NASDAQ:TKNO Alpha Teknova Q4 2024 Earnings Report $6.64 +0.21 (+3.25%) As of 01:51 PM Eastern This is a fair market value price provided by Polygon.io. Learn more. Earnings HistoryForecast Alpha Teknova EPS ResultsActual EPS-$0.11Consensus EPS N/ABeat/MissN/AOne Year Ago EPSN/AAlpha Teknova Revenue ResultsActual Revenue$9.27 millionExpected Revenue$9.10 millionBeat/MissBeat by +$170.00 thousandYoY Revenue GrowthN/AAlpha Teknova Announcement DetailsQuarterQ4 2024Date3/4/2025TimeAfter Market ClosesConference Call DateTuesday, March 4, 2025Conference Call Time5:00PM ETUpcoming EarningsAlpha Teknova's Q1 2025 earnings is scheduled for Monday, May 12, 2025, with a conference call scheduled on Thursday, May 8, 2025 at 5:00 PM ET. Check back for transcripts, audio, and key financial metrics as they become available.Conference Call ResourcesConference Call AudioConference Call TranscriptSlide DeckPress Release (8-K)Annual Report (10-K)Earnings HistoryCompany ProfileSlide DeckFull Screen Slide DeckPowered by Alpha Teknova Q4 2024 Earnings Call TranscriptProvided by QuartrMarch 4, 2025 ShareLink copied to clipboard.There are 8 speakers on the call. Operator00:00:00Thank you for standing by, and welcome to Technova's Fourth Quarter and Full Year twenty twenty four Earnings Conference Call. At this time, all participants are in a listen only mode. After the speaker presentation, there will be a question and answer session. I would now like to hand the call over to Jennifer Henry, Senior Vice President of Marketing. Please go ahead. Speaker 100:00:33Thank you, operator. Welcome to Technova's fourth quarter and full year twenty twenty four earnings conference call. With me on today's call are Steven Gundstream, Technova's President and Chief Executive Officer and Matt Lowell, Technova's Chief Financial Officer, who will make prepared remarks and then take your questions. As a reminder, the forward looking statements that we make during this call, including those regarding business goals and expectations for the financial performance of the company, are subject to risks and uncertainties that may cause actual events or results to differ. Additional information concerning these risk factors is included in the press release the company issued earlier today, and they are more fully described in the company's various filings with the SEC. Speaker 100:01:18Today's comments reflect the company's current views, which could change as a result of new information, future events or other factors, and the company does not obligate or commit itself to update its forward looking statements except as required by law. The company's management believes that in addition to GAAP results, non GAAP financial measures can provide meaningful insight when evaluating the company's financial performance and the effectiveness of its business strategies. We will therefore use non GAAP financial measures of certain of our results during this call. Reconciliations of GAAP to non GAAP financial measures are included in the press release that we issued this afternoon, which is posted to Technova's website and at www.sec.gov/edgar. Non GAAP financial measures should always be considered only as a supplement to and not as a substitute for or as superior to financial measures prepared in accordance with GAAP. Speaker 100:02:16The non GAAP financial measures in this presentation may differ from similarly named non GAAP financial measures used by other companies. Please also be advised that the company has posted a supplemental slide deck to accompany today's prepared remarks. It can be accessed on the Investor Relations section of Technovo's website and on today's webcast. And now, I will turn the call over to Stephen. Speaker 200:02:40Thank you, Jen. Good afternoon and thank you everyone for joining us for our fourth quarter and full year twenty twenty four earnings call. I am very pleased with the progress we made in 2024. Technova is in a better position than ever to deliver on a plan we laid out in 2021 that we believe will generate long term sustainable growth. We continue to execute on our growth strategy. Speaker 200:03:09In 2024, we supported 48 clinical customers, up from 34 at the end of 2023, a 41% annual increase. We recognized $37,700,000 in total revenue. When adjusted to exclude revenue from a single large clinical solutions order of $2,700,000 in 2023, total revenue growth was 11%. Revenue from sales to cell and gene therapy related customers increased from 23% in 2023 to 27% in 2024. We maintained our service levels to customers despite reduced headcount and launched three new offerings in 2024, BuildTech, ExpressTech and RUO plus Each of these offerings improve the customer experience while also adding to our top and bottom lines. Speaker 200:04:09We aggressively managed our operating expenses, which we reduced by $8,100,000 in 2024 compared to 2023 excluding non recurring charges. We finished the year with a total cash outflow of $13,500,000 substantially better than our initial guidance of $18,000,000 We also raised additional capital in July increasing our confidence that we will become cash flow positive without additional funding. Before we dive into the details around our 2024 performance, I would like to take a moment here to thank all past and present Technova associates for putting us in position of strength as we lift to 2025 and beyond. Our associates' ability to execute on our strategy while reducing costs is a testament to the culture and commitment we have here at Technova. Now, I want to provide more