▼	-100.0%	0	0.0%	Medical
INBX Inhibrx	$0	$45,540,469 ▼	-100.0%	0	0.0%	Medical
SILK Silk Road Medical	$0	$21,782,920 ▼	-100.0%	0	0.0%	Medical
SWAV Shockwave Medical	$0	$11,397,050 ▼	-100.0%	0	0.0%	Medical
FUSN Fusion Pharmaceuticals	$0	$3,350,907 ▼	-100.0%	0	0.0%	Medical
Cooper Cos Inc	$0	$2,154,605 ▼	-100.0%	0	0.0%	COM
NCNA NuCana	$0	$884,192 ▼	-100.0%	0	0.0%	Medical
Perspective Therapeutics Inc	$0	$511,825 ▼	-100.0%	0	0.0%	COM
Nucana PLC	$0	$340,048 ▼	-100.0%	0	0.0%	COMMON SHARES
MIRM Mirum Pharmaceuticals	$0	$75,661 ▼	-100.0%	0	0.0%	Medical