Royalty Pharma Q3 2023 Earnings Call Transcript

Quartr
Provided by Quartr
November 8, 2023

There are 12 speakers on the call.

Operator

Ladies and gentlemen, thank you for standing by. Welcome to the Royalty Farmer Third Quarter 2023 Earnings Conference Call. I would like now to turn the conference over to George Grofik, Senior Vice President, Head of Investor Relations and Communications. Please go ahead.

Speaker 1

Good morning and good afternoon to everyone on the call. Thank you for joining us to review Royalty Pharma's Q3 2023 results. You can find the press release with our earnings results and slides of this call on the Investors page of our website at royaltypharma.com. Moving to Slide 3, I would like to remind you that information presented in this call contains forward looking statements that involve known and unknown risks, uncertainties and other factors that may cause actual results to differ materially from these statements. I refer you to our 10 ks on file with the SEC for a description of these risks.

Speaker 1

All forward looking statements are based on information currently available to Royalty Pharma, and we assume no obligation to update any such forward looking statements. Non GAAP financial measures will be used to help you understand our financial performance. The GAAP to non GAAP reconciliations are provided in the earnings press release available on our website. And with that, please advance to Slide 4. Our speakers on the call today are Pablo Legaretta, Founder and Chief Executive Officer Chris Hite, EVP, Vice Chairman Marshall Yoojouris, EVP, Head of Research, Investment and Terri Coyne, EVP, Chief Financial Officer.

Speaker 1

Pablo will discuss key highlights. Chris will then provide an update on the PTC partnership, after which Marshall will discuss other portfolio updates. Next, Terry will review the financials. Following concluding remarks from Pablo, we will hold the Q and A session. And with that, I'd like to turn the call over to Pablo.

Speaker 2

Thank you, George, and welcome to everyone on the call. I am delighted to report another successful quarter of execution against our strategy as a leading funder of innovation in Life Sciences. Slide 6 summarizes our financial portfolio and portfolio achievements in the 3rd quarter, which again underscored tremendous momentum in our business. First, we delivered strong financial performance. Adjusted cash receipts, our top line, grew by 9%, Adjusted EBITDA by 9% and adjusted cash flow grew by 10%.

Speaker 2

All of these metrics are prior to the Biohaven related payment, which we received in the Q3 of 2022. 2nd, on capital allocation, We had a very active past few months acquiring royalties on attractive therapies with announced transactions of $2,200,000,000 I am particularly pleased with our recently expanded PPC partnership, where we acquired incremental royalties on ABRISI, which is for the treatment of spinal muscular atrophy. This transaction enhances our long term growth, Diversifies our portfolio and is expected to generate an attractive unlevered return in the double digits. As Chris will explain later, this transaction was a great example of our unique ability to create Tailored Win Win Solutions. This was also our busiest quarter ever for synthetic royalty acquisitions With exciting transactions on 2 approved therapies, SKYTROFA and ABLSTELADRIEN.

Speaker 2

On a year to date basis, we have announced Royalty transactions of up to $3,800,000,000 including $2,100,000,000 in upfront payments. Lastly, We continue to believe our shares are fundamentally undervalued and we repurchased an additional 144,000,000 of our shares in the 3rd quarter, taking our total year to date repurchases to 305,000,000 dollars as of last night's close. 3rd, we're raising our full year guidance for adjusted cash received to between $2,950,000,000 $3,000,000,000 Our guidance reflects expected underlying growth from our portfolio of around 10% prior to the bihaven related payments. Consistent with our standard practice, our guidance is based on our current portfolio and does not include the benefit of any future acquisitions. On Slide 7, you can see our financials in more detail.

Speaker 2

We delivered 9% growth in our top line prior to the ByHavan related payment In the prior period and 7% growth if we include these payments. Unlike the last several quarters, the impact of foreign exchange had a negligible impact Similar to our top line, we grew adjusted EBITDA by 9% in the quarter, prior to the Bahiaveen related payments and 6% including these payments. Lastly, adjusted cash flow Grew by 10% in the quarter prior to the Bahama related payment and 8% including this payment. Both this quarter and the prior period included development stage payments. Slide 8 shows our impressive track record of strong top line growth since our IPO in June of 2020.