color than in years past about our performance by product type and end market. Speaker 200:05:14Technova is a leading supplier of both research and clinical grade catalog and customer agents. Our catalog business supports research and discovery across the entire life science community by providing over 1,400 SKUs of commonly used reagents. These reagents are a cornerstone to basic molecular and cellular biology experiments, which is why about 3,000 customers use our products annually. In 2024, catalog reagents represented approximately 60% of our total revenue. While we grew low single digit in this segment in 2024, we exited the second half of the year with 7% growth compared to the second half of twenty twenty three, which we believe reflects an improvement in the general R and D funding environment and strong commercial and operational execution internally. Speaker 200:06:10The diversity of our end markets we serve and the lack of customer concentration with no direct catalog customer representing more than 4% of total catalog revenue in 2024 provides not only an entry point for our faster growing custom products, but also a stable and predictable foundation for us as we execute on our growth strategy. The remaining 40% of our revenue is generated from custom research or clinical grade reagents that are manufactured to a customer specification and other non product revenue related primarily to services and shipping. Our ability to quote, manufacture, QC and ship custom products in weeks instead of months is a critical differentiator for us in the market. Our largest end market for these custom products is biopharma, which includes sales to large pharma, small and mid sized biotech, including cell and gene therapies and CDMOs. We believe this segment reflects our exposure to the bioprocessing end market. Speaker 200:07:17Sales to these customers represented approximately 70% of custom revenue and 25% of our total revenue in 2024. The remaining custom revenue is from regions predominantly sold to the life science tools and diagnostics customers and other end markets such as academic institutions, animal health and agriculture. The performance of our custom biopharma business demonstrates the progress we have made in executing on our growth strategy. In 2024, this segment grew about 40% compared to 2023, attributable in part to the onboarding of a new therapeutic clinical customer. But excluding that new customer, our growth was still robust at approximately 25%. Speaker 200:08:08Of the 48 total clinical customers we served in 2024, '30 '9 were biopharma related and of those 23 were cell and gene therapy related. We often support many or all the therapies in a customer's pipeline. Based on our own analysis, we believe we now support at least 50 therapies in preclinical trials, 10 therapies in Phase one trials and three therapies in Phase two or later trials. As a reminder, based on our market research, we expect revenue per therapy to increase on average approximately 30 fold as a therapy moved from Phase one to commercialization. For the remainder of the revenue generated from customer agents, those associated with accounts outside of biopharma, twenty twenty four was a challenging year. Speaker 200:08:58First, we had a large single order from a diagnostics company in 2023 that made for a difficult year on year comparison. In addition, a few of our larger life science tools companies in the sequencing and spatial genomics segments ordered significantly less than in the prior year. Looking ahead, we believe many of these account specific headwinds will subside. Taking these product and market segments together, we still expect 2025 to be a recovery year and we are optimistic that the market will return to more historically typical rates of growth as we enter 2026. We expect to see mid single digit growth in our catalog business this year considering the market's recent stabilization and that we have little to no direct exposure to NIH or tariff related policies. Speaker 200:09:51We also believe customer agents in the Life Science Tools and Diagnostics segment will grow mid single digits. Given our recent conversations with these customers and a more favorable year on year comparison. Regarding the custom products we sell to biopharma accounts, while we exited 2024 with momentum, we believe uncertainty in the current macro environment has caused some of our customers to delay orders and others to reduce their annual budgets. We are nonetheless confident that we will achieve at least 15% growth in this segment. Therefore, we believe our guidance for revenue growth of 7% at the midpoint fairly reflects the current overall market environment and the specific end markets we serve. Speaker 200:10:36Lastly, we believe there is an opportunity over the next twelve to twenty four months to expand our product portfolio through collaborations and acquisitions. While we have spent the past couple of years investing in infrastructure, systems and scalability, numerous other companies have focused on developing novel products and technologies. By working closely with these companies, we believe we can expand our product portfolio and geographic footprint. The combination of our operational and commercial scale with our collaborators' novel products and technologies creates a great opportunity to drive additional top line growth and margin expansion over the longer term. In summary, while we still expect 2025 to be a recovery year, we are confident in our strategy, ability to execute and capital