Soleus Capital Management, L.P. Top Holdings and 13F Report (2025) About Soleus Capital Management, L.P.Investment ActivitySoleus Capital Management, L.P. has $1.59 billion in total holdings as of December 31, 2024.Soleus Capital Management, L.P. owns shares of 81 different stocks, but just 28 companies or ETFs make up 80% of its holdings.Approximately 46.78% of the portfolio was purchased this quarter.About 22.58% of the portfolio was sold this quarter.This quarter, Soleus Capital Management, L.P. has purchased 87 new stocks and bought additional shares in 22 stocks.Soleus Capital Management, L.P. sold shares of 23 stocks and completely divested from 30 stocks this quarter.Largest Holdings SPDR S&P Biotech ETF $270,180,000NovoCure $81,643,179TG Therapeutics $80,705,384BioMarin Pharmaceutical $65,822,022Krystal Biotech $56,143,654 Largest New Holdings this Quarter NovoCure $81,643,179 HoldingBioMarin Pharmaceutical $65,822,022 HoldingTeva Pharmaceutical Industries $46,129,720 HoldingIntegra LifeSciences $28,939,680 HoldingAstraZeneca $26,797,680 Holding Largest Purchases this Quarter SPDR S&P Biotech ETF 2,100,000 shares (about $189.13M)NovoCure 2,739,704 shares (about $81.64M)BioMarin Pharmaceutical 1,001,400 shares (about $65.82M)Teva Pharmaceutical Industries 2,093,000 shares (about $46.13M)Integra LifeSciences 1,276,000 shares (about $28.94M) Largest Sales this Quarter Revolution Medicines 503,500 shares (about $22.02M)BeiGene 81,600 shares (about $15.07M)Iovance Biotherapeutics 1,968,500 shares (about $14.57M)Castle Biosciences 409,415 shares (about $10.91M)Elevance Health 29,100 shares (about $10.73M) Sector Allocation Over TimeMap of 500 Largest Holdings ofSoleus Capital Management, L.P. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorXBISPDR S&P Biotech ETF$270,180,000$189,126,000 ▲233.3%3,000,00017.0%ETFNVCRNovoCure$81,643,179$81,643,179 ▲New Holding2,739,7045.1%MedicalTGTXTG Therapeutics$80,705,384$4,415,730 ▲5.8%2,681,2425.1%MedicalBMRNBioMarin Pharmaceutical$65,822,022$65,822,022 ▲New Holding1,001,4004.1%MedicalKRYSKrystal Biotech$56,143,654$22,151,724 ▲65.2%358,3793.5%MedicalGRFSGrifols$49,144,362$15,502,892 ▲46.1%6,605,4253.1%MedicalAXGNAxoGen$48,713,941$824,000 ▼-1.7%2,955,9433.1%MedicalIOVAIovance Biotherapeutics$48,544,000$14,566,900 ▼-23.1%6,560,0003.1%MedicalTEVATeva Pharmaceutical Industries$46,129,720$46,129,720 ▲New Holding2,093,0002.9%MedicalTERNTerns Pharmaceuticals$45,109,450$10,631,016 ▲30.8%8,142,5002.8%MedicalORGOOrganogenesis$39,951,603$2,064,000 ▲5.4%12,484,8762.5%MedicalNRIXNurix Therapeutics$39,617,374$19,537,061 ▲97.3%2,102,8332.5%MedicalUTHRUnited Therapeutics$38,598,579$2,646,300 ▲7.4%109,3942.4%MedicalCELCCelcuity$33,576,989$17,274,873 ▲106.0%2,565,0872.1%MedicalSNDXSyndax Pharmaceuticals$32,944,240$18,521,432 ▲128.4%2,492,0002.1%MedicalJASPER THERAPEUTICS INC$31,950,700$3,223,142 ▲11.2%1,494,4202.0%COM NEWIARTIntegra LifeSciences$28,939,680$28,939,680 ▲New Holding1,276,0001.8%MedicalNPCENeuroPace$27,227,1500.0%2,433,1681.7%MedicalAZNAstraZeneca$26,797,680$26,797,680 ▲New Holding409,0001.7%MedicalCCCCC4 Therapeutics$25,124,191$1,349,806 ▲5.7%6,978,9421.6%MedicalQDELQuidelOrtho$24,372,503$6,188,797 ▼-20.3%547,0821.5%MedicalINSMInsmed$22,111,579$20,021,600 ▲958.0%320,2721.4%MedicalIKTInhibikase Therapeutics$20,556,250$20,556,250 ▲New Holding6,325,0001.3%MedicalASNDAscendis Pharma A/S$19,824,480$19,824,480 ▲New Holding144,0001.2%MedicalRIGEL PHARMACEUTICALS INC$19,018,021$3,294,887 ▲21.0%1,130,6791.2%COMPRAXIS PRECISION MEDICINES I$18,742,838$1,220,432 ▼-6.1%243,5401.2%COM NEWALNYAlnylam Pharmaceuticals$18,071,808$4,094,394 ▲29.3%76,8001.1%MedicalADPTAdaptive Biotechnologies$17,883,936$11,213,006 ▲168.1%2,983,1421.1%MedicalEDAPEdap Tms$16,153,4510.0%7,309,2541.0%MedicalTAKTakeda Pharmaceutical$15,623,200$9,003,200 ▲136.0%1,180,0001.0%MedicalPHVSPharvaris$15,616,879$4,149,979 ▲36.2%814,6521.0%MedicalSRDXSurmodics$15,604,776$9,648,065 ▼-38.2%394,0601.0%MedicalSEPTERNA INC$15,466,866$15,466,866 ▲New Holding675,4091.0%COMMRUSMerus$13,133,098$3,616,300 ▼-21.6%312,3210.8%MedicalOFIXOrthofix Medical$11,984,090$1,387,040 ▲13.1%686,3740.8%MedicalANIPANI Pharmaceuticals$11,348,652$3,521,668 ▼-23.7%205,2940.7%MedicalVSTMVerastem$11,291,414$3,329,154 ▼-22.8%2,184,0260.7%MedicalPTGXProtagonist Therapeutics$10,615,000$10,615,000 ▲New Holding275,0000.7%MedicalDCTHDelcath Systems$9,644,040$9,644,040 ▲New Holding801,0000.6%MedicalCG ONCOLOGY INC$9,423,818$344,160 ▼-3.5%328,5850.6%COMACLXArcellx$9,281,867$2,147,320 ▲30.1%121,0310.6%MedicalLLYEli Lilly and Company$8,999,976$5,899,624 ▼-39.6%11,6580.6%MedicalRVMDRevolution Medicines$8,795,414$22,023,090 ▼-71.5%201,0840.6%MedicalTHERATECHNOLOGIES INC$8,690,4910.0%4,801,3760.5%COM NEWNUVLNuvalent$8,169,066$2,348,400 ▲40.3%104,3570.5%MedicalPCVXVaxcyte$8,108,233$5,893,920 ▲266.2%99,0500.5%MedicalEOLSEvolus$7,696,624$3,759,363 ▼-32.8%697,1580.5%MedicalIMUXImmunic$7,293,0070.0%7,293,0070.5%MedicalSRRKScholar Rock$7,241,208$7,241,208 ▲New Holding167,5430.5%MedicalCSTLCastle Biosciences$6,740,238$10,910,910 ▼-61.8%252,9170.4%MedicalMYOMyomo$5,796,000$5,796,000 ▲New Holding900,0000.4%MedicalANABAnaptysBio$5,481,360$5,481,360 ▲New Holding414,0000.3%MedicalERASErasca$5,427,0270.0%2,162,1620.3%MedicalEWTXEdgewise Therapeutics$4,894,110$4,894,110 ▲New Holding183,3000.3%MedicalVCELVericel$4,431,017$4,431,017 ▲New Holding80,6960.3%MedicalCRNXCrinetics