Telephone and Data Systems Q1 2024 Earnings Call Transcript

Quartr
Provided by Quartr
May 7, 2024

There are 8 speakers on the call.

Operator

Greetings, and welcome to Rigel Pharmaceuticals Financial Conference Call for the Q1 2024. At this time, all participants are in a listen only mode. A brief question and answer session will follow the formal presentation. As a reminder, this conference is being recorded. It is now my pleasure to introduce our first speaker, Ray Furey, Rigel's Executive Vice President, General Counsel and Corporate Secretary.

Operator

Thank you, Mr. Furey. You may now begin.

Speaker 1

Thank you. Welcome to our Q1 2024 financial results and business update conference call. The financial press release for the Q1 2024 was issued a short while ago and can be viewed along with the slides for this presentation in the News and Events section of our Investor Relations site on ryder.com. As a reminder, during today's call, we may make forward looking statements regarding our financial outlook and our plans and timing for regulatory and product development. These statements are subject to risks and uncertainty that may cause actual results to differ from those forecasted.

Speaker 1

A description of these risks can be found in our most recent annual report on report on Form 10 ks for the year ended December 31, 2023, and subsequent filings with the SEC, including our quarter 1, quarterly report on Form 10 Q on file with the SEC. Any forward looking statements are made only as of today's date, and we undertake no obligation to update these forward looking statements to reflect subsequent events or circumstances. At this time, I would like to turn the call over to our President and Chief Executive Officer, Raul Rodriguez. Raul? Thank you, Ray,

Speaker 2

and thank you, everyone, for joining today. With me today are Dave Santos, our Chief Commercial Officer and Dean Schorno, our Chief Financial Officer. Additionally, I'd like to introduce Lisa Roycare, our new Chief Medical Officer. Lisa joined us in March and brings over 20 years of clinical development, regulatory and medical affairs experience to Rigel. We are thrilled to have her on the team.

Speaker 2

Now beginning on Slide 4. We continue to grow our hematology and oncology business in the Q1 of the year, positioning us well for the remainder of 2024 and beyond. We started 2024 with strong commercial demand for our 2 marketed products, TAVALISSEIN ITP and RESLIDIA in mutant IDH1 relapse or refractory AML, with demand bottles for each of these two products reaching a new quarterly high since their launch. This is particularly impressive since the Q1 of the year is typically one where our industry faces headwinds due to insurance co pays and resets and the medical donut hole. The decline in net product sales from the prior quarter is primarily due to a decrease in Tavalise bottles remaining in our distribution channel or inventory.

Speaker 2

In addition, we are also expanding our commercial product portfolio with the recent acquisition of Gabretto, an FDA approved therapy for the treatment of red fusion positive metastatic non small cell lung cancer and advanced or metastatic thyroid cancer. Gabretto offers a valuable targeted treatment option for non small cell lung cancer patients with redfusion positive disease. Gabretto will provide us with top line growth as well as leverage our existing commercial and medical affairs infrastructure. We remain on track to complete the transition of this asset in July of this year. In parallel, we are advancing our development programs, including the evaluation of Reslydia in a broad range of IDH1 mutant cancers with our strategic partners, MD Anderson Cancer Center and Connect.

Speaker 2

These alliances greatly enhance our ability to further evaluate Reslydia's potential in a cost and time efficient manner. As we grow our commercial product portfolio and prioritize prudent clinical development, we are well positioned to advance our business and work towards financial breakeven. Before I turn the call over to Dave, I will provide a summary of our previously announced acquisition of U. S. Rights to Gabretto.

Speaker 2

On Slide 5, we are working diligently to ensure a smooth transition of Ganbaretto into our commercial product portfolio, which we expect to complete in July. There are strong synergies between this product and our existing portfolio, infrastructure and expertise. We believe we have the right people and systems in place to bring this product to physicians and their patients. Gabretto is a once daily oral RET inhibitor with an established foothold in the U. S.

Speaker 2

Market, having generated $28,000,000 in U. S. Net product sales in 2023. Further, with patents that have issued or expected to issue with statutory expiration dates between 2,036 and 2,041, we are well positioned to make Gabrieto available for years to come. In exchange for U.

Speaker 2

S. Rights to Gabrieto, we will pay our partner, Blueprint, a purchase price of $15,000,000 $10,000,000 of which is payable upon first commercial sale and $5,000,000 of which is payable upon the first anniversary of the closing date. The deal also includes potential future regulatory and commercial milestone payments to BLUEPRINT as well as tiered royalties on net sales of Fabryto. We believe this puts Rigel in a favorable position to begin capturing value from this program in the near term. Now, I will turn the call over to Dave to provide updates on our commercial product portfolio.

Speaker 2

Dave?

Speaker 3

Thank you, Raul. First, on to growing demand of TAVALISSE and ITP. I have a few brief comments on our continued momentum with TAVALISSE in Q1. On Slide 7. You will see our FDA approved indication, which is for adult patients with chronic immune thrombocytopenia or CITP who had an insufficient response to a previous treatment.

Speaker 3

Moving to Slide 8, I'm happy to report that in Q1, TAVALISSE achieved its 6th consecutive quarterly record high for bottles shipped to patients in clinics. Over those 6 quarters, we have increased TAVALISSE quarterly demand volume by 23%. And Q1 2024 demand grew 10% over the same period last year. We are pleased that our team has continued to produce double digit year over year growth starting our 6th full year after approval. Total bottles sold in Q1 were 2 90 bottles less than our bottles shipped to patients and clinics as our distribution channel reduced inventory.

