Illumina Q1 2024 Earnings Call Transcript

AlphaStreet
Provided by AlphaStreet
May 2, 2024
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Operator

Good day, ladies and gentlemen, and welcome to the First Quarter 2024 Illumina Earnings Conference Call. [Operator Instructions] Please be advised that today's conference is being recorded. I would now like to hand the conference over to Salli Schwartz, Vice President of Investor Relations.

Sallilyn Schwartz
Vice President of Investor Relations at Illumina

Hello, everyone, and welcome to our earnings call for the first quarter of 2024. During the call today, we will review the financial results we released after the close of market and offer commentary on our commercial and regulatory activity, after which we will host a question-and-answer session. Our earnings release can be found in the Investor Relations section of our website at illumina.com. Providing prepared remarks for Illumina today will be Jacob Thaysen, Chief Executive Officer; and Ankur Dhingra, Chief Financial Officer. Jacob will provide an update on the state of Illumina's business and Ankur will review our financial results, which include GRAIL. Joydeep Goswami, who is serving as an adviser to the company through June 30, will then join us for Q&A. As a reminder, GRAIL must be held and operated separately and independently from Illumina pursuant to the transitional measures ordered by the European Commission, which prohibited our acquisition of GRAIL under the EU merger regulation. This call is being recorded, and the audio portion will be archived in the Investors section of our website. It is our intent that all forward-looking statements regarding our financial results and commercial activity made during today's call will be protected under the Private Securities Litigation Reform Act of 1995. Forward-looking statements are subject to risks and uncertainties. Actual events or results may differ materially from those projected or discussed. All forward-looking statements are based upon current available information, and Illumina assumes no obligation to update these statements. To better understand the risks and uncertainties that could cause actual results to differ, we refer you to the documents that Illumina files with the Securities and Exchange Commission, including Illumina's most recent Forms 10-Q and 10-K. With that, I will now turn the call over to Jacob.

Jacob Thaysen
Chief Executive Officer at Illumina

Thank you, Salli. Good afternoon, everyone. Before going into our first quarter results, I want to take a moment to thank our former Chief Financial Officer and Chief Strategy and Corporate Development Officer, Joydeep Goswami, for his many contributions to Illumina over more than four years. As Salli noted, Joydeep will stay on an advisory role through June to support a smooth transition. I also wanted to welcome our new CFO, Ankur Dhingra, who you will hear from shortly, and congratulate Jakob Wedel, who has now been named as Chief Strategy and Corporate Development Officer. Jakob joined Illumina in November and has been heavily involved in our long-term strategy planning. Throughout the quarter, I continued to meet with customers around the world and have the opportunity to bring a number of them to our San Diego headquarters to discuss new ways to collaborate, innovate and shape what their future looks like with Illumina. Some of our customers shared how they are scaling up their projects with NovaSeq X to unlock greater discovery power. One key area of focus is harnessing whole genome opportunities in minimal residual disease. Other customers are starting to sequence deeper and are adding multiomics layers to their projects, while others are looking at epigenomic biomarkers and methylation to help diagnose and characterize disease.

We are seeing a significant opportunity to expand in multiomics. Customers are looking for more sophisticated solutions to support their work, and we are exploring all avenues to create value in this space. Our recent acquisition of Partec, a specialized multiomics software solution, is the building block of our expansion into this space. Our intent is to collaborate with our customers to understand how we can provide more sample-to-answer solutions. Illumina is at the heart of the ecosystem, and we will continue to catalyze the industry with an even greater focus on our customers' priorities. Turning to our first quarter results. I'll focus my comments on core Illumina. In Q1, we delivered core Illumina revenue of approximately $1.06 billion ahead of our expectations. While it was a decent start to the year, we remain cautious due to the persistently challenging global macro environment where customers are still constrained in their purchasing decisions. As expected, we are seeing this playing out across our regions notably with lower NovaSeq X placements versus the first quarter of 2023, where we shipped our first X instrument to fulfill a strong preorder book. three of our regions declined year-over-year. Americas revenue was down 4%, EMEA revenue was down 3%, and Greater China revenue was down 14%. Europe revenue was up 7% year-over-year although we expect a decline in Q2 given the last year's strong X shipment in Europe in the second quarter.

Nonetheless, Illumina management team continues to make significant progress executing against my three key priorities to accelerate value creation across the company. My first priority, driving our topline, is grounded in a growing installed base and helping customers realize the full potential of our instruments. In Q1, we shipped an additional 55 NovaSeq X instruments, bringing our total X installed base to more than 400 instruments. This is a solid start of the year, and we expect momentum to continue to build. We also saw promising consumables demand throughout the quarter as our customers continue to scaling their operations and expanding their sequencing projects. With the launch of the 25B reagent kit in Q4 and the 1.5B in Q1, and alongside with the well-received upgrade of the 10B flow cell, we are now providing our customers with the full suite of NovaSeq X products. In Q1, we also made XLEAP-SBS chemistry available to our mid-throughput customers with the launch of our P4 flow cell on the existing NextSeq 1000, 2000 instruments. In the first several weeks post launch, we have received exceptional feedback from customers who are reporting reads that exceed specs for quantity and quality. Customers are positive about the simple migration that's enabled them to run spatial and single-cell projects and they are impressed with the accuracy they see with the DRAGEN onboard. Illumina continues to pursue strategic partnerships and alliances to drive the entire genomics ecosystem forward. As a recent example, Pillar Biosciences announced FDA approval for its pan-cancer IBD for general tumor profiling on the Illumina MiSeqDx system.