runway. Speaker 200:11:26I will now hand the call over to Matt to talk through the financials. Speaker 300:11:32Thanks, Stephen. Good afternoon, everyone. I'm pleased with our financial performance in 2024. As Stephen mentioned, we finished the year with momentum, delivering 1718% year over year revenue growth in the third and fourth quarters respectively. And we significantly improved free cash outflow from $26,700,000 in the full year 2023 to $13,500,000 for the full year 2024. Speaker 300:12:00On to revenue, total revenue for the fourth quarter twenty twenty four was $9,300,000 an 18% increase from $7,900,000 for the fourth quarter twenty twenty three and thirty seven point seven million dollars for the full year 2024, a 3% increase from $36,700,000 for the full year 2023. When adjusted to exclude revenue from a single large clinical solutions order of $2,700,000 in 2023, total revenue growth was 11% in 2024. Lab Essentials products are targeted at the Research Use Only or RUL market and include both catalog and custom products. Lab essentials revenue was $6,800,000 in the fourth quarter twenty twenty four, a two percent increase from $6,700,000 in the fourth quarter twenty twenty three. Slight increase in Lab essentials revenue in fourth quarter twenty twenty four was attributable to an increased number of customers, partially offset by lower average revenue per customer. Speaker 300:13:07For the full year, Lab Essentials revenue was $28,900,000 in 2024, consistent with $28,800,000 in 2023, driven by an 8% increase in the number of customers to 3,045 that was somewhat offset by a 7% decrease in the average revenue per customer to $9,486 Clinical solutions products are made according to good manufacturing practices or GMP quality standards and are primarily used by our customers as components or inputs in the development and manufacture of diagnostic and therapeutic products. Clinical solutions revenue was $1,900,000 in the fourth quarter of twenty twenty four, a 110% increase from $900,000 in the fourth quarter of twenty twenty three. The increase in clinical solutions revenue in the fourth quarter of twenty twenty four was attributable to an increased number of customers, partially offset by lower average revenue per customer. For the full year, clinical solutions revenue was $7,100,000 in 2024, a 5% increase from $6,700,000 in 2023. Excluding revenue of $2,700,000 from a single large order in 2023, clinical solutions revenue was up 76% in 2024. Speaker 300:14:40We added clinical solutions customers in 2024, growing from 34 customers in 2023 to 48 that spend more than $5,000 annually. Average revenue per customer in 2024 decreased 25% to $148,000 We expect revenue per customer to increase over time as customers ramp up their purchase volumes when they move through clinical trial phases. However, this metric can be affected by the addition of newer clinical customers who typically order less. Just as a reminder, due to the larger average order size and clinical solutions compared to Lab Essentials, there can be more quarter to quarter revenue lumpiness in this category. Looking at the income statements, gross profit for the fourth quarter of twenty twenty four was $2,100,000 compared to $1,300,000 in the fourth quarter twenty twenty three and $7,200,000 for the full year 2024 compared to $10,300,000 for the full year 2023. Speaker 300:15:50Gross margin was 23% in the fourth quarter twenty twenty four, which is up from 17% in the fourth quarter twenty twenty three and nineteen point two percent for the full year 2024, which is down from 28.1% for the full year 2023. The increase in gross profit percentage for the fourth quarter twenty twenty four was primarily driven by higher clinical solutions revenue coupled with reduced headcount, partially offset by increased overhead costs. The decrease in gross profit percentage for the full year 2024 was primarily driven by the $2,800,000 non recurring non cash charge related to the disposal of expired inventory and write down of excess inventory created in the second half of twenty twenty two as discussed in the prior quarter. Excluding the impact of this charge, gross margin would have been 26.5% for the full year 2024. The decrease in gross profit in 2024 was also driven by increased overhead costs, largely depreciation expense following the completion of our new manufacturing facility in 2023, which were partially offset by reduced headcount. Speaker 300:17:15Operating expenses for the fourth quarter twenty twenty four were $7,800,000 compared to $12,200,000 for the fourth quarter twenty twenty three. Excluding the non recurring charges of 300,000 related to a loss contingency accrual and the non cash trading impairment charge of $2,200,000 in the fourth quarter twenty twenty three. Operating expenses were down $2,000,000 The decrease was was driven primarily by reduced headcount and spending in particular in professional fees. Operating expenses for 2024 were $33,400,000 compared to $45,900,000 in 2023. Excluding the non recurring charges of $1,400,000 for the full year 2024 and May for the full year 2023, Operating expenses decreased $8,100,000 The decrease was driven by reduced headcount and spending primarily on professional fees and insurance, partially offset by increased stock based compensation expense related to the stock option repricing as well as facility costs. Speaker 300:18:31At the end of fourth quarter twenty twenty four, we had 173 associates compared to two eleven a year prior. Net loss for the fourth quarter twenty twenty