Neurotrope Q1 2024 Earnings Call Transcript

Quartr
Provided by Quartr
May 9, 2024

There are 13 speakers on the call.

Operator

Ladies and gentlemen, thank you for standing by. Welcome to Royalty Pharma First Quarter 2024 Earnings Conference Call. I would like now to turn the conference over to George Grofik, Senior Vice President, Head of Investor Relations and Communications. Please go ahead, sir.

Speaker 1

Good morning and good afternoon to everyone on the call. Thank you for joining us to review Royalty Pharma's Q1 2024 results. You can find the press release with our earnings results and slides to this call on the Investors page of our website at royaltypharma.com. Moving to Slide 3, I would like to remind you that information presented in this call contains forward looking statements that involve known and unknown risks, uncertainties and other factors that may cause actual results to differ materially from these statements. I refer you to our 10 ks on file with the SEC for a description of these risks.

Speaker 1

All forward looking statements are based on information currently available to Royalty Pharma, and we assume no obligation to update any such forward looking statements. Non GAAP liquidity measures will be used to help you understand our financial performance. The reconciliation of these measures to our GAAP financials is provided in the earnings press release available on our website. And with that, please advance to Slide 4. Our speakers on the call today are Pablo Legaretta, Founder and Chief Executive Officer Marshall Uris, EVP, Head of Research and Investments Chris Hite, EVP, Vice Chairman and Terry Coyne, EVP, Chief Financial Officer.

Speaker 1

Pablo will discuss the key highlights, after which Marshall will give a portfolio update. Next, Chris will discuss our Hilton Days portfolio, after which Terry will review the financials. Following concluding remarks from Pablo, we will hold the Q and A session. And with that, I'd like to turn the call over to Pablo.

Speaker 2

Thank you, George, and welcome to everyone on the call. I am delighted to report a successful start to 2024 as we execute against our vision to be the leading partner funding innovation in the Life Sciences. In terms of the financials, we delivered 40% growth in royalty receipts. This represents our recurring cash flows. And the strong performance in our quarter reflects the quality of our diversified portfolio of more than 35 commercial products.

Speaker 2

Milestones and other contractual payment receipts, which are more variable declined, reflecting the high base effect of the year ago quarter from a nonrecurring Bioheaven related payment. As a result, portfolio receipts, our top line declined to 717,000,000 dollars which was in line with our expectations. Turning to capital allocation. Today, we're announcing an exciting transaction, which is expected to take our capital deployment to approximately $670,000,000 Marshall will take you through the details. But in summary, we have agreed to acquire royalties and milestones on Sanofi's frexalumab for approximately 525,000,000 dollars including estimated transaction costs.

Speaker 2

This is an exciting development stage therapy with multi blockbuster potential in multiple sclerosis and other immune indications. Following the 5% increase in our dividend in the Q1, I'm also delighted to announce today a new commitment to grow our dividend by mid single digit percentage on an annual basis. Looking at our portfolio, we will have 15 development stage therapies, which we estimate have the combined potential to generate significantly greater than $1,000,000,000 in peak royalties. Most of these therapies have blockbuster sales potential and are in development by premier global marketers. We believe our development stage portfolio is highly attractive and underappreciated by the market.

Speaker 2

And Chris will expand on the multiple potential events we expect over the next year. Lastly, I am pleased to reconfirm our 2024 full year guidance. We continue to expect portfolio receipts to be between $2,600,000,000 $2,700,000,000 dollars based on expected growth in royalty receipts of around 5% to 9%. Consistent with our standard practice, our guidance is based on current on our current portfolio and does not include the benefit of any future transactions. Slide 7 shows our impressive track record of strong growth since our IPO.

Speaker 2

As I noted earlier, we delivered 14% growth in royalty receipts in our Q1. This is the highest quarter growth rate we have achieved since the Q1 of 2022 and sets us up well to deliver our full year guidance. The slide also illustrates the variable contribution from milestones and other contractual receipts when we look at the overall trend in portfolio receipts. Overall, this track record of strong growth speaks to our ability to execute successfully and consistently against our strategy in the growing market for biopharma royalties. With that, I will hand it over to Marshall to update you on our portfolio.

Speaker 3

Thanks, Pablo. I want to focus today on the exciting transaction we just announced for Sanofi's ruxalumab. Slide 9 summarizes the details of the transaction and the scale of the opportunity. We have agreed to purchase a royalty interest in frexalamab from Immunext, a privately held biotech and expect to pay approximately $525,000,000 including estimated transaction costs. In return, we will be entitled to receive a royalty ranging from high single to low double digits on worldwide sales.

