NASDAQ:SEER Seer Q1 2023 Earnings Report $1.99 -0.05 (-2.45%) As of 04/24/2025 04:00 PM Eastern Earnings HistoryForecast Seer EPS ResultsActual EPS-$0.38Consensus EPS -$0.37Beat/MissMissed by -$0.01One Year Ago EPSN/ASeer Revenue ResultsActual Revenue$4.05 millionExpected Revenue$4.00 millionBeat/MissBeat by +$50.00 thousandYoY Revenue GrowthN/ASeer Announcement DetailsQuarterQ1 2023Date5/9/2023TimeN/AConference Call DateTuesday, May 9, 2023Conference Call Time4:30PM ETUpcoming EarningsSeer's Q1 2025 earnings is scheduled for Tuesday, May 6, 2025Conference Call ResourcesConference Call AudioConference Call TranscriptPress Release (8-K)Quarterly Report (10-Q)Earnings HistoryCompany ProfilePowered by Seer Q1 2023 Earnings Call TranscriptProvided by QuartrMay 9, 2023 ShareLink copied to clipboard.There are 6 speakers on the call. Operator00:00:00Day and thank you for standing by. Welcome to the SEER First Quarter 2023 Earnings Conference Call. At this time, all participants are in listen only mode. After the speakers' presentation, there will be a Q and A session. Please be advised today's conference is being recorded. Operator00:00:30I would like to hand the conference over to your speaker today, Carrie Mendivil, Investor Relations, please go ahead. Speaker 100:00:40Thank you. Earlier today, SEER released financial results for the quarter ended March 31, 2023. If you have not received this news release or if you'd like to be added to the company's distribution list, Please send an email to investorseer. Bio. Joining me today from SEER is Omid Farrokhzad, Chief Executive Officer, President and Chair and David Horn, Chief Financial Officer. Speaker 100:01:03Before we begin, I'd like to remind you that management will make statements during this call that are forward looking statements within the meaning of federal securities laws. These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated. Additional information regarding these risks and uncertainties appears in the section entitled Forward Looking Statements in the press release SEER issued today. For a more complete list and description, please see the Risk Factors section of the company's quarterly report on Form 10 Q for the quarter ended March 31, 2023, and in its other filings with the Securities and Exchange Commission. Except as required by law, Spirit disclaims any intention or obligation to This conference call contains time sensitive information and is accurate only as of the live broadcast, May 9, 2023. Speaker 100:01:58With that, I'd like to turn the call over to Omid. Speaker 200:02:02Thanks, Carrie, and thank you, everyone, for joining us this afternoon. I will begin our call today with a review of our Q1 results as well as the progress we're making across our core focus areas to drive growth. Then I will turn the call over to David to provide more detail on our financial results. Thanks to the tremendous effort Of the entire team at SEER, we had a solid start to the year and ended the Q1 with $4,100,000 in revenue and continued growth in our installed base. Even more importantly, we're increasingly seeing more and more data being shared by our customers, The initiation of larger studies with a growing interest in population scale studies and the first customer publications making their way through the peer review We have consistently said that the increased publication of customers and third party data will be critical to developing the market and this is exactly what we're seeing. Speaker 200:03:06We now have more than 150 public presentations on SEER's technology to date with additional data expected at the American Society of Mass Spectrometry or AFMS Annual Conference in early June. With this solid start, we're reiterating our 2023 guidance and continue to expect revenue in the range of $23,000,000 to $25,000,000 for 2023, representing significant year over year growth of 48% While we continue to drive top line growth, we're taking a very disciplined approach with our operating expenses In order to protect our robust balance sheet, with over $410,000,000 in cash, we're well positioned to execute on our multiyear And our building a resilient organization that can make a meaningful impact on the advancement of science and medicine. We're committed to leveraging our resources to drive innovation, creating value for our customers and investors and contributing to the positive trajectory of the proteomics field and human health overall. As mentioned on the last earnings call this year, we're focused on executing across our 4 core areas. 1st, enabling breakthrough discoveries with the ProtegeGraft product suite. Speaker 200:04:312nd, demonstrating the power of our technology. 3rd, catalyzing new applications and markets. And finally, 4th, expanding our industry leading team. Starting with our first objective. The proteoGraft product suite is highly extensible and is providing reproducible unbiased access to the proteome with flexibility and scale, allowing us to address many unmet needs in our customers' hands. Speaker 200:05:01We're encouraged by the growing enthusiasm for what the As I mentioned in my opening remarks, more customer data is being shared publicly. Doctor. Karsten Suri, a leading multiomics researcher and a professor of physiology and biophysics at Weill Cornell Medicine Has a manuscript under peer review that is now available as a preprint in bio archive. This is the first study using the proteograft product suite to perform protein quantitative trait loci or PQTL analysis. I view this study as an important milestone in which the biological value of connecting genomic variant data to deep unbiased proteomic data at the peptide level has been robustly exemplified. Speaker 200:05:52In a cohort 3,000 proteins and over 18,000 peptides and associated these with genetic variants across the study, allowing him to identify variation in plasma protein concentration among subjects. Importantly, this publication highlights the shortcoming of affinity based approaches in which the measured abundance of a target protein may be impacted by protein altering variants that change the binding epitope of the Affinity reagent. Doctor. Asuri's work highlights the importance of peptide level resolution to more deeply understand the proteome, which the proteograph product suite is uniquely able to deliver at scale. Another interesting emerging application of the proteograph It's targeted mass spectrometry workflows for quantifying specific high value human plasma and serum proteins, For example, in obesity and diabetes research. Speaker 200:06:58Most assay today in obesity and diabetes research rely exclusively on antibodies, Yes, certain publications have shown this approach has limitations, including failure to detect the intended target for the post transitionary modified biologically active forms. The combination of mass spec based targeted proteomics combined with the proteograft workflow provides a solution to this problem with a robust, highly reproducible method for detecting and quantifying the desired protein variants Across a wide range of concentrations at the peptide level, Doctor. Jenny Van Eyck, who is a Professor of Cardiology Director of the Advanced Clinical Biosystem Research Institute and Founder of the Precision Biomarket Labs at Cedars Sinai is leading this work. Doctor. Van Eijk is an international leader in clinical proteomics and current President of the Human Proteome Organization or HUPL. Speaker 200:07:54Her team has leveraged the proteograft product suite to identify and quantify clinically relevant biomarkers that are inaccessible to immunoassays. The targeted methods they perform using the protege graph ensures accurate quantitation of lower abundance proteins that are not easily accessible by standard proteomics workflow, while also allowing the monitoring of several 100 other plasma proteins of interest, which may contain additional biomarker needs. Importantly, this method allows for rapid completion of large scale studies and the potential for quick diagnostic turnaround in an assay that can be offered as a service to stratify obese and diabetic patients into optimal treatment groups. Pertine presented the protegep evaluation data At the targeted mass spectrometry assays in diabetes and obesity research meeting that is funded by the National Institute of Diabetes and Digestive and Kidney Diseases late last year and are currently in the process of scaling up the study toward a publication later this year. Doctor. Speaker 200:09:00Van Eyck's research It's a great illustration of the unmet needs that the proteograft workflow can address in the hands of customers and speaks directly whose potential to deliver new clinical applications that have not been possible with existing methods. In January, One of our multi omic liquid biopsy customers, Prognomic, announced early results for what they believe to be the largest deep multi omic Study to date. This study was run across 1031 subjects with non small cell