Speaker 3

Dean will discuss this later in our presentation. This resulted in TAVALISSE net sales of $21,100,000 for Q1. On Slide 9, the driver of our continued demand growth with TAVALISSE is our new patient starts. The graph on the left shows that since 2021, after we emerged from the pandemic, our new patient starts have continued to improve each year. In Q1, we achieved the highest first quarter new patient starts since launch.

Speaker 3

We generated this new patient start growth through continued focus on expanding the breadth and depth of prescribers, ensuring strong coverage and reimbursement with greater than 95% commercial customers. I want to thank our entire team for their continued focus and execution to impact more CITP patients with TAVALISSE. We are very pleased with the consistent growth in new patient starts and how that has continued to drive our demand both in Q1 and as we move forward through 2024. Moving to Slide 10, Now I'd like to take a few minutes to discuss our strong quarter growing Reslydia sales. On Slide 11, you will see our FDA approved indication for Reslydia, which is for adult patients with relapsed or refractory acute myeloid leukemia with the susceptible IDH1 mutation as detected by an FDA approved test.

Speaker 3

Moving to Slide 12, we shipped 326 bottles of Resideo to patients in clinics in Q1, representing strong 17% growth versus Q4 of 2023 and nearly tripling the demand generated a year ago in Q1, our first full quarter of launch. We sold 3.90 bottles of Resideo into our distribution channel, resulting in $4,900,000 in Q1 net twenty twenty four net sales. This was 26% above what we sold in Q4 and more than triple the net sales of the same period last year. We are very encouraged by the momentum we are now building with Reslidya. On Slide 13, I wanted to update you on how our Reslidia institutional business continues to be the driver of our growth.

Speaker 3

84% of our total bottles shipped to patients in clinics were generated from use in institutional accounts. Our breadth and depth of use in institutions continues to grow as more academic leukemia treaters are becoming more aware of Reslidius data in relapsedrefractorymutant IDH1 AML. As we've discussed on prior calls, we believe we have an opportunity to grow resiliency use further in the community. As in that segment of our business, quarterly demand has remained stable. We did see a highly encouraging trend in Q1 as the community drove more than 1 quarter of our new patient starts.

Speaker 3

This signals that community leukemia treaters are also becoming aware of Resideo and are trying it in their mutant IDH1 AML relapsed or refractory patients. We believe a significant opportunity remains to grow Reslyde use among community AML treaters, particularly because their adoption of venetoclax based regimens for their newly diagnosed patients. We feel Reslyde's data in post venetoclax patients will be particularly compelling to them. I want to thank our entire team for their hard work and growing awareness of Reslydia, both in academic institutions and community practices. They have worked closely across functions as one united team to broaden Resideo's impact on mutant anti H1 relapsedrefractory AML patients.

Speaker 3

Moving to Slide 14, I wanted to provide an update on our commercialization plans for GIVEreta. On Slide 15, I'll begin by reviewing the FDA approved indications for Givaretto, which include the treatment of adult patients with metastatic positive with advanced RET fusion positive thyroid cancer who requires systemic therapy and who are radioactive iodine refractory. Moving to Slide 16, I want to reiterate why we believe Givretto is an important strategic addition as the 3rd FDA approved oral targeted therapy in our Rigel commercial portfolio. As you'll recall from Raul's remarks, GIVEreta generated nearly $28,000,000 in U. S.

Speaker 3

Net sales last year. So this is an excellent opportunity for us to continue providing meaningful therapy to RET fusion positive patients with non small cell lung cancer and advanced thyroid cancer. We believe this compelling Gavrto opportunity suits our business well for a few reasons. Number 1, it enables us to immediately and efficiently move into a large solid tumor market where most clinicians are already testing patients and immediately recognize Rett as a biomarker associated with FDA approved therapies. So we anticipate that the Rett market will continue to expand as more Rett fusion positive non small cell lung cancer and advanced thyroid patients are identified.

Speaker 3

Number 2, we believe we have built strong access capabilities that we can fully leverage to ensure current and newly prescribed patients have access to Gevreto. Our efficient and customer friendly distribution network with TAVALISSE and RESUDIA will soon be ready to accommodate Gevreto as well our Rigel One Care Patient Services Hub that has established a reputation for being highly responsive to patients and providers. We also have a track record of ensuring strong coverage and reimbursement for oral targeted therapies in difficult to treat diseases that we plan to continue with Givoretto. And number 3, this opportunity makes perfect sense for us because it is a highly complementary one to both the commercial and medical affairs teams we have in place to call on both academic centers and community oncology practices. With our Rigel footprint already in these accounts, we'll be able to be even more efficient with our time and resources as we discuss multiple products within these accounts.

Speaker 3

On the right side of the slide, I wanted to highlight our biggest opportunity with Gevreto and that is in non small cell lung cancer. As you'll recall, approximately 1% to 2% of the 194,000 non small cell lung cancer patients each year will test positive for the RET fusion, translating to approximately 3,000 RET fusion positive non small cell lung cancer patients this year. The graphic shows research done last year on the first line therapies that were used in RET fusion positive patients who were eligible for treatment. 3 quarters of the patients were treated with 1 of the 2 FDA approved RET inhibitors with Gevreta used in about a 5th of patients prescribed a RET inhibitor. Importantly, there is still approximately a quarter of the market being treated by chemotherapy with or without an immune checkpoint inhibitor or multi kinase inhibitor.

