Bio-Techne Q2 2025 Earnings Report

Bio-Techne EPS Results

• Actual EPS: $0.35
• Consensus EPS: $0.38
• Beat/Miss: Missed by -$0.03
• One Year Ago EPS: N/A

Bio-Techne Revenue Results

• Actual Revenue: N/A
• Expected Revenue: $285.84 million
• Beat/Miss: N/A
• YoY Revenue Growth: N/A

Bio-Techne Announcement Details

• Quarter: Q2 2025
• Date: 2/5/2025
• Time: Before Market Opens
• Conference Call Date: Wednesday, February 5, 2025
• Conference Call Time: 9:00AM ET

Bio-Techne (NASDAQ:TECH), together with its subsidiaries, develops, manufactures, and sells life science reagents, instruments, and services for the research and clinical diagnostic markets in the United States, the United Kingdom, rest of Europe, Middle East, and Africa, Greater China, rest of Asia-Pacific, and internationally. The company operates through two segments, Protein Sciences, and Diagnostics and Genomics. The Protein Sciences segment develops and manufactures biological reagents used in various aspects of life science research, diagnostics, and cell and gene therapy, such as cytokines and growth factors, antibodies, small molecules, tissue culture sera, and cell selection technologies. This segment also offers proteomic analytical tools for automated western blot and multiplexed ELISA workflow consists of manual and automated protein analysis instruments and immunoassays for use in quantifying proteins in various biological fluids. The Diagnostics and Genomics segment develops and manufactures diagnostic products, including controls, calibrators, and diagnostic assays for regulated diagnostics market, exosome-based molecular diagnostic assays, advanced tissue-based in-situ hybridization assays for spatial genomic and tissue biopsy analysis, and genetic and oncology kits for research and clinical applications; and sells products for genetic carrier screening, oncology diagnostics, molecular controls, and research, as well as instruments and process control products for hematology, blood chemistry and gases, and coagulation controls and reagents used in various diagnostic applications. The company was formerly known as Techne Corporation and changed its name to Bio-Techne Corporation in November 2014. Bio-Techne Corporation was incorporated in 1976 and is headquartered in Minneapolis, Minnesota.

Bio-Techne Q2 2025 Earnings Call Transcript

Presentation

[Operator]

Good morning, and welcome to the Bio Techne Earnings Conference Call for the Second Quarter of Fiscal Year twenty twenty five. At this time, all participants have been placed in a listen only mode, and the call will be open for questions following management's prepared remarks.

[Operator]

During our Q and A session, please limit yourselves to one question and one follow-up.

[Operator]

I would now like to turn the call over to David Clare, Bio Techne's Vice President, Investor Relations.

[David Clair, Investor Relations at Bio-Techne]

Good morning, and thank you for joining us. On the call with me this morning are Kim Kelderman, President and Chief Executive Officer and Jim Hippel, Chief Financial Officer of Bio Techne. Before we begin, let me briefly cover our Safe Harbor statement. Some of the comments made during this conference call may be considered forward looking statements, including beliefs and expectations about the company's future results. The company's 10 K for fiscal year twenty twenty four identifies certain factors that could cause the company's actual results to differ materially from those projected in the forward looking statements made during this call.

[David Clair, Investor Relations at Bio-Techne]

The company does not undertake to update any forward looking statements because of any new information or future events or developments. The 10 K, as well as the company's other SEC filings, are available on the company's website within its Investor Relations section. During the call, non GAAP financial measures may be used to provide information pertinent to ongoing business performance. Tables reconciling these measures to most comparable GAAP measures are available in the company's press release issued earlier this morning on the Investor Relations section of our Bio Techne Corporation website at www.biotechne.com. Separately, in the coming weeks, we will be participating in the Cowen, Leerink and Barclays Healthcare Conferences.

[David Clair, Investor Relations at Bio-Techne]

We look forward to connecting with many of you at these upcoming events. I will now turn the call over to Kim.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Thanks, Dave, and good morning, everyone. Thank you for joining our second quarter conference call. I'm pleased to report that we delivered yet another strong fiscal quarter that exceeded the initial projections that we made at the beginning of our fiscal year. The improving biopharma end market, particularly on the large pharma side benefited our GMP reagents and their protein analytical implementation. This combined with continued traction in our ExosomeDx and Spatial Biology franchises drove our 9% organic revenue growth for the quarter.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

We are also seeing the benefits of the organizational and operational efficiency improvements that we have implemented over the last year and a half. During the second quarter, our adjusted operating margin increased 110 basis points sequentially to 30.1% and I'm confident that we are well positioned for ongoing improvement in our peer leading operating margin profile as our end markets continue to recover. Jim will provide more details on these results later in the call. I hope that many of you had a chance to see the latest corporate presentation we provided last month during the JPMorgan Healthcare Conference. For those that have not seen it, I would encourage you to visit the Investor Relations section of Bio Techne's website.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

We presented the company's strategy through a slightly different lens this year by outlining three major challenges we help our customers solve. We enable the discovery of novel biological insights. We support the development and manufacturing of advanced therapeutics, and we enable precision diagnostics. Our product portfolio and solutions are uniquely positioned to reliably and efficiently support our customers in advancing science across these sectors. Now let's review our Q2 results, beginning with an overview across our end markets and geographies.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Sales to our biopharma end markets increased mid teens in the quarter as we experienced strength in both The U. S. And European regions. This strong performance included a notable improvement from large pharma customers with particular strength in bulk GMP and reagent orders as well as in our protein analysis instrument portfolio. For our academic end market, the team delivered mid single digit revenue growth.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