lung cancer or NSCLC and non cancer controlled and demonstrated the power of diverse molecular biomarker to improve Sensitivity and specificity are in early detection of NSCLC. Last month, They presented new data in 2 posters at the American Association For Cancer Research Annual Meeting that demonstrated novel biomarker discovery and the potential feasibility of their approach for early cancer detection. Their first poster Leverage deep multiomics profiling of proteins, metabolize transcripts and cell free DNA in blood from NSCLC patients for biomarker discovery. Speaker 200:10:20Data showed multiple biomarkers for NSCLC detected across all omic types With many overlapping biomarkers of interest and demonstrated a broad ability to distinguish between individuals with and without cancer, The proteograph played a significant role in biomarker identification, demonstrating the importance of peptide level resolution to drive novel discovery. The second poster demonstrated that a multi omic classifier achieved high sensitivity and specificity for detection of In the case control study of 146 subjects, in this proof of concept study, prognomic levers for detection and discrimination of PDAC from non cancer controls. The high performance of analytes collected from blood draws makes this panel amenable to rapid development and utilization. Results support the feasibility of this approach as a potentially clinically useful test for early detection of PDAC. These results from prognomic Illustrate how the proteograft can drive the identification of novel biomarkers, which can then be utilized in clinical application. Speaker 200:11:51This is just the beginning of what we believe the proteograft will enable in the hands of customers. In late March, At the U. S. Human Podium Organization Conference, there was 1 podium presentation and 9 posters Highlighting SEER Technology, including customer data on COVID-nineteen vaccine response and an optimized method for the protograph with the Thermo Fisher Orbitrap EXPLORERIS 4 80 using SAMES Pro. The oral presentation covered the first look at the Alzheimer's disease cohort of approximately 1800 plasma samples using our next product, which is in the hands of several early access customers. Speaker 200:12:34We also hosted a well attended industry workshop With 3 featured presentations highlighting proteograft performance, flexibility to address multiple sample times and ability to drive large scale studies. In June, at the upcoming American Society For Mass Spectrometry or AFMS annual conference. We are looking forward to more exciting data with 15 SEER and 12 customer abstracts in the program. Customer posters and presentations include using an aging in mouse model, translational pharmacoproteomics in nonalcoholic and host cell proteins for biologic manufacturing among others. And we're continuing to drive standardization and partnership demonstrating the exceptional performance of the proteograph across these leading mass spec platforms. Speaker 200:13:46One customer study of note at AFMS is from Doctor. Steve Carr's lab at the Broad Institute. Doctor. Carr will have an oral presentation demonstrating the performance of the proteograft in plasma from multiple myeloma patients using the Bruker timsTOF HD and DIA PASAS. These results are particularly exciting as they show how larger scale studies that are enabled by the protograph With optimized mass spec protocol, can get us deeper into the proteome than previously possible. Speaker 200:14:24In 2017, Doctor. Carr published a seminal paper that achieved a depth of 4,500 proteins in plasma and this paper has remained the benchmark for deep unbiased proteomics in plasma until now. Importantly, the 2017 study, Given the complexity of the workflow was accomplished on only 16 samples, Doctor. Carr's current study identified over 5,900 and is being applied to 300 samples. This is yet another example of the step function increase in the depth and throughput of proteomic that has been enabled by the Protegrav product suite. Speaker 200:15:06It is exciting to see an combined with additional multi omic data to further understand the body's response to spaceflight. This project is providing new opportunities to understand the molecular and cellular changes that occur in humans during space travel. We look forward to sharing more detail following the publication of this study. We have visibility to multiple additional manuscripts being submitted by customers In the coming months, as more third party data is generated, we will see more proof of the unique value of proteograft to drive novel biological insight that will accelerate the next generation of multiomics studies. We feel very confident about our market opportunities I'm thrilled by the emerging validation of the photograph in Ananta customers and expect a progressive increase in the velocity of adoption in the coming several Turning our attention to the second objective, demonstrating the power of the Protograph product suite. Speaker 200:16:24We continue to innovate, extend the capabilities of our technology and drive our own abstract and publication. In March, we announced that our paper on bone morphogenetic protein 1 or BNP1 was published in PLOS 1. This peer reviewed publication highlighted the importance of the proteograph in identifying peptide level insights that discovered links between protein variants and lung cancer progression at the protein isoform level. In upcoming months, we expect to have multiple papers released from SEER in addition to what we are expecting from our customers. These papers will continue to advance the field of nano bio interactions, proteomic workflows and large scale data science, showcasing the disruptiveness of our technology and its unique ability to push the boundaries in proteomics. Speaker 200:17:19We remain committed to delivering cutting edge solutions that drive more access to proteomic data. We know that enabling streamlined data processing, analysis and interpretation is key. Throughout 2023, We will continue to expand our software capabilities and lay the roadmap for large scale studies with our proteograph analysis suite. We believe that this will be an important component of our workflow and will serve to enable more customers to onboard deep unbiased proteomic at scale. From the very beginning, we believe there would be broad interest to incorporate unbiased deep plasma proteomics into studies at scale, well beyond the existing installed base of mass spec users engaged in proteomic research. Speaker 200:18:08That is exactly what we're seeing play out In our discussion, consistent with our original vision, the market opportunity is large spanning the mass Our next product is meant to capitalize on this need to serve a broader audience. It is already In early access with multiple sites and we're getting great feedback on its performance. Our first product Delivered a step function change in unbiased proteomic and this next product does the same. We are really excited about what it will enable in the market, and we look forward to sharing more with you in the upcoming months. Turning to our 3rd objective, catalyzing new applications and markets. Speaker 200:19:04Our technology is inherently extensible. It is species agnostic and is compatible with a diverse range of sample types. The Fertigraft product suite It's being used in a range of applications across our growing customer base in academic research, translational, commercial, Pharma, CROs and even applied markets. One example of a new application that has emerged from our customer base is the use of the proteograft to detect host cell proteins or HCPs. HCPs are proteins produced or encoded by the host organism used to produce recombinant therapeutic protein such as those used in biomanufacturing of vaccines. Speaker 200:19:48Removal of HCP is one of the biggest challenges for the production of Biopharmaceuticals. An ideal HCP screening assay is high throughput, reproducible, quantitative and sensitive with high dynamic range. The Proteograph fits this bill. In a study in partnership with a major pharmaceutical company, We demonstrated that the Proteograph product suite detects 2 to 6 times more HCPs than traditional methods identifying 98% of the HCPs and overall improving measurements across purification steps. A poster on this work will be presented at the upcoming AFMS biopharma partner. Speaker 200:20:33Customers Continue to find value in Proteograph proof of principle studies as they build the case for capital equipment funding within their organization, including the grant submission process for academic customers. These small studies of 40 to 100 samples are a key enabler for customers can be uncovered even from small studies of this size. We had the shipment of a proteograph to a non human health company in the first quarter, for example, following a small proof of principle study conducted for this organization. With our proof of principle study program, We