Speaker 2

We delivered 9% growth prior to the BioHimand related payment through the 1st 3 quarters of 2023 After strong growth in 2021 2022, this speaks to our ability to execute successfully and consistently against our strategy in the growing market for biopharma royalties. Slide 9 shows why we're well positioned in the evolving interest rate environment. We're committed to maintaining an investment grade credit rating and our existing capital structure benefits from a long duration low cost debt profile. That being said, when making investments In a higher rate environment, our marginal cost of borrowing will inevitably rise. However, what is critical to recognize and that is Our royalty return expectations also adjust to this higher rate environment.

Speaker 2

This allows us to continue to deliver attractive returns above our cost of capital. The other important asset to consider is that our opportunity set has expanded dramatically, driven by the huge capital needs of the industry and the increased role of royalties. And this trend has been accelerated by the macro environment, which has increased the cost of other sources of financing for both for biopharma companies. So taken together, We're confident that Royalty Pharma will continue to thrive and perform strongly in an evolving rate environment. On Slide 10, we want to unpack why we remain so excited about our ability to create compounding value for shareholders.

Speaker 2

When we make investments, we focus on our cost of capital and then the spread that we're able to generate in excess of our cost of capital. The beauty of our business is that we can quickly adjust to changing to the changing macro environment. Historically, When we look at the period from 2012 to 2021, our cost of capital was roughly 6%. We were very fortunate to take advantage Of all time low interest rate environment in 2020 2021, locking

Operator

Ladies and gentlemen, please standby. Ladies and gentlemen, please standby. Ladies and gentlemen, please standby. Ladies and gentlemen, please standby. The call will resume momentarily.

Speaker 1

Slide no, start on slide 10.

Speaker 2

Okay. Hello? Operator, are we on?

Operator

Yes, Sheila. Yes, you may resume your call.

Speaker 2

Okay. Apologies for that. On Slide 10, we want to unpack why we remain so excited about our ability When we make investments, we focus on our cost of capital and then the spread that we're able to generate in excess of our cost of capital. The beauty of our business is that we can quickly adjust to changing macro environments. Historically, when we look at the period from 2012 to 2021, Our cost of capital was roughly 6%.

Speaker 2

We were very fortunate to take advantage of the all time Low rate environments in 2020 2021, locking in long duration low cost debt at around 2.25. However, For most of this time period, the business was funded consistently with around 4% debt. When we look at the investments for approved Therapies we made over this period, we expected them to generate effective returns with spreads above our cost of capital. When we shift to the current environment, Our cost of capital has increased to around 7% to 8%, as our marginal cost of debt has increased to 5% to 7%. However, the returns we're targeting on approved royalties have risen as well, allowing us to maintain attractive spreads above our cost of capital.

Speaker 2

Equally important is that the opportunity set has expanded dramatically with the value of announced transactions of nearly 2 times With our pipeline showing no signs of slowing down. Taken together, these factors will result in greater value creation for our shareholders. With that, I will hand it over to Chris to update you on the PTC partnership.

Speaker 3

Thanks, Pablo. Since our last earnings call, we have been quite busy getting some really exciting royalty transactions over the finish line. I want to focus on Slide 12 on our expanded partnership with PTC on evarizd. We gained our first exposure to this exciting therapy in July 2020 when we acquired 43% of PTC royalties interest for $650,000,000 upfront, giving us a royalty that equated to 3.4% to 6.9% of global Everisde sales. This transaction was structured so that the royalties to Royalty Pharma would cease once we had received $1,300,000,000 and aggregate royalties or double our original investment.

Speaker 3

At the time of our 2020 investment, EVERISD was on the cusp of FDA approval. Since then, our initial conviction in the profile of EVORISTI has been validated by strong global launch by Roche. More than 11,000 SMA patients have now been treated with Everisti and sales reached $1,200,000,000 in 2022. Everisbee is now approaching global category leadership and consensus forecast has risen substantially with sales now expected to reach $3,300,000,000 by 2,030. Last month, in return for an upfront payment of 1,000,000,000 We acquired 67% of PTC's remaining royalty without any cap.

Speaker 3

This takes our ownership to 81% of the TIER royalties Before the cap, we're an effective royalty of 6.5% to 13% of EVRISD global sales. The duration of the royalty now extends to 2,035 to 2,036 from the early 2030s. Additionally, there is a joint option structure for the remainder of PTC's royalty interest. This allows PTC to sell all of its residual 19% of the royalty to us by the end of 2025 in return for a $500,000,000 payment less royalties received. Alternatively, If PTC chooses not to exercise this option, we have the right to purchase half of PTC's remaining residual royalty for $250,000,000 In the Q1 of 2026, less royalties received.