Speaker 3

We view this quarter of patients as the growth opportunity for RET inhibitors and Givrado. Slide 17 reviews what we believe are the 4 key drivers for continued growth as we begin our commercialization journey with Givretto. The first driver is patient identification. It is important that as many as possible of the 3,000 potential RET fusion positive non small cell lung cancer patients are identified each year. Fortunately, even if clinicians aren't specifically looking for RET fusion positive patients when they do test, about 90% of them immediately recognize the RET biomarker as being associated with an FDA approved therapy.

Speaker 3

Also in research conducted last year, about 80% of non small cell lung cancer patients are being tested and that rate is improving. When clinicians don't test, it is more likely due to not having adequate tissue available. And in addition to inadequate tissue being the top barrier for testing, a significant portion of HCPs are concerned about delaying treatment while waiting for test results. We believe that especially with the recent data and adjuvant approvals of targeted therapies for biomarkers such as EGFR and ALK in early stage lung cancer. Biomarker testing to identify appropriate test patients will expand even further in non small cell lung cancer.

Speaker 3

Both patient and HCP education on biomarker testing and the importance of targeted therapies in non small cell lung cancer are growing. And that's a laying clinicians concerns about delaying treatment. Secondly, and more importantly for Givrado, optimizing the choice of therapy in those identified patients who are treatment eligible is an impactable growth opportunity for us. Most oncologists have yet to try Givretto in the front line. And the biggest reason for that is comfort and familiarity with other drugs.

Speaker 3

From the prior slide, the use of chemotherapy with or without immune checkpoint inhibitors and multi kinase inhibitors represents about 1 quarter of the use in the first line treatment of RET fusion positive patients. By growing awareness of Givrado's efficacy, safety and once daily oral dosing, we believe we can grow future use of Gubrato among current non users. And importantly, as more clinicians are educated about testing and the impact of targeted therapies in lung cancer, we believe the number of clinicians who are concerned about delaying treatment and therefore initially treat with a non targeted treatment will decrease, resulting in more RET fusion positive non small cell lung cancer patients currently treated with chemotherapy based regimens or other agents moving to RET targeted therapy like Gevreto. 3rd, we believe that Gevreto will continue to grow due to its high response rates, long duration of response and convenient once daily dosing. Lisa will discuss these and other impressive Gavreto efficacy data in her presentation.

Speaker 3

These important drivers of persistency should continue to grow our carryover business each month as patients refill their prescriptions. And finally, as we have discussed, as we leverage our strengths in coverage, reimbursement and patient services with Rigel One Care, we believe we can gain loyal Givrado users from clinicians who view out of pocket costs and difficulty obtaining reimbursement as barriers for the use of RET inhibitors. In summary, we are well positioned to continue growing Gavrato through positive momentum in these 4 key drivers. On Slide 18, we have made continued progress in working closely with Genentech and BLUEPRINT to ensure both current and newly prescribed patients continue to have access to Gavreto without interruption. Rigel One Care is preparing to work with providers to assist in transitioning patients from the existing Genentech network and access programs to the Rigel network and Rigel OneCare patient programs, ensuring patients experience no interruption to therapy.

Speaker 3

Our distribution network ensures patient and provider choice in where their prescription is filled and we will have Rigel One Care staff fully dedicated to GIVEreta to ensure the highest level access support and customer service. I am pleased to report that everything is on track for Rigel to begin supplying patients and clinics with Givretto in July. And to wrap up Givretto with Slide 19, I just wanted to update our high level timeline of our plans for the rest of the year. Our market access team made excellent progress in preparing our distribution network for the addition of Gevreto in Q1 and everything is on track for this quarter to prepare Rigel One Care and our field teams for this transition. We anticipate that in July, we will begin shipping GIVERETA to patients and clinics and Rigel One Care will transition the majority of current and newly prescribed GIVERETA patients.

Speaker 3

Our field teams will simultaneously begin discussing Givrtta with customers with a focus on the accounts that have current patients on Gavreto. Then in Q4, we will continue expanding our breadth of prescribers by calling on users and non users, particularly in the community setting. It will be an exciting year bringing Gavrato into our portfolio of oral targeted therapies. And I look forward to continuing to update you on our progress as the year moves ahead. Now, I'd also like to say how thrilled we are to have our new Chief Medical Officer with us.

Speaker 3

And I'll now turn the call over to her for an update on our development activities. Welcome, Lisa.

Speaker 4

Thank you, Dave, and good afternoon, everyone. I'm excited to have joined Rigel just a couple of months ago at an important inflection point for the company as we expand our hematology and oncology portfolio. First, I'd like to begin by underscoring how precision medicine approaches to lung cancer are positively impacting patient outcomes, including those patients with RET fusions, and why, from the clinical perspective, we are excited about Gabretto. On Slide 21, RET fusions are present in approximately 2% of all non small cell lung cancers, representing approximately 3,000 new patients per year in the U. S.