have demonstrated use of the protograph in chicken, dog, cat, baboon and plant tissue across studies looking at Cold exposure, diet, aging, cognitive impairment, multiple cancers and transplant. We will continue to drive market development efforts such as these studies, ASH Lab Collaborations and KOL work to accelerate and enable broad market adoption. Speaker 200:21:47Through these efforts, we're building relationships with key opinion leaders and expanding our scientific advisory board with the recent addition of Doctor. Josh Kuhn, Doctor. Chris Mason and Doctor. Jenny Lanayk. Doctor. Speaker 200:22:02Coon is a Professor of Chemistry and Biomolecular Chemistry at University of Wisconsin Madison. Doctor. Mason He's a professor of genomics, physiology and biophysics at Weill Cornell Medicine and the Director of the WorldQuant Initiative for qualitative prediction as well as an affiliate of Memorial Sloan Kettering Cancer Center, Rockefeller University, Harvard Medical School and Yale Law School. As mentioned earlier, Doctor. Van Eijk is Professor of Cardiology at Cedars Sinai as well as the Director of the Advanced Clinical Biosystem Research Institute, Founder of the Precision Biomarker Labs and the current President of the HUFO. Speaker 200:22:45These relationships are reinforcing the power of the protograph in the hand of these luminaries in their field. They're partnering with us to imagine a new future in multiomics, and I'm excited to continue our engagement to push the boundaries of what's possible together. Before I turn the call over to David, I want to share an update on our leadership team. Scott Thomas, our Chief Commercial Officer, will be transitioning from SEER in July. I want to thank Scott for his contribution, leading and developing a commercial organization. Speaker 200:23:16Our 2 senior regional vice presidents will lead commercial in the Americas and EMEA APAC, respectively. We have an excellent team in place, and we're confident we will continue to deliver on the promise of our transformational technology. With that, I will now turn the call over to David. Speaker 300:23:38Thanks, Omid. Total revenue for the Q1 of 2023 was $4,100,000 representing an increase of 22% compared to the $3,300,000 in the Q1 of 2022. The increase in Q1 revenue was primarily due to increased consumable kit sales related to the Proteograph product suite. Revenue recognized primarily consisted Sales of proteograph, SP100 instruments and consumable kits. Additional sources of revenue include platform evaluation, service grant and lease revenue. Speaker 300:24:09Product related revenue for the Q1 of 2023 was $3,600,000 including related party revenue of $1,300,000 consisted of sales of SB-one hundred instruments, consumable kits and platform evaluations. Service revenue was $69,000 in the Q1 of 2023 It was primarily derived from the completion of a customer service project. As we have mentioned previously, we will continue to be strategic in undertaking Certain service projects for customers that we ultimately believe lead to purchases of the Permian graph. Grant and other revenue was $335,000 in the Q1 As discussed last quarter, contributions from grant and research related collaborations will resume beginning in Q4 of require these customers to purchase consumables, we recognize a portion of this revenue as lease revenue. Total gross profit was 2,100,000 for the Q1 of 2023, representing a gross margin of 51%. Speaker 300:25:14Gross margins were aided by the mix of consumable versus instrument revenue additional grant revenue in the Q1. This was offset by overhead expenses and other costs of revenue. We expect to see variability in our overall gross margin Q1 of 2023 were $29,500,000 including $8,700,000 of stock based compensation, an increase of 18% compared to $25,000,000 including $8,100,000 of stock based compensation in the Q1 of 2022. Research and development expenses for the Q1 of 2023 were $14,500,000 an increase of 35% compared to $10,700,000 in the Q1 of 2022. The increase in R and D expenses was primarily due to an increase in product development efforts related to the Proteograph product suite, including employee compensation costs and other related expenses due to growth in R and D personnel and expenses associated with the build out of our facility. Speaker 300:26:20Selling, general and administrative expenses for the Q1 of 2023 were $15,000,000 an increase of 5% compared to $14,300,000 in the Q1 of 2022. The increase in SG and A expenses was primarily driven by greater employee compensation expenses due primarily to growth in personnel for our global commercial organization. Net loss for the Q1 of 2023 was $24,000,000 compared to $23,600,000 in the Q1 of 2022. We ended the quarter with $410,500,000 in cash, cash equivalents and investments. As Amit mentioned, while we continue to drive growth on the top line, we're taking a very disciplined approach to spend in order to protect our robust balance sheet. Speaker 300:27:05We'll continue to be very mindful of our level of spend as the year progresses in light of the volatile macroeconomic environment and its potential impact on demand. With disciplined deployment of capital, we believe we are well funded to execute on our strategic plan for many years to come. Turning to our outlook for the year. Continue to expect revenue to be in the range of $23,000,000 to $25,000,000 for 2023, representing significant year over year growth of 48% to 1% similar to 2022. We expect revenue to be more weighted to the second half of the year. Speaker 300:27:38At this point, I would like to turn the call back to Amit for closing comments. Speaker 200:27:42Thanks, David. We started the year off with a good momentum As more and more customers generated data using the proteograph, further solidifying the need for large scale unbiased deep proteomic studies. It is exciting to see the Proteograph enabling breakthrough science as shown through its power, extensibility and ability to catalyze new applications and markets. I have never been more excited about the opportunity ahead. With that, we will now open it up to questions. Operator00:28:12Thank you. At this time, we will conduct our question and answer session. Our first question comes from TJ Savant from Morgan Stanley. Please go ahead. Speaker 400:28:42Hi, this is Gabby on for Tejas. Thanks for taking my question. So maybe just to Start with what you're seeing right now with your customer base. What impact are you seeing currently from elongated sales cycles in academic versus biopharma customers? And are you seeing any constrained spending from Chinese CDMO customers? Speaker 400:29:01Thanks. Speaker 300:29:04Yes. Thanks, Gabby. It's David. In terms of the customer base, we are continuing to see a somewhat elongated sales cycle. Again, I think the environment continues to be cautious, but at the same time, we are seeing capital being deployed. Speaker 200:29:21It's just I think as we've said Speaker 300:29:23Historically, that for a new disruptive technology, it is just a little bit of longer sales cycle for us in terms of The data coming out and the proof points and a lot of customers choose to run a proof of principles study with us. And so that's really what's creating some of the elongated sales cycle. But I'll note that we have had some publications that Omid mentioned during his remarks, One from Doctor. Sure and another one coming out. So we're excited about those presentations. Speaker 300:29:53We're also excited about what's coming up at the ASMS conference in June To kind of continue to have those customer proof points. But again, we are continuing to see, it just takes some time for people to get comfortable with the technology and ultimately decide to bring it in house. In terms of China, we do feel like the market has been Has opened up. We still, in terms of working with our distribution partner over there, are still seeing, again, Some kind of ramping back up and getting back up to speed, but certainly the access over there has certainly improved. Speaker 400:30:35Great. Thanks. And then just on your plans to further build your commercial org, Could you share maybe progress on that and how many reps you're planning to add before year end? Speaker 200:30:49Yes. I mean, this is Omid. So we've said that we're not going to be disclosing The specifics of the size of our commercial organization. That said, in terms of the number of sales, That said, the total organization right now that includes sales, support, marketing is around 50 people. We think that's the right size. Speaker 200:31:16We're going to continue to scale commensurate to demand and revenue coming in, Trying to stay about 1 to 2 quarters ahead of it, and I think we're well in that pace right now. Speaker 400:31:35Okay, great. And then you had mentioned at a conference that you believe other Ohmic integration will be in Sears future. So what is your next focus for enhancing the Proteograph suite and moving towards achieving