Speaker 3

Also, we will share a minority of the royalty with the former Immunax shareholders on sales above $2,000,000,000 Importantly, the royalty has long duration running to 2,041, which is central when we think about the returns. In addition to royalties, we will be entitled to receive significant potential milestones. In terms of the commercial opportunity, Sanofi has stated that frexelimab has the potential to achieve non risk adjusted peak sales of over €5,000,000,000 across multiple indications. In our view, the multiples grosses opportunity alone has the potential to generate over $3,000,000,000 in peak sales based on its differentiated profile. Should Proxelimab is a 1st in class antibody with a novel mechanism of action targeting CD40 ligand.

Speaker 3

This pathway is thought to be involved in the development and progression of multiple sclerosis and may play a critical role in other immune diseases. Sanofi's Phase 2 data was recently published in New England Journal of Medicine and highlights the clear potential of frexelimab as a high efficacy non lymphocyte depleting therapy for multiple sclerosis. Frexelimab significantly reduced disease activity as measured by MRI and the clinical relapse rate was close to 0 at 48 weeks. Importantly, the treatment was well tolerated with no notable safety signals. Based on this compelling profile, Sanofi has initiated Phase 3 clinical development in multiple sclerosis with results and regulatory submissions anticipated for 2027.

Speaker 3

Phase 2 studies were are also underway in Type 1 diabetes and lupus, 2 immune diseases in which a role for the CD40 pathway has also been implicated. Slide 11 provides an overview of the fundamental drivers of our excitement in the exceptional opportunity offered by frixelimab. On top of the compelling Phase 2 efficacy, the differentiated emecanovaction may provide a potential safety differentiator versus existing high efficacy multiple sclerosis therapies. We would also note that strong Phase 2 data in MS has historically been highly predictive of success in the Phase 3 setting. Furthermore, our statistical analyses confirm that Sanofi studies are well designed and powered for success.

Speaker 3

Commercially, our proprietary U. S. Claims analyses suggest that nearly 100,000 patients will have discontinued anti CD20 therapy by the time frixolumab launches in 2028, a large addressable market that alone supports blockbuster potential for frixolumab, although we anticipate use in a broader set of MS patients if approved. Moving to Slide 12, frexelimab checks all the boxes for us. Clearly aligning with our product selection framework, it's a potential 1st in class therapy with strong scientific rationale and a clear commercial position.

Speaker 3

It has very supportive Phase 2 clinical data and it will be marketed by a leading global immunology company. Brexelumab is, as Sanofi describes it, a pipeline and a product across several immunology indications and importantly has the potential to contribute significantly to our growth in our royalty receipts with an attractive returns profile and long duration. And with that, I'll hand it over to Chris.

Speaker 4

Thanks, Marshall. I want to expand on the trexalumab transaction and highlight the broader potential of our growing development stage pipeline, which we think is underappreciated by the market. A strong pipeline is central to our strategy. Instead of focusing on any one project in detail, we want to provide an overview of our current development stage portfolio. Slide 14 summarizes the key take home messages.

Speaker 4

In short, since our IPO, we have assembled a portfolio that consists of 15 development stage therapies, which we believe have the potential to contribute greater than 1,000,000,000 dollars combined peak annual royalties. Most of these therapies in development are potential blockbusters and are in the hands of powerful marketers. We have carefully managed the risk profile of this portfolio by selecting therapies which meet our product framework and that are primarily in late stage development. We have also built in risk mitigating deal structures where possible. Lastly, we see the potential to begin unlocking the value of this exciting portfolio through multiple clinical and regulatory events, which we expect over the next 12 to 18 months.

Speaker 4

These include the FDA action date for CAR XT, FDA filings for apicamten and palaprasib and pivotal study results for seltorexant, Teva-seven forty nine and TREMFYA in Crohn's. And in 2025, we expect outcomes data for pelicarsen, which has the potential to be a very significant royalty for our portfolio. Slide 15 highlights that we have deployed capital of close to 23,000,000,000 dollars since 2012 with a healthy balance between approved and development stage therapies. Over the period, the majority of our capital has been deployed to acquire royalties on approved products. And even with the expansion of our development stage pipeline I just referenced, this weighting towards approved products has remained the case since our IPO.

Speaker 4

However, when we look on an annual basis, there is considerable variability in this mix, which reflects the opportunistic nature of our business. Slide 16 shows that our development stage pipeline has grown fivefold since our June 2020 IPO. The graphic on the right hand side illustrates that our pipeline is nicely diversified by therapeutic area, including neurology, psychiatry, cardiology, cancer, rare disease and immunology. When it comes to investing in development stage therapies, we have a strong track record. On Slide 17, you can see that we have invested around $9,000,000,000 in this category and that our success rate has been high.