We've been partnering with Pillar since 2017 and are excited for this important milestone. Also in the quarter, Bristol Myers Squibb joined our previously announced collaboration with Johnson & Johnson innovative medicine on the development of our multi-cancer whole-genome sequencing-based molecular residual disease assay to better understand disease recurrence. You should expect to see more of these types of activities going forward. Now turning to my second priority. I'm continuing my focus on delivering operational excellence by driving margin improvement through increased productivity while sustaining innovation and growth. It has been my goal to align our organization in a way that best supports our customers' evolving needs. In March, we brought together our marketing and commercial teams under one customer first global function. I'm confident that combining these teams into one global commercial organization will build our agility to better serve customers while delivering more sustained growth and margins over time. Additionally, we are focused on driving further improvements throughout our end-to-end supply chain and are taking a disciplined approach to improve our cost structure. In Q1, we implemented new initiatives to adjust pricing across our portfolio to better cover our global operational cost. We also made progress in streamlining our real estate footprint as we exited select facilities in the Bay Area and in San Diego. These actions add to the number of ongoing initiatives that will continue to support our margins and increase further flexibility for investment in high-growth areas. We are also tightly focused on stabilizing our Greater China business. And in Q1, we brought on Jenny Zheng as Head of region. Jenny has deep expertise in health care and global organization and a strong leadership and execution mindset. He is already proving to be a great leader of our China team and is introducing changes to make our business more in China for China, which will include improving our local manufacturing and partnerships in the region.

Moving on to my third priority, which is working to resolve GRAIL as quickly as possible. In April, we reached an important milestone in the divestment process when the European Commission approved our divestment plan for GRAIL. The approved plan contemplates both sales and capital markets options, and we have made progress on both paths, consistent with the European Commission's divestiture. In the event of a capital market transaction, we are required to capitalize GRAIL with approximately $1 billion, reflecting 2.5 years of funding based on GRAIL's long-range plan. The amount includes cash on GRAIL's balance sheet. We are on track to finalize the terms of the transactions by the end of the second quarter. I look forward to having additional updates for you soon. Overall, I'm encouraged by the progress we have achieved in the quarter and optimistic about delivering on our initiatives here in 2024. Now I'll ask Ankur to share more detail on our first quarter results and outlook.

Ankur Dhingra
Chief Financial Officer at Illumina

Thank you, Jacob, and hello, everyone. I'm very excited to join Team Illumina to improve human health by unlocking the power of the genome. I'm passionate about making a positive meaningful impact in health care. I am very familiar with the rule -- the role Illumina has played in establishing and advancing the genomics industry over the last 25 years. Building on that strong foundation, I'm confident we can continue leading, supporting our customers and delivering on the promise of what genomics can do for patients around the globe. I would also like to express my thanks to Joydeep for his support as I transition into my role. It's been a great first 2.5 weeks. I'll start by reviewing our segment results for core Illumina and GRAIL followed by consolidated financial results and then conclude with my remarks on our current outlook for 2024. I will be discussing non-GAAP results, which include stock-based compensation. I encourage you to review the GAAP reconciliation of these non-GAAP measures, which can be found in today's release and in the supplementary data available on our website. Starting with our segment financials. Core Illumina first quarter revenue was $1.06 billion, which is down 2% year-on-year, both on a reported and constant currency basis.

This revenue performance exceeded our expectations and was primarily driven by three areas: first, strong performance in high-throughput consumables; second, timing of revenue from certain strategic partnerships; and third, some customers accelerating delivery of a few NovaSeq X instruments from Q2 into Q1. Core Illumina sequencing consumables revenue of $698 million was up 1% year-over-year, primarily due to growth in high throughput. On a sequential basis, NovaSeq X consumables grew in the double digits following the successful launch of the 25B flow cell. Total sequencing GB output on our connected high and mid-throughput instruments grew over 35% year-over-year and grew at a high single-digit rate quarter-over-quarter. Research and applied activity benefited as transition to the NovaSeq X continues to ramp and 25B adoption grew at large core labs. Clinical activity continued to be driven predominantly by the NovaSeq 6000. As a reminder, we believe this data is a useful reference that shows the general activity trends across our installed base and is directionally correlated with revenue over time. Sequencing instruments revenue for core Illumina of $110 million declined 29% year-over-year in Q1 2024. The year-over-year decline was driven both by one, an expected decline in mid-throughput shipments as capital and cash flow constraints continue to impact purchasing behavior and moderate instrument placements; and second, lower NovaSeq X placements as compared to significant preorder launch-related shipments in the first quarter of 2023.