As a reminder, our academic end markets grew upper single digits in the prior year period and we achieved this quarter's mid single digit revenue growth despite the challenging comp as well as the reduced number of selling days related to the mid week holidays in December. Now for our regions. In The Americas, we grew low double digits for the quarter. This performance was primarily driven by the aforementioned strong demand from our cell therapy customers as well as the strength in our automated protein analysis portfolio. Our EMEA region grew low double digits as well, which was also driven by our automated protein analysis portfolio, which grew more than 20%.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

In addition, we expanded our geographic reach through two new distribution agreements. First, we announced a partnership of Leader Life Sciences to fortify access to our portfolio across The Gulf cooperating countries. We followed this with a distribution agreement with MedSomTeq to expand access to our portfolio in Turkey and Azerbaijan. In China, sales declined low single digits as the challenging economic environment remained a headwind to growth in the geography. It's worth noting that the Q2 performance is in line with our expectations that the negative growth would ease and will shift to modest positive growth in our fiscal Q3 due

[Kim Kelderman, CEO, President & Director at Bio-Techne]

to

[Kim Kelderman, CEO, President & Director at Bio-Techne]

the expectation that a targeted stimulus program and a modest improvement in government funding will slowly materialize. As a side note, Jim and I were just in China to visit their team and of course to meet a variety of our customers. It was clear that our team remains extremely motivated and committed to our mission and our customers continue to value the consistent quality across the breadth of our portfolio. In the long term, the modernization of healthcare will remain a high priority for the Chinese government and Bio Techne is looking forward to playing a key role in enabling the evolution of healthcare for its citizens and the world. Now let's discuss our growth pillars starting with our portfolio of cell therapy workflow solutions.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

During the quarter, we experienced robust growth within our GMP reagent portfolio as customers that are progressing their advanced therapeutics through later stage clinical trials require materially more GMP reagents. We now have over 500 customers relying on our GMP reagents for their cell therapy across all stages of development. Within this expanding customer base, 85 are in various phases of clinical trials, including six currently in Phase three. For Q2, our GMP reagents revenue increased over 90%. As a reminder, our GMP reagents business can be lumpy as orders from customers further along their clinical trials can be much larger.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Therefore, order timing can make quarterly growth volatile. So we view trailing twelve month revenue as a better performance indicator. Our current TTM for our GMP regions, it's just over 40% organically. Now let's discuss our protein analysis growth pillar, where we experienced strong sales momentum across our portfolio of automated workflow solutions. Once again, the ease of use, precision and reproducibility offered by our Simple Western automated Western blood instrument, our SimplePlex automated multiplexing immunoassay system and ThermoRIS Biologics platform drove strong consumable utilization on our installed base.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Customers continue to appreciate the labor and cost savings these innovative platforms bring to their laboratories. Overall, instrument specific consumables increased high teens in the quarter. This marks eight out of the last nine quarters where we delivered at least double digit consumable growth across our growing installed base. It was not just consumables that showed strength though, we also experienced growth in new instrument placements. Globally, our instruments increased low single digits for the quarter and grew mid single digits excluding China.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

This marks the first quarter in the last two years in which we delivered positive instrument growth. Separately, I'd like to congratulate the team on the successful early access launch of our next generation high throughput simple western platform called LEO. The team capitalized on our growing order funnel and shipped several of these high end LEO instruments at the end of the quarter. Wrapping up our platform discussion, I'd like to give an update on Marie's Flex. Our biopharma customers are increasingly utilizing Marie's Flex for protein analysis in a rapidly growing number of gene therapy applications as well as sample fractionation methods for mass spectrometry sample preparation.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

During the quarter, we announced a co marketing agreement with Waters Corporation aiming to expand the market awareness of the biotherapeutic characterization capabilities of the Maurice Flex. Now let's turn to our core portfolio of Research Use Only or RUO, Proteomic Reagents. Let me highlight that over the last forty eight years we've amassed a catalog of over 6,000 proteins and 400,000 antibody types. This biological content is relied upon by customers across the globe to gain novel insights into biological pathways to develop and manufacture advanced therapeutics and to enable precision diagnostics. Our everyday run rate business continued to modestly improve sequentially while larger bulk orders of our RUO reagents to biopharma customers also picked up in the quarter.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

We view this as an indicator that our end markets are gradually starting to improve. All in, our core portfolio of RUL reagents grew low single digits in the quarter. Sticking with our core reagent portfolio, I wanted to give an update on our AI initiatives within Bio Techne. As we have mentioned in the past, we see tremendous potential leveraging AI to develop proteins and antibodies with enhanced functionality. During the quarter, we continued to utilize our internal know how and our vast data set which we generated over the last several decades to train our generative AI models and develop designer proteins.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

These patentable proteins are engineered to exhibit hyperactive properties, enhanced heat stability and other novel features. These attributes are relevant for many applications, including cell therapies. We added four new designer proteins to our catalog in Q2, bringing the total portfolio to six. You can expect steady cadence of new designer protein launches going forward. Overall, I'm very excited for the Protein Sciences team as they delivered 8% organic revenue growth.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

This is the best performance of this segment since the market headwinds that were related to the aftermath of the pandemic began in the first quarter of our fiscal twenty twenty three. Now we will move to the growth pillars within our Diagnostics and Spatial Biology segment, which delivered 12% organic growth in the quarter. Let's start with our Spatial Biology business where we continue to make significant progress with the launch of the COMET system, a fully automated multi omics spatial rheology instrument. As a reminder, we recently enabled our in scope capabilities on the COMET to allow for visualization of up to 24 proteins and 12 RNA targets simultaneously. We are actively upgrading COMET's installed base to enable researchers to fully leverage the multi omic capabilities of the platform.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Additionally, we continue to launch Bio Techne's R and D Systems branded antibodies for use on the COMET system. The RNAscope capabilities paired with the growing portfolio of validated antibodies will support a consumable stream that is expected to be the highest pull through of any instrument under the Bio Techne umbrella. During the quarter, our spatial biology revenue increased mid teens and we are positioned for continued leadership in this fast evolving space. Next, I'd like to give an update on our Precision Diagnostic Tools business, previously referred to as the Molecular Diagnostics business. We believe the new name is a better reflection of the focus of this team, which is to provide clinical laboratories with precise diagnostic tools that leverage our exosome based diagnostic technology combined with Assurant's proprietary chemistries.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