Speaker 3

This creative structure highlights our unique ability to tailor win win solutions with our partners. As a result of this transaction, Eversity is expected to become a top four royalty for us By 2025, with a contribution to adjusted cash receipts in excess of $200,000,000 It ticks all of the boxes for us, Clearly aligning with our product selection framework, on a purely financial basis, it diversifies our portfolio, enhances our growth, And we expect it to deliver an unlevered return in the double digits based on consensus sales forecast. And with that, I'll hand it over to Marshall.

Speaker 4

Thanks, Chris. Let's now move to Slide 14 to discuss our recent synthetic royalty transaction. Their combined value of up to $650,000,000 sets a record for synthetic royalty financing in a quarter and we believe is clear evidence addseladrine from Ferring for up to $500,000,000 which is approved for bladder cancer. This is the first gene therapy in our portfolio. Our royalty is expected to increase to 8% in 2025, assuming a manufacturing milestone is achieved and extends to the early to mid-two thousand and thirty.

Speaker 4

Then in September, we acquired a royalty of 9.15 percent on U. S. Sales of SKYTROPHA from Ascendis for $150,000,000 This is the 1st FDA approved weekly growth hormone therapy for pediatrics and addresses a significant unmet patient need, which is reflected in consensus sales forecast of around $450,000,000 by 2,030. In both cases, our partner had a need for non dilutive capital to advance their commercial strategy and we were able to provide a flexible funding solution that met their needs and our return requirements. On Slide 15, the Everisti transaction illustrates an important feature of our business model, namely our unique ability to invest multiple times in the same therapeutic area and even in the same product.

Speaker 4

We've demonstrated this across a number of therapeutic areas, including prostate cancer, migraine, multiple sclerosis, schizophrenia and the emerging Lp class and the expanded investment in Everisde for SMA is the latest example of these unique aspects of our business model. Slide 16 provides our perspective on how we approach contribution of approved and development stage therapies to our portfolio growth strategy. Of the approximately $23,000,000,000 in capital deployed Since we started investing in development stage therapies, around 60% has been in approved products. This balanced approach has allowed us to maintain strong risk adjusted returns and sustain attractive growth. On my final slide, I wanted to take a step back to underscore the growth in our opportunity to fund life science innovation.

Speaker 4

Over the past 3 years, we have seen a substantial increase in the announced value of transactions with 2023 tracking to be among our best years ever. We have averaged $3,400,000,000 over the past 3 years, which is almost double the announced value of transactions compared to the prior 3 years. This speaks to the powerful secular growth behind royalty based funding as an attractive way to fund the life sciences. With that, I'd like to hand it over to Jerry.

Speaker 5

Thanks, Marshall. Let's move to Slide 19. Total royalty receipts grew 5% in the Q3 versus the year ago period. Excluding the Biohaven related payment in the prior year period, royalty receipts grew approximately 7%. The increase was mainly due to the strong performance of the cystic fibrosis franchise and TRELEGY as well as newly acquired royalties on SPINRAZA.

Speaker 5

We also saw growth contributions from the majority of our other key royalties, including Ibrisdi, TREMFYA, Trodelvi, Promacta and CABOMETYX. These positive factors were partially offset by weakness in IMBRUVICA and TYSABRI. Slide 20 provides a deeper dive into our top line performance in the quarter to show the various moving parts. Solid performance of our base business together with new royalty acquisitions allowed us to deliver 9% top line growth before the impact of the prior period Biohaven related payment. Royalty expiries, primarily Lexiscan, represented a headwind to growth of around 2%.

Speaker 5

As Pablo noted, the impact of foreign exchange was negligible this quarter. These strong underlying dynamics Slide 21 shows how our efficient business model generates substantial cash flow to be redeployed. As you're aware, we arrive at adjusted cash receipts after deducting distributions to non controlling interests. This amounted to $637,000,000 in the quarter, representing growth of 7% compared with last year's Q3 or 9% if we adjust for the prior period Biohaven related payment. Operating and professional costs were approximately 9% of adjusted cash receipts in the quarter.