that? And I guess just what is the latest feedback you've received from your customers and how are you thinking about improvements to the platform based on the customer feedback? Thanks. Speaker 200:31:59Sure. Yes, we released the Proteograph Analysis Suite 2.0, PAS 2.0, that was last August. That software allows A user customer to integrate genomic information and proteomic information as part of their analysis. It was the first step to help a customer achieve Purdue Genomic Look at a particular subject that they're looking at. We're going to continue to innovate in that space. Speaker 200:32:43That looks at genomic information, but we can bring it in transcriptomic information as well on top of that. And so those innovations in terms of analysis is forthcoming. With regards to feedback from customers, Look, feedback in terms of Product 1 has been fantastic. We made Some claims in terms of how we would see the ecosystem develop, the product to be used, And it's playing out exactly as we had predicted. If you look at the paper that Professor Carsten Suri has under review, and he was kind enough to put it on bio archive, which is now available if you want to look at it. Speaker 200:33:35That paper has generated incoming interest from genomic scientists. I personally view that paper to be a watershed moment, a moment where it becomes clear And when you do that, you begin to look at changes that happen in terms of protein up and down regulation In response to genetic variance of the population at the protein variant level, fundamentally disruptive. I think that's the way these kind of studies should be. So we're beginning to see customers publish papers that validate that we need to look at the proteome at the level of the protein variant because the complexity of the proteome exists because it's biologically relevant. And SEER uniquely enables that to be done Accurately, precisely and at scale. Speaker 200:34:46Now we released product 1 and it was a step Increase in terms of being able to go deep at a scale and throughput. The feedback that we got from customers was, look, can we go deeper? Can we go faster? And can we lose smaller amount of sample volume because our biological samples are precious to us? And so we have product number 2 that's now in the hands of our early access customers. Speaker 200:35:20The feedback has been fantastic. More to come on that. Suffice it to say that, that product, in my mind, is yet another It certainly addresses some of the feedback that we have gotten from customers on Product 1, and I'm super, super excited To be able to reveal more and tell you more about it in over the upcoming weeks months as we put that product Broadband commercial and handset customers. Speaker 400:36:03Great. Thank you for the color. Operator00:36:13Thank you. Our next question comes from Dan Brennan from TD Cowen. Speaker 500:36:18Hey, good afternoon. This is Kyle on for Dan. Thanks for taking the questions. So how meaningful will 3rd party publications be to your customer conversations? And is a notable pickup in customer interest instrument purchases post these publications implied in the 2023 guide? Speaker 500:36:35And then maybe just going off of that, after the Q1, What's your confidence and visibility into the back half ramp here? Speaker 200:36:45Hey, Tyler, let me I'll take a Part of that and I'll have maybe David answer part of it as well. So we have visibility To at least a handful of customer papers that are on various stages of publications, including one that you saw is now publicly available on bioRxiv, but others that are in late stage reviewed that should be coming and then others that being submitted. I had predicted late last year that we would see probably about 5 customer papers And kind of tilted toward the second half of the year, it may actually be more than that. And then interestingly and importantly, and related to this is also the number of presentation from customers. So we're now seeing Customer presentations at conferences where we weren't even aware of those studies being done or those studies being presented, That's exactly what you want to see, in that you put up the abstract book and you see one of your customer has something going on That they're sharing and they're talking about it. Speaker 200:38:03And I think we're also seeing that. So I'm super optimistic, Tyler, in that The velocity of customer data presentation is going to be increasing at a progressively sharper slope as we head into the second half of twenty twenty three and then kind of the balance of the year heading into 2024, Kyle. So with that, let me turn this to David and see if he can give you additional color in terms of revenue. And before I do, I would say that I reiterated the guidance, so I'm confident about the year being in that 23 to $25,000,000 that we have guided. So with that, let me hand it to David. Speaker 300:38:48Yes, Kyle, just in terms of the 2023 guide, as Amit said, we did reiterate Guidance, and so we feel comfortable with that. And as Amit also mentioned, we did have some visibility into some of these papers coming When we did provide our initial guidance, so we certainly had some of those papers baked in. To the extent there Other papers that come out or presentations, again, we feel like that could potentially be A benefit, but I think that would be a benefit in terms of just helping kind of shorten that sales cycle a little bit for us In terms of getting other folks interested in evaluating the technology. So I think we feel pretty good where we are and we did have the fact that Some of these papers would be out as part of our original guidance. Speaker 500:39:43Got it. Thank you. And then so how is customer interest in the lease program? Is it something you're actively offering So all potential share customers or is it just a select number of potentially more meaningful customers? Speaker 300:39:57Yes. Great question. So we what we've decided to do is, we've rolled out what we call our strategic instrument placement program. And really what we're looking to do is identify key parties, whether they be KOLs or large Customers with large sample sets, people who can again help drive awareness of the technology And really just trying to lower barriers to accessing the technology in the short term. And so we did Some of the instruments we placed in the Q1, it does require consumable purchase. Speaker 300:40:40So there's a Consumable purchase that goes along with that. And then they have essentially, we agreed to place the instrument for a period of time. The customer has the option to purchase it at the end of that. And again, it just helps facilitate The getting up and using the technology and ultimately help drive a consumable revenue stream for us. I will say the amount of lease revenue that we recognize part of that is pretty de minimis. Speaker 300:41:14And it's really about continuing to drive consumables and consumable revenue around that. But again, I think the overall objective is to find ways to improve access And help drive, again, presentations, papers, publications with accounts that are going to be leaders, either thought leaders and others or large accounts that have large sample sets to help drive consumable volume over the long term. So it's been a really it's been a great it's been well received by customers. And so we again, we'll see how it plays out over the balance of the year, but We certainly feel like it's a good program that's helping us. But from a obviously, there's consumable revenues That is meaningful, but from overall lease revenue, it's not really significant. Speaker 500:42:15Got it. Thank you. Operator00:42:19Thank you. Thank you for your participation in today's conference. This does conclude the program. You may now disconnect.Read morePowered by Conference Call Audio Live Call not available Earnings Conference CallSeer Q1 202300:00 / 00:00Speed:1x1.25x1.5x2x Earnings DocumentsPress Release(8-K)Quarterly report(10-Q) Seer Earnings HeadlinesSeer (NASDAQ:SEER) Shares Down 2.5% - Here's WhyApril 25 at 2:37 AM | americanbankingnews.comSeer to Report First Quarter 2025 Financial Results on May 13, 2025April 24 at 4:05 PM | globenewswire.comReal Americans Don’t Wait on Wall Street’s Next MoveWhat's happening in the markets right now should concern every freedom-loving American who's worked hard and saved smart. Your 401(k) doesn't deserve to be dragged through the mud by tariffs, trade wars, reckless spending, and political standoffs. And you don't have to stand by while Wall Street plays roulette with your future.April 25, 2025 | Premier Gold Co (Ad)Man Who Prophesied About Pope Francis's Death 2 Weeks Before it Happened Speaks Again in New VideoApril 22 at 9:58 AM | msn.comNostradamus' eerie Pope Francis prophecy as new seer got his death all wrongApril 21, 2025 | msn.comChina Just Lost Access to a Major U.S. Health Database—Here’s WhyApril 17, 2025 | msn.comSee More Seer Headlines Get Earnings Announcements in your inboxWant to stay