four was $5,700,000 or $0.11 per diluted share compared to a net loss of $10,700,000 or $0.26 per diluted share for the fourth quarter twenty twenty three. Net loss for the full year 2024 was $26,700,000 dollars or $0.57 per diluted share compared to a net loss of $36,800,000 or $1.16 per diluted share for the full year 2023. Adjusted EBITDA, a non GAAP measure was negative $3,200,000 for the fourth quarter of twenty twenty four compared to negative $6,000,000 for the fourth quarter of twenty twenty three. Adjusted EBITDA for the full year 2024 was negative $14,500,000 compared to negative $19,800,000 for the full year 2023. Speaker 300:19:43Excluding the $2,800,000 inventory charge, adjusted EBITDA would have been negative $11,700,000 in 2024. Cash flow and balance sheet highlights. Capital expenditures for the fourth quarter twenty twenty four were $600,000 compared to $300,000 for the fourth quarter twenty twenty three. Capital expenditures for the full year 2024 were $1,100,000 dollars compared to $7,900,000 for the full year 2023. Free cash flow, a non GAAP measure, which we define as cash provided by or used in operating activities, less purchases of property, plant and equipment was negative $1,500,000 for the fourth quarter twenty twenty four compared to negative $3,200,000 for the fourth quarter twenty twenty three. Speaker 300:20:40Free cash flow for the full year 2024 was negative $13,500,000 compared to $26,700,000 for the full year 2023. This decrease compared to prior periods for both the quarter and full year was due to lower cash used in operating activities and a decrease in capital expenditures. Note that for the financial periods in 2025, we are changing the definition of free cash flow to cash provided by or used in operating activities plus cash provided by or used in investing activities. This definition better aligns with our current reporting method for short term investments. Turning to the balance sheet as of 12/31/2024, we had $30,400,000 in cash, cash equivalents and short term investments and $12,100,000 in gross debt. Speaker 300:21:41For 2025 outlook, we are providing twenty twenty five total revenue guidance of $39,000,000 to $42,000,000 At the midpoint, this implies 7% revenue growth compared to 2024. While we saw a nice rebound in 2024 from our biopharma customers, we believe 2025 is another recovery year. There remains cautiousness across some of our customer base, which we believe is related to macroeconomic uncertainty, particularly as it relates to the rate of capital flowing into the sector. The low end of our range assumes these headwinds worsen and the high end assumes some easing. As we have indicated before, due to the high percentage of fixed costs associated with our operations, we estimate that each additional dollar of revenue drops through at a marginal cash rate of approximately 70% with some variability year to year. Speaker 300:22:41We expect to see gross margins in the high 20s percentage range in 2025 compared to a normalized mid 20s percentage range in 2024. The company posted operating expenses excluding non recurring charges below $8,000,000 for the third quarter in a row. That reflects steps we took during 2024 aimed at reducing operating expenses, which resulted in total cost savings of $8,100,000 excluding non recurring charges in 2024 compared to 2023. We believe that we are appropriately sized at operating expenses of approximately $8,000,000 per quarter, allowing us to moderately increase our investment in sales and marketing to position ourselves for the market recovery. At this spending level, we continue to expect to achieve adjusted EBITDA positive in the range of $50,000,000 to $55,000,000 in annualized revenue. Speaker 300:23:48The company saw a reduction in free cash outflow during the fourth quarter twenty twenty four, both sequentially and versus prior year. This is the lowest free cash outflow since first quarter twenty twenty one. Once again, the company is pleased to report that free cash outflow for the full year 2024 of $13,500,000 was significantly below our most recent guidance of less than $16,000,000 As we turn to 2025, the company expects free cash outflow to be less than $12,000,000 We are also pleased to announce the amendment and extension of our credit facility. First and foremost, we have reset the maturity date of the credit facility to March 2030 with no scheduled repayment of principal for the next three years. However, we are increasing the principal amount on our term loan to $13,200,000 representing a 1,100,000 increase rather than paying cash at closing for the exit fee owed to our lender. Speaker 300:24:55Through covenant changes, we have effectively increased our liquidity by $4,000,000 giving us additional cash runway. In conclusion, we're excited about the future and the company's competitive positioning in the market with attractive fundamentals and believe there is significant margin expansion potential when top line growth accelerates. With that, I'll turn the call back to Stephen. Thanks, Matt. Speaker 200:25:21Overall, we were pleased with our fourth quarter and full year 2024 performance and the progress we made against our strategic priorities. We believe the long term outlook for our end markets remains positive and we are committed to executing on our strategy to help our customers accelerate the introduction of novel therapies, diagnostics and other products that improve human health. We will now take your questions. Our first Operator00:26:04question comes from Matt LaRue of