Speaker 5

As a consequence, we reported 6% growth in adjusted EBITDA in the quarter, broadly consistent with our top line growth. When we think of the cash generated by the business to be redeployed into new value enhancing royalties, We look to adjusted EBITDA less net interest paid. Net interest paid in the quarter of $54,000,000 reflected the semiannual timing of the payments on our unsecured notes, which occur in the 1st and third quarters and interest received on our cash balance. You should note that we repaid $1,000,000,000 of these notes in the quarter, so that our balance now stands at $6,300,000,000 Development stage funding payments amounted to $51,000,000 in the quarter, substantially all of which related to the initiation of the pivotal study of apacamten in non obstructive hypertrophic cardiomyopathy. Taking this into account, adjusted cash flow, our bottom line grew by 8% to $474,000,000 or $0.79 per share for the quarter.

Speaker 5

This resulted in an adjusted cash flow margin of 74%, which again highlights the efficiency of our business model. Let's move now to Slide 22 and our financial position. Following the recent PTC transaction, we continue to maintain significant financial capacity for future royalty acquisitions. With around $3,000,000,000 available through a combination of cash on our balance sheet, the cash our business generates and access to the debt markets. At the end of the Q3, we had cash and equivalents of $936,000,000 After quarter end, we funded the $1,000,000,000 upfront payment to PTC through cash on our balance sheet and a $350,000,000 draw on our revolving If we adjust for this transaction together with projected net cash flow from our business of approximately $425,000,000 to $475,000,000 in the 4th quarter, we expect to have projected cash and equivalents of around $700,000,000 to $750,000,000 at the end of 2023.

Speaker 5

With $6,300,000,000 of investment grade bonds, plus the $350,000,000 pre payable revolver draw. This results in pro form a leverage of around 2 times EBITDA on both a total and net debt basis. Keep in mind that we are comfortable taking gross leverage up to around 4x for the right royalty acquisition opportunity. Furthermore, we have additional financial capacity from the $1,150,000,000 balance of the revolver as well as the strong cash generation that I've already highlighted. Consequently, we feel good about our ability to continue to execute transactions Slide 23 updates our full year 2023 financial guidance.

Speaker 5

We now expect adjusted cash receipts to be in the range of $2,950,000,000 to $3,000,000,000 We have raised the midpoint of the range by approximately $40,000,000 compared with the previous guidance based on our strong portfolio performance. As a reminder, This guidance includes the $475,000,000 absapret milestone we received in the Q1. Additionally, for your modeling consideration, Looking ahead to 2024, we are currently estimating around $200,000,000 to $250,000,000 in other product royalty receipts. Importantly and consistent with our standard practice, this guidance is based on our portfolio as of today and does not take into account the benefit of any future royalty acquisitions. As it relates to operating professional costs and interest paid, There is no change to our previous guidance.

Speaker 5

However, please note that the interest paid guidance does not take into account interest received on our cash balance, which was $63,000,000 year to date. My final slide drills down further on our adjusted cash receipts guidance. The graphic is illustrative, but sets out the various pushes and pulls behind our outlook for 2023. Starting with the left hand side, We face a high base of comparison due to the $509,000,000 of Biohaven related payments, which we received in 2022. Adjusting for these payments brings the underlying base for 2022 adjusted cash receipts to $2,280,000,000 On the right hand side, if we start from the adjusted cash receipts base prior to Biohaven, we expect underlying growth of 9% to 11% this year.

Speaker 5

Including the $475,000,000 payment on Zavzapret, we arrive at our raised top line guidance of $2,950,000,000 to $3,000,000,000 With that, I would like to hand the call back to Pablo for his closing comments.

Speaker 2

Thanks, Terry. Let me start by concluding my concluding remarks by saying how pleased I am with this Q3 report. Today, you have heard about strong financial performance and some really exciting new royalty transactions, which put 2023 On track to be one of our best years ever for capital deployment. My next slide puts this into perspective. Slide 26 highlights that we have announced transactions worth up to $7,300,000,000 since the start of 2022 with a healthy balance Between approved and development stage therapies, this extraordinary level of activity highlights The power of our business model as well as the tailwinds in our industry.

Speaker 2

It also puts us on track to meet or exceed Our 5 year capital deployment target of $10,000,000,000 to $12,000,000,000 My final slide highlights some of our key accomplishments since 2020. The strong performance taken together with our fast expanding opportunity set and powerful competitive mode makes me highly confident We will deliver our attractive long term financial outlook. That means a top line CAGR of 11% to 14% over 2020 to 2025 And 10% plus when we look to 2,030. With that, we would be happy to take your questions.

Operator

The first question comes from Chris Schott with JPMorgan. Your line is open.

Speaker 6

Great. Thanks so much for the questions here. Maybe just 2 for me. First, you talked about the macro environment expanding Your opportunity set dramatically. And I'm just interested to see where you're seeing kind of maybe the greatest incremental opportunities.