For NovaSeq X, as Jacob noted, we shipped 55 instruments in Q1. Core Illumina sequencing service and other revenue of $151 million was up 27% year-over-year, driven primarily by an increase in revenue from strategic partnerships and hired instrument service contract revenue on a growing installed base. Moving to the rest of the core Illumina P&L. Core Illumina non-GAAP gross margin of 67.1% for the quarter increased 190 basis points year-over-year, driven primarily by a more favorable mix of sequencing consumables and execution of our operational excellence priorities that delivered cost savings, including freight and improved productivity. This was partially offset by certain strategic partnership revenue that is lower margin and increased warranty and field service costs. Core Illumina non-GAAP operating expenses of $491 million were down $23 million year-over-year primarily due to decreased labor expense as a result of reduced headcount and continued savings from our cost containment initiatives. Core Illumina non-GAAP operating expenses were lower than expected due to timing of project spend shifting from Q1 into Q2 and lower stock-based compensation expense due to onetime reversals. Putting it all together, core Illumina non-GAAP operating margin was 20.6% in Q1 2024 compared to 17.4% in Q1 2023.

Transitioning to financial results for GRAIL. GRAIL revenue of $27 million for the quarter grew 35% year-over-year driven primarily by adoption of Galleri. GRAIL non-GAAP operating expenses totaled $197 million and increased $24 million year-over-year driven primarily by increased headcount to support commercial expansion and research and development. Moving to consolidated financial results. In the first quarter, consolidated revenue of $1.08 billion was down 1% year-over-year, both on a reported and constant currency basis. Non-GAAP net income was $14 million or $0.09 per diluted share, which included dilution from GRAIL's non-GAAP operating loss of $185 million for the quarter. Non-GAAP EPS exceeded our expectations driven primarily by higher core revenue and lower core operating expenses in the quarter. Our Q1 non-GAAP tax rate was 46.4% compared to 27.3% in Q1 2023, with both periods including a meaningful impact from the consolidations of GRAIL's operating loss, which increased by $21 million year-over-year. Absent the impact of GRAIL, our Q1 2024 and Q1 2023 tax rates were in the mid-20s. Our non-GAAP weighted average diluted share count for the quarter was approximately 159 million. Moving to consolidated cash flow and balance sheet items for the quarter. Cash flow provided by operations were $77 million. Capital expenditures were $36 million and free cash flow was $41 million, and we did not repurchase any common stock.

We ended the quarter with approximately $1.12 billion in cash, cash equivalents and short-term investments. Moving now to 2024 guidance. As a reminder, Illumina is moving as quickly as possible to resolve GRAIL and the company is focusing its 2024 financial outlook on core Illumina given the uncertainty around the specific timing and impact of the GRAIL divestment. Our guidance does not assume any impact from the potential divestment of GRAIL in 2024. We will provide non-GAAP EPS guidance for 2024 upon completion of the divestment. We are encouraged by our results in Q1 that came in ahead of our expectations both for topline and margins. We've also seen the seasonal rebuild of our total performance obligations or backlog, which increased more than 20% from the end of Q4. At the same time, we're not -- still not seeing any significant improvement in the macroeconomic environment or our business in China, and we are monitoring the impact of a strengthening U.S. dollar. While we are seeing early strength in consumables to start the year, it's being offset by capital constraints that are continuing to weigh on instrument purchases.

As such, we are reiterating our full year 2024 core Illumina revenue guidance of approximately flat from 2023 and non-GAAP operating margin of approximately 20%. Our operating margin expectations continue to reflect the benefit of gross margin improvement and disciplined management of our expenses, including reduced headcount, offset by normalization of our performance-based compensation as well as the impacts of inflation. For the second quarter of 2024, we expect core Illumina revenue in the range of $1.072 billion to $1.084 billion, reflecting a year-over-year decline of 6.5 to 7.5 percentage points. The year-over-year decline is predominantly because of the lower NovaSeq X instrument shipments given the significant backlog we worked through early last year following the launch. At the midpoint, this guidance reflects a $22 million sequential increase from Q1 of 2024. For the second quarter, we expect core Illumina non-GAAP operating margin of approximately 18%, resulting from a seasonal step-up in operating expenses in Q2 compared to Q1 primarily due to an increase in stock-based compensation expenses from the timing of equity grants. We also expect an increase due to some project spending shifting into Q2 from Q1. With that, I will now turn it back over to Jacob for his closing remarks. Thank you.

Jacob Thaysen
Chief Executive Officer at Illumina

Thanks, Ankur. Before we close and move to Q&A, I would like to comment on our upcoming strategy update event. Illumina's leadership team has been reexamining our strategy, the road map and initiatives for achieving it and the profitable growth we believe it can produce. Our strategy will continue to play to Illumina's strength of building the genomics ecosystem and maintaining a tight customer focus in an increasingly competitive space. Central to this is our goal of making customers the heroes in their labs. In every customer meeting, we are listening intently to understand what they need to unleash the full power of their Illumina instruments and making their priorities the core of our strategy. You will see us continue to develop more sample-to-answer solutions to enable the genomics and multiomics ecosystems. We'll maintain our open platform approach and continue to drive the innovation that our customers need to succeed and for which Illumina is known. Illumina has long been the standard in NGS. Our strategic hands-on support for customers globally, our deep experience and expertise across multiple research and clinical markets and our decade-long technology road map position us well to continuing leading the industry and enabling our customers to improve human health. I am excited to announce that we will be sharing our comprehensive strategy work with you during a virtual event in the fall of this year. We will have more information in the coming months. Thank you for joining. I'll now invite Ankur and Joydeep to join me for Q&A.

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Operator

[Operator Instructions] Our first question comes from the line of Doug Schenkel with Wolfe Research.