During the quarter, we announced the launch of a test for ESR1 mutations in breast cancer. This is the first kitted test to utilize our exosome based technology and Asurion's chemistries. We commercialized this test through a laboratory channel, which we also obtained for the acquisition of Asurion. Meanwhile, our ExoDx prostate catheter test continues to enjoy rapid adoption as unit volume grew more than 30% in the quarter. In summary, I'm extremely pleased with the execution by the Bio Techne team across all our businesses globally.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

We believe that the strength of our growth pillars in cell and gene therapy and proteomic analysis combined with the momentum that we saw in our core products are indicative of an early stage recovery in key biopharma end markets. If you then add to that the performance of our best in class spatial biology franchise and our high value precision diagnostic tools platform, you will understand why I'm confident that we have positioned Bio Techne for continued differentiated growth going forward. With that, I will turn the call over to Jim. Jim?

[Jim Hippel, Chief Financial Officer at Bio-Techne]

Thank you, Kim. I'll start with some additional details on our Q2 financial performance and then give some thoughts on the financial outlook for the remainder of the fiscal year. Starting with the overall second quarter financial performance, adjusted EPS was $0.42 compared to $0.4 in the prior year with foreign exchange having an unfavorable 0.02 impact. GAAP EPS for the quarter was $0.22 compared to $0.17 in the prior year. Q2 revenue was $297,000,000 an increase of 9% year over year on both a reported and organic basis.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

Recapping our organic growth by region and end market in Q2 that you previously heard from Kim, North America and Europe increased low double digits year over year, driven by strength from our biopharma customers, particularly in our cell therapy and proteomic analysis portfolios, while China and APAC decreased low single digits. By end market in Q2, excluding China, Biopharma increased mid teens and academia increased mid single digits in the quarter. Our biopharma business benefited from larger reagent and instrument orders in our pharma and cell therapy end markets, while our run rate business in biopharma showed modest improvement year over year. Below revenue on the P and L, total company adjusted gross margin was 70.5% in the quarter compared to 69.7% last year, driven by the impact of favorable product mix and productivity initiatives. Adjusted SG and A in Q2 was 32 of revenue compared to 31.2% in the prior year, while R and D expense in Q2 was 8.5% of revenue compared to 8.4% in the prior year.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

The increase in SG and A was driven primarily by the reinstatement of incentive compensation accruals, partially offset by the benefit of structural streamlining and diligent expense control. Adjusted operating margin for Q2 was 30.1%, up 110 basis points sequentially and flat compared to the prior year due to the impact of favorable volume leverage and cost controls offset by the reinstatement of incentive compensation accruals. We continue to execute cost containment measures and prioritize our growth initiatives to drive efficiencies throughout the organization with the goal of optimizing operating leverage during the ensuing market recovery. Looking at our numbers below operating income, net interest expense in Q2 was $700,000 decreasing $2,700,000 compared to the prior year due to lower net debt levels. Our bank debt on the balance sheet as of the end of Q2 stood at $300,000,000 unchanged from last quarter.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

Other adjusted non operating expense was $1,300,000 in the quarter, an increase of $4,400,000 compared the prior year. The increase was driven by the foreign exchange impact related to our overseas cash pooling arrangements. Moving further down the P and L, our adjusted effective tax rate in Q2 was 21.5%, down 50 basis points compared to the prior year due to geographic mix. Turning to cash flow and return of capital, $84,300,000 of cash was generated from operations in the quarter and our net investment in capital expenditures was $6,800,000 Also during Q2, we returned capital to shareholders by way of $12,700,000 in dividends and $75,600,000 through a $1,100,000 share stock buyback. We finished the quarter with $160,600,000 average diluted shares outstanding.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

Our balance sheet finished Q2 in a strong position with $177,500,000 in cash and our total leverage ratio remains well below one times EBITDA. Going

[Jim Hippel, Chief Financial Officer at Bio-Techne]

forward, M

[Jim Hippel, Chief Financial Officer at Bio-Techne]

and A remains a top priority for capital allocation. Next, I'll discuss the performance of our reporting segments starting with the Protein Sciences segment. Q2 reported sales were $211,600,000 with reported revenue increasing 7% compared to the prior year. The exclusion of the Fetal Bovine Serum business, which was classified as a held for sale business and subsequently divested in the quarter, unfavorably impacted reported segment revenue growth by 1%. Thus organic revenue for the segment increased 8%.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

As Kim previously mentioned, the strength in the segment's organic growth was driven by our Protein Analysis portfolio, as well as our GMP protein business. For several large orders that we initially expected to be placed in our third quarter were requested by our self therapy customers in Q2. Operating margin for the Protein Sciences segment was 41.2%, an increase of 90 basis points compared to prior year as the impact of favorable volume leverage, cost management and structural alignment initiatives were partially offset by the reinstatement of incentive compensation accruals. Turning to the Diagnostics and Spatial Biology segment, Q2 sales were $84,100,000 with both reported and organic growth increasing 12% compared to the same quarter last year. All three businesses within this segment, our core diagnostics reagents, spatial biology and precision diagnostic tools all contributed nicely to growth.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