Speaker 4

Approximately 70% of our development stage investments have gone on to receive a regulatory approval, Around 20% are still in development and only 10% have not reached the market. This record reflects our diligence process including the product selection framework Marshall spoke to, our ability to identify therapies with unmet and underserved patient needs and our large opportunity set. To balance the higher inherent risk versus approved products, we target returns in the teens for development stage investments. Expanding on my previous point on Slide 18, we believe we have a unique and powerful approach to development stage investing. In terms of product selection, in addition of requiring strong proof of concept data, we often partner directly with the innovators so that we have access to additional insights into the clinical program and sales potential.

Speaker 4

Once we have made the product selection, we typically then structure the transaction to include risk mitigation strategies and also ensure we are strongly aligned with the interests of our partner. These strategies can include investing in post pivotal study therapies, our deep due diligence supported by patient level data and regulatory correspondence and receiving a portion of returns through milestones and staged investing to name a few. You can see here a number of examples that illustrate our unique approach including our investments in CAR XT, apukantin, frexelimab and Merck 8189. Slide 19 is my final slide, shows our late stage development pipeline by potential peak sales and the associated royalty we could receive expect to receive. Importantly, these all have 1st or best in class potential and are supported by world class marketers.

Speaker 4

The majority have multi blockbuster potential and in aggregate, we estimate the combined peak sales at over $25,000,000,000 on a non risk adjusted basis. Based on the respective royalty rates, this could potentially translate to over $1,250,000,000 in annual peak royalties for Royalty Pharma, with Olpasiran potentially the largest individual contributors. I would also add that we are pleased with the positive news announced by Teva that Teva-seven forty nine, a long acting injectable version of the antipsychotic elansapine achieved its primary efficacy endpoint in its Phase 3 study and continues to have an encouraging safety profile. We look forward to additional updates in the second half of the year. As a reminder, in the fall of 2023, Royalty Pharma partnered with Teva to provide up to $125,000,000 in R and D funding for the TEVA-seven forty nine Phase 3 program.

Speaker 4

We will receive a milestone payment on FDA approval as well as lowtomidsingledigit royalties on its sales. Given its emerging differentiated safety profile in a market with significant unmet need, we are excited about the commercial potential for TEVA-seven forty nine. This once again highlights our unique ability to identify attractive products across the biopharma industry and partner with innovators to accelerate development. As these products become commercial, they will contribute to our attractive compounding growth in the years ahead. To close, we have an exciting development stage portfolio with multiple expected upcoming events, so you can see why we expect to continue to deliver attractive compounding growth in the years ahead.

Speaker 4

With that, I would like to hand it over to Terry.

Speaker 5

Thanks, Chris. Let's move to Slide 21. Royalty receipts grew by 14% in the Q1, reflecting the strength of our diversified portfolio. The key drivers of growth were the strong performance of our base business, notably our cystic fibrosis franchise and Trelegy, as well as the acquisition of incremental Energia royalties. Portfolio receipts, our top line declined by 37%, reflecting the impact of non recurring items in milestones and other contractual receipts in the year ago quarter.

Speaker 5

Specifically, in the Q1 of 2023, we received a $475,000,000 milestone payment following the FDA approval of Pfizer's Zazepret. As a result of this nonrecurring item, milestones and other contractual receipts declined to $12,000,000 in the quarter. This decline was entirely consistent with expectations and fully reflected in our full year 2024 guidance. Slide 22 shows how our efficient business model generates substantial cash flow to be reinvested. Portfolio receipts amounted to $717,000,000 in the Q1.

Speaker 5

As we move down the column, operating and professional costs equated to 8.4 percent of portfolio fees. Net interest paid of $73,000,000 reflected the semi annual timing of our interest payment schedule, with payments falling due in the 1st and third quarters. Moving further down the column, we have consistently stated that when we think of the cash generated by the business to then be redeployed into value enhancing royalties, we look to adjusted EBITDA less net interest paid, or as we call it, portfolio cash flow. This amounted to $584,000,000 in the quarter, equivalent to a margin of around 81%. This high level of cash conversion once again highlights the efficiency of our business model.

