Rainer M. Blair
President and Chief Executive Officer at Danaher
Thank you, John and good morning, everyone. We appreciate you joining us on the call today. Our team executed well and delivered our quarterly revenue, earnings and cash flow expectations, despite a more dynamic operating environment. The resilience of our portfolio showed through in the second quarter. High single-digit base business, core revenue growth in Life Sciences and Diagnostics paired with better-than-expected respiratory testing revenue helped offset softer base business demand in bioprocessing.
Our team's ability to navigate these challenging operating conditions is a testament to their commitment to leading and executing with the Danaher Business System. Their actions are helping mitigate supply-chain constraints, enhanced productivity and improve manufacturing throughput. And we are proactively addressing structural costs, while maintaining a healthy cadence of growth investments.
Now our second quarter results also highlight the durable balance positioning of our portfolio. We have an exceptional group of businesses, all powered by DBS, that serve attractive end-markets with favorable long-term secular growth drivers. This powerful combination of our talented team, the strength of our portfolio and balance sheet optionality differentiates Danaher and positions us well to operate through today, more dynamic operating environment.
So with that, let's turn to our second quarter results in more detail. Sales were $7.2 billion in the second quarter and core revenue declined 7%. We delivered 2% growth in our base business, which was more than offset by a COVID-19 revenue headwind of approximately 9%. Geographically, core revenues in developed markets declined high-single-digits, primarily driven by lower COVID-19 revenues. High growth markets declined low-single digits with China down approximately 10%.
In China, our Diagnostics business has benefited from continued recovery in hospital patient volumes, while stimulus initiatives helped drive strength in Life Sciences. This was more than offset by a decline in our biotechnology business, where a significant deterioration in the funding environment during the quarter led to project delays and an increase in order cancellations. Our gross profit margin for the second quarter was 56.5%. Our operating margin of 20% was down 840 basis points due to the impact of lower volume in our Biotechnology and Diagnostics segments and costs incurred to adjust our capacity and cost structure in response to COVID transitioning to an endemic state.
These actions in this transition year are intended to ensure that we're in the best position to deliver on our long-term growth and margin objectives while maintaining an accelerated cadence of innovation investments. Adjusted diluted net earnings per common share were $2.05. We generated $1.6 billion of free cash flow in the quarter and $3.3 billion year-to-date. This results in a year-to-date free cash flow to net income conversion ratio of more than 125%. Our notable strength in free cash flow generation differentiates Danaher and illustrates the quality of our portfolio, business models, and our team's consistent execution.
Now let's take a closer look at our results across the portfolio and give you some color on what we're seeing in our end markets today. Reported revenue in our Biotechnology segment declined 17% and core revenue was down 16.5%. In bioprocessing, underlying market conditions weakened further as we move through the quarter, resulting in a high single-digit base business decline. Larger customers are still working through inventory they built during the pandemic and emerging biotech customers, which we define as customers without a commercialized therapy continued their efforts to conserve capital. In addition, we saw the ongoing biopharma market correction in China, intensify as the second quarter progressed. Given these dynamics, where we can, we've started actively working with our larger customers to help them more quickly manage their inventory down to normalized levels.
Now, while market dislocations are impacting our near-term growth, recent positive developments have only strengthened our conviction in the tremendous long-term opportunity ahead in the biologics market and for our leading bioprocessing franchise. The number of biologic and genomic medicines in development is meaningfully higher than at any point in history. And during the quarter, we saw notable regulatory approvals for a novel gene therapy for Duchenne muscular dystrophy and the monoclonal antibody-based Alzheimer's therapeutic. These groundbreaking therapies are not only poised to improve quality of life for patients around the world, they're also serving as validation of these emerging therapeutic classes and reinforcing the potential of drugs currently in the development pipeline.
Now in May, we completed the combination of Cytiva and Pall Life Sciences, creating a premier global bioprocessing franchise. The combined business, which will go to market under the Cytiva name, uniquely positions us to support customers as they pursue these life-changing breakthroughs. Cytiva's portfolio has the broadest offering in the industry with end-to-end solutions across all major therapeutic modalities and an innovation engine geared towards helping customers bring life-saving therapies to market faster and more efficiently. A great example is the AcelRx X-platform bioreactor Cytiva launched in the second quarter. Now this new bioreactor is optimized to enhance cell culture productivity and increase process intensity to improve manufacturing yields. The X platform's modular design also enables customers to more predictively scale from the lab to production across all modalities, including monoclonal antibodies and cell and gene therapies, helping reduce time and cost in biologic drug production.
Turning to our Life Sciences segment. Reported revenue grew 5.5% and core revenue was also up 5.5%, including high single-digit growth in our base business. Our Life Sciences instrument businesses collectively delivered mid-single-digit core revenue growth, led by nearly 10% growth at Leica Microsystems and high single-digit growth at SCIEX. Healthy demand across our life science, research, academic and applied markets, particularly for our more advanced instrumentation, helped offset softness at pharma and biopharma customers. Our genomics consumables based business was up low single digits in the quarter. Growth in plasmids, proteins and gene-writing and editing solutions, which are primarily used in projects that are commercialized or in later stages of the drug development pipeline, remained robust. This strength was partially offset by declines in next-generation sequencing and basic research.
Our Life Sciences businesses continue to deliver innovative solutions that are helping accelerate the discovery and development of biologic medicines. IDBS recently released Polar Insight, a biopharma data management platform that is leveraging artificial intelligence to help researchers more quickly analyze datasets to accelerate drug discovery, regulatory filings and technology transfer in the therapeutic development process. And SCIEX launched the Intabio ZT, a front end to the ZenoTOF 7600 that enables research, researchers to more quickly and more securely identify and validate drug candidates, improving development workflows and pipeline yields.