Speaker 4

And then around 20% of papillary thyroid cancers for around 1,000 new cases per year. Testing for RET fusions is an essential part of the pretreatment evaluation of non small cell lung cancer. In fact, clinical practice guidelines recommend the use of targeted therapies as first line treatment for eligible patients with metastatic non small cell lung cancer, harboring actionable genetic variants such as RET fusions. Prior to the advent of RET targeted therapy, patients with advanced RET fusion positive non small cell lung cancer received platinum based chemotherapy regimens with overall response rates in the 50% range and median progression free survival of 6 to 8 months. The use of non selective multi kinase inhibitors with anti RET activity has shown only modest efficacy and high rates of treatment related toxicity.

Speaker 4

Because RET fusion positive non small cell lung cancers exhibit low PD L1 expression, immune checkpoint inhibitors have demonstrated only limited efficacy here with overall response rates less than 10% and progression free survival in the range of 2 to 3 months. Gabretto is an oral, highly potent selective RET inhibitor with once daily dosing that is FDA approved for RET fusion positive non small cell lung cancer or thyroid cancer as first line or subsequent line therapy. On the next slide, I will review updated clinical data from the Phase III ARROW study, which led to the approvals. Slide 22 summarizes updated clinical results from the ARO study with a data cutoff date of March 2022. This Phase onetwo multicenter open label dose escalation and expansion study was conducted at 71 sites in 13 countries with an original data cutoff date of May 2020.

Speaker 4

In Phase 1, pralsetinib at a dose of 400 milligrams daily was determined to be the recommended Phase 2 dose. In Phase 2, the safety and efficacy of pralsetinib 400 milligrams daily was evaluated in patients with RET fusion positive advanced non small cell lung cancer, thyroid cancer and other RET fusion positive solid tumors. The primary endpoint was overall response rate. In the lung cancer subgroup, clinical activity was observed irrespective of prior therapy. The overall response rate in 130 patients with previous platinum based chemotherapy was 63% and 74% to 80% in 107 treatment naive patients, with tumor shrinkage observed in all previously untreated patients.

Speaker 4

In the overall subset of 260 non small cell lung cancer patients, median duration of response, one of the key secondary endpoints, was 19.1 months. Pralsetinib was generally well tolerated with predominantly low grade toxicity with only 10% discontinuing therapy due to treatment related adverse events. In the subgroup of 22 patients with RET fusion positive thyroid cancer, 91% of previously treated patients achieved a response. And finally, in the subgroup of 23 patients with RET fusion positive solid tumors, the overall response was 57%. These results underscore the benefit of utilizing RET targeted therapy with pralsatinib in first or later lines of treatment for patients with RET fusion positive non small cell lung and thyroid cancer.

Speaker 4

Moving to slide 23, patients with RET fusion positive non small cell lung cancer have a high rate of brain metastases, which are present in 25% of patients at the time of diagnosis, and approximately 50% of patients will develop brain metastases over the course of their lifetime. In the ARROW study, the intracranial response rate for 15 patients with brain metastases was 53% and complete responses were seen in 3 patients. Overall, the median duration of response was 11.5 months. On slide 24, based on these data, we believe that pralsetinib has a differentiated value proposition. It's the only once daily oral RET inhibitor approved for patients with non small cell lung and thyroid cancer with RET gene fusions.

Speaker 4

When considering the spectrum of prior treatment approaches we previously reviewed, pralsetinib is associated with favorable response rates and durable activity regardless of prior treatment history. Prasitinib has also demonstrated promising intracranial activity in patients with brain metastases and has an established safety profile with manageable adverse events and a low discontinuation rate. Finally, pralsetinib is a recommended treatment option for patients with RET fusion positive non small cell lung cancer and advanced thyroid cancer. So to summarize, we believe that pralsetinib is a differentiated target treatment option for patients, and we look forward to fully integrating the product into our portfolio. I would now like to provide an update on our development programs and clinical research collaborations, which foster continued growth of our HemOnc pipeline.

Speaker 4

Moving to Slide 26, we shift focus to our strategy to continue expanding our hematology and oncology pipeline. First, we are focused on advancing our IDH1 inhibitor, olutacitinib, into new clinical indications. We believe olutacitinib has potential in a number of cancers where mutated IDH1 plays a role such as additional AML segments, myelodysplastic syndrome or MDS and glioma either as a monotherapy or in combination. To further evaluate olutacitinib in these indications, we've entered into strategic development collaborations with the MD Anderson Cancer Center and the CONNECT Consortium. We are also advancing R289, our novel IRAK1four inhibitor in patients with lower risk MDS.

Speaker 4

Enrollment continues into our Phase Ib trial and we expect to have preliminary data from the first part of this trial later this year. In addition, we remain focused on evaluating potential opportunities to in license or acquire products that would be a strategic fit for our portfolio. We are looking for differentiated products in hematology, oncology or related areas, products that are late stage, possibly with registrational data, soon to have registrational data or more advanced, and products that can leverage our hematology and oncology infrastructure. As demonstrated with our acquisitions of olutacitinib and pralsitinib, our goal is to continue to find assets that are strategic fit with our organization, pipeline and ability to execute. 1st, we're very pleased to have started a development collaboration with the MD Anderson Cancer Center to advance olitacitinib more broadly into AML, MDS and beyond.