Speaker 6

So Is this development stage deals of companies that need funding? Is the companies needing launch capital to get products off the ground? Or is it deals more like the PTC deal where Companies looking to monetize existing royalties. I'm just trying to get a sense of like is of those buckets, is one really standing out over the other? And then my second question was just on competitive environment.

Speaker 6

I think you're in an enviable position that you're able to kind of recycle capital and self fund much of your BD in this environment, which is a bit different than peers. So can you just talk about what you're seeing for the competitive environment for deals out there? And has that set changed at all versus where we were a year or 2 ago? Thanks.

Speaker 2

Thank you, Chris. So I'll ask Chris Guy to take the first part of the question.

Speaker 3

Sure. Thanks, Pavel. Thanks for the question, Chris. The macro environment between development stage, launch capital, Monetization of existing royalties like the PTC deal. Look, it's we're I think last year we Showed a slide that we looked at 350 opportunities greater than that at the top of our funnel.

Speaker 3

And as you might imagine, that comprised all of those different sets of opportunities. And Yes, when we've done deals around development stage like in funding R and D like we did with Merck last year And the synthetic royalties like we've done this year, I would what I would tell you is the entire environment is increasing. It's Hard for me to say, we're getting more development stage deals or more monetization deals right now. All I can really tell you is, And I think as Pablo highlighted, just the amount of opportunities and the opportunity set Has grown dramatically, and we don't see any slowdown in that. And it's really evidenced by the fact that we've deployed Since 2020, announced deal volume of nearly $13,000,000,000 with nearly $9,000,000,000 upfront.

Speaker 3

So That's sort of the proof in the pudding, I guess.

Speaker 2

Yes. And Chris, Marshall can answer the second part of your question related to the competitive environment.

Speaker 4

Hey, Chris. Good morning. It's a good question. Overall, I think the message is no real change in the competitive Environment, I think we've talked in the past about we have always operated in a competitive environment and certainly The kind of complexion of the competition changes depending on the type of deal, but I think no real change. I think the really important thing is as we continue to execute against our strategy as the business It gets bigger and bigger.

Speaker 4

It really continues to expand our competitive advantages versus the rest of the market in terms of Our flexibility, our ability to do large deals, our ability to really partner long term with our partners, our creativity, to continue to evolve how we work with companies to meet the needs of life science innovators across So I think we feel really confident about where we are and overall no real change on the competitive front.

Speaker 2

Great. Thanks so much.

Operator

Please standby for the next question. The next question comes from Steven Scala with T. V. Cohen. Your line is open.

Speaker 7

Thank you very much. I have two questions. I assume that Royalty Pharma analyzes clinical trials prior to their readout. What is your analysis telling you on the readouts of the new Vertex triple studies? Does your analysis suggest that they will achieve their endpoints?

Speaker 7

If they don't achieve their endpoints, then what is the most likely reason? Your answer may be that you don't Talk about other companies' trials, but this is material to your stock. So I think your view would be useful to your shareholders. 2nd question is, I'm curious what surprised you regarding the initial list of 10 drugs from the IRA negotiation Procedure, whether it be what was included or excluded and how does it influence your future progression relative to investments? Thank you.

Speaker 2

Sure. So Terry will take your the first question related to cystic fibrosis and then Marshall can talk about the IRA, the list of the 10 drugs And I

Speaker 5

already? Yes, sure, Steve. So, yes, of course, we're focused on this readout As well as I'm sure many investors are. Our expectation is that the trial will succeed, And I think we'll have to wait to see the full data to sort of get a sense of the overall benefit. But based on what we've seen in the Phase II trial, it's hard to say at this point that it's clearly better than Trikafta.

Speaker 5

So we'll wait and see there. But I think the key thing for Royalty Pharma is that last quarter, we really tried to unpack The potential impact to our business under a range of scenarios, including Share conversion scenarios where a lot of patients switch and also lower royalty rate scenarios. And What we've pointed to and we still feel really good about this is that the impact on our business Under any scenario is very manageable, a couple of $100,000,000 is how we've described it and we still feel really good about that. And We still feel also feel really good about our ability to grow over this decade by 10% or more, Even under those scenarios. So we'll wait and see the full data.

Speaker 5

The bar is obviously really high with Trikafta, but it sounds like we'll see something in early 1Q.