Now moving to our Diagnostics segment. Reported revenue declined 13% and core revenue declined 11.5%, with high single-digit growth in our base business, more than offset by lower COVID-related respiratory testing volumes at Cepheid. Our clinical diagnostics businesses collectively delivered mid-single-digit core revenue growth. Leica Biosystems led the way with high single-digit core growth driven by strength in core histology and advanced staining. Beckman Coulter Diagnostics was up mid-single digits again this quarter, with solid performance across both instruments and consumables and notable strength in immunoassay.
In May, Beckman Coulter launched the DxI 9000, their next-generation immunoassay analyzer that automates up to 90% of standard daily maintenance routines while delivering best-in-class throughput. In addition to significantly improving laboratory workflows and efficiency, the DxI 9000 will enable Beckman to provide a full menu of blood virus assays over time, closing an important menu gap and further enhancing the breadth and clinical value of our test menu. That is just one example of how the Beckman team is improving their competitive positioning through innovation, which is helping drive consistent mid-single-digit growth rates.
In Molecular Diagnostics, broad-based strength across Cepheid test menu drove another quarter of more than 30% core growth in non-respiratory testing. Customers who benefited from the workflow advantages, Cepheid's GeneXpert delivered for COVID-related testing, are increasingly adding additional assays from our leading test menu, most notably Group A Strep, and hospital acquired infection assays. And strong momentum for our recently introduced multiplex vaginitis panel, the Xpert Xpress MVP, contributed to mid-teens growth in sexual health testing. In COVID-related testing, Cepheid's respiratory testing revenue of approximately $300 million in the quarter exceeded our expectation of $175 million. This was driven both by higher volumes and a preference for our 4-in-1 test for COVID-19, Flu A, Flu B and RSV. We continue to expect approximately $1.2 billion of respiratory testing revenue for the full year.
With COVID now in endemic state, we believe Cepheid is continuing to take share as many customers look to consolidate their point-of-care, PCR, testing platforms on to the gene expert for both respiratory and non-respiratory testing. Their preference for the GeneXpert within their labs and across their health care networks is a testament to the significant value, the unique combination of fast, accurate lab quality results and the best-in-class workflow provides clinicians.
Now moving to our Environmental & Applied Solutions segment. Reported revenue grew 2% and core revenue was up 1.5%. Water quality core revenue grew mid-single digits and product identification was down mid-single digits. In water quality, DBS-led execution drove solid growth on top of a double-digit prior year comparison. Strong performance at ChemTreat and Hach was balanced across industrial and applied end markets. At Trojan, equipment sales and order rates remained strong as customers are continuing to invest in larger municipal projects.
At product identification, Videojet declined low single digits against the high single-digit prior year comparison. We're also seeing lower activity levels at our industrial and consumer packaged goods customers who are aligning their production schedules with end-use demand. The Videojet team continued their strong cadence of new product innovation this quarter with the release of the 3350 laser marking system. This impressive addition to Videojet's portfolio enables users to mark different sized products and multiple levels of the same product without adjusting the laser, resulting in increased uptime and higher throughput. This is one of several product introductions planned for the year that are helping position the product identification platform for success as they begin their journey as part of Veralto.
So speaking of Veralto, we remain on track for a fourth quarter 2023 separation. Veralto will be well positioned in some of the most attractive areas of water quality and product identification. Their portfolio will be comprised of leading companies with durable high-margin business models, supporting customers' mission-critical operations. The Veralto team is looking forward to hosting an Analyst Day in Chicago on September 6, and we hope many of you will attend.
So now let's briefly look ahead at expectations for the third quarter and the full year. In the third quarter, we expect core revenue in our base business to be down low single digits year-over-year. We also expect total core revenue to decline in the low to mid-teens percent range primarily as a result of lower demand for COVID-19 testing, vaccines and therapeutics. Additionally, we expect a third quarter adjusted operating profit margin of approximately 26%, which includes the impact of efforts to adjust our cost structure and capacity in response to COVID transitioning to an endemic state, particularly within our Diagnostics and Biotechnology businesses.
Now turning to the full year 2023. Due to the near-term challenges within bioprocessing, we now anticipate low single-digit core revenue growth in our base business. We also expect total core revenue to decline high single to low double digits for the year as a result of lower demand for COVID-19 testing, vaccines and therapeutics. Additionally, we expect a full year adjusted operating profit margin of approximately 29%.
So to wrap up, our team remains focused on consistent execution in the face of a challenging and more dynamic macroeconomic environment. We're confident about the bright future ahead for Danaher. Our talented associates are innovative and passionate about their work and committed to our culture of continuous improvement. Across our portfolio, we're helping customers solve some of the world's biggest health care challenges, including faster, more accurate disease diagnosis and accelerating the discovery, development and manufacture of therapies.
Our solutions are at the forefront of improving patient outcomes and ensuring more patients around the world have access to quality care. Financially, we've got a great lineup of leading franchises in attractive end markets with durable, high recurring revenue business models, and our strong free cash flow generation positions us well to further enhance our portfolio going forward. The unique combination of our talented team, differentiated portfolio and balance sheet optionality, all powered by the Danaher Business System, provide a strong foundation for creating shareholder value, while helping to meaningfully improve human health.
So with that, I'll turn the call back over to John.