Speaker 5

Capital deployment in the Q1 was a little under $100,000,000 but will be approximately $670,000,000 after we acquire the frexalimab royalty. Slide 23 shows that we continue to maintain significant financial capacity for future royalty acquisitions. In total, we have over $3,500,000,000 available through a combination of cash on our balance sheet, the cash our business generates and access to the debt markets. At the end of the Q1, we had cash and equivalents of $843,000,000 Following the approximately $525,000,000 of cash payments related to the Immunnex transaction, this will take our cash and equivalents to approximately $320,000,000 on a pro form a basis. When we turn to our borrowing position, on top of our $6,300,000,000 of investment grade bonds, we maintain significant leverage capacity, which we can take up to 4 times if the right opportunity arose.

Speaker 5

Furthermore, we have additional undrawn financial capacity from the $1,800,000,000 revolver. Taken together with our strong cash generation, we feel good about our ability to continue to execute transactions and create shareholder value. Slide 24 sets out our unchanged full year 2024 financial guidance. We expect portfolio receipts to be in the range of $2,600,000,000 to $2,700,000,000 Let me walk you through our assumptions. 1st, within our overall top line guidance, we expect to deliver continued attractive growth in royalty receipts of around 5% to 9%.

Speaker 5

We anticipate the strength of our diversified portfolio will more than offset IMBRUVICA and Tysabri headwinds. 2nd, we face a high base of comparison in 2023 as a result of the $525,000,000 of Biohaven related payments we received last year. As you have seen today, the largest element, the $475,000,000 davazopret milestone was received in the Q1 of 2023. Milestones and other contractual receipts are therefore expected to decline from around $600,000,000 in 2023 to approximately $30,000,000 in 2024. Lastly, our guidance assumes a negligible foreign exchange impact.

Speaker 5

Importantly and consistent with our standard practice, this guidance is based on our portfolio as of today, does not take into account the benefit of any future royalty acquisitions. For the Q2, we also anticipate portfolio receipts to grow in the high single digits compared to last year's Q2. Turning to operating costs. Payments for operating and professional costs are expected to be approximately 8% to 9% of portfolio receipts in 2024. We continue to believe that the degree of margin protection provided by our unique business model is impressive.

Speaker 5

Interest paid for full year 2024 is expected to be around $160,000,000 with de minimis amounts to be paid in Q2 and Q4. This does not take into account any interest received on our cash balance, which was $6,000,000 in the first quarter. With that, I would like to hand the call back to Pablo for his closing comments.

Speaker 2

Thanks, Terry. Let me begin my concluding remarks by saying how delighted I am with our start to 2024. We delivered double digit growth in royalty receipts. We strengthened our exciting development stage pipeline and we have announced a strong new commitment on our dividend growth. On my final slide, I want to highlight our incredible track record of consistently identifying exciting ways of biopharma innovation and finding ways to participate from Rituxan, the 1st monoclonal antibody for cancer to Gilead's HIV franchise to Humira, where we invested in 2006 and it later became the industry's biggest selling product to more recent life changing therapies like Trikafta for cystic fibrosis and Abrisde for spinal muscular atrophy.

Speaker 2

And when we look ahead, we expect to see a number of the exciting relevant stage therapies we talked about today joins this list, transforming the lives of patients with multiple sclerosis, cardiovascular disease and schizophrenia among others. The ability to identify new waves of innovation and to constantly replenish our portfolio with life changing therapies is our DNA and we're confident that it can continue. With our simple but powerful business model, our deep access to capital, we're confident we can continue to deliver attractive compounding growth over the remainder of this decade and beyond. With that, we would be happy to take your questions.

Operator

One moment. So, I'll ask the first question. And our first question comes from Chris Shibutani with Goldman Sachs. Your line is

Speaker 6

Congratulations on the deal with frexelimab. The opportunity that is at the forefront clearly in MS, but they're also in advanced clinicals. Maybe Marshall, can you help us how you risk assess and think about the potential in the other indications? I think there's Sjogren's as well as type 1 diabetes and lupus, the latter 2 in particular, historically quite challenging.

Speaker 3

Yes. Hey, Chris, good morning. Absolutely, we are really excited to be adding a praxolamab to the portfolio. And as you correctly observed, the core of our thesis and our view was really based on MS where there's a very consistent and compelling set of Phase 2 data. As we mentioned Sanofi is going forward in other indications, type 1 diabetes and lupus.

Speaker 3

Both are interesting. I think certainly we'll wait to see how the Phase 2 data there works out. There's not a lot of precedent data for CD40 in those areas, but I think they would definitely add potential sources of upside to the transaction. And then just as a reminder, Sanofi has said that in Sjogren's, they actually aren't going forward there in Phase 2. But I think but as we said, based on MS was really the base of this investment and we're really excited to have this as part of the portfolio.

Speaker 6

Thank you.

Operator

One moment for the next question. Our next question comes from Geoff Meacham with Bank of America Securities. Your line is open.