Douglas Anthony Schenkel
Analyst at Wolfe Research

Jacob, I want to start with a high level on that kind of builds off of the announcement you just made and then I want to ask a specific cleanup question on the quarter. So first, it's hard to believe, but we're now just over, I think it's eight months into your tenure as CEO of the company. From the outside, we see the changes you are starting to make to leadership, to the broader organization and in moving towards a resolution on GRAIL. That said, there continues to be a lot of uncertainty about things like, first, I'd say, your view on Illumina's long-term growth profile especially given uncertainty about the competitive landscape and the outlook for market elasticity? Secondly, what are reasonable operational targets? And then thirdly, ultimately, whether the company as we sit here today, is positioned to play offense. Would you be willing to share at least a little bit more today about where you are in the process of moving from data gathering and business assessment to maybe putting some stakes in the ground regarding the medium and long-term outlook for the company from a growth and operating margin standpoint? And I know that was a lot, but let me sneak in the mathematical follow-up question on the quarter. It seems like high throughput sequencing consumable revenue grew low to mid-teens. Is that right? And if so, what does that tell you about evolving competitive dynamics and questions regarding elasticity?

Jacob Thaysen
Chief Executive Officer at Illumina

Well, Doug, thank you very much. That was a long question, and I think also a happy birthday to you. So I'll do my best here to answer the first question. And I think actually, I'm just a little bit over seven months into my tenure. So maybe I should have another month before we really ask this question. But definitely, I'm spending -- I continue to spend a lot of time with our customers, with our employees. I'm excited every time I go and walk over in the R&D building and uncover new innovations that we are doing. There's a lot going on in this company. In the meantime, we are also spending a lot of energy on looking into, of course, where -- how are we -- in what direction are we putting Illumina going forward. And I think we covered a little bit that in my prepared remarks is that we see a lot of opportunities in both in genomics, but now with the X coming out there, and we see a lot of elasticity in that area already with many customers are using that to go into single cell into spatial and doing bigger and bigger program and deeper and deeper analysis. This is not something that is in the future. It's already happening now. But obviously, at the same time, we running through that change in price point. And of course, we expect to see elasticity to really help us here over the next period of time. So while I'm not ready to share with you where we would go from an overall growth perspective, long range, I can guarantee you that we still are optimistic about the growth of Illumina going forward.

Secondly, as I think you saw here in Q1, we are highly dedicated to continue to expand our margins. And I'm really pleased with what all the work we're into with the team here and how we saw the gross margin expansion here for the quarter. So I think that's just an evidence on what we are committed to do to continue to drive up. And I don't think there's anything that holds us back to drive up margins over the next period of time to where we have been at historic levels. But then again, I do want to wait a little more to have everything lined up from a strategic point of view and thereby also our growth algorithm and our cost structure algorithm to really go out and share the details. But fundamentally, I truly believe that Illumina has a great opportunity of being and continuing to what we have done in the last decade of leading the genomics industry, being in the middle of the ecosystem, really go out there and support our customers. But now in the future, where the customer expectations are different from what they have been in the past to really focus on end-to-end workflows, but also new innovations into the multiomic space that we're highly committed to. So that was where I'm right now. I think then maybe yes, on -- Joydeep can help us a little bit on the consumable question.

Joydeep Goswami
Advisor at Illumina

Yes. Look, I think and happy birthday again, Doug. On consumables, we, as expected, saw strong growth with X consumables, and we saw X consumable revenues offset our growth in X consumables revenues offset the decline in -- the expected decline in 6K consumers, right? So that's a good piece. We also are seeing very strong sequencing activity growth driven by X and X customers, right? So this is a really positive thing, and it underpins a lot of what Jacob talked about in terms of new applications or expanded applications in clinical and in research, right? So we're excited about that, and we expect that to continue as the 25B flow cell gets more adopted and more used in regular activities at our customers.

Operator

Your next question comes from the line of Puneet Souda with Leerink Partners.

Puneet Souda
Analyst at Leerink Partners

Let me focus a bit on the mid-throughput segment. I just want to understand, can you provide us what was the growth in that mid-throughput segment for both consumables and more importantly, instrumentation. There's -- there are increasingly more questions as customers and the core labs that don't necessarily have an X or a 6K are taking on a competitor system because it's lower price -- I mean lower cost per gigabase almost half of what XLEAP is an the NextSeq. So just wondering, can you elaborate a bit more on what's happening in that segment? And how do you address that?

Jacob Thaysen
Chief Executive Officer at Illumina

Yes. Thanks for that, Puneet. I think as a starting point, we are not providing details on the growth on mid-throughput segment. But let me just try to address some of your questions anyway, is that we, of course, are very committed to the mid throughput, and I'm really excited with the X's chemistry now coming out on the 1K, 2K. It's only been a few weeks out there, but we have seen, as I mentioned also before, tremendous excitement from our customers that this doesn't need a new instrument, you can pretty much with a software upgrade, you can add -- you can use the new flow cells that you can get higher quality scores, you can get more capacity and you can also, of course, with a low price point. So a lot of our customers are super excited about that, and it really makes us highly competitive in that space. That said, you're right, there's competition. And by the way, we take competition very seriously in our whole segments, but mid-throughput is clearly where there's more activity -- competitive activities than maybe other spaces. We are seeing that mostly in China still. But in rest of world, there is also that. But we will continue to innovate in this space. I think the XLEAP as I mentioned, was a good step in that direction. But it's an area we will continue to compete in. And also, we expect to fight for every market share points out there.