Moving on to the Diagnostics and Spatial Biology segment operating margin at 3.9%, the segment's operating margin decreased compared to the prior year 6%. Excluding the impact of incentive compensation accrual reinstatement, operating margins would have expanded approximately 200 basis points year over year due to the impact of favorable volume leverage. We anticipate improvement in the Diagnostics and Spatial Biology operating margin as Lunaford continues to scale. In summary, Q2 was a very solid quarter. Earlier than expected in the fiscal year, we saw improvements in all types of order activity from our larger pharma customers, including CapEx spend for instruments, bulk order reagent requests and increased daily run rate purchases.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

We view this as a positive sign that much of the R and D pipeline repositioning by our large pharma customers is behind us and that a more broad based increase in R and D funding from discovery through the clinic is more likely in calendar year 2025. We also saw continued outperformance in our GMP protein business in Q2, although much of this unexpected upside came from the timing of large orders by several cell therapy customers who are progressing their programs through clinical trials. Thus, the organic growth outlook for the second half of fiscal year twenty twenty five that we've provided the past two quarters is still intact. For Q3 specifically, this means the upper range of mid single digit organic growth. As you think about our expected organic growth performance in Q3 relative to Q2, there are a couple of headwinds to consider.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

First, the year over year comp in Q3 is more difficult by four percentage points than it was in Q2, as our revenue declined 2% in Q2 of last year and then grew 2% the following Q3. Also, the previously mentioned timing of several large GMP protein orders that we had in our recent Q2 are not expected to reoccur in Q3. However, on a more positive note, the earlier than expected momentum we are seeing from our larger pharma customers, as well as an expected return to growth in China in Q3, allows us to hold the organic revenue outlook that we shared since the beginning of our fiscal year. The early improvement in large pharma activity also strengthens our confidence that we can exit our Q4 with organic growth in the high single digits as we have predicted all year. As it pertains to reported revenue growth with the recent strengthening of the U.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

S. Dollar at current foreign exchange rates, we do expect a headwind of approximately 1% of sales in the back half of our fiscal year. As much of the top line foreign exchange falls directly to the bottom line of our P and L, we do expect a negative impact to adjusted operating margins by approximately 50 basis points. Thus, we are now forecasting adjusted operating margins in the second half of fiscal year twenty twenty five to be between 5,150 basis points higher than the prior year. This still represents a significant step up in margin from the first half of the fiscal year due to higher volume leverage, continued improving product mix and the full impact from productivity initiatives.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

That concludes my prepared comments. And with that, I'll turn the call back over to the operator to open the line for questions.

[Operator]

Thank you. We will now be conducting a question and answer session. We ask that all callers limit themselves to one question and one follow-up. If you have additional questions, you may be queue and those questions will be addressed time permitting. Thank you.

[Operator]

Our first question comes from the line of Puneet Souda with Leerink Partners. Please proceed with your question.

[Puneet Souda, Senior MD at Leerink Partners]

Hi, guys. Thanks for taking my questions. First of all, congrats on the quarter here, really strong. But can you talk a little bit about the pull forward that you saw from 3Q to 2Q in selling gene therapy GMP products, you seem to be talking about essentially the biopharma momentum continuing, China also improving. So that is offsetting.

[Puneet Souda, Senior MD at Leerink Partners]

But can you elaborate a bit on where you have more confidence in recovery among those sort of three vectors that you talked about? Where you think you will have recovery in the third quarter, whereas where there things could be a more a little bit softer, just given the backdrop of the market right now and sort of the concerns around NIH as well?

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Yes, Puneet, thank you very much for your question. First of all, I think let me talk about the cell and gene therapy orders you mentioned. Fortunately, we're very happy to see that there is tremendous traction there, right. We grew about 90% on the GMP proteins. And some of these larger orders, right, from customers that are further down in their clinical studies, We have anticipated for the second half of the fiscal year and upon customers demand, these were pulled into Q2 and were delivered earlier than we originally anticipated.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

This of course drove several points of growth and we feel confident that this is also a very positive sign for the overall markets and we're quite happy with the traction we have there. Going to China, we did see that the replacement funding, some earlier facts in our Q2 and a handful of instruments were sold related to this replacement funding. We know it's a three year plan. So we expect continued traction related to the funding. And then the interesting thing is that the China National Science Funding, which you can apply for during the calendar Q1 and the deadline is March 20, that should also provide some additional lift in China that eventually our forecast or our original projection that we anticipated for China where we would go from slight negative to positive growth in Q3, we're still very confident with that view.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

And maybe Jim, you want to add something?

[Jim Hippel, Chief Financial Officer at Bio-Techne]

Yes, sure. So Puneet, I

[Jim Hippel, Chief Financial Officer at Bio-Techne]

think the only I'd add is that it gives us confidence with regards to holding our forecast in Q3 despite the timing of the cell and gene therapy large orders is really the broad based strength we saw across pharma. As I mentioned in my comments, it wasn't just Cell and Gene Therapy. We saw it of course in our instrument portfolio, our ProteinSimple franchise did phenomenally well, especially in large pharma. And even our run rate business within the large pharma also improved from our prior quarter. So it's that's what gives us some confidence that it's a broad base large pharma start of recovery.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

It's not back to normal yet. Our run rates are back to normal, but it was a noticeable improvement from the prior quarter. And you mentioned NIH and concern around that, so I'll kind of hit that head on as well. It is very early days and all the kind of noise and chatter and a lot of what's happening, what we're reading is that not all that unusual in terms of what happens in administrative change with regards to kind of freezing or holding certain department funds as the new administration comes in and assesses. All I can tell you is that so far in January, we've seen no we've actually seen improvement in our academic overall growth rates and improvement in our run rate as well.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

So we're not overly concerned about the noise you're hearing out of Washington right now regarding NIH.

[Puneet Souda, Senior MD at Leerink Partners]

Got it. Thanks for touching on all those. Just quickly, if I could ask on your updated thoughts on M and A, your ability to lever just given the backdrop of the market and some of the challenges that some of the small cap tools companies are seeing, how does that shape your opportunity base when looking at M and A?