William Blair. Please go ahead, Matt. Speaker 400:26:12Hey guys and congrats on the nice progress. Stephen, I wanted to focus on the comments you made around sort of softening into the beginning of the year in order to perhaps some conservative customer budgets, delayed purchases. Is that something that February relative to January you saw the softening, moving to the first part? And then was this really regardless of customer designation, meaning large biopharma or small biotech or has change behavior mostly been within those kind of cash burn biotechs? Speaker 200:26:48Yes. Thanks, Matt. So I would say, yes, it's a little bit more recent that we're continuing to see this. It is a the phenomenon we've seen for the last couple of years where some customers are very excited. In December, we've talked about left with a lot of momentum. Speaker 200:27:08January still felt pretty good, but then you started to hear about, well, maybe we'll order that in Q2 instead of Q1 type of conversations. That said, of course, we still believe in that 15% growth I mentioned in biopharma in the script here. So, there's still some companies out there that are very positive. I think there's still some others are trying to figure out in this environment what that's going to mean for them in terms of their capital runway. So it's not all bad, but it is definitely picking up a little bit more in this to late January, February timeframe. Speaker 200:27:45We are seeing it more in the smaller companies, I would say. I think large pharma, we're still seeing pretty good pieces in the catalog business. It continues to do fairly well. Now we have very little academic exposure there as you know, but it's really more and maybe some life science tools and small, mid sized biotech that are kind of more in a tougher situation with regard to capital raise. Speaker 400:28:14Okay. Thanks. And then you give some numbers around on the clinical side where your own customers are out with respect to preclinical Phase I and Phase II and beyond. I understand the progression of that is in large part dependent on your customer's clinical success. But I was curious maybe if you could help us with what is the composition of your new customer pipeline look like? Speaker 400:28:36Is it all on the preclinical side or are you having opportunities to win business in the clinical stages as well? Speaker 200:28:46Yes. Obviously, as you get further down that pipeline, it's much harder to convert business. We have been successful moving a Phase two or later customer therapy over to us and then expanding within that pipeline to get the remaining therapies that they're working on, particularly on the downstream processing, which covers preclinical all the way through Phase two. So it can be done at the twelve to eighteen month process and it requires work on both sides to make that happen. Most of our new customers are coming in either preclinical or Phase one. Speaker 200:29:22And so that is where we typically attract them and we continue to see that go up despite them rationalizing some pipelines over the last couple of years and some difficult macro environments. But I think we are able to convert these customers given the platform. Speaker 400:29:41Okay. And then just last one would be for Matt. Obviously, you had the large clinical solutions order in 2023 that you were copping in 2024. Just as we're thinking about 2025, any kind of large one time ish kind of things to be aware of from 2024? Speaker 300:30:00No, I wouldn't highlight anything in particular in 2024. I'd just say generally with the business of our scale and then we are going to have times when there's lumpiness in the revenue and clinical solutions and even in lab essentials where we have some of our custom orders and larger customers there. But no, I think really with that one in particular was so large that it warranted calling out and of course it was disclosed in our filings, but I don't see anything so large like that to call out, but there will at times be some lumpiness. Speaker 200:30:35Yes, I think it's fair to say that in 2024 as a whole, we didn't have any single customer represent more than 4% of our total revenue. But to Matt's point, around $1,000,000 can shift a quarter and that obviously has a big impact. Speaker 400:30:52Okay, fair enough. Thanks a lot guys. Speaker 300:30:55Thanks Matt. Operator00:30:57Thank you. Our next question comes from Matthew Parisi of KeyBanc Capital Markets. Please go ahead, Matthew. Speaker 500:31:06Hi, yes. This is Matt Parisi on for Paul Knight at KeyBanc. I believe you mentioned on the call, but I was sure if you could just say it again, provide a number or the updated number of cell and gene therapy customers. And then if you could provide any insight to how many of the newly approved cell and gene therapies you are involved with or any the total commercial cell and gene therapies you are involved with? Speaker 200:31:32Yes. So we said on the call that now 27% of our total revenue is made up of cell and gene therapy related companies. And that includes obviously their discovery work revenue as well as their sort of clinical trial of work. So catalog, custom and our clinical solutions products. We also had 23 clinical customers in that category. Speaker 200:32:01We now support it will be updated in the slide deck as well, but you'll see that over 100 total cell and gene therapy customers. As of this point in time, we are not supporting any commercialized cell and gene therapies. If you remember, we really started down this pathway