Speaker 4

Through our partnership, we are planning to evaluate olutacitinib in combination with other agents in first line IDH1 mutated AML and higher risk MDS. We also plan to evaluate olutacitinib as a monotherapy in lower risk MDS and CCUS, a condition associated with an increased risk of developing MDS and in the post transplant maintenance setting. That's 4 potential clinical trials on the horizon with up to $15,000,000 paid over 5 years. We expect these trials to position us to conduct a subsequent registrational trial or trials. And we look forward to working with MD Anderson and providing updates as our collaboration progresses.

Speaker 4

Moving to Slide 28, another important development collaboration we have is with CONNECT Consortium to conduct a Phase II trial in patients with IDH mutated IDH1 mutated glioma. Gliomas account for around 30% of CNS tumors in children, adolescents, and young adults with approximately 1 third of these being high grade gliomas, translating to approximately 800 to 1000 new cases each year in the U. S. High grade gliomas are a leading cause of cancer related death in adolescents and young adults. Despite available therapies, the 5 year survival of this population is less than 10%.

Speaker 4

IDH1 mutations are found in approximately 6% of pediatrics and up to 36% of high grade gliomas in adolescents and young adults. The safety and preliminary activity of single agent elutacitinib in a cohort of 26 patients with relapsed or refractory high grade IDH1 mutant gliomas were recently reported. Based on these data, we believe that alutacitinib has potential in this indication and olutasitinib will be included in CONNECT's TARGET D trial, a molecularly guided Phase II umbrella clinical trial for high grade glioma. The Phase 2 CONNECT open label study intends to enroll approximately 60 patients. In the Rigel sponsored arm, adolescents and young patients that are 39 years old and younger with newly diagnosed IDH1 mutation positive high grade glioma will receive maintenance therapy with olitacitinib in combination with temozolomide for the 1st year after radiotherapy followed by a lutacitinib monotherapy for the 2nd year.

Speaker 4

The primary objectives are to evaluate safety and tolerability of a lutacitinib with and without temozolomide and progression free survival. We anticipate the trial to initiate this summer. We will provide funding of up to $3,000,000 in study material over the 4 year collaboration. We, along with CONNECT, are excited about olitasitinib's potential to provide a much needed new treatment option to this underserved patient population. And finally, on Slide 29, I'd like to tell you about our novel dual IRAK1-four inhibitor, R289, which we are evaluating in a Phase 1b trial in patients with lower risk MDS.

Speaker 4

This is another area of high unmet need in a primarily elderly patient population facing progressive cytopenias, particularly anemia resulting in transfusion dependency and increased risk of infections and a risk of progression to acute leukemia. The therapeutic strategy for MDS depends upon the patient's MDS risk classification. For lower risk MDS patients, first line treatment options include the use of red cell transfusions, erythroid stimulating agents, luspatercept and lenalidomide for those with a deletion 5q abnormality. In second and later lines of therapy, durable responses are difficult to attain and toxicity becomes more of an issue. There are currently no approved therapies for lower risk MDS patients that have failed hypomethylating agents.

Speaker 4

We believe that R289 has the potential to address the unmet needs in this patient population. Moving to Slide 30, I'd like to highlight why we are excited about R289. Dysregulation of the immune and inflammatory signaling pathways is associated with MDS, with chronic stimulation of both the toll like and IL-one receptor pathways involving IRAK1 and IRAK4, leading to a pro inflammatory marrow environment and cytopenias. The activation of IRAK1 and 4 were recently reported to also occur independently of this signaling pathway, leading to persistent inhibition of hematopoietic cell differentiation, and that co targeting both is required to fully suppress inflammation, leukemic stem cell progenitor function, and restore hematopoiesis and MDS. Clinically, IRAQ4 inhibitors in MDS and AML have thus far shown only modest activity supporting this concept.

Speaker 4

In preclinical and healthy volunteer studies, R835, a dual IRAK1four inhibitor suppressed pro inflammatory cytokine production. R289, an oral prodrug that is rapidly converted to R835 was well tolerated with once and twice daily dosing and is now being evaluated in a Phase Ib study in lower risk MDS. Slide 31 shows the design of our ongoing open label multicenter Phase Ib study of R289 patients with relapsed refractory lower risk MDS, which has a dose escalation phase with a standard 3 plus 3 design and a dose expansion phase for confirmatory safety. The primary endpoints for this trial are safety and selection of the recommended dose for expansion and secondary endpoints include response rates and PK. Based on emerging data from the study, we have recently included 2 additional dose levels with twice daily dosing regimens.

Speaker 4

The study continues to progress well. We completed enrollment in the 3rd cohort and we anticipate presenting preliminary data from the 1st part of the trial later this year. Lastly, on Slide 32, our RipK1 inhibitor programs are progressing well with our partner Lilly. RIPK1 is implicated in a broad range of inflammatory cellular processes and plays a key role in tumor necrosis factor signaling. OCADUSERTIB, our non CNS penetrant RRPK1 inhibitor, previously referred to as R552 or LY3871-eight zero one is currently being studied in an adaptive Phase IIa2b clinical trial in up to 380 patients with active moderate to severe rheumatoid arthritis.

Speaker 4

Phase IIa enrollment of approximately 100 patients is advancing well with preliminary analysis of the Phase IIa results anticipated by the end of the year. Our preclinical CNS penetrant RYK1 inhibitor program is also progressing toward lead candidate nomination. We are excited about the progress of our programs and their broad potential in RA and other immune and CNS diseases. To conclude, I'm excited to have joined Rigel at this time in progress and expansion in our development programs. I look forward to contributing to the growth of our hematology and oncology portfolio.