updated on the latest earnings announcements and upcoming reports for companies like Seer? Sign up for Earnings360's daily newsletter to receive timely earnings updates on Seer and other key companies, straight to your email. Email Address About SeerSeer (NASDAQ:SEER), a life sciences company, engages in developing and commercializing products to decode the biology of the proteome. It develops Proteograph Product Suite, an integrated solution that includes proprietary engineered nanoparticles, consumables, automation instrumentation, and software to perform proteomic analysis to provide a solution that can be incorporated by nearly any lab for research use only. The company intends to sell its products for research use only, which cover academic institutions, life sciences, and research laboratories, as well as biopharmaceutical and biotechnology companies for non-diagnostic and non-clinical purposes. It operates in China, Australia, Eastern Europe, Israel, and Japan. The company was formerly known as Seer Biosciences, Inc. and changed its name to Seer, Inc. in July 2018. Seer, Inc. was incorporated in 2017 and is headquartered in Redwood City, California.View Seer ProfileRead more More Earnings Resources from MarketBeat Earnings Tools Today's Earnings Tomorrow's Earnings Next Week's Earnings Upcoming Earnings Calls Earnings Newsletter Earnings Call Transcripts Earnings Beats & Misses Corporate Guidance Earnings Screener Earnings By Country U.S. Earnings Reports Canadian Earnings Reports U.K. Earnings Reports Latest Articles Seismic Shift at Intel: Massive Layoffs Precede Crucial EarningsRocket Lab Lands New Contract, Builds Momentum Ahead of EarningsAmazon's Earnings Could Fuel a Rapid Breakout Tesla Earnings Miss, But Musk Refocuses and Bulls ReactQualcomm’s Range Narrows Ahead of Earnings as Bulls Step InWhy It May Be Time to Buy CrowdStrike Stock Heading Into EarningsCan IBM’s Q1 Earnings Spark a Breakout for the Stock? 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There are 6 speakers on the call. Operator00:00:00Day and thank you for standing by. Welcome to the SEER First Quarter 2023 Earnings Conference Call. At this time, all participants are in listen only mode. After the speakers' presentation, there will be a Q and A session. Please be advised today's conference is being recorded. Operator00:00:30I would like to hand the conference over to your speaker today, Carrie Mendivil, Investor Relations, please go ahead. Speaker 100:00:40Thank you. Earlier today, SEER released financial results for the quarter ended March 31, 2023. If you have not received this news release or if you'd like to be added to the company's distribution list, Please send an email to investorseer. Bio. Joining me today from SEER is Omid Farrokhzad, Chief Executive Officer, President and Chair and David Horn, Chief Financial Officer. Speaker 100:01:03Before we begin, I'd like to remind you that management will make statements during this call that are forward looking statements within the meaning of federal securities laws. These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated. Additional information regarding these risks and uncertainties appears in the section entitled Forward Looking Statements in the press release SEER issued today. For a more complete list and description, please see the Risk Factors section of the company's quarterly report on Form 10 Q for the quarter ended March 31, 2023, and in its other filings with the Securities and Exchange Commission. Except as required by law, Spirit disclaims any intention or obligation to This conference call contains time sensitive information and is accurate only as of the live broadcast, May 9, 2023. Speaker 100:01:58With that, I'd like to turn the call over to Omid. Speaker 200:02:02Thanks, Carrie, and thank you, everyone, for joining us this afternoon. I will begin our call today with a review of our Q1 results as well as the progress we're making across our core focus areas to drive growth. Then I will turn the call over to David to provide more detail on our financial results. Thanks to the tremendous effort Of the entire team at SEER, we had a solid start to the year and ended the Q1 with $4,100,000 in revenue and continued growth in our installed base. Even more importantly, we're increasingly seeing more and more data being shared by our customers, The initiation of larger studies with a growing interest in population scale studies and the first customer publications making their way through the peer review We have consistently said that the increased publication of customers and third party data will be critical to developing the market and this is exactly what we're seeing. Speaker 200:03:06We now have more than 150 public presentations on SEER's technology to date with additional data expected at the American Society of Mass Spectrometry or AFMS Annual Conference in early June. With this solid start, we're reiterating our 2023 guidance and continue to expect revenue in the range of $23,000,000 to $25,000,000 for 2023, representing significant year over year growth of 48% While we continue to drive top line growth, we're taking a very disciplined approach with our operating expenses In order to protect our robust balance sheet, with over $410,000,000 in cash, we're well positioned to execute on our multiyear And our building a resilient organization that can make a meaningful impact on the advancement of science and medicine. We're committed to leveraging our resources to drive innovation, creating value for our customers and investors and contributing to the positive trajectory of the proteomics field and human health overall. As mentioned on the last earnings call this year, we're focused on executing across our 4 core areas. 1st, enabling breakthrough discoveries with the ProtegeGraft product suite. Speaker 200:04:312nd, demonstrating the power of our technology. 3rd, catalyzing new applications and markets. And finally, 4th, expanding our industry leading team. Starting with our first objective. The proteoGraft product suite is highly extensible and is providing reproducible unbiased access to the proteome with flexibility and scale, allowing us to address many unmet needs in our customers' hands. Speaker 200:05:01We're encouraged by the growing enthusiasm for what the As I mentioned in my opening remarks, more customer data is being shared publicly. Doctor. Karsten Suri, a leading multiomics researcher and a professor of physiology and biophysics at Weill Cornell Medicine Has a manuscript under peer review that is now available as a preprint in bio archive. This is the first study using the proteograft product suite to perform protein quantitative trait loci or PQTL analysis. I view this study as an important milestone in which the biological value of connecting genomic variant data to deep unbiased proteomic data at the peptide level has been robustly exemplified. Speaker 200:05:52In a cohort 3,000 proteins and over 18,000 peptides and associated these with genetic variants across the study, allowing him to identify variation in plasma protein concentration among subjects. Importantly, this publication highlights the shortcoming of affinity based approaches in which the measured abundance of a target protein may be impacted by protein altering variants that change the binding epitope of the Affinity reagent. Doctor. Asuri's work highlights the importance of peptide level resolution to more deeply understand the proteome, which the proteograph product suite is uniquely able to deliver at scale. Another interesting emerging application of the proteograph It's targeted mass spectrometry workflows for quantifying specific high value human plasma and serum proteins, For example, in obesity and diabetes research. Speaker 200:06:58Most assay today in obesity and diabetes research rely exclusively on antibodies, Yes, certain publications have shown this approach has limitations, including failure to detect the intended target for the post transitionary modified biologically active forms. The combination of mass spec based targeted proteomics combined with the proteograft workflow provides a solution to this problem with a robust, highly reproducible method for detecting and quantifying the desired protein variants Across a wide range of concentrations at the peptide level, Doctor. Jenny Van Eyck, who is a Professor of Cardiology Director of the Advanced Clinical Biosystem Research Institute and Founder of the Precision Biomarket Labs at Cedars Sinai is leading this work. Doctor. Van Eijk is an international leader in clinical proteomics and current President of the Human Proteome Organization or HUPL. Speaker 200:07:54Her team has leveraged the proteograft product suite to identify and quantify clinically relevant biomarkers that are inaccessible to immunoassays. The targeted methods they perform using the protege graph ensures accurate quantitation of lower abundance proteins that are not easily accessible by standard proteomics