Joydeep Goswami
Advisor at Illumina

Maybe to add, right, so two things. We continue to see consumables growth. So elasticity in that mid-throughput segment. So that's one. And two, we had, as we had told you when we said our budget for the year. We had already anticipated a certain level of competition and what we are seeing in the market is in line with what we had expected. And again, I want to emphasize that some of the forecast that we have given from that throughput accounted for the macroeconomic headwinds that we had expected to see going through this year, and we -- actually, those have come to bear, right? So Again, it's in line with what we had told you.

Operator

Your next question comes from the line of Vijay Kumar with Evercore ISI.

Vijay Muniyappa Kumar
Analyst at Evercore ISI

Ankur, welcome. I guess my first question is -- my first question is on the guidance here. And Jacob, maybe you can chime in on this, right? So sequentially, core revenues are up by about $30 million-ish. Is that all being driven by consumables. I think you mentioned you saw improving consumable pull-through on the X throughout the quarter as the quarter progressed. So maybe some color on what the exit rate is and where is that increase coming from?

Jacob Thaysen
Chief Executive Officer at Illumina

Yes. I think Ankur can certainly also chime in here, but we saw actually strength throughout the quarter. There was nothing of this being the last few weeks of the quarter. But we continue to see customers adopt the X consumables now where we have a full portfolio about the 25B, the 10B and the 1.5B. We see a lot of more applications coming onboard from our customers. So it has really been truly by the X as Joydeep also was talking about before that we have seen improvement. Besides that, we have also -- so the beat was very nice on the consumables. But we've also seen our BD revenue growth. We have seen some partnerships that has been accelerated. And we're just excited about that because it's a big part of our strategy also to continue to develop together with our partners. So that was also part of our performance. Ankur, you have more comments?

Ankur Dhingra
Chief Financial Officer at Illumina

Yes. I think thanks that was well covered. The only thing I would add specifically that the sequential increase in business that we are forecasting and building the guidance comes both from instruments and consumables. So expecting both of that positive trend to continue here.

Operator

Your next question comes from the line of Dan Brennan with TD Cowen.

Daniel Gregory Brennan
Analyst at TD Cowen

Ankur, welcome aboard. Maybe just a question on multiomics and some of the new products that, Jacob, you've been talking about, and it's been kind of in the Illumina proxy as well. Can you just give us some color maybe start with maybe the SomaLogic kind of partnerships? Is that the multiomic excitement that you're expressing. And then any other color you could provide about like sample-to-answer and some of the newer areas that you're looking to explore timing-wise, when do you think we'll get an update on that? Will it be on Investor Day? Or just how do we think about potential opportunity for Illumina?

Jacob Thaysen
Chief Executive Officer at Illumina

Yes, for sure. Thanks, Dan. And you're absolutely right. I mean, overall, I'm excited about the way that sequences can play in multiomics. And I'm excited about what -- how we can help also partners and customers stimulate that market. And that goes for all the multiomic spaces, if you look into them. But of course, we are -- if you just look short term here, we're, of course, very excited about our relationship with SomaLogic and where we can go with the proteomics. We are still in early access. So '24 will be the year where we are going out with a few handfuls of customers and really going in and make sure we truly understand the power but already the feedback from customers so far has been very positive on that. So I'm certainly excited about that. But we will continue to look into options for us to play even stronger into multiomics going forward across all the opportunities there, both organically, but of course, also together with our partners out there. If you look into end-to-end workflows, I think that's really a great opportunity, as I mentioned also before, that I see customers obviously, are looking for the best technology, but they're also looking for ease of use. That is not only about the sequence itself, but sample-to-answer. And the more we can automate, the more we can simplify both from, of course, sample prep, but of course, also from informatics, I think we can really make sure that our customers can spend the time on where they can create most value. So we'll speak more about that, as you mentioned also in our strategy update. And I think Illumina has a great opportunity to cover whole workflows and create great applications for our customers.

Operator

Your next question comes from the line of Daniel Arias with Stifel.

Unidentified Participant
at Illumina

This is Paul on for Dan. I think just one from us. In terms of POPSEQ, could we get some commentary on that? It seems like all of us has seen some budget pressure. There's been some news flow there with recent cuts. Does that create any risk to the consumables forecast for the year? And maybe on the flip side, in Europe with genome of Europe, there's been some chatter about that picking up? Is that something you could see increased activity in 2025 that would be meaningful?

Jacob Thaysen
Chief Executive Officer at Illumina

I think overall, we have -- if you look at the longer run, we are -- long horizon or midterm horizon. I'm very excited about the PopGen -- not only for PopGen but what it really constitute in terms of [Indecipherable] really looking into big genomic studies to -- in the end to implement into the health care system. And we have more than 30 programs ongoing right now, and we have at least the same number in the funnel for opportunities for the future. But we're not banking on any one individual program. So it's clear with these big programs, where you have sovereigns have to make the systems and budgets and so on that there's a little bit puts and takes in that. And thereby, we are not really budgeting and building our budgets based on individual programs. So I don't foresee that any of them are making a big impact on our either '24, '25 opportunity. But obviously, we are doing our best to stimulate the market out there.