Speaker 7

Hey, guys. Thanks so much for the question. Just have a couple. The first maybe for Marshall, another one on frexelimab. Just walk us through kind of the idea here of the MS market being kind of a void to fill with respect to Tysabri.

Speaker 7

Is there a thought that maybe you had to ultimately replace the economics from Tysabri in the longer term? Obviously, the MS market can be a little challenged when it comes to generics today. And then the second question maybe for Terry or Pablo. On capital deployment, when you think about the share buybacks, you guys didn't do a lot share buybacks when that was first announced. And just wanted to know the context for the commitment now to a dividend versus buyback.

Speaker 7

You guys generate a lot of cash. And so I wanted to kind of get that perspective from you guys. Thank you.

Speaker 2

Thanks for the question, Jeff. And I think Marshall can definitely take the question on frexelimab. And then I think Terry will talk about capital deployment and our commitment to building growth.

Speaker 3

Absolutely. So hi, Jeff. Good morning. So just quickly on fexelimab. So no, the rationale behind fexelimab was not to fill any sort of void around TESABRI, it was the outcome of the strategy and our approach to building the portfolio that we've talked about, that we talked about with everyone, which is looking for really exciting quality products that have that check all the boxes in our product selection framework that we talked about at the beginning of the call.

Speaker 3

And I think that was really the core of it in our approach and we are really excited to have it as part of the portfolio. And specifically on the commercial opportunity, the way we thought about it was there are certainly the dominance of the CD20 class today is really compelling and has been really important for patients. But what we see is as this market develops that there's going to be a need for high efficacy alternative frexelimab offers. And so that was really the core of our thesis and why we think this is going to be an exciting product for patients and for Royalty Pharma.

Speaker 2

I mean, one thing just to quickly add to what Marshall said is there's no question that Royalty Pharma has had great success investing in diseases like multiple sclerosis with DYSABRI and also may remember that we had a royalty on TECFIDERA. So in total, I think we had invested $3,400,000,000 in MS with great results. And now with this, another $500,000,000 or So it's an area we like, where we see still huge potential for improvement in current therapies.

Speaker 5

And then Jeff, on your question on capital allocation, as we said in the past, our number one priority is buying new royalties. We think that's how we can drive the most long term value. We have been paying a dividend since our IPO and actually the 20 years prior to our IPO and been growing it consistently every year. Since the IPO, we've grown it mid single digits or better. And so and it was fully our plan to continue to grow at mid single digits.

Speaker 5

So I think that the commitment today is simply sort of a reflection of what our current what our plans had already been. We thought it was important to sort of put that out there. So investors understood that aspect of our capital allocation. And then in terms of the share buyback, it's certainly something that it's as we've said before, it's a tool that we really like having. I think when we think about the buyback, we also think about it in the context of some of the opportunities that we're seeing out there as well.

Speaker 5

And I would say that the team is extremely busy. We're really excited about the overall opportunity set. We never know when transactions are going to happen, but that I think is a factor when we think about deploying capital because as I mentioned, our number one use of capital that we think is buying new royalties.

Operator

One moment for the next question. Our next question comes from Chris Schott with JPMorgan. Your line is open.

Speaker 6

Hi, this is Ethan on Chris Schott. Thanks for taking our questions. I just have 2 quick ones. So first off, with the 15 development stage assets that you noted, how do you think about the balance of royalties portfolio at this point? And maybe more specifically, as the company becomes larger and more diversified going forward, is there an ability or desire to skew capital deployment more towards the development stage where you might get greater potential returns?

Speaker 6

And then the second question is just how you think about the 2025 Medicare Part D redesign and any estimate on the impact to your portfolio at this point? Thanks for the questions.

Speaker 2

Sure. So I'm going to ask Marshall and Chris to talk about the Medicare and other questions, but just the very top level. The business has been incredibly successful over many decades by and actually really over a decade when we started to invest in unapproved. And we think that this balance that has been sixty-forty of approved and unapproved is a good way to continue to grow our business. Could it be fifty-fifty?

Speaker 2

Sure. But what really happens in our business, that measurement of sixty-forty is sort of the cumulative capital deployed in approved and unapproved. But in reality, what happens with our business is that the $9,000,000,000 or so that we've invested in unapproved, so many of those got approved, as you saw on the slide 70% or so. I think we also have really good data on several others that are not yet approved, like CAR XT and afacamten, seltorexant that those we view as very high probability of approval. But the point is that this is sort of a moving average suggestion because the $9,000,000,000 reflects the cumulative.