workflow, while also allowing the monitoring of several 100 other plasma proteins of interest, which may contain additional biomarker needs. Importantly, this method allows for rapid completion of large scale studies and the potential for quick diagnostic turnaround in an assay that can be offered as a service to stratify obese and diabetic patients into optimal treatment groups. Pertine presented the protegep evaluation data At the targeted mass spectrometry assays in diabetes and obesity research meeting that is funded by the National Institute of Diabetes and Digestive and Kidney Diseases late last year and are currently in the process of scaling up the study toward a publication later this year. Doctor. Speaker 200:09:00Van Eyck's research It's a great illustration of the unmet needs that the proteograft workflow can address in the hands of customers and speaks directly whose potential to deliver new clinical applications that have not been possible with existing methods. In January, One of our multi omic liquid biopsy customers, Prognomic, announced early results for what they believe to be the largest deep multi omic Study to date. This study was run across 1031 subjects with non small cell lung cancer or NSCLC and non cancer controlled and demonstrated the power of diverse molecular biomarker to improve Sensitivity and specificity are in early detection of NSCLC. Last month, They presented new data in 2 posters at the American Association For Cancer Research Annual Meeting that demonstrated novel biomarker discovery and the potential feasibility of their approach for early cancer detection. Their first poster Leverage deep multiomics profiling of proteins, metabolize transcripts and cell free DNA in blood from NSCLC patients for biomarker discovery. Speaker 200:10:20Data showed multiple biomarkers for NSCLC detected across all omic types With many overlapping biomarkers of interest and demonstrated a broad ability to distinguish between individuals with and without cancer, The proteograph played a significant role in biomarker identification, demonstrating the importance of peptide level resolution to drive novel discovery. The second poster demonstrated that a multi omic classifier achieved high sensitivity and specificity for detection of In the case control study of 146 subjects, in this proof of concept study, prognomic levers for detection and discrimination of PDAC from non cancer controls. The high performance of analytes collected from blood draws makes this panel amenable to rapid development and utilization. Results support the feasibility of this approach as a potentially clinically useful test for early detection of PDAC. These results from prognomic Illustrate how the proteograft can drive the identification of novel biomarkers, which can then be utilized in clinical application. Speaker 200:11:51This is just the beginning of what we believe the proteograft will enable in the hands of customers. In late March, At the U. S. Human Podium Organization Conference, there was 1 podium presentation and 9 posters Highlighting SEER Technology, including customer data on COVID-nineteen vaccine response and an optimized method for the protograph with the Thermo Fisher Orbitrap EXPLORERIS 4 80 using SAMES Pro. The oral presentation covered the first look at the Alzheimer's disease cohort of approximately 1800 plasma samples using our next product, which is in the hands of several early access customers. Speaker 200:12:34We also hosted a well attended industry workshop With 3 featured presentations highlighting proteograft performance, flexibility to address multiple sample times and ability to drive large scale studies. In June, at the upcoming American Society For Mass Spectrometry or AFMS annual conference. We are looking forward to more exciting data with 15 SEER and 12 customer abstracts in the program. Customer posters and presentations include using an aging in mouse model, translational pharmacoproteomics in nonalcoholic and host cell proteins for biologic manufacturing among others. And we're continuing to drive standardization and partnership demonstrating the exceptional performance of the proteograph across these leading mass spec platforms. Speaker 200:13:46One customer study of note at AFMS is from Doctor. Steve Carr's lab at the Broad Institute. Doctor. Carr will have an oral presentation demonstrating the performance of the proteograft in plasma from multiple myeloma patients using the Bruker timsTOF HD and DIA PASAS. These results are particularly exciting as they show how larger scale studies that are enabled by the protograph With optimized mass spec protocol, can get us deeper into the proteome than previously possible. Speaker 200:14:24In 2017, Doctor. Carr published a seminal paper that achieved a depth of 4,500 proteins in plasma and this paper has remained the benchmark for deep unbiased proteomics in plasma until now. Importantly, the 2017 study, Given the complexity of the workflow was accomplished on only 16 samples, Doctor. Carr's current study identified over 5,900 and is being applied to 300 samples. This is yet another example of the step function increase in the depth and throughput of proteomic that has been enabled by the Protegrav product suite. Speaker 200:15:06It is exciting to see an combined with additional multi omic data to further understand the body's response to spaceflight. This project is providing new opportunities to understand the molecular and cellular changes that occur in humans during space travel. We look forward to sharing more detail following the publication of this study. We have visibility to multiple additional manuscripts being submitted by customers In the coming months, as more third party data is generated, we will see more proof of the unique value of proteograft to drive novel biological insight that will accelerate the next generation of multiomics studies. We feel very confident about our market opportunities I'm thrilled by the emerging validation of the photograph in Ananta customers and expect a progressive increase in the velocity of adoption in the coming several Turning our attention to the second objective, demonstrating the power of the Protograph product suite. Speaker 200:16:24We continue to innovate, extend the capabilities of our technology and drive our own abstract and publication. In March, we announced that our paper on bone morphogenetic protein 1 or BNP1 was published in PLOS 1. This peer reviewed publication highlighted the importance of the proteograph in identifying peptide level insights that discovered links between protein variants and lung cancer progression at the protein isoform level. In upcoming months, we expect to have multiple papers released from SEER in addition to what we are expecting from our customers. These papers will continue to advance the field of nano bio interactions, proteomic workflows and large scale data science, showcasing the disruptiveness of our technology and its unique ability to push the boundaries in proteomics. Speaker 200:17:19We remain committed to delivering cutting edge solutions that drive more access to proteomic data. We know that enabling streamlined data processing, analysis and interpretation is key. Throughout 2023, We will continue to expand our software capabilities and lay the roadmap for large scale studies with our proteograph analysis suite. We believe that this will be an important component of our workflow and will serve to enable more customers to onboard deep unbiased proteomic at scale. From the very beginning, we believe there would be broad interest to incorporate unbiased deep plasma proteomics into studies at scale, well beyond the existing installed base of mass spec users engaged in proteomic research. Speaker 200:18:08That is exactly what we're seeing play out In our discussion, consistent with our original vision, the market opportunity is large spanning the mass Our next product is meant to capitalize on this need to serve a broader audience. It is already In early access with multiple sites and we're getting great feedback on its performance. Our first product Delivered a step function change in unbiased proteomic and this next product does the same. We are really excited about what it will enable in the market, and we look forward to sharing more with you in the upcoming months. Turning to our 3rd objective, catalyzing new applications and markets. Speaker 200:19:04Our technology is inherently extensible. It is species agnostic and is compatible with a diverse range of sample types. The Fertigraft product suite It's being used in a range of applications across our growing customer base in academic research, translational, commercial, Pharma, CROs and even applied markets. One example of a new application that has emerged from our customer base is the use of the proteograft to detect host cell proteins or HCPs. HCPs are proteins produced or encoded by the host organism used to produce recombinant therapeutic protein such as those used in