Operator

Your next question comes from the line of David Westenberg with Piper Sandler

David Michael Westenberg
Analyst at Piper Sandler Companies

So I just want to start with the continuation of Puneet's question on the mid-throughput side. How has XLEAP helped maybe in that mid-throughput -- or how do you anticipate it helping it. And Joydeep, I think you mentioned some -- there is some elasticity there. I think there, it's a little bit less clear in the X department, you definitely see the whole genome from, you see a lot more single cell kind of stuff. Can you just reiterate some of that elasticity and how to prevent that from being a race to the bottom, just given that the -- as you mentioned, the competitor is using price there? And then on the high throughput side, you did say that you expect the order rate momentum to build. Is that based on actual orders in the book? Is it and very late in the cycle orders or it's just anticipation of budgets? I mean, any way you can walk us through how -- make us a little more clear on that?.

Jacob Thaysen
Chief Executive Officer at Illumina

Yes. No, thanks. Let me try to give a little more color on the mid-throughput is that we're actually seeing with -- XLEAP's chemistry is -- as I said, there's really three dimension to it is high quality of sequencing, but it's also higher capacity with a lower cost. So it really gives customers an opportunity to do more with the sequences. And thereby, we also see that there are customers that were looking to maybe go into single cell or even spatial that they felt they couldn't afford or they couldn't do on -- with the capacities or with the cost positioning that was previously that now opens up for that space. So I think we are seeing again an elasticity game that will play out over the next period of time. I think in the end, customers are really looking to work with innovators here in the field. And they -- I think XLEAP chemistry is just another example that we continue to innovate in all our segments. And so while it is an environment right now that's also been impacted by the macro, I actually am pretty excited about what the XLEAP chemistry will do for us over the next period of time and what new applications it will bring on also in the mid throughput. As you mentioned, there are a lot of things going on in high throughput also but we see some of the same things happening in mid throughput.

Joydeep Goswami
Advisor at Illumina

Yes. I think I think just to comment on and add to what Jacob has said, right? XLEAP, remember, was a way for us to help our customers use the same instruments that are already out in the field and with a simple software change, right, they basically can get increased output, better accuracy, better performance. And I think we saw that come through very clearly with our launch in Q1. I want to emphasize too, right? You're seeing the elasticity and really immediately in the research domain, right, where a lot of what Jacob was talking about in terms of multiomics, single cell, spatial things do tend to get performed first on the research side on mid-throughput. We are also continuing to see that we can maintain, because of our innovation and our technical superiority, a price premium over what others are offering in the market, right? So we're seeing a lot of that continue, and we are encouraged by that. The macroeconomic pieces are there, but they will end at some point, and we do expect that at that point, some of the cash constraints that our customers are facing will lift.

Jacob Thaysen
Chief Executive Officer at Illumina

Yes. And then I think you had the question about how orders on the X. And I would say, first of all, the -- we've seen the X orders being up year-over-year. So we're certainly encouraged by that. And as you know also know that we actually expect that we will have improvements during the -- momentum during the year. So at this point, we are just expecting this to look better. And especially since we have a lot of customers that bought one or maybe two Xs have done validation work on that. And we are starting to see these multiple orders coming in now up to 10 instruments at a time. So I think you will see that momentum go through the year also.

Joydeep Goswami
Advisor at Illumina

But Dave, this is not based on some magic new budget thing, right? We as -- just to reiterate, we have expected to see the macroeconomic conditions continue as they are right now.

Operator

Your next question comes from the line of Subbu Nambi with Guggenheim.

Subhalaxmi T. Nambi
Analyst at Guggenheim Securities

You reiterated guidance for the core sequencing revenue growth this year. And I apologize if I missed it, but do you still expect the mix of consumables and instruments to be the same? Or is the expected trajectory now or a bit different?

Ankur Dhingra
Chief Financial Officer at Illumina

Yes. Great question. This is Ankur. So you're right. We reiterated our guidance for the full year, both for revenue as well as for the operating margin. Actually, we're off to a great start for the year as well with the Q1 performance, certainly looking at that derisking the performance a little bit. Now overall, we'll be confirming our guidance. So the construct is still there. The -- and you've seen the Q1 performance. Just to add a little bit more color there, if you think from a half 1, half two perspective, et cetera, our instrument growth rates given how the shipments of X were last year, those growth rates have a variability during the year between half and in half 2, although consumables as they're starting now should have a more steady kind of profile. Now we saw good pricing. We've seen good pull-through during the quarter as well. So as of now, we're just reiterating the overall guidance for the year.

Operator

Your next question comes from the line of Sung Ji Nam with Scotiabank.

Sung Ji Nam
Analyst at Scotiabank

And also welcome to Ankur and congrats, and thank you to Joydeep. Just a quick one on the status of the jurisdictional appeal in Europe and whether the resolution of that -- the timing of that, if it doesn't happen before the end of 2Q, would you still be providing your final terms of the divestiture?