[Puneet Souda, Senior MD at Leerink Partners]

Thank you.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Yes, M and A will continue to be a priority for our capital deployment. And during the JPMorgan Healthcare Conference, we've been relatively clear as to our strategy and where we feel we would like to add to our portfolio. Fortunately, we don't really have any huge gaps. So it's not that we have to move, but we do like the area of discovery of novel biological insights, right. There are various analytical platforms that we will be interested in.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

And we would love to continue to support the development and manufacturing of advanced therapeutics. And you ought to think about any processes that are sitting before and or after the G Rex and any analytical tools that would support the cell and gene therapy workflows. So those are really the areas that we are very interested in. And we do have a nice timeframe here between the acquisition of Wilson Wolf at the end of twenty twenty seven and right now with a very strong balance sheet and a very precise strategy and capable management to integrate a new M and A activity.

[Puneet Souda, Senior MD at Leerink Partners]

Okay. Helpful guys. Thank you.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Thank you.

[Operator]

Our next question comes from the line of Dan Leonard with UBS. Please proceed with your question.

[Dan Leonard, Managing Director - Research Analyst at UBS Group]

Thank you. I want to circle back on a couple of Puneet's points. I guess first off, when you think about your current run rate business, where do you think you're currently trending? Is it that upper mid single digit figure you talked about for Q3 and then you need progressive market improvement to hit the high single digit for Q4? Is that the way to the right way to normalize what you called out as being positive lumps in the December?

[Jim Hippel, Chief Financial Officer at Bio-Techne]

And I'll try to answer your question if I understand it correctly about our run rate. So our day to day run rate business is going to perform closer to the overall market and it's our growth vectors, our growth pillars that we talk about that really cause us to have us the differentiation and acceleration versus the market. And so the way to think about that is that our run rate is performing closer to market, but the market is gradually improving and thus so are our run rates. So our run rate growth is lagging the overall company growth. In a normalized market of mid single digit growth, we do expect our run rate business to be at least mid single digit growth.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

And when it is, we expect to be a double digit growth company because of our growth vectors and the acceleration that provides. Hope that helps.

[Dan Leonard, Managing Director - Research Analyst at UBS Group]

Okay. And just a quick follow-up, Jim. That comment you made on January run rates, was that in academic, a U. S. Academic and government comment specifically or were you more commenting broadly on your run rate business in the month of January?

[Jim Hippel, Chief Financial Officer at Bio-Techne]

That was a specific comment regarding The U. S. Academic market.

[Dan Leonard, Managing Director - Research Analyst at UBS Group]

Thanks for the help.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

This is Ki Malik. To help you quantify the NIH exposure, Jim was talking about the overall academic market globally, which represents about 21% of our revenues. And then if you think about The U. S. Portion of that is about half of that, which is 11%.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

And then if you think about NIH exposure, we'd sit about more or less half of that. So that would be mid single digits. And then revenue directly related to NIH itself would be less than 1% of our revenue. So that really kind of scopes for you

[Kim Kelderman, CEO, President & Director at Bio-Techne]

the exposure there.

[Dan Leonard, Managing Director - Research Analyst at UBS Group]

Sure. Thank you. But the January comment was specific to that 10 ish percent of revenue that's U. S. Academic and government, correct?

[Jim Hippel, Chief Financial Officer at Bio-Techne]

Yes. That is correct, Dan.

[Dan Leonard, Managing Director - Research Analyst at UBS Group]

Okay.

[Dan Leonard, Managing Director - Research Analyst at UBS Group]

All right, perfect.

[Dan Leonard, Managing Director - Research Analyst at UBS Group]

Thank you.

[Operator]

Our next question comes from the line of Jacob Johnson with Stephens. Please proceed with your question.

[Hannah Hefley, Senior Research Associate at Stephens Inc.]

Hi. This is actually Hannah on for Jacob. Thanks for taking the question. How much of a benefit from larger cell therapy customers do you think there was in the quarter? Is there any way you

[Hannah Hefley, Senior Research Associate at Stephens Inc.]

could quantify this for us?

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Yes, I can give it a initial shot and then Jim can follow-up. So I don't think we really quantify the mix there, but we did see a very nice traction of our customers in general. So overall order rate from our by now 500 customers in this field is doing really well. But in the meantime, several of these customers are moving up the chain if it comes to their clinical studies. And we used to talk about 57 of those being in clinicals rather than in pre clinicals.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

And by now those are 85 customers that are in the clinical stages of which 13 or so in Phase II and then a little bit more than a handful of six to eight that are sitting in the Phase III clinical stages. And of course, these the customers that are sitting in these later stage clinical trials, those orders are also relatively larger and that creates some of the lumpiness that we've talked about in the past. But nonetheless, we are growing 40% organically. If you look at the twelve months trailing, which is very encouraging and that's also where we hope to or expect to be.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

And I'll just add a little bit to an answer Kim gave to Puneet around the same topic around the larger cell and gene therapy customers and what got accelerated into Q2 that was originally forecasted in Q3. It was about two points of overall growth that was attributed to that for cell and gene therapy. I think Kim mentioned three, but that's because there was probably another point of revenue that also moved within our core diagnostics reagent division. So we talked about that for years. It's a very lumpy business and it's not always easy to predict exactly when those orders will come through from our large customers there.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

And we saw some orders there come in earlier than expected as well and that won't necessarily repeat either. So I'd say about two points that's coming from cell and gene therapy, large customers and about one point is from our diagnostic reagents to visit core division.

[Hannah Hefley, Senior Research Associate at Stephens Inc.]

Thanks. And then you also mentioned that instruments grew in 2Q. Could you just talk about is this comment around placements growing again versus consumables?