biomanufacturing of vaccines. Speaker 200:19:48Removal of HCP is one of the biggest challenges for the production of Biopharmaceuticals. An ideal HCP screening assay is high throughput, reproducible, quantitative and sensitive with high dynamic range. The Proteograph fits this bill. In a study in partnership with a major pharmaceutical company, We demonstrated that the Proteograph product suite detects 2 to 6 times more HCPs than traditional methods identifying 98% of the HCPs and overall improving measurements across purification steps. A poster on this work will be presented at the upcoming AFMS biopharma partner. Speaker 200:20:33Customers Continue to find value in Proteograph proof of principle studies as they build the case for capital equipment funding within their organization, including the grant submission process for academic customers. These small studies of 40 to 100 samples are a key enabler for customers can be uncovered even from small studies of this size. We had the shipment of a proteograph to a non human health company in the first quarter, for example, following a small proof of principle study conducted for this organization. With our proof of principle study program, We have demonstrated use of the protograph in chicken, dog, cat, baboon and plant tissue across studies looking at Cold exposure, diet, aging, cognitive impairment, multiple cancers and transplant. We will continue to drive market development efforts such as these studies, ASH Lab Collaborations and KOL work to accelerate and enable broad market adoption. Speaker 200:21:47Through these efforts, we're building relationships with key opinion leaders and expanding our scientific advisory board with the recent addition of Doctor. Josh Kuhn, Doctor. Chris Mason and Doctor. Jenny Lanayk. Doctor. Speaker 200:22:02Coon is a Professor of Chemistry and Biomolecular Chemistry at University of Wisconsin Madison. Doctor. Mason He's a professor of genomics, physiology and biophysics at Weill Cornell Medicine and the Director of the WorldQuant Initiative for qualitative prediction as well as an affiliate of Memorial Sloan Kettering Cancer Center, Rockefeller University, Harvard Medical School and Yale Law School. As mentioned earlier, Doctor. Van Eijk is Professor of Cardiology at Cedars Sinai as well as the Director of the Advanced Clinical Biosystem Research Institute, Founder of the Precision Biomarker Labs and the current President of the HUFO. Speaker 200:22:45These relationships are reinforcing the power of the protograph in the hand of these luminaries in their field. They're partnering with us to imagine a new future in multiomics, and I'm excited to continue our engagement to push the boundaries of what's possible together. Before I turn the call over to David, I want to share an update on our leadership team. Scott Thomas, our Chief Commercial Officer, will be transitioning from SEER in July. I want to thank Scott for his contribution, leading and developing a commercial organization. Speaker 200:23:16Our 2 senior regional vice presidents will lead commercial in the Americas and EMEA APAC, respectively. We have an excellent team in place, and we're confident we will continue to deliver on the promise of our transformational technology. With that, I will now turn the call over to David. Speaker 300:23:38Thanks, Omid. Total revenue for the Q1 of 2023 was $4,100,000 representing an increase of 22% compared to the $3,300,000 in the Q1 of 2022. The increase in Q1 revenue was primarily due to increased consumable kit sales related to the Proteograph product suite. Revenue recognized primarily consisted Sales of proteograph, SP100 instruments and consumable kits. Additional sources of revenue include platform evaluation, service grant and lease revenue. Speaker 300:24:09Product related revenue for the Q1 of 2023 was $3,600,000 including related party revenue of $1,300,000 consisted of sales of SB-one hundred instruments, consumable kits and platform evaluations. Service revenue was $69,000 in the Q1 of 2023 It was primarily derived from the completion of a customer service project. As we have mentioned previously, we will continue to be strategic in undertaking Certain service projects for customers that we ultimately believe lead to purchases of the Permian graph. Grant and other revenue was $335,000 in the Q1 As discussed last quarter, contributions from grant and research related collaborations will resume beginning in Q4 of require these customers to purchase consumables, we recognize a portion of this revenue as lease revenue. Total gross profit was 2,100,000 for the Q1 of 2023, representing a gross margin of 51%. Speaker 300:25:14Gross margins were aided by the mix of consumable versus instrument revenue additional grant revenue in the Q1. This was offset by overhead expenses and other costs of revenue. We expect to see variability in our overall gross margin Q1 of 2023 were $29,500,000 including $8,700,000 of stock based compensation, an increase of 18% compared to $25,000,000 including $8,100,000 of stock based compensation in the Q1 of 2022. Research and development expenses for the Q1 of 2023 were $14,500,000 an increase of 35% compared to $10,700,000 in the Q1 of 2022. The increase in R and D expenses was primarily due to an increase in product development efforts related to the Proteograph product suite, including employee compensation costs and other related expenses due to growth in R and D personnel and expenses associated with the build out of our facility. Speaker 300:26:20Selling, general and administrative expenses for the Q1 of 2023 were $15,000,000 an increase of 5% compared to $14,300,000 in the Q1 of 2022. The increase in SG and A expenses was primarily driven by greater employee compensation expenses due primarily to growth in personnel for our global commercial organization. Net loss for the Q1 of 2023 was $24,000,000 compared to $23,600,000 in the Q1 of 2022. We ended the quarter with $410,500,000 in cash, cash equivalents and investments. As Amit mentioned, while we continue to drive growth on the top line, we're taking a very disciplined approach to spend in order to protect our robust balance sheet. Speaker 300:27:05We'll continue to be very mindful of our level of spend as the year progresses in light of the volatile macroeconomic environment and its potential impact on demand. With disciplined deployment of capital, we believe we are well funded to execute on our strategic plan for many years to come. Turning to our outlook for the year. Continue to expect revenue to be in the range of $23,000,000 to $25,000,000 for 2023, representing significant year over year growth of 48% to 1% similar to 2022. We expect revenue to be more weighted to the second half of the year. Speaker 300:27:38At this point, I would like to turn the call back to Amit for closing comments. Speaker 200:27:42Thanks, David. We started the year off with a good momentum As more and more customers generated data using the proteograph, further solidifying the need for large scale unbiased deep proteomic studies. It is exciting to see the Proteograph enabling breakthrough science as shown through its power, extensibility and ability to catalyze new applications and markets. I have never been more excited about the opportunity ahead. With that, we will now open it up to questions. Operator00:28:12Thank you. At this time, we will conduct our question and answer session. Our first question comes from TJ Savant from Morgan Stanley. Please go ahead. Speaker 400:28:42Hi, this is Gabby on for Tejas. Thanks for taking my question. So maybe just to Start with what you're seeing right now with your customer base. What impact are you seeing currently from elongated sales cycles in academic versus biopharma customers? And are you seeing any constrained spending from Chinese CDMO customers? Speaker 400:29:01Thanks. Speaker 300:29:04Yes. Thanks, Gabby. It's David. In terms of the customer base, we are continuing to see a somewhat elongated sales cycle. Again, I think the environment continues to be cautious, but at the same time, we are seeing capital being deployed. Speaker 200:29:21It's just I think as we've said Speaker 300:29:23Historically, that for a new disruptive technology, it is just a little bit of longer sales cycle for us in terms of The data coming out and the proof points and a lot of customers choose to run a proof of principles study with us. And so that's really what's creating some of the elongated sales cycle. But I'll note that we have had some publications that Omid mentioned during his remarks, One from Doctor. Sure and another one coming out. So we're excited about those presentations. Speaker 300:29:53We're also excited about what's coming up at the ASMS conference in June To kind of continue to have those customer proof points. But again, we are continuing to see, it just takes some time for people to get comfortable with the technology and ultimately decide to bring it in house. In terms of China, we do feel like