Speaker 4

And Steve, good morning. Briefly on the IRA, so we were really focused on the impact to Realty Pharma. And I think there, it was we had highlighted 2 products for this year that could have been on there IMBRUVICA and Xtandi. IMBRUVICA obviously was, Xtandi was not. And so I guess that was a little bit of a surprise.

Speaker 4

But like we have said, with Xtandi's Patent Life ending shortly thereafter, it wasn't really a material impact to Realty Pharma. Anyway, beyond that, In terms of what was on the list or the approach that was taken to put the list together, we'll probably refrain from commenting there. I think it's so early in terms of How that of how the list is generated, what factors come in, there just isn't a lot of insight to be added there. But Certainly with respect to Realty Pharma, we felt like it was a constructive outcome. Thank you.

Operator

Please stand by for the next question. The next question comes from Andrew Baum with Citigroup. Your line is open.

Speaker 8

Good morning. Thank you. A couple of questions. Firstly, for Terry, just following on your comments on the ability to increase leverage at royalty. Should I read into this a guide to larger capital deployment or alternatively even a big upsizing of your buyback given The comments about the undervaluation of the stock.

Speaker 8

2nd, if you could just update us on the sell down of your pre IPO Shareholders. And then finally, could you just confirm there's no impact from the AMP cap removal in Medicaid on your portfolio. Many thanks.

Speaker 5

Sure. So on the question about leverage, I think the message there is that we have A lot of dry powder and a lot of financial flexibility. And so, if the right opportunities come along and We've been deploying a lot of capital. And as Chris mentioned, we're not seeing any signs of that slowing down. We feel like we have access to the capital that we'll need to take advantage of those opportunities if and when they present themselves.

Speaker 5

So we feel really good about that. On the question about share buyback, we've Repurchased around a little over $300,000,000 year to date. We have $1,000,000,000 repurchase authorization. And I think we'll continue to be opportunistic and balance that against other opportunities, particularly Opportunities to buy really excite royalties on really exciting products like the announcement that we made a couple of weeks ago on Abrisdi. So as you know, our number one priority is buying royalties.

Speaker 5

But we do think that with our stock at these levels, it's Returning some share some capital to shareholders through share repurchases is also a really attractive tool that we will certainly Look at from time to time. Your second question On pre IPO shareholders, yes, on pre IPO shareholders, so we did see a major shift in the shareholder base Over the last couple of years, we feel like that has Mostly run it actually, it's really run its course at this point. So there's not really much left that is really obvious to us. But that was definitely something that was a headwind for the business as we saw that transition. But we do feel like that's largely run its course.

Speaker 4

And then just quickly on your last question, Andrew, so the answer is no, we don't think that there's any kind of major material exposure there. The only caveat I would say is, and we've discussed this before that we don't always have perfect insight into the payer mix of some of our royalties. So we so there is some lack of precision there. But as of right now, no, we don't think there is a material impact.

Speaker 8

Many thanks.

Operator

Please standby for the next question. The next question comes from Umer Raffat with Evercore. Your line is open.

Speaker 9

Hi, guys. This is Mike DiFiori in for Umer. Thanks so much for taking our questions and congrats on all the progress this quarter. Two questions, one big picture, 1 in the pipeline. The big picture one dovetails on what was asked previously a little bit.

Speaker 9

I mean clearly Royalty Pharma has been pursuing less development stage deals since 2020 despite deploying increasingly greater capital. And my question is, are compelling or high conviction Phase 2, 3 opportunities becoming increasingly scarce Despite a growing opportunity set or has there been a fundamental change in Royalty Pharma's risk tolerance or could it be more macro or interest rate driven? I have a follow-up.

Speaker 2

Sure. Thank you, Marshall. Do you want to take that question?

Speaker 4

Sure, Mike. Thanks for the question. So overall, no, there's no change in strategy or how we think about approved versus unapproved investments. We've shown from one of the slides in the prepared remarks about how it has really Varied when you see approved and unapproved from year to year. We have seen more We have seen greater levels of investment in approved products over the past couple of years, but I wouldn't interpret that to say that that's A permanent sort of strategic positioning as we've talked about in the past, it really is about finding the things that We are most excited about in any period of time.

Speaker 4

And so that's what that looked like over the past couple of years. But I think we do think about the business and the Strategy over years over many years at a time. And so I would continue to expect there to be some variance in approved in development stage investments from year to year like you've seen historically.