Speaker 4

And I will now turn the call over to Dean.

Speaker 5

Thank you, Lisa. I'm on Slide 34. For the Q1 of 2024, we shipped 2,193 bottles of TAVALISSE to our specialty distributors, resulting in $21,100,000 in net product sales. 2,483 bottles of TAVALISSE were shipped to patients and clinics, while 290 bottles decreased the levels remaining in their distribution channels at the end of the quarter. For the Q1 of 2024, we shipped 3.90 bottles of Reslidia to our specialty distributors, resulting in $4,900,000 in net product sales.

Speaker 5

326 bottles of Rhizlydia were shipped to patients in clinics, while 64 bottles increased the levels remaining in our distribution channels at the end of the quarter. We reported net product sales in TAVALISSE of $21,100,000 in the Q1 of 2024, 5% decrease compared to the same period in 2023, resulting from the decrease in bottles remaining in our distribution channels at the end of the quarter. I will describe this in a bit more detail on the next slide. We reported net product sales from Reslidy of $4,900,000 in the Q1 of 2024 compared to $1,500,000 in the same period in 2023. As a reminder, Brasilia was launched in the United States in December of 2022.

Speaker 5

Our net product sales from TAVALISSE and Brasilia were recorded net of estimated discounts, chargebacks, rebates, returns, co pay assistance and other allowances of $12,400,000 For the Q1 of 2024, our gross to net adjustment for topoisomerasylvia was approximately 34% 24% of gross product sales respectively. Before we move on from net product sales, let me review our expectations for the Q2 of 2024. We're pleased with the strength of our business and expect to see continued growth in bottles shipped to patients and clinics for both TAVALISSE and RESLIDIA. We expect our gross to net adjustment in the Q2 of 2024 to be approximately 35% for TAVALISSE and approximately 26% for Reslidia. On Slide 35, before I move on to a review of our financials for the quarter, I want to provide a brief review of the dynamics of the sequential decrease in net product sales we saw during the quarter.

Speaker 5

Starting with the orange bars, in the Q4 of 2023, we saw 2,463 bottles shipped to patients in clinics. This is our key demand metric as Dave highlighted our highest demand volume since launch. Incrementally, we saw a significant increase in bottles remaining in distribution channel of 208 bottles. This resulted in total bottles for the Q4 of 2023 of 2,671 bottles, which generated $25,700,000 of net product sales. Now to discuss the green bars.

Speaker 5

In the Q1 of 2024, we saw 2,483 bottles shipped to patients at clinics. This small increase is despite the typical Q1 industry challenges associated with resetting of co pays and the Medicare donut hole to laying both new prescriptions and refills that both we and our industry experience each year. You'll note in the thin green bar that this small increase in demand volume resulted in a sequential increase in net product sales of $200,000 The bigger impact in this sequential reduction in net product sales came from the reduction of inventory levels at our distributors. The reduction from 13 74 bottles of inventory at our distributors in Q4 of 2023 down to 10.84 bottles at the end of Q1 of 2024 contributed to a sequential decline in our net product sales of $4,800,000 the thick red bar in this graphic. Inventory levels at our distributors are variable, though we do expect them to generally increase over time as our business grows.

Speaker 5

To illustrate the effect of change in inventory levels on our net revenues, let me provide an example. What we have said that we expect to see continued growth in bottle shift to patients in clinics for TAVALISSE and that our inventory levels are variable. If we assume that both inventory levels and demand volume are flat as compared to the Q1 of 2024, we would expect to see quarter over quarter growth of approximately 12% for the Q2 of 2024. This is calculated with our current wholesale price and anticipate gross to net adjustment. Again, this calculation is intended to be illustrative.

Speaker 5

Under the next slide. In addition to net product sales, our contract revenues from collaborations were $3,500,000 in the Q1 of 2024. Contract revenues from collaborations consisted of $2,300,000 from Keysight, dollars 1,100,000 from Grifols and $100,000 from MedAssign. Moving on to cost and expenses, our cost of product sales was approximately $2,000,000 for the quarter of 2024. Total cost and expenses were $36,500,000 compared to $38,800,000 in the same period for 2023.

Speaker 5

The decrease in costs and expenses was primarily due to decreased research and development costs due to the timing of clinical trial activities related to the REC14 inhibitor program as well as the timing of trial completion activities related to 2 Phase 3 clinical trials of fostamatinib in patients with COVID-nineteen and warm autoimmune hemolytic anemia. In addition, the decrease was also due to lower consulting and third party services as well as lower facility related costs. These decreases were partially offset by higher stock based compensation expenses, mainly from performance based awards. We ended the quarter with cash, cash equivalents and short term investments of $49,600,000 We look to maintain our focus and disciplined financial approach into the future. Lastly, in April, we entered into an amendment to our credit agreement with MidCap Financial.

Speaker 5

As part of the amendment, we extended the maturity date and interest only period by 1 year. Our principal repayment period now starts in Q4 of 2025 and extends for 24 months. With that, I'd like to turn the call back over to Raul. Raul?