Jacob Thaysen
Chief Executive Officer at Illumina

Yes. So thanks for that. And overall, as you know, we are moving forward with GRAIL as fast as we can, and we have committed to provide of course, insight here by end of Q2. And I would say at this point, there's nothing, no information, nothing that holds us back from that. So -- we don't know when the ECJ information is coming. And as I said, we're not waiting for it. If it comes before Q2, it really doesn't change the timeline, end of Q2.

Operator

Your next question comes from the line of Tejas Savant with Morgan Stanley.

Tejas Rajeev Savant
Analyst at Morgan Stanley

Just a few cleanups on the high-throughput side things, Jacob, if I may. So on the 25B flow cell, it sounds like you're getting really good traction there. Can you give us an update on that 40% number you provided in the past and X customers who adopted 25B? Where is that number today? Second, any update on where high clinical customers are in their X validation process? Any metrics you could share? Or should we think of the production workflows and clinical ramping is mainly a 2025 dynamic? And then last one, just on excess high throughput capacity. That's a dynamic that comes up every once in a while. Is that starting to weigh on customer purchase decisions for these high throughput customers at all? You've got Ultima launching as well here. So just curious as to the macro headwinds versus the digestion of that high throughput capacity that's been added given the NovaSeq X and the 25B launch but also the competition?

Jacob Thaysen
Chief Executive Officer at Illumina

Yes. Overall, I think we're very pleased with seeing where the X and also the 25B consumers where it's going. And right now, we are -- approximately half of our customers have -- are using the 25B flow cell. So that's really exciting for us, and we are encouraged by that momentum. I think many of our clinical customers, I know they're still on running most of their of their assays on the 6K. We are tracking very closely each of them and seeing where they are and where they're doing from validation and when they're going into production. So we have deeper that insight. I don't think we at this point, we are ready to share that. But we have a very good understanding on that. But I still think there is -- that is -- a lot of them are still working through the validation and then they will bring on one by one of new types of assays that likely have higher, deeper depth or more insights for -- in these assets that they had on the 6K.

Operator

Your next question comes from the line of Mason Carrico with Stephens.

Mason Owen Carrico
Analyst at Stephens

Sorry if these have been addressed as I joined a bit late here. Could you update us on win rates outside of China last quarter? I think you said they had stabilized in Q3 and Q4. Have you seen that stability continue throughout 2024 so far? And then second, could you give us any insight into the mix of orders coming -- that are coming in terms of 6K upgrades, fleet expansions, new customers, new to high-throughput customers?

Jacob Thaysen
Chief Executive Officer at Illumina

So I think overall, we are, of course we are following very closely, of course, where we are on the win rate. And as we also mentioned, it's stabilized, and we are looking at that regularly and ensuring that we continue to hone in on how we can do even better. So I'm actually pleased with the performance out there. But obviously, we're keeping a very close sight on this. As I mentioned before, we take competition very seriously. We are doing everything we can to keep our customers being very highly supported and make sure that they are successful in laboratories, which I think in the end, in the long run is the winning formula for being the preferred partner for our customers. And I think on mix of orders. I don't know whether we normally are sharing that information. But I think there are -- at this point, there's certainly still more research customers that have moved on to the X. And we have seen customers with multiple 6Ks that are now starting to move over to the expert. I would say the vast majority still are in the transition phase.

Operator

Your next question comes from the line of Rachel Vatnsdal with JPMorgan.

Rachel Marie Vatnsdal Olson
Analyst at JPMorgan Chase & Co.

So I want to question a little bit on the instrument placement number for the X this quarter. You mentioned 55 placements, but you also highlighted that there were a number of places that were pulled forward from 2Q into 1Q. So first, can you just quantify how many placements were pulled forward? And then just in terms of full year dynamics, you continue to highlight that the macro backdrop remains difficult. We've seen that really across the sector this quarter. But can you just give us in light of that assumption, what are your latest assumptions on placements for the year?

Jacob Thaysen
Chief Executive Officer at Illumina

Yes. I'd say, overall, as we mentioned that we're -- we didn't pull anything forward. We were -- there was customers that was requesting to put forward because some of their programs were running faster than anticipated. But there's only a few so it was not really a big change in expectations. But in the end I like that because it shows that there are a lot of interest out there and customer that has already purchased one is looking to accelerate now their transition into the X. So we are -- so I'm excited about that. At this point, we're not providing a number, but we know that as we entered into 2023, we had a very, very strong backlog, of course, as you know, coming into 2023. So -- and thereby, 2023 was a very strong placement year of high throughput. So we do expect to be lower than that as we also communicated in our original guidance. But we haven't -- we are not able to provide -- or we're not -- at this point, we're not changing really our expectation for the year.

Ankur Dhingra
Chief Financial Officer at Illumina

The only thing I would add, Richard, for you, just in terms of our topline performance was quite better than what we were expecting. Relative to that overall achievement or overachievement only a small portion, say, about 1/4 or so came from these customers who asked to for an earlier delivery of the instrument. So relatively small portion from that phenomenon.

Operator

Your next question comes from the line of Patrick Donnelly with Citi.

Patrick Bernard Donnelly
Analyst at Smith Barney Citigroup

Can you just talk through the margins? 2Q, obviously, a little bit of a step down. I know you guys mentioned maybe some product cost there. But can you just give a little more color in terms of what spend picks up in 2Q and then how we should think about that metric as we work our way through the year. And then just a quick cleanup, just on the service revs, those came quite a bit higher than we were expecting. If you could just flesh out what happened there as well, that would be helpful.