in 2021 and those have not migrated through, but that is obviously the strategy here is to get these customers in and go down that pipeline. Speaker 500:32:26Thank you. And then one other one would be, if you could just more around the modeling, if you could provide some detail on the phasing for revenues in 2025 and if we should expect the usual seasonal phasing throughout the year? Speaker 300:32:40Yes, I'll make this comment about 2025. I do expect the first quarter to be the lowest quarter of the year, probably similar to the year ago quarter, maybe a little bit below that. And that's in part due to some of the reasons that Stephen was just talking about. There's I mean, some always some lumpiness in there, but also the current market environment, but we're confident in the full year guidance. So I would expect to see from Q1 at the low point, moving up to Q2 and then into Q3 and then per our usual seasonality might expect a little bit less in Q4 just because of the fewer business days, which impacts the catalog part of our business in particular. Speaker 300:33:27So Q1 the lowest kind of progressing up to Q3 and maybe a little less than Q4, all getting us in that 39% to 42% range. Speaker 500:33:38Sounds great. Thank you so much. Thank you. Operator00:33:41Thank you. Our next question comes from Mark Massaro of Deutsche Bank. Please go ahead, Mark. Speaker 600:33:51Hey, guys. Thanks for taking the questions. Maybe a two parter. I understand that the revenue per customer declines as newer customers come on board. New customers typically order less than more mature customers. Speaker 600:34:08Can you give us a sense for how long it typically takes a new clinical customer to reach a similar level of a more mature customer? And then the second part of that, has there been any changes to any of the pricing of the reagents? I assume it's been flat to slightly up, but I just wanted to check on that. Speaker 200:34:31Sure, Mark. So on the revenue ramp, I'll just give you from a sales cycle perspective, right? We typically engage with the customer, present to them our capabilities, and then there's a process of where they come visit the facility, and then a quick little validation piece. And I'd say quick, but quick for us could be a couple months of work, to get them to validate that we can manufacture the product the way that they're looking for us to make. And then we're then very much dependent on their trial timelines, right. Speaker 200:35:00So what we've seen is, you know, some customers come in pretty early, they're spending the tens of thousands of dollars and then it takes about a year to year and a half to really get it ramped it up to the hundreds of thousands of dollars to give you that kind of perspective. And of course, every customer varies a little bit, but that kind of gives you an idea. On the pricing side, yes, we do annual price increases and it's based our portfolio, how unique each product is in the space and the market pricing. And so we go through that process and we've implemented new pricing for our entire catalog product as well as new algorithms for our custom pricing and we did that at the beginning of the year. Speaker 600:35:46Okay. And any chance that you could try to quantify what the price increases were? Were they consistent with general levels of inflation? Or is there any additional color you could provide? Speaker 200:36:00Yes, sure, Mark. About mid single digit increase on average overall. Speaker 600:36:05Yes. Okay. That makes sense. And then I think I heard you talk about your 2025 guidance, bakes in, if I heard correctly, mid single digit growth among, I think, some of your diagnostics customers. Did I hear that correctly? Speaker 600:36:21And is it safe to say that that might be the fastest growing segment relative to perhaps the cell and gene therapy customers that may be under more pressure from a capital markets perspective? It would just be helpful to get a sense of also how you're thinking about the sequencing and spatial space? Speaker 200:36:43Yes, absolutely. So let me break it down for you. On the catalog side, which represents 60% of our business, we believe mid single digit. We exited the year as you're going to say with 7% growth in the back half of twenty twenty four. We're thinking this year it will be in the mid single digits there. Speaker 200:37:02Life science tools diagnostics, difficult year on year comparison, some challenges just with a few accounts. We think we're kind of over that now, but I do believe it will still be mid single digits to some of these companies are still struggling to ramp up a bit. And then the fastest growing segment is the biopharma, the custom biopharma, which we think represents the bioprocessing segment. And yes, we're seeing some headwinds, but remember, we grew 40% last year. And so we believe this is more of a 15% growth in 2024, given the current macro environment, right? Speaker 200:37:36And so the bookends of our guide is things get worse versus things get better. Speaker 600:37:43Yes, that makes sense. And then maybe one more, should we you might have mentioned it, should we assume flat headcount and flat commercial organization? Speaker 300:37:55I would say generally so, Mark. As I mentioned, we're going to we are going to tweak up the commercial investment a little bit this year and it won't be headcount driven. There may be a couple of headcount here and there. But by and large, as we've communicated in the past, we believe the infrastructure we have in the company, including our