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Yes, it is. We're very proud that we on the consumable side have had eight out of the last nine quarters in which we grew double digits on the consumable side. And we always anticipated that such growth in consumables kind of indicates a capacity constraint eventually in the market. And therefore, we anticipated that at some point in placements of our instruments would be growing again. And this quarter, we indeed went back into the black if it comes to growth in our instrument base.

[Hannah Hefley, Senior Research Associate at Stephens Inc.]

All right. Thanks. I'll leave it there.

[Operator]

Our next question comes from the line of Matt Larew with William Blair. Please proceed with your question.

[Matt Larew, Research Analyst - Healthcare at William Blair]

Hi, good morning. You referenced us the academic market and mentioned that within biopharma mid teens. Wondering if you could break that out, is it still sounds like it's mainly large pharma where most of the recovery is. What if any recovery are you seeing in terms of the smaller customers for the biotech customers? Or if not, are you seeing any signs of green shoots?

[Kim Kelderman, CEO, President & Director at Bio-Techne]

I

[Kim Kelderman, CEO, President & Director at Bio-Techne]

can answer high level and then have Jim double click on it. The overall, the biotech portion of our end markets, which is around 30% of our revenues was more or less recovering in line with our expectations. And you might remember how we laid out the year and our expectations in the different markets. And we certainly expected some of the good biotech funding to trickle through into that market. And that is some happening in line with our expectations.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

A little bit better than expected is large pharma. And that's that's driving some additional momentum in our Q2, the last quarter of the fiscal year, so of the calendar year, sorry. And we're quite happy to see that momentum. It gives us confidence that our second half will also roll out in line with our expectations.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

Yes. The only thing I would add, Kim, is that we're not claiming full recovery mode yet in either one of those markets, but we did continue to see the smaller biotechs gradually progress. And as Kim alluded to, what was nice surprise was with the beginning of the recovery in larger pharma that we weren't really expecting until April, May timeframe, we started to see that already here in our Q2, which was nice.

[Matt Larew, Research Analyst - Healthcare at William Blair]

Okay, thanks. And then flipping to the diagnostics and spatial side, I want to focus on Lunaford. Obviously, there's been a couple of mergers in the space in the past six months. You now are about a year or so into launching the Multi Omic solution with RNAscope. What is your assessment of the competitive landscape at this point?

[Matt Larew, Research Analyst - Healthcare at William Blair]

And then what's key to flipping that from really a significant operating margin headwind into more of a tailwind? Is it just a function of consumable pull through or are you having any issues on the manufacturing side with the instruments? It'd be good to get a sense for how that will progress throughout the year?

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Yes. Thanks for the question. So there has been activity in the market, which we deem positive, a positive sign overall that spatial biology is a market to be in. Yes, a year ago we launched the COMET. We have been very happy with the uptake and the capabilities of the instrument.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

I do want to correct you a little bit that the RNAscope capabilities, at least in the multiomic setting have been launched last quarter. So those are rolling out as we speak. And then we've also been able to launch 45 R and D systems branded antibodies on the instrument. And if that we expect the pull through of consumables on the Komet to be one of the higher pull through instruments in our portfolio. We do not have any manufacturing constraints anymore on this product line, which is good to know.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

And I forgot the third leg of your question, but do you mind repeating that part?

[Matt Larew, Research Analyst - Healthcare at William Blair]

Yes. Just had you've obviously called it out as a headwind to operating margins on that segment. So just that's looking.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Yes. So the two components there of course will help. And one is continued uptake of selling the instruments, right. And then the pull through if it comes to the reagents. And both will be very important going forward to us.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

So we are measuring us against hitting certain milestones and we see positive traction in both these aspects as well. So our profitability will increase as a result of those finding the traction.

[Operator]

Our next question comes from the line of Catherine Schulte with Baird. Please proceed with your question.

[Catherine Schulte, Senior Research Analyst at Robert W. Baird & Co]

Hi, guys. Thanks for the question. Maybe first on China. What was reagent performance versus instrumentation in the quarter? And how do you expect that to trend in 3Q as that region returns to growth?

[Jim Hippel, Chief Financial Officer at Bio-Techne]

I would say that the growth was relatively comparable for the two. Again, it was very stable at low single digit declines in China. And we see it gradually improving and turning into the black in Q3. And I think it will be very comparable again both on the instrument side as well as the reagents. So not a notable difference there.

[Catherine Schulte, Senior Research Analyst at Robert W. Baird & Co]

Okay, great. And then maybe for RUO reagents, you set up low single digits in the quarter. What was academic versus pharma performance there? And what's your expectation for that as we get into the back half of the year?

[Jim Hippel, Chief Financial Officer at Bio-Techne]

I'm sorry, Catherine, the academic versus pharma performance with regards to what?

[Catherine Schulte, Senior Research Analyst at Robert W. Baird & Co]

Within RUO reagents.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

RUO reagents. Actually it was again relatively comparable, but slightly stronger in Europe. With respect to RUO run rate reagents, both in biopharma and in academic. But again, both are European and U. S.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

Growth totals were like within a point or two of each other. So we're not talking about a massive difference.

[Catherine Schulte, Senior Research Analyst at Robert W. Baird & Co]

Great. Thank you.

[Operator]

Our next question comes from the line of Dan Arias with Stifel. Please proceed with your question.

[Dan Arias, Analyst at Stifel Financial]

Good morning, guys. Thanks for the questions. Jim, two for you on GMP reagents, if I could. Number one is, what kind of growth expectations do you have for that piece next quarter? Obviously, you have the pull forward that you mentioned, but it does sound like you like the overall direction that that business is headed in.