Speaker 2

And what happens is that several of those get approved and it gives us the capacity, the opportunity to actually continue to invest significantly in non approved. And as the business grows, I think maintaining that balance of around half in approved and half in unapproved is probably a good target for us. But Marshall,

Speaker 3

back to you. Great. Yes, good morning. And then your the last part of your question was on the 2025 Medicare Part D redesign. And so I think like a lot of the world, the specifics of that on a product by product basis are something that we're still thinking through.

Speaker 3

But just to remind everyone, the Royalty Pharma portfolio doesn't have at a high level a lot of exposure to Medicare Part D. And we've highlighted 3 products, in the context of certainly the potential for IRA negotiation, Xtandi, IMBRUVICA and Trelegy that are significant products in our portfolio. But I think specifically, but the same conclusion I think holds for the Medicare Part D redesign, which is that we don't think there's going to be a significant impact on our portfolio. And certainly, we have a balance there of products that are higher priced and something like Trelegy, which is lower priced and obviously we'll see very different dynamics and puts and takes within the Medicare Part D redesign. But I think the important thing is there isn't a lot of exposure right now and as we continue to invest and build the portfolio with products like prexelimab, we will continue to add more and more diversity to the portfolio.

Operator

The next question comes from Peter Verdult with Citi. Your line is open.

Speaker 8

Yes, thank you. It's Peter Verdult here from Citi. Just a few questions, please. Just kicking off with Fruxelimab. We like this answer a lot, so nice to see the deal.

Speaker 8

Just to be clear, Marshall, is this deal is it all valued and structured around MS? Or have you put in any sort of placeholder value for lupus in type 1? That's question number 1. Number 2 is lots of good stuff going on in terms of development pipeline, but there have been some, should we say, recent setbacks. So I would be interested to hear how you're thinking about the risk profile around olaparib in light of the emerging safety concerns, anything you're able to say right now?

Speaker 8

And then lastly, Marshall, just a clarification, sorry to be gnarly, but when I look at the Immunax press release, they're stating that if Rex sales exceed $2,000,000,000 the royalty goes from having all the royalties to a minority share. So I just want to make sure that that's still is your comment earlier in the presentation about getting $400,000,000 royalties or $5,000,000,000 does that chime with what is in that Immunex press release? Thank you.

Speaker 9

Hey, Pete. Welcome to the call. So just to

Speaker 3

make sure I hit all of those. So first on praxelumab, the core of our thesis was definitely centered on MS. So our kind of base view is a MS driven one. Certainly, one thing we really like about the transaction is the potential for further indications to come along for Sanofi invest in those, which would drive further sales as well. So not part of the base case, but we definitely like investments like this where there is optionality on indication expansion.

Speaker 3

The second question was on palabrasib. So not much to say beyond what's in the public domain, we're following the same thing you guys are. But I would just recommend I would just remind everyone that to think about palabrasib in the broader context of the MorphoSys investment. So Plabrasib was a is an interesting product. We're excited to see what happens with it, but was a small overall part of that transaction, which was really focused on the great royalty on Tremfya that we acquired there.

Speaker 3

And then your third question was the royalty structure. So no. So the way it works is we always have a majority of the royalty, a significant majority of the royalty. Once sales exceed $2,000,000,000 there is some sharing with the former shareholders of Immunext. But no, we still maintain the majority of the royalty, which is a structure that that sort of sharing in that structure is something we've used in the past in other transactions.

Speaker 8

Great. Thanks, Paul.

Operator

Paul. Our next question comes from Umer Raffat with Evercore. Your line is open.

Speaker 10

Hey, guys. This is Mikey Furey in for Umer. Thanks for taking my question and congrats on the deal. A few for me on frexelimab and then one follow-up. On frexelimab, would you be able to quantify the minority share of royalties like what percentage you get above $2,000,000,000 and also the total amount of milestone payments and the cadence of them?

Speaker 10

And also on Slide 11 regarding the unmet need, it implies that there is significant opportunity after patients discontinue anti CD20s, which also implies that either patients are still not too far along in their disease after they could discontinue or they have entered the non relapsing SPMS phase and that prexelimab can be efficacious in this setting. What gives you confidence that this may be the case? And I have a follow-up. Thank you.

Speaker 3

Sure. So just to make sure I hit all of those. So, Mike, we haven't quantified the amount of sharing, but I think just to reiterate the answers the answer to Pete's question is that we maintain a majority of the royalty above $2,000,000,000 And then on the milestones, we haven't given

Speaker 5

a lot of detail there. Mike, we did say though in the press release that just to give you some context, that sorry, we said it in the slides that nearly half of the purchase price could potentially be returned in what we view as higher probability milestones. So that gives you a little bit of a context of the scale.