operating expenses and the headcount associated with that is generally where we needed to be right now as a company. So we're not looking to grow there. Speaker 300:38:26It's more just one off type of thing. So I would say, yes, generally flat, although not precisely there could be a couple here and there. Speaker 600:38:36All right, great. Thank you for taking my questions. Speaker 300:38:38Thanks, Mark. Operator00:38:40Thank you. Our next question comes from Matt Hewitt of Craig Hallum. Please go ahead, Matt. Speaker 700:38:49Good afternoon and thanks for taking the questions. Maybe first up, I was hoping we could dig in a little bit more on the market commentary. As you listen to earnings calls over the past few weeks, the bioprocessing sector in particular, commentary has been pretty healthy saying that in 2026, everyone expects the market to kind of get back to where it has been historically. It sounds like you're kind of calling for a similar, but maybe things have changed here over the past few weeks. Am I hearing that correctly? Speaker 200:39:23I think we'll put it this way, right? We're basically saying that we'll grow in the 15% range in that bioprocessing segment, which I think is probably similar to some of the peers. I still don't think we're back to what was historically normal rates of growth in that space. And if that happens, we think we could grow more like we did in 2024, right? We grew 40%. Speaker 200:39:46We were coming into the end of the year feeling pretty good about where we sat with those customers and then we did see some footage. So it is more recent, Matt, that we're starting to see things, some of these orders that we would have expected in Q1 get pushed to Q2, that sort of thing. So yes, does that help? Speaker 700:40:07Yes, it does. Thank you. And then maybe a little bit of an off question versus your comments earlier that you're really not impacted by NIH funding and tariffs and whatnot, but there has been some discussion about implementing like a 25% tariff on drugs that are imported to The U. S. How would that impact your business? Speaker 700:40:30I think you're largely a domestic provider, but is there a chance that you could potentially see some double dipping where maybe your customers that were manufacturing OUS say, you know what, we need to shift this production to The U. S. And therefore, the products that we've been ordering before, we now have to actually order a second round of those. Is that possible or am I thinking too far afield on that? Speaker 200:40:56It's certainly possible. First, I would say, yes, on the NIH side, 4% of our sales are related to academic institutions, of course, which are not all funded by the NIH. So pretty limited exposure there. Around 95% of our sales are domestic. And we manufacture everything here in The United States. Speaker 200:41:16So we're relatively insulated from that perspective. Now if we believe things are being brought more onshore here, we some of those 48 customers, clinical customer support are CDMOs. And if they get more busy, then we will likely get more busy and that could be an opportunity for additional growth. So I think it's possible there. I haven't really thought about the double dipping piece. Speaker 200:41:42I guess we'd have to wait and see. Speaker 700:41:45Got it. All right. Thank you very much. Operator00:41:50Thank you. And that is all the time we have for Q and A today. This concludes today's conference call. Thank you for participating. You may now disconnect.Read morePowered by Conference Call Audio Live Call not available Earnings Conference CallAlpha Teknova Q4 202400:00 / 00:00Speed:1x1.25x1.5x2x Earnings DocumentsSlide DeckPress Release(8-K)Annual report(10-K) Alpha Teknova Earnings HeadlinesAlpha Teknova, Pluristyx launch proprietary PluriFreeze cryopreservation systemMarch 20, 2025 | markets.businessinsider.comTeknova and Pluristyx Launch Proprietary PluriFreeze™ Cryopreservation System to Accelerate the Development of Cell TherapiesMarch 19, 2025 | markets.businessinsider.comSilicon Valley Gold RushA new technology has sparked a modern-day gold rush in Silicon Valley. OpenAI’s Sam Altman invested $375M. Bill Gates has backed four companies in this space. The World Economic Forum calls it “the most exciting human discovery since fire.” Whitney Tilson believes this trend could mint a new class of wealthy investors—and he’s sharing one stock to watch now, for free.April 24, 2025 | Stansberry Research (Ad)Teknova and Pluristyx Launch Proprietary PluriFreeze™ Cryopreservation System to Accelerate the Development of Cell TherapiesMarch 19, 2025 | globenewswire.comTeknova, Pluristyx announce collaboration over next-generation cell therapiesMarch 11, 2025 | markets.businessinsider.comTeknova and Pluristyx Announce Collaboration to Streamline the Manufacture of Next-Generation Cell TherapiesMarch 11, 2025 | globenewswire.comSee More Alpha Teknova Headlines Get Earnings Announcements in your inboxWant to stay updated on the latest earnings announcements and upcoming reports for companies like Alpha Teknova? Sign up for Earnings360's daily newsletter to receive timely earnings updates on Alpha Teknova and other key companies, straight to your email. Email Address About Alpha TeknovaAlpha Teknova (NASDAQ:TKNO) produces critical reagents for the research, discovery, development, and commercialization of novel therapies, vaccines, and molecular diagnostics in the United States and internationally. The company offers pre-poured media plates for cell growth and cloning; liquid cell