Vr Adviser, LLC Top Holdings and 13F Report (2025) About Vr Adviser, LLCInvestment ActivityVr Adviser, LLC has $1.46 billion in total holdings as of December 31, 2024.Vr Adviser, LLC owns shares of 37 different stocks, but just 14 companies or ETFs make up 80% of its holdings.Approximately 6.50% of the portfolio was purchased this quarter.About 9.22% of the portfolio was sold this quarter.This quarter, Vr Adviser, LLC has purchased 38 new stocks and bought additional shares in 5 stocks.Vr Adviser, LLC sold shares of 10 stocks and completely divested from 4 stocks this quarter.Largest Holdings APOGEE THERAPEUTICS INC $384,747,441Ocular Therapeutix $108,991,425Enliven Therapeutics $90,592,448PRAXIS PRECISION MEDICINES I $76,189,246Viridian Therapeutics $74,431,532 Largest New Holdings this Quarter UPSTREAM BIO INC $37,735,044 HoldingCIDARA THERAPEUTICS INC $20,582,634 HoldingGlycoMimetics $747,000 Holding Largest Purchases this Quarter UPSTREAM BIO INC 2,295,319 shares (about $37.74M)PRAXIS PRECISION MEDICINES I 283,854 shares (about $21.85M)CIDARA THERAPEUTICS INC 765,723 shares (about $20.58M)ENGENE HOLDINGS INC 1,480,573 shares (about $9.85M)ORUKA THERAPEUTICS INC 200,000 shares (about $3.88M) Largest Sales this Quarter Merus 315,552 shares (about $13.27M)Terns Pharmaceuticals 2,332,968 shares (about $12.92M)Aquestive Therapeutics 2,925,769 shares (about $10.42M)Taysha Gene Therapies 5,774,820 shares (about $9.99M)Astria Therapeutics 1,001,297 shares (about $8.95M) Sector Allocation Over TimeMap of 500 Largest Holdings ofVr Adviser, LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorAPOGEE THERAPEUTICS INC$384,747,4410.0%8,493,32126.4%COMOCULOcular Therapeutix$108,991,4250.0%12,762,4627.5%MedicalELVNEnliven Therapeutics$90,592,4480.0%4,026,3316.2%MedicalPRAXIS PRECISION MEDICINES I$76,189,246$21,845,404 ▲40.2%989,9855.2%COM NEWVRDNViridian Therapeutics$74,431,5320.0%3,882,7095.1%MedicalORUKA THERAPEUTICS INC$63,708,172$3,878,000 ▲6.5%3,285,6204.4%COMSPYRE THERAPEUTICS INC$62,517,2290.0%2,685,4484.3%COM NEWPHVSPharvaris$61,729,892$3,363,875 ▼-5.2%3,220,1304.2%MedicalKALVKalVista Pharmaceuticals$52,935,2220.0%6,249,7313.6%MedicalDYNE THERAPEUTICS INC$51,217,3900.0%2,173,9133.5%COMCOGTCogent Biosciences$44,338,406$1,903 ▲0.0%5,684,4113.0%MedicalERASErasca$40,702,7020.0%16,216,2162.8%MedicalDIANTHUS THERAPEUTICS INC$38,027,3310.0%1,744,3732.6%COMUPSTREAM BIO INC$37,735,044$37,735,044 ▲New Holding2,295,3192.6%COMORICORIC Pharmaceuticals$35,463,8330.0%4,394,5272.4%MedicalENGENE HOLDINGS INC$33,558,653$9,845,810 ▲41.5%5,046,4142.3%COMMRUSMerus$24,910,883$13,268,962 ▼-34.8%592,4111.7%MedicalATXSAstria Therapeutics$21,968,691$8,951,595 ▼-29.0%2,457,3481.5%MedicalCIDARA THERAPEUTICS INC$20,582,634$20,582,634 ▲New Holding765,7231.4%COM NEWCGEMCullinan Therapeutics$16,807,9740.0%1,379,9651.2%MedicalFDMT4D Molecular Therapeutics$16,444,706$8,063,293 ▼-32.9%2,952,3711.1%MedicalARTIVA BIOTHERAPEUTICS INC$16,224,4560.0%1,609,5691.1%COMMRSNMersana Therapeutics$14,668,640$1,530,400 ▼-9.4%10,257,7901.0%MedicalABIVAX SA$9,851,1100.0%1,345,7800.7%SPONSORED ADSAQSTAquestive Therapeutics$9,362,038$10,415,737 ▼-52.7%2,629,7860.6%MedicalAPLTApplied Therapeutics$8,553,944$141,779 ▲1.7%9,990,5910.6%MedicalPERCEPTIVE CAP SOLUTIONS COR$7,635,0000.0%750,0000.5%CL A ORD SHSTERNTerns Pharmaceuticals$5,967,079$12,924,644 ▼-68.4%1,077,0900.4%MedicalTSHATaysha Gene Therapies$5,579,561$9,990,438 ▼-64.2%3,225,1800.4%MedicalTRVITrevi Therapeutics$5,217,803$8,883,540 ▼-63.0%1,266,4570.4%MedicalZURAZura Bio$5,057,9150.0%2,023,1660.3%MedicalIPSCCentury Therapeutics$3,996,758$1,446,394 ▼-26.6%3,957,1860.3%MedicalCASICASI Pharmaceuticals$2,793,9430.0%987,2590.2%MedicalTNYATenaya Therapeutics$2,224,4450.0%1,555,5560.2%MedicalTENAX THERAPEUTICS INC$1,289,5810.0%208,3330.1%COM NEWGLYCGlycoMimetics$747,000$747,000 ▲New Holding3,000,0000.1%MedicalINSTIL BIO INC$633,3490.0%33,1770.0%COM NEWEWTXEdgewise Therapeutics$0$26,690,000 ▼-100.0%00.0%MedicalARVNArvinas$0$11,193,104 ▼-100.0%00.0%MedicalADVERUM BIOTECHNOLOGIES INC$0$10,298,677 ▼-100.0%00.0%COM NEWCABACabaletta Bio$0$7,381,853 ▼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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