[Dan Arias, Analyst at Stifel Financial]

So just given how wide the range has been for that piece, it will be helpful if you could kind of put some guardrails just on what we might see there? And then the second question is, can you comment on where the margin profile for that business is? I mean, I know you don't get too specific on individual parts of the portfolio, but it's a piece that's moving the needle. And so it would just be helpful to understand the mix impact that that business has as it accelerates. Thanks a bunch.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

Sure. I appreciate the question, Dan. And as you know, we don't give guidance down to that level of fidelity. What I'd say is that it is as we talk about with these large orders, it can be very lumpy. If you back out the larger orders, the underlying growth of our customers continues to increase every quarter in cell and gene therapy and the revenues do as well.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

We talked about the TTM being roughly 40%. I cannot say it's going to be that next quarter, but it will definitely not be the large contributor to growth that it was this quarter, which again, I think says a lot about the underlying strength of the rest of the business and the end markets improving the fact that we can still hold our forecast for Q3 that we've been saying all year. With regards to the margin profile, it is a very nice profitable business for us and not quite as profitable as our core RUO reagents, but very, very close. It's probably the second most profitable product line within our business. But again, we're not necessarily calling that out as any kind of margin issue for Q3, even though that mix will change just because we do see continued improvement within our RUO business that will compensate for that.

[Dan Arias, Analyst at Stifel Financial]

Okay. Just to maybe get you on the growth. So it sounds like for GMP reagents, we can model that up decently up, but not anywhere near where it's been for the first half of the year. Is that fair?

[Jim Hippel, Chief Financial Officer at Bio-Techne]

That's fair.

[Dan Arias, Analyst at Stifel Financial]

Okay. Thank you.

[Operator]

Our next question comes from the line of Connor McNamara with RBC. Please proceed with your question.

[Conor McNamara, Equity Research Analyst at RBC Capital Markets]

Hey guys, thanks for the time and congrats on a really strong quarter. First off, on the handful of programs in solid gene therapy that are in late stage Phase II or Phase III, is there any way you could quantify or give us color on those programs and the incremental opportunity as those advance either from Phase II to Phase III or

[Conor McNamara, Equity Research Analyst at RBC Capital Markets]

as they come to market?

[Kim Kelderman, CEO, President & Director at Bio-Techne]

That's really hard, Conor. The so in general, you would see roughly double the size and orders each time there is a clinical progress to the next stage. But then again, it really varies with how often the customer orders and how large the clinical study really is. So it's really hard to give you a standard template there. It really depends on each customer.

[Conor McNamara, Equity Research Analyst at RBC Capital Markets]

Okay. That two axis. That's helpful. Thanks for that. And then just on cell and gene therapy strength, how did Wilson and Wolf do in the quarter?

[Conor McNamara, Equity Research Analyst at RBC Capital Markets]

And can you remind us if there's any opportunity to consolidate that prior to 2027 given this rebound you're seeing in that end market? Thanks for that.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

Yes, I'll take that one. So with regards to Wolfson and Wolf, I would say that their core growth business, meaning their non commercialized businesses was consistent with our earlier stage growth. So we're seeing consistency across the cell and gene therapy market there. I will remind you that they have five, I mean flat five customers now that are commercialized and just the preliminary forecast from just the three from three of those alone will be enough to put them into very, very, very solid double digit growth for calendar year 2025. So future is very bright there.

[Operator]

Our next question comes from the line of Patrick Donnelly with Citi. Please proceed with your question.

[Patrick Donnelly, Analyst at Citigroup]

Hey guys, thanks for taking the questions. Maybe a follow-up on China. I know you guys mentioned you were over there last month. Can you just talk about, I guess, what you saw in terms of the environment, confidence level in terms of the recovery? Obviously, a lot of noise over there.

[Patrick Donnelly, Analyst at Citigroup]

Just curious from the ground what you guys saw and the expectations there.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Yes, I think a couple of aspects. The drive to continue to research in life sciences continues to be there. I am certain the country would love to make big steps forward in designing treatments and helping the Chinese citizens as well as the world getting access to better treatments. On the other hand, we are encouraged that there are some more activities on the funding, government funding level, which historically has been elevated compared to the last couple of years. So we do see some increased activity there again and that's also why our expectations are that China is going to be back into the positive growth slightly.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

But on the other hand, there is no doubt that there is a tough economic environment in China and that things are not all in the green just yet. And we just continue to hope that things will improve and that and Bio Techne will be ready to support all the science activities in order to get to a better situation there.

[Patrick Donnelly, Analyst at Citigroup]

Okay, that's helpful. And then Jim, maybe one for you, it sounds like the margins in 2H FX a little bit of an offset there. Can you just talk about the moving pieces, the expansion opportunity and again anything else under the hood other than FX in terms of the shift for 2H? Thank you guys.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

Yes, sure. So nothing's changed with regards to our outlook in the second half margin. We knew we initially guided to 100 basis points to 200 basis points higher in the beginning of the year. Now with the changes in FX, as you heard me say in this call earlier, there's about 50 headwind into that, but still significant margin improvement year over year at 50 basis points to 150 basis points in that range. And even more significant step up when you think about it sequentially from the first half to the second half, and it just shows the power of our contribution margin that comes from our products.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

And so with the both the seasonality and the continued acceleration of our growth year over year, but also sequentially seasonality wise that step up in revenue has very nice pull through and we've done a lot to make organizational efficiencies over the past year and a half to be ready more ready than ever for margin expansion when the growth returns. So that's been the story all year and hasn't changed and that coupled with not just the volume leverage, but also the mix improvement as we saw this quarter when PSS returns to solid growth, you can see the great pull through that we get from that and we expect that to continue in the second half.

[Patrick Donnelly, Analyst at Citigroup]

Thank you, guys.

[Operator]

Our next question comes from the line of Sunji Nam with Scotiabank. Please proceed with your question.