Pharmaceuticals$4,346,050$4,346,050 ▲New Holding85,0000.3%MedicalEPIXESSA Pharma$4,049,027$3,626,793 ▼-47.2%2,262,0260.3%MedicalNSPRInspireMD$3,624,4770.0%1,378,1280.2%MedicalRCKTRocket Pharmaceuticals$3,414,754$3,414,754 ▲New Holding271,6590.2%MedicalMDGLMadrigal Pharmaceuticals$3,363,413$3,363,413 ▲New Holding10,9000.2%MedicalREPLReplimune Group$3,178,875$3,178,875 ▲New Holding262,5000.2%MedicalAPOGEE THERAPEUTICS INC$3,171,000$3,171,000 ▲New Holding70,0000.2%COMCALCCalciMedica$2,775,0200.0%783,9040.2%MedicalMREOMereo BioPharma Group$2,754,336$210,000 ▼-7.1%786,9530.2%MedicalYMABY-mAbs Therapeutics$2,740,359$391,500 ▼-12.5%349,9820.2%MedicalESTAEstablishment Labs$2,736,5580.0%59,4000.2%MedicalBLCOBausch + Lomb$2,176,230$3,458,490 ▼-61.4%120,5000.1%MedicalMDXHEALTH SA$2,018,501$600,350 ▼-22.9%851,6880.1%SHS NEWELVNEnliven Therapeutics$1,696,613$3,696,751 ▼-68.5%75,4050.1%MedicalREGNRegeneron Pharmaceuticals$1,638,359$1,638,359 ▲New Holding2,3000.1%MedicalTECTONIC THERAPEUTIC INC$1,470,099$1,470,099 ▲New Holding31,8410.1%COMADVERUM BIOTECHNOLOGIES INC$1,341,4390.0%287,2460.1%COM NEWAADIAadi Bioscience$1,051,3310.0%333,2270.1%MedicalABIVAX SA$915,0000.0%125,0000.1%SPONSORED ADSVRDNViridian Therapeutics$872,235$948,915 ▼-52.1%45,5000.1%MedicalGSKGSK$341,920$926,329 ▼-73.0%10,1100.0%MedicalWGSGeneDx$307,440$307,440 ▲New Holding4,0000.0%MedicalTHCTenet Healthcare$255,868$255,868 ▲New Holding2,0270.0%MedicalBGNEBeiGene$212,417$15,072,371 ▼-98.6%1,1500.0%MedicalELVElevance Health$202,895$10,734,990 ▼-98.1%5500.0%MedicalIOBTIO Biotech$177,2560.0%192,6700.0%MedicalSNYSanofi$0$35,269,560 ▼-100.0%00.0%MedicalIDYAIDEAYA Biosciences$0$33,242,268 ▼-100.0%00.0%MedicalTXG10x Genomics$0$21,473,580 ▼-100.0%00.0%MedicalKROSKeros Therapeutics$0$13,042,522 ▼-100.0%00.0%MedicalBHCBausch Health Companies$0$11,619,840 ▼-100.0%00.0%MedicalLBPHLongboard Pharmaceuticals$0$10,607,906 ▼-100.0%00.0%MedicalENTAEnanta Pharmaceuticals$0$8,138,257 ▼-100.0%00.0%MedicalKIDSOrthoPediatrics$0$7,833,299 ▼-100.0%00.0%MedicalKINIKSA PHARMACEUTICALS INTL$0$7,559,475 ▼-100.0%00.0%ORD SHS CL ABDSXBiodesix$0$7,187,756 ▼-100.0%00.0%MedicalRLAYRelay Therapeutics$0$6,442,800 ▼-100.0%00.0%MedicalSMMTSummit Therapeutics$0$6,241,500 ▼-100.0%00.0%MedicalAPLTApplied Therapeutics$0$5,786,664 ▼-100.0%00.0%MedicalARVNArvinas$0$5,635,344 ▼-100.0%00.0%MedicalALECAlector$0$5,626,349 ▼-100.0%00.0%MedicalENGENE HOLDINGS INC$0$5,280,000 ▼-100.0%00.0%COMTMCITreace Medical Concepts$0$5,150,058 ▼-100.0%00.0%MedicalSLNSilence Therapeutics$0$4,726,800 ▼-100.0%00.0%MedicalBCABBioAtla$0$4,430,761 ▼-100.0%00.0%MedicalShowing largest 100 holdings. 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