Speaker 9

Got it. And my product specific question is on trontinumab from Roche. The CTAD data showed very little ARIA And some folks out there think that Roche simply got lucky, given the notably high C MAX. My question is what gives you confidence that ARIA rates will remain low and that this investment in trintinumab will remain competitive? Thank you.

Speaker 4

Sure, Mike. We were excited to see the trantinumab data, and I think We are looking forward to seeing more. As to your specific question on ARIA, very hard to generalize right now. I think Given the technology, given the dynamics of how the drug is taken up into the brain, It's probably very hard to compare it to historical data sets, and I think we're just going to have to see, how Roche moves it forward. But I do think it at a high level, it really speaks to how we do build the portfolio And how it's really nice to have things like truntinumab in the portfolio that do give us some option value and flexibility As that development moves forward.

Speaker 9

Great. Thanks so much.

Operator

Please standby for the next question. The next question comes from Terence Flynn with Morgan Stanley. Your line is open.

Speaker 4

Hi, this is Dan on for Terrence. Thanks for taking our questions. Just 2 from us. First, on the opportunity set, maybe can you talk a little more about the current state of the And any common themes that are coming up in those discussions? And then second, On the pipeline, can you maybe talk about what you're hoping to see from the TREMFYA versus STELARA head to head study in Crohn's disease following recent data from SKYRIZI and mirikizumab?

Speaker 4

Thank you.

Speaker 2

Thank you, Dan. So Chris can answer the first question about the opportunity set and then Marshall will take the question on Stelara and TREMFYA.

Speaker 3

Sure. Thanks Dan for the question. Look, I think I probably referenced it a little bit in my answer to one of the questions earlier, but we continue to see opportunities to invest with large pharma in their pipelines. That has not slowed down. I think there's in fact, there's probably a growing interest Amongst them to share risk and partner with us, the for us, it's really we want to be very And really pick the quality assets that they are most excited about.

Speaker 3

And that's really keeping a very high bar for us. So we are seeing an increasing set of opportunities To help fund R and D, it's just a question of making sure we choose the right asset and being very disciplined.

Speaker 4

Hi, Dan. Good morning. So on Tremfya, yes, thanks for bringing that up. This is one of our portfolio products we are really excited About the growth has really been spectacular. And as we've discussed in the past, IBD As that gets into the label is going to drive another wave of growth.

Speaker 4

And as you point out, I think it's Pretty interesting to see the head to head studies that we've seen from other IL-twenty three's and no reason to think Tremfya is not going to participate In that going forward. So I think we're really excited about it. And again, Tremfya is exactly the type of product that we're looking to add to the portfolio With incredible science, incredible benefit to patients, super strong marketer in Janssen Who can support the label development and run big head to head studies like that to continue to expand this marketplace. So We're really excited to have that in the portfolio for years to

Operator

come. Please standby for the next question. Question comes from Geoff Meacham with Bank of America Securities. Your line is open.

Speaker 10

Hi, good morning. This is Susan on for Geoff. Just a related question. So on the upcoming catalysts in 4th quarter, when should we Back to see top line growth contributions if the catalysts are positive. And then just a follow-up on one of the products, palaprasib.

Speaker 10

If the primary endpoints are mixed, as we saw with navitoclaxdramabvi, are there any special economics You should be aware of, is there any sort of optionality on continuing to at additional royalties or milestone payments?

Speaker 2

Sure. Thank you for the question.

Speaker 3

Terry, do

Speaker 2

you want to take the question on growth and then, Marshall, the second question?

Speaker 5

Sure. So yes, there are a number of Upcoming catalysts, as you mentioned in the Q4, Tremfya was one of them, afacamten, We're going to see the Phase III data. Plabrasiv is another. So we're excited to see those readouts. And I think that our expectation is that hopefully, if they're positive that They would start contributing to growth, maybe Tremfya a little sooner and the others obviously We need to go through the regulatory approval process, so probably more like 2025 beyond.

Speaker 5

So that's the great thing about How we sort of build the portfolio is that we are we have a regular flow of catalysts like these, but also, a lot of sort of Just organic growth within the portfolio as well. So we that's one of the strengths of our business model.

Speaker 4

And then on your question on palabrasib, so nothing special in the agreement with respect To that outcome, I would just remind everyone, we acquired that royalty as part of our Transaction with MorphoSys to support their acquisition of the Palabrasit program. So and it really was centered on TREMFYA, the TREMFYA royalty, which we just discussed in the last question. We are excited to see the outcome like I know many others are, but overall Remain really happy with the MorphoSys transaction and the great royalty like Tremfya that really anchored it.