Speaker 2

Thank you, Dean. Looking ahead to the remainder of 2024, we are focused on continuing to grow sales of RESLIDIA and TAVALISSE, while adding GABRETTO to our commercial operations in July of this year. With the help of our strategic collaborators, we look forward to initiating additional oleucitinib clinical studies, and we will evaluate other opportunities for expanding the development of our products. We'll also enroll and generate preliminary data from our Phase Ib clinical trial of R289 in lower risk MDS. And lastly, we will continue we will actively pursue additional in licensing deals and acquisitions, similar to our strategy with Reslidea and Gabriero.

Speaker 2

And as we execute on our strategy to grow our hematology and oncology business, we remain committed to working towards financial breakeven and making Rigel a self sustaining company. With that, I thank you for your interest in our progress in the Q1. And now we will open the call to your questions. Operator?

Operator

Thank you. And our first question is from the line of Yigal Nochomovitz with Citigroup. Please proceed with your question.

Speaker 6

Hi, thank you very much for taking the question. On the cash guidance, you're burning about $8,000,000 a quarter. You're mentioning getting to breakeven and also investing in licensing activities. Could you just help us walk through the path to getting to breakeven as far as the existing burn and the revenue picture as well as the investment in the portfolio? Thank you.

Speaker 2

Thanks, Yigal. I'll ask Dean to comment on that and I'll add on to that.

Speaker 5

Sure. Hi, Yigal. So as it relates to the current quarter and from a cash burn perspective, I'd encourage you to look back a couple of quarters and then as some general comments as we look forward. We haven't given top line guidance. In the last quarterly call in March, we did describe our expectations for 2024 OpEx.

Speaker 5

So that's available. With respect to Q1, I would note a couple of things. One is the dynamic of the net sales that I described. So we did have the inventory reduction, which impacted net sales also impacted our cash flows as a result of that. Incrementally, I would note that we paid $2,000,000 and this is in our queue.

Speaker 5

We paid $2,000,000 on the MD Anderson collaboration. So from a cash flow perspective, there's a variety of elements going into that burn that you described. With respect to our future point of financial breakeven and that continues to be a focus of the business. We do expect to see revenues increase. We look to launch Gavreto and start to recognize revenues in the Q3.

Speaker 5

With that, we've described that we believe that there's less than $10,000,000 of SG and A and clinical spend with respect to Gabretto. So we believe that that will become rapidly accretive. All that said, we believe we're on a path to financial breakeven. We just haven't provided the guidance to say exactly when that will occur.

Speaker 2

Thank you, David.

Speaker 6

Okay. Thanks. And then switching to clinical science question, it's interesting regarding the BRAIN activity for the Gareto as well as your interest in glioma for olitucitinib. I'm just curious, could you comment on the if you have details on the brain plasma ratio, ratio, whether you have information on that for both of those drugs. Just curious how brain penetrant are they each?

Speaker 2

Yes. Yigal, thank you for the question. I think it's very helpful. Clearly, they cross the blood brain barrier, which is critical. And we've been able to show in clinical studies for Gabretto, as Lisa discussed, as well as we also know that olitucitinib also crosses the BBB.

Speaker 2

And so we're excited about opportunity of trying both of those molecules in this area and obviously generating the data on Gabretto already based on the ARROW study, which is very helpful. Anything else, Lisa?

Speaker 4

Yes. I would say that the actual ratios that you're asking about though aren't known. That hasn't been determined.

Speaker 2

But we know that there is a therapeutic effect on

Speaker 4

both in

Speaker 2

relevant studies, one already with the ARROW study in the BRAIN meds. And then we did publish and Lisa referenced this on ALUDA, a smaller study that showed a benefit in patients that were highly refractory.

Operator

Our next question is from the line of Kristin Kluska with Cantor Fitzgerald. Please proceed with your questions.

Speaker 7

Hi, everyone. Thanks for taking the question. Maybe to follow-up on the last one and ask in a different way. Can you talk about how you're going to balance the current pipeline where each of these assets in itself could potentially be evaluated in other indications? And then also the continued appetite for more of these bolt on deals, which fit your pipeline?

Speaker 7

And maybe another way to ask it is like, where do you see the company maybe in 2 years somehow?

Speaker 2

Yes, let me take a crack at that if I may. Thank you for the question, Chris. Appreciate that. So we're excited to have Tavalise and Tavalise continues to grow very nicely. And the demand models were again a new quarterly high and that's really the fundamental basis of that excitement in terms of the growth of the product.

Speaker 2

Inventories go up and down on a quarterly basis. They were huge last quarter, I mean, in Q4 and even in Q3 of last year in the other way. And Reslydia, we're excited because of the launch of the product is really just underway in many ways and it's being introduced to clinicians and we think there's good opportunity there as well. And with the addition of Gabriela, again, a oral targeted therapy, having 3 products in the bag where our sales organizations, institutional and community can make tremendous headway with all of those. So we look for the top line to continue to grow very nicely.

Speaker 2

We also can look for the OpEx to be growing, but relatively more much more modestly than the top line. That was two things and we gave some guidance as Dean said last quarter in terms of our view of the year that still holds. And so put those together, we see us being able to generate sufficient resources to be able to execute on clinical trials ourselves. And we're looking at various opportunities, particularly with Aluda in areas like MDL, AML and glioma, which are very exciting in terms of the things that we could do ourselves. We're delighted to have Lisa with us now and her experience in this very area to be able to help us evaluate, design and then launch studies in this area in future years based on increased cash flows from the ongoing business.