the market has been Has opened up. We still, in terms of working with our distribution partner over there, are still seeing, again, Some kind of ramping back up and getting back up to speed, but certainly the access over there has certainly improved. Speaker 400:30:35Great. Thanks. And then just on your plans to further build your commercial org, Could you share maybe progress on that and how many reps you're planning to add before year end? Speaker 200:30:49Yes. I mean, this is Omid. So we've said that we're not going to be disclosing The specifics of the size of our commercial organization. That said, in terms of the number of sales, That said, the total organization right now that includes sales, support, marketing is around 50 people. We think that's the right size. Speaker 200:31:16We're going to continue to scale commensurate to demand and revenue coming in, Trying to stay about 1 to 2 quarters ahead of it, and I think we're well in that pace right now. Speaker 400:31:35Okay, great. And then you had mentioned at a conference that you believe other Ohmic integration will be in Sears future. So what is your next focus for enhancing the Proteograph suite and moving towards achieving that? And I guess just what is the latest feedback you've received from your customers and how are you thinking about improvements to the platform based on the customer feedback? Thanks. Speaker 200:31:59Sure. Yes, we released the Proteograph Analysis Suite 2.0, PAS 2.0, that was last August. That software allows A user customer to integrate genomic information and proteomic information as part of their analysis. It was the first step to help a customer achieve Purdue Genomic Look at a particular subject that they're looking at. We're going to continue to innovate in that space. Speaker 200:32:43That looks at genomic information, but we can bring it in transcriptomic information as well on top of that. And so those innovations in terms of analysis is forthcoming. With regards to feedback from customers, Look, feedback in terms of Product 1 has been fantastic. We made Some claims in terms of how we would see the ecosystem develop, the product to be used, And it's playing out exactly as we had predicted. If you look at the paper that Professor Carsten Suri has under review, and he was kind enough to put it on bio archive, which is now available if you want to look at it. Speaker 200:33:35That paper has generated incoming interest from genomic scientists. I personally view that paper to be a watershed moment, a moment where it becomes clear And when you do that, you begin to look at changes that happen in terms of protein up and down regulation In response to genetic variance of the population at the protein variant level, fundamentally disruptive. I think that's the way these kind of studies should be. So we're beginning to see customers publish papers that validate that we need to look at the proteome at the level of the protein variant because the complexity of the proteome exists because it's biologically relevant. And SEER uniquely enables that to be done Accurately, precisely and at scale. Speaker 200:34:46Now we released product 1 and it was a step Increase in terms of being able to go deep at a scale and throughput. The feedback that we got from customers was, look, can we go deeper? Can we go faster? And can we lose smaller amount of sample volume because our biological samples are precious to us? And so we have product number 2 that's now in the hands of our early access customers. Speaker 200:35:20The feedback has been fantastic. More to come on that. Suffice it to say that, that product, in my mind, is yet another It certainly addresses some of the feedback that we have gotten from customers on Product 1, and I'm super, super excited To be able to reveal more and tell you more about it in over the upcoming weeks months as we put that product Broadband commercial and handset customers. Speaker 400:36:03Great. Thank you for the color. Operator00:36:13Thank you. Our next question comes from Dan Brennan from TD Cowen. Speaker 500:36:18Hey, good afternoon. This is Kyle on for Dan. Thanks for taking the questions. So how meaningful will 3rd party publications be to your customer conversations? And is a notable pickup in customer interest instrument purchases post these publications implied in the 2023 guide? Speaker 500:36:35And then maybe just going off of that, after the Q1, What's your confidence and visibility into the back half ramp here? Speaker 200:36:45Hey, Tyler, let me I'll take a Part of that and I'll have maybe David answer part of it as well. So we have visibility To at least a handful of customer papers that are on various stages of publications, including one that you saw is now publicly available on bioRxiv, but others that are in late stage reviewed that should be coming and then others that being submitted. I had predicted late last year that we would see probably about 5 customer papers And kind of tilted toward the second half of the year, it may actually be more than that. And then interestingly and importantly, and related to this is also the number of presentation from customers. So we're now seeing Customer presentations at conferences where we weren't even aware of those studies being done or those studies being presented, That's exactly what you want to see, in that you put up the abstract book and you see one of your customer has something going on That they're sharing and they're talking about it. Speaker 200:38:03And I think we're also seeing that. So I'm super optimistic, Tyler, in that The velocity of customer data presentation is going to be increasing at a progressively sharper slope as we head into the second half of twenty twenty three and then kind of the balance of the year heading into 2024, Kyle. So with that, let me turn this to David and see if he can give you additional color in terms of revenue. And before I do, I would say that I reiterated the guidance, so I'm confident about the year being in that 23 to $25,000,000 that we have guided. So with that, let me hand it to David. Speaker 300:38:48Yes, Kyle, just in terms of the 2023 guide, as Amit said, we did reiterate Guidance, and so we feel comfortable with that. And as Amit also mentioned, we did have some visibility into some of these papers coming When we did provide our initial guidance, so we certainly had some of those papers baked in. To the extent there Other papers that come out or presentations, again, we feel like that could potentially be A benefit, but I think that would be a benefit in terms of just helping kind of shorten that sales cycle a little bit for us In terms of getting other folks interested in evaluating the technology. So I think we feel pretty good where we are and we did have the fact that Some of these papers would be out as part of our original guidance. Speaker 500:39:43Got it. Thank you. And then so how is customer interest in the lease program? Is it something you're actively offering So all potential share customers or is it just a select number of potentially more meaningful customers? Speaker 300:39:57Yes. Great question. So we what we've decided to do is, we've rolled out what we call our strategic instrument placement program. And really what we're looking to do is identify key parties, whether they be KOLs or large Customers with large sample sets, people who can again help drive awareness of the technology And really just trying to lower barriers to accessing the technology in the short term. And so we did Some of the instruments we placed in the Q1, it does require consumable purchase. Speaker 300:40:40So there's a Consumable purchase that goes along with that. And then they have essentially, we agreed to place the instrument for a period of time. The customer has the option to purchase it at the end of that. And again, it just helps facilitate The getting up and using the technology and ultimately help drive a consumable revenue stream for us. I will say the amount of lease revenue that we recognize part of that is pretty de minimis. Speaker 300:41:14And it's really about continuing to drive consumables and consumable revenue around that. But again, I think the overall objective is to find ways to improve access And help drive, again, presentations, papers, publications with accounts that are going to be leaders, either thought leaders and others or large accounts that have large sample sets to help drive consumable volume over the long term. So it's been a really it's been a great it's been well received by customers. And so we again, we'll see how it plays out over the balance of the year, but We certainly feel like it's a good program that's helping us. But from a obviously, there's consumable revenues That is meaningful, but from overall lease revenue, it's not really significant. Speaker 500:42:15Got it. Thank you. Operator00:42:19Thank you. Thank you for your participation in today's conference. This does conclude the program. You may now disconnect.Read morePowered by