Ankur Dhingra
Chief Financial Officer at Illumina

Yes, sure. Good question. So let me address them both. This is Ankur. So on the OpEx, as I said in my prepared remarks, yes, there is a step-up in spending from Q1 to Q2, primarily coming from two factors. One of them relates to just the timing of our merit increases in the annual stock branch cycle. So we end up getting the full impact of that cost in Q2. So that's seasonal, typically happens every year for the company. So roughly about half of our sequential increase in the OpEx comes from that. The other half is generally around certain project-related spend, that we've pushed out either pushed out into Q2, or there are milestones into Q2 that will happen. In terms of going forward, as you think about your P&L for the rest of the year, I do expect the overall operating margin performance to continue to improve sequentially every quarter. So Q3 better than Q2 and then Q4 better than Q3.

Joydeep Goswami
Advisor at Illumina

And then on the service?

Ankur Dhingra
Chief Financial Officer at Illumina

And then on the services side, again, very strong overall growth, about 27% year-over-year growth, two main components. One part of that is little less than half is coming from specific pharma customer services, which had the timing of that in the quarter. So that was less than half of it, but roughly half of that growth is coming from just the excellent performance in our core instrument services business.

Joydeep Goswami
Advisor at Illumina

You would expect that given the number of instruments we placed. And just to add to Ankur's comments, right? We are expecting and delivered better gross margin performance, right? So that should help our operating margin. We expect to continue strong performance on gross margins. So that should help us and as revenue steps up as well. And given that we have taken measures to control our costs, we've reduced our headcount overall by about 12% compared to last year. That should also add benefits to the operating margin line as we go through the year.

Operator

Your next question comes from the line of Eve Burstein with Bernstein Research.

Eve Burstein
Analyst at Sanford C. Bernstein

Earlier this week, the FDA published a final rule exercising regulatory power over a lab developed tests. For you guys, you have the benefit of having IVD compliant machines when a lot of the companies that are emerging to challenge you don't have those yet. However, our understanding is that research use only machines are actually used quite a bit for FDA-approved tests. It's a little bit harder, but it can be done. So we don't expect this to affect you that much or give you a big competitive advantage. Is that the right way to think about it? Or could there be more upside from the role for you?

Jacob Thaysen
Chief Executive Officer at Illumina

Yes. No, first of all, I think we are pleased for sure that we have now more of greater clarity on the FDA ruling and the direction of this. But there's still a lot of detail that needs to be clarified. But overall, you're right that with our positioning, both with our DX portfolio and the investment we have made into the high-quality and also helping with required documentation for our customers to go in there and get their PMAs approved. I think we're very well positioned. You mentioned that LDTs are used for FDA approval. Well, really only if you go into a single site PMA setup. And that requires actually a lot of work for vendors like Illumina to help our customers with that with the right level of documentation and so on. So I think it actually plays to our strength going forward, and we are committed to support this area and help our customers be successful independent on whether it's a full PMA single site or other types of opportunities that this new world will bring us.

Operator

Your next question comes from the line of Conor McNamara with RBC Capital Markets.

Conor Noel McNamara
Analyst at RBC Capital

I know you talked about not giving too much detail on the consumable adoption with X customers. But is there any -- can you quantify at all like of the 400-or-so boxes placed, how many of those customers are just would you say are at scale and ordering at what your demand is versus those that are still validating or whether for economic conditions haven't really ordered what you expect from them? And vice versa, has there been any stock orders with any of the X customers?

Jacob Thaysen
Chief Executive Officer at Illumina

Yes, that's a good question. And at this point, we still see that most of our customers are still in the ramp. I think there are, of course, research customers that have us very fast out and really run bigger programs. We have seen the [Indecipherable], we have seen single cell being some elements or areas where there's been a lot of interest in running. And I think that we have seen some of those research customers already been on scale at least with one of the instruments they have bought and now maybe they're starting to move on to the next one. But then again, if you look at the broader 400, I think most of the general is still that this is still in a ramp positioning. Now -- yes, so that's where we are right now.

Joydeep Goswami
Advisor at Illumina

And the stocking?

Jacob Thaysen
Chief Executive Officer at Illumina

Yes, yes, go ahead, Joydeep.

Joydeep Goswami
Advisor at Illumina

I mean, on the stocking side, look, when we haven't seen too much stocking on the 25B because as a standard, right, the initial shelf life is shorter, so you wouldn't expect people to stock up too much. On the 10B side, it's very early in that stock up phase. Again, we expect to see a little bit more as we go through the year, but not yet.

Operator

Thank you. That concludes our Q&A session. I will now hand the call back over to Salli Schwartz.

Sallilyn Schwartz
Vice President of Investor Relations at Illumina

Thank you for joining us today. As a reminder, a replay of this call will be available in the Investors section of our website. This concludes our call, and we look forward to seeing you at upcoming conferences and other events.

Operator

[Operator Closing Remarks]

Corporate Executives
  • Sallilyn Schwartz
    Vice President of Investor Relations
  • Jacob Thaysen
    Chief Executive Officer
  • Ankur Dhingra
    Chief Financial Officer
  • Joydeep Goswami
    Advisor
Analysts

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