Speaker 9

Got it. Okay. Okay, great.

Speaker 3

And then that I hope that helps. And then the last piece was on the unmet need. So what we were trying to say was not and your question is a good one, was not that we're taking a view on secondary progressive MS at this point, but that when we look into our claims data closely, what we see is that patients are on CD20s for a very long time. They're great drugs, but we do see that patients do come off over time and that population is at least one that will be pretty significant by the time frexelimab launches. And if you do at the MS conferences and neurology conferences, we are starting to see KOLs and others talk about some of the long term side effects of chronic B cell depletion over the long term.

Speaker 3

And so when we put that together, I think that's one potential interesting and attractive and large market for frexelimab. That being said, we think there's use well beyond that population as well. We were really trying to focus on how that there is an unmet there's an unmet need here, a need for new mechanisms and we think frexelimab is well positioned to be a part of the solution there.

Speaker 10

Got it. And then my follow-up is just on the pace of deals. Can we expect the deal pay to pick up in the back half of the year, recognizing that today's deal was phenomenal? And how might the higher for longer outlook on interest rates factor into the types of deals that Royalty Pharma is considering? Thank you.

Speaker 2

Yes. Chris can take the question on deal flow and what to expect. And I think maybe Terry can talk about interest rates.

Speaker 4

Yes. Thanks Mike for the question. We continue to see a very robust environment when we look at potential investments and we're super excited about the opportunity set in front of us. As you know, it's hard to predict when the deals will actually happen, but we're very encouraged with what we're seeing from a funnel perspective and the opportunity fit in front of us.

Speaker 5

And then on rates, Mike, I think what we've tried to reiterate is that our business is really sort of agnostic to the rate environment. And we've been sort of highlighting this with the deals that we've done, I think even including the deal today, which we think is going to generate really attractive returns longer term. But I think that the key for us is that we feel like we're able to continue to maintain the same spreads above our cost of capital on new investments, regardless of the rate environment. And so you'll see that as rates are sort of as they drifted higher, we're targeting slightly higher returns. And I think that that really shows how our business really is agnostic to the rate environment.

Speaker 10

Super helpful. Thanks again.

Operator

One moment for the next question. Next question comes from Steve Scala with TD Cowen. Your line is open.

Speaker 11

Thank you so much. Just to be clear on frexelimab, it sounds as though Type 1 diabetes and lupus are not part of the initial deal, maybe you can confirm that, but is subcu part of the initial deal? And what aspects of the molecule were the toughest for you to become comfortable? So that's the first question. 2nd question, Chris, you mentioned milestones for this year.

Speaker 11

Apologies if I missed it, but did you mention the PDE10A inhibitor Phase 2 data from Merck, which is expected? And if not, why didn't you mention it? And then the last question is, you've gotten the obesity question, I think every quarter for a while now and every quarter you say you're always looking. But within obesity, does RPRx have a preference for oral versus subcu, muscle sparing versus not muscle sparing and degree of weight loss? So in other words, is more the better always the case or is it not necessary for the masses, so you're not necessarily pursuing that?

Speaker 11

Thank you.

Speaker 2

Yes. Thanks for the question, Steve. I mean, just to clarify, I think, for whatever reason, the terms of the Fraxelimab deal might be a bit confusing to several of you. But the license that underlies our transaction, enables us to receive royalties on all potential indications for the product. And that they're all included.

Speaker 2

All we were saying is that for us to get comfortable with a really attractive investment with really attractive returns, we had to get comfortable that this product was going to achieve a good level of sales MS. And we think that in MS, we're very comfortable with it getting to the $3,000,000,000 plus range. And then we see as upside other indications, and obviously the 2 that are interesting and sort of being looked at are type 1 diabetes and lupus. And the terms of the transaction are such that we would be entitled to receive royalties on those. And there is, in the structure, in addition to the $525,000,000 upfront payment, some sharing with the shareholders of indianxt above $2,000,000,000 of sales.

Speaker 2

But as we have said, the sharing is sort of percentage that is less than 50%. In fact, we've just said that we're going to retain a significant majority of all of the royalties above $2,000,000,000 And also regarding the milestones, when we looked at the total milestones that the license produces, which is over north of $400,000,000 we've identified about half of those 240 or so as high probability milestones that are tied to things like filing and dosing in other indications, Phase III trials and things like that, which we think is highly likely to happen. And we saw that as an attractive part of the transaction. But let me turn it over to Marshall that can talk about Merck and then obesity.