Operator

Please standby for the next question. The next question comes from Chris Shibanti with Goldman Sachs. Your line is open.

Speaker 11

Thank you. Good morning. I think when we think about the stock, which has been challenging, You guys have been communicating effectively in terms of addressing, tackling some of the debates, the pre IPO shareholders, the Vertex Triple, Yes, the interest rate environment, etcetera. One of the questions that comes up for us is this question of who are the right comps? And this came up in a recent discussion in part because when we see some royalty trusts, which are obviously not exactly the same, These in the Metal and Mining and Oil Explorer, for instance, with kind of similar risk profiles though created a premium.

Speaker 11

Can you comment about how you think of comparable companies from an investment vehicle standpoint? And maybe if there are any other Sort of debates that are net of some that you feel that you have to address. And then secondly, on the creativity, with Erisbi, obviously, there was Does your creativity extend into thinking about Existing royalties, given the fact that you have the relationship due diligence, etcetera, or with the same entities, perhaps for other assets, is that part of a

Speaker 2

Yes. So I'll answer Briefly the question on the second question on creativity. And I think the way we approach The business and we've done it the same way for several decades is that we try to get to know management teams, Get to know the companies that they're running, the products they're developing really well, and then have a constant dialogue with them about the challenges they face, the capital they need and then see how we can best help them Fund their programs and solve problems. And we always approach this dialogue and with a super open mind, I always We need to start with a sort of blank piece of paper and not come with any preconceived ideas. Let's understand the problem first, understand the issues, the challenges, the need.

Speaker 2

And then let's reflect and see how we can come up with creative structures. But I think the business also has this very unique characteristic A repeat business with many companies and even Cystic Fibrosis Foundation and others, MSK, where we've done multiple deals. And we had a slide, I think, Recently, when we announced the PTC transaction of the volume of repeat business, which is very significant, So it is definitely something that we've become known for because I think a lot of these management teams in these companies I believe that once they establish a partnership with us and we know each other and are easy very easy to work with and very creative, They can then continue to work with us over time and helping them with other challenges they face. But I'll turn it over to, I guess, the first question was For Terry, yes.

Speaker 5

Yes. So Chris, you raised a really good point and it's something we've thought a lot about is The comps. And we really are at N of 1. And There are elements of our business that look a lot like pharma, and then there are elements that are different. And there are elements that look Like another sort of gold mining royalty company or even an alternative asset manager.

Speaker 5

And so we don't fit squarely into any one bucket. We think that that's a benefit Of the business, but also is does require more education on our part And just sort of meeting with investors and being out in front of people and explaining why this business is so unique and how you can get exposure to Some of the amazing elements of biopharma without some of the challenges that the biopharma sector faces. And that's taking time. And I think that we're going to continue to work at it. In the meantime, we feel Like we're continuing to execute really well.

Speaker 5

And hopefully, over time, Investors start to be rewarded with a much stronger share price performance.

Speaker 2

Yes. I'll just add to what Terry said. One concept that I think is really critical here, because the question of comps is an important one And one that, as you said, you're getting often. But I think just a much more fundamental consideration is Really what drives the performance of Royalty Pharma. And when you think about it, it's really No different than a pharma company, biopharma company, it's sales of pharma products and what drives the sales of pharma products.

Speaker 2

It's new indications, penetration into new markets. We have so many new therapies in our portfolio. We've been Able over many decades to always invest in the most exciting new products that every wave of innovation has generated. So we have the drivers of biopharma, which is the top line driven by New products and markets that didn't exist and as they get penetrated, they have very, very strong Underlying growth. And then as Terry points that, again, we were not exposed to some of the headwinds of this industry.

Speaker 2

So I think it's a very, very unique investment proposition and one that investors When we really sit down with them and investors understand what's unique about Royalty Pharma, I think the real is that this presents a very unique opportunity to invest in Life Sciences in a very attractive diversified way with significant predictable growth And low risk.

Speaker 11

Great. Thanks for the comments.

Operator

I show no further questions at this time. I would now like to turn the call back over to Pablo for closing remarks.

Speaker 2

Thank you, operator, and thank you to everyone on the call for your continued interest in Royalty Pharma. If you have any follow-up questions,

Operator

This concludes today's conference call. Thank you for participating. You may now disconnect.

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Earnings Conference Call
Royalty Pharma Q3 2023
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