Speaker 2

We also want to continue to grow the business and the addition of each of these two products, Reslydia and then Gavreto in sequence have been very, very useful in terms of growing the top line and importantly fully leveraging the infrastructure that we have in place. It's really an excellent oncology oriented and ability to sell into both organization with fairly small increments in terms of infrastructure growth to be able to do that. The result of that is that we're all that much further along in terms of reaching that financial breakeven and then subsequently generating cash to do more, more clinical studies on our own, registrational studies and more continued acquisitions or in licenses of other products. So that's how we see the business growing in the next few years, 2 years for sure and beyond that. I think it's very exciting to be able to have a growing base business, exciting trials that we may launch that are addressing major areas in AML and glioma, say, and then continuing to look externally for additional products to add on that do so without having to increase our infrastructure very much if at all.

Operator

Our next question is from the line of Farben Hajde with Jefferies. Please proceed with your question.

Speaker 7

Thank you for taking our questions. So for Taplyse, based on the distribution channels inventory in 1Q, how should we think about this for the rest of the year? And how variable is it like? You just showed the numbers for the 4Q levels, but is it really variable across quarters?

Speaker 2

Yes, I'll ask Dave to comment on that and then we can point you to another place you can look at the variability of that.

Speaker 3

Yes. It's a I understand your question as kind of the variability of inventory through the quarters. And I will say Q1 was a bit unique in terms of again, that's why Dean explained the drawdown of inventory of 2 90 bottles. We do believe that we have inventory because it's sitting in either our distributors, which distribute to our direct accounts or SPs, which distribute to patients. And they purchase from us and then they sell out to those two portions of the network and what's left is the inventory.

Speaker 3

And so they did purchase a little bit more in Q4, but I think the key is that in Q1 that kind of went down. But as Dean kind of demonstrated in his example, even if we don't build any inventory this quarter and we stay flat on demand, we're expecting double digit growth versus last year in terms of net sales. So we wouldn't expect continued significant variability, but this does happen particularly with Q4 around the holidays moving into Q1. And also as Dean mentioned, you start out the quarter with usually a little bit lower demand. And I think that was reflected in the purchases that happened early in the quarter.

Speaker 3

And then we ended the quarter with very high demand, which is why we increased our demand quarter over quarter. So I think there's a number of variables that contributed to this drawdown in particular this quarter, but we don't see any significant variability up or down as we move forward. And I would invite Broward D Day at provide any more clarity on that, but that's my view.

Speaker 2

Yes. I think we have seen some in some cases, highly larger numbers. In fact, this drawdown wasn't in the largest. We've had a larger one in early 'twenty one, for example. So it does vary substantially.

Speaker 2

I think the what is consistent though in the longer term, the inventory levels grow as the business grows. And that is consistent. It's not in any specific quarter or any one quarter, We see oscillations in both sides. It's just the overall trajectory is a growth trajectory when the business is growing. TAVALISSE is growing.

Speaker 7

Got it. That makes sense.

Speaker 2

And I could share some prior quarter numbers as well. If you wish, you could in our corporate deck, we include a nice little table that has the inventory changes on a quarterly basis, going back to as early as 2021.

Speaker 7

Got it. Helpful. And then for Resideo, you had a nice uptick. So wondering what proportion of the sales were from new patients versus the existing patients? And then what needs to be done to better compete with Servier's tip servo in de novo patients?

Speaker 2

Go ahead, David.

Speaker 3

Sure. Actually, if you look at total demand bottles, the percentages I showed you is pretty still strongly toward institutions. And similarly, our demand bottles are strongly from patients who previously started. And that's because, as you know, you only have at max 3 months to get business from the patients who started in Q1. And actually, we did have a number of patients starts in March.

Speaker 3

So those would have only had a small number of bottles. So, I don't have the exact percentage, but it's around the percentage of, I'd say, around 20 or so percent of the bottles, were in new patients in Q1. And so we think that's an excellent sign. Obviously, that new patients more new patients started in Q1 that clearly drove the sales. But I think what you're also seeing is that carryover growing from last year.

Speaker 3

And then secondly, in terms of I wouldn't say we're competing. I would just say that we are really trying to differentiate in mutant IDH 1 relapsedrefractory disease. We feel we have a very long duration of response that's getting out there. And in particular, when you look at the subset of patients who've had previous venetoclax, we believe we have a great story to tell there in terms of response rates and duration of response. So at the end of the day, those are the pieces when you're able to talk about the duration of response that we have in a relapsed refractory setting And then talk about that in a venetoclax pop treated population, you have Because I think, as you're probably aware, venetoclax continues to grow use, particularly in first line AML.

Speaker 2

Thank you, Percy.

Speaker 7

Thank you.

Speaker 2

Any other questions?

Speaker 7

Thank you.

Speaker 2

Okay. Thank you.

Operator

Thank you. There are no further questions at this time. I would like to turn the floor back over to Mr. Raul Rodriguez for closing comments.

Speaker 2

Thank you. In closing, I'd like to thank everyone on this call and for your continued interest in Rigel in our progress. And as always, I'd like to thank our employees for their commitment to improving the lives of patients because every single day does count. We look forward to updating you on our progress in future calls. And with that, have a great day.

Operator

This concludes today's teleconference. You may disconnect your lines at this time. Thank you for your participation.

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Earnings Conference Call
Telephone and Data Systems Q1 2024
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