Speaker 3

Sure. So on Merck, Steve, nothing to interpret there. I think much of Chris's most of Chris's comments were really focused on the later stage, the later stage programs within our pipeline. As a reminder, 8,189 has a Phase 2b trial that reads out relatively soon. And so we and so that was maybe why it was not sort of discussed as prominently as some of the others, but we remain excited about the potential there and look forward to learning more.

Speaker 3

Finally, in obesity, yes, no, I think you're going to hear a similar answer in our approach there. But I think part of your but implicit in your question, I think is the key thing, which is there are a lot of different approaches to what is obviously a very, very large and attractive market. And we're continuing to look at our opportunities within all of those different dynamics in terms of form of delivery, biology, etcetera. And our view at a high level is that there's going to be opportunities for multiple types of products different for different patients at different times in the management of their obesity and that's going to create opportunity and we'll continue to take the same opportunistic approach of looking for the right thing at the right time that makes sense for us and our partner.

Speaker 11

Thank you.

Operator

One moment for the next question. The next question comes from Terence Flynn with Morgan Stanley. Your line is open.

Speaker 9

Hi, this is Dan on for Terrence. Thanks for taking our question. I was just wondering on TREMFYA in Crohn's disease at this point kind of how you're thinking about market share capture in the indication and views on the competitive profile versus SKYRIZI? Thank you.

Speaker 3

Sure. Thanks for the question on TREMFYA. So that's one that we remain really excited about. So I think with the recent updates from Janssen, we're as part of our thesis when we added that to the portfolio and continue to be excited about the potential in IBD. The data so far that we've seen looks very compelling and competitive.

Speaker 3

And just as important in this space, as data is the strength of the marketer and the scale of their platform behind it. And so we're really happy to have this product in the hands of J and J who is one of the biggest marketers in this space. And we think we'll be able to maximize the value of Tremfya in IBD in the IL-twenty three class, which is attractive and growing really nicely.

Operator

We stand by for the next question. Next question comes from D Zhao with UBS. Your line is open.

Speaker 12

Hi, good morning. This is D on behalf of ASH. Thanks for taking our questions. We have one for faxitamab. Since like CD40s have had a complex history with some bovinex events.

Speaker 12

So I understand from your perspective, like Flexa may now have these issues, but has Sanofi provided you any data beyond what was shown in the Phase 2 that gives you a strong conviction on asset here? Thanks.

Speaker 2

Sure. Marshall, why don't you take this question?

Speaker 3

Yes. No, good question on the history of these antibodies. So as you might imagine, that history was something we looked at closely in the diligence and the team did a really good job in terms of the diligence process. We also had the luxury and the benefit of working with the ImmuneX team who did a lot of the work to generate, frexelimab with all the learnings from the 1st generation antibodies, which as you mentioned did have a safety issue. But what got us comfortable, I think was 2 things I'd mentioned, which is 1, the engineering and the design of the antibody was designed with certain changes to engineer out that risk and certainly all of the basic science and preclinical work supports that.

Speaker 3

But more importantly, the proof is in what we've seen so far in from clinical data is that patients have been that there's a significant treated patient base at this time. As we mentioned, the MS data, these patients have now been treated out to a year and we haven't seen that safety signal. So certainly that was what went into our view that this was an issue with the 1st generation antibodies and we look forward to learning more about fraxelimab's clinical profile in MS and other indications in the future.

Speaker 12

Thank you. Very helpful.

Operator

I show no further questions at this time. I would now like to turn the call back to Pablo for closing remarks.

Speaker 2

Sure, operator. Thank you. And I think maybe just before we wrap up today, one of the things that I just wanted to highlight for all of you listening, our shareholders and analysts, is that we actually had this great deal announced today that is again a demonstration of how Royalty Pharma has been able to consistently identify really attractive potential blockbusters marketed by super strong companies. And we have the slide that really shows how we've been able to consistently make investments in the most exciting new drugs in sort of every wave of innovation. And the other thing that we've done today is really spend time talking about this incredible pipeline that we have in unapproved products that we've considered we've sort of assembled over sort of a decade or so or 5 years of investing and really try to highlight the very significant potential that Royalty Pharma has in all of this unapproved products that will over the next 2 or 3 years progress and result in attractive events as data that we have data readouts and then approvals.

Speaker 2

And I think, as I said, it's sort of an underappreciated part of Royalty Pharma that we're very, very excited about. So with that, I'd like to thank everyone on the call for your continued interest in Royalty Pharma. And again, if you have any follow-up questions, please feel free to reach out to George Grofik and his team. But thank you, everyone.

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Earnings Conference Call
Neurotrope Q1 2024
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