[Sung Ji Nam, Managing Director, Senior Equity Research Analyst at Scotiabank]

Hi. Thanks for taking the questions. Maybe on the AI capabilities and the new designer proteins, would you be able to comment on kind of how Bio Techne stacks up against competitors on that front? How game changing is this capability in this industry right now? And kind of what the competitive advantages are moving forward?

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Yes. Thank you for the question. We do believe that this the AI engineered antibodies as well as proteins will are truly a stepwise change in innovation. We do believe there are sustainable advantages because these products are patentable and we have combined our tremendous internal know how and fast database that we build over last couple of decades and invested very early in the AI capabilities and you really need all three to be successful there. And I know that we were uniquely positioned to grab this opportunity and run with it.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

And if you think about the benefits of having these AI engineered proteins, the hyperactivity, temperature stable, so you can really boost your cell based work and then the enhanced receptor binding are all very differentiated features and really things that were not possible in the past. And, yes, we think we will create a real nice stepping letter for customers where you would normally be constrained to only RUO versions of these proteins, but now you can get enhanced activities by picking the AI designed proteins. And then of course you can step up to the GMP versions of our proteins and eventually we will launch the GMP AI engineered protein. So we will have a real nice continuum for customers to lean on.

[Sung Ji Nam, Managing Director, Senior Equity Research Analyst at Scotiabank]

Great. That's super helpful. And then just on the Spatial Bio side, the RNAscope assays on the comment that you just launched, just curious how quickly do you expect the customers to adopt the multi omic capabilities, whether that would require further market development? And then also how for the clinical market, I think you're gaining good traction there as well, whether the multi omic capabilities also will be a competitive advantage? Thank you.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Thanks for that question as well. Yes, I think that having the multi omic capability and we're truly the only provider of multi omics in the spatial market where our customers can look at 12 RNA targets and 24 protein targets all in parallel on the same slide. And then having the comment with the features of very high throughput, you can use off the shelf antibodies that you've been using in the past. So you don't have to change your experiments. Four slides simultaneously that will give you 20 slides throughput in a week.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Those are all market leading performances. And I think that we're really set up to continue to do really well in the spatial markets. Currently, we have key opinion leaders really working with the multi omic capabilities and we envision this rolling out throughout the market. The instrument is very stable, easy to use and so are the agents. So I don't feel that there's a lot of market development to be done.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

It was truly the rollout of the product and the solution. And then last but not least, you're right, our footprint in clinical has continued to outpace the growth of this overall spatial biology market. So we're really happy that our RNAscope product line for example is stable enough and relevant enough to perform in the clinical markets. And also there we feel that we're one of the few spatial biology solutions that have been successful clinical space. So I think we're very, very confident that we are really well positioned to continue to outperform there.

[Operator]

Thank you. Our final question comes from the line of Paul Knight with KeyBanc. Please proceed with your question.

[Lucas Baranowski, Equity Research Associate - Healthcare at KeyBanc Capital Markets]

Hi, this is Lucas on for Paul Knight. Just kind of sticking with the theme of the previous question. In the press release, you called out signs of improvement for some of your instrumentation businesses. Was the Komet one of those instruments you saw an uptick in interest for and how are placements for that trending generally? Thanks.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Yes. When we talk about our instruments, we really talk mostly about our protein analytical implementation portfolio, which we were very encouraged about getting back into the black. And this is excluding the spatial biology, COMET platform that still sits and gets reported in the spatial biology vertical. That answers your question.

[Jim Hippel, Chief Financial Officer at Bio-Techne]

I'll just follow on to say that the interest in that still remains very, very high and the growth rates are still very, very, very strong.

[Lucas Baranowski, Equity Research Associate - Healthcare at KeyBanc Capital Markets]

And then just one final question. I believe you were expecting China's stimulus to primarily benefit your automated Western blot equipment. Is that still what you are seeing or has interest broadened out to other product groups?

[Kim Kelderman, CEO, President & Director at Bio-Techne]

I think you're correct that that will be the primary product line that we will see traction. But then again, we have really good traction in the biological platform as well. So we feel that all three of our platforms will be in a much better position in China going forward.

[Lucas Baranowski, Equity Research Associate - Healthcare at KeyBanc Capital Markets]

Excellent. That's all I had.

[Operator]

Thank you. Mr. Kelderman, I would now like to turn the floor back over to you for closing comments.

[Kim Kelderman, CEO, President & Director at Bio-Techne]

Yes. Thank you. And thanks everybody for joining the call today and of course for your insightful questions. I'm extremely proud of the accomplishments and the results the Bio Techne team has been able to deliver this quarter and our differentiated portfolio addresses some of the highest growth markets in Lyme Sciences and is positioned to deliver best in class performance for all our stakeholders going forward. So with that, I want to thank you and have a great day.

[Operator]

Ladies and gentlemen, this does conclude today's teleconference. You may disconnect your lines at this time. Thank you for your participation, and have a wonderful day.

Participants

Executives

• David Clair, Investor Relations
• Kim Kelderman, CEO, President & Director
• Jim Hippel, Chief Financial Officer

Analysts

• Puneet Souda, Senior MD at Leerink Partners
• Dan Leonard, Managing Director - Research Analyst at UBS Group
• Hannah Hefley, Senior Research Associate at Stephens Inc.
• Matt Larew, Research Analyst - Healthcare at William Blair
• Catherine Schulte, Senior Research Analyst at Robert W. Baird & Co
• Dan Arias, Analyst at Stifel Financial
• Conor McNamara, Equity Research Analyst at RBC Capital Markets
• Patrick Donnelly, Analyst at Citigroup
• Sung Ji Nam, Managing Director, Senior Equity Research Analyst at Scotiabank
• Lucas Baranowski, Equity Research Associate - Healthcare at KeyBanc Capital Markets