culture media and supplements for cellular expansion; and molecular biology reagents for sample manipulation, resuspension, and purification. It provides lab essentials which provides chemical formulations for use in biological research and drug discovery; and clinical solutions, a custom product used in the development and production of protein therapies, gene therapies, mRNA vaccines, and diagnostic kits. The company serves its products to life sciences market, including pharmaceutical and biotechnology companies, contract development and manufacturing organizations, in vitro diagnostic franchises, as well as academic and government research institutions. Alpha Teknova, Inc. was founded in 1996 and is headquartered in Hollister, California.View Alpha Teknova ProfileRead more More Earnings Resources from MarketBeat Earnings Tools Today's Earnings Tomorrow's Earnings Next Week's Earnings Upcoming Earnings Calls Earnings Newsletter Earnings Call Transcripts Earnings Beats & Misses Corporate Guidance Earnings Screener Earnings By Country U.S. Earnings Reports Canadian Earnings Reports U.K. Earnings Reports Latest Articles Seismic Shift at Intel: Massive Layoffs Precede Crucial EarningsRocket Lab Lands New Contract, Builds Momentum Ahead of EarningsAmazon's Earnings Could Fuel a Rapid Breakout Tesla Earnings Miss, But Musk Refocuses and Bulls ReactQualcomm’s Range Narrows Ahead of Earnings as Bulls Step InWhy It May Be Time to Buy CrowdStrike Stock Heading Into EarningsCan IBM’s Q1 Earnings Spark a Breakout for the Stock? 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There are 8 speakers on the call. Operator00:00:00Thank you for standing by, and welcome to Technova's Fourth Quarter and Full Year twenty twenty four Earnings Conference Call. At this time, all participants are in a listen only mode. After the speaker presentation, there will be a question and answer session. I would now like to hand the call over to Jennifer Henry, Senior Vice President of Marketing. Please go ahead. Speaker 100:00:33Thank you, operator. Welcome to Technova's fourth quarter and full year twenty twenty four earnings conference call. With me on today's call are Steven Gundstream, Technova's President and Chief Executive Officer and Matt Lowell, Technova's Chief Financial Officer, who will make prepared remarks and then take your questions. As a reminder, the forward looking statements that we make during this call, including those regarding business goals and expectations for the financial performance of the company, are subject to risks and uncertainties that may cause actual events or results to differ. Additional information concerning these risk factors is included in the press release the company issued earlier today, and they are more fully described in the company's various filings with the SEC. Speaker 100:01:18Today's comments reflect the company's current views, which could change as a result of new information, future events or other factors, and the company does not obligate or commit itself to update its forward looking statements except as required by law. The company's management believes that in addition to GAAP results, non GAAP financial measures can provide meaningful insight when evaluating the company's financial performance and the effectiveness of its business strategies. We will therefore use non GAAP financial measures of certain of our results during this call. Reconciliations of GAAP to non GAAP financial measures are included in the press release that we issued this afternoon, which is posted to Technova's website and at www.sec.gov/edgar. Non GAAP financial measures should always be considered only as a supplement to and not as a substitute for or as superior to financial measures prepared in accordance with GAAP. Speaker 100:02:16The non GAAP financial measures in this presentation may differ from similarly named non GAAP financial measures used by other companies. Please also be advised that the company has posted a supplemental slide deck to accompany today's prepared remarks. It can be accessed on the Investor Relations section of Technovo's website and on today's webcast. And now, I will turn the call over to Stephen. Speaker 200:02:40Thank you, Jen. Good afternoon and thank you everyone for joining us for our fourth quarter and full year twenty twenty four earnings call. I am very pleased with the progress we made in 2024. Technova is in a better position than ever to deliver on a plan we laid out in 2021 that we believe will generate long term sustainable growth. We continue to execute on our growth strategy. Speaker 200:03:09In 2024, we supported 48 clinical customers, up from 34 at the end of 2023, a 41% annual increase. We recognized $37,700,000 in total revenue. When adjusted to exclude revenue from a single large clinical solutions order of $2,700,000 in 2023, total revenue growth was 11%. Revenue from sales to cell and gene therapy related customers increased from 23% in 2023 to 27% in 2024. We maintained our service levels to customers despite reduced headcount and launched three new offerings in 2024, BuildTech, ExpressTech and RUO plus Each of these offerings improve the customer experience while also adding to our top and bottom lines. Speaker 200:04:09We aggressively managed our operating expenses, which we reduced by $8,100,000 in 2024 compared to 2023 excluding non recurring charges. We finished the year with a total cash outflow of $13,500,000 substantially better than our initial guidance of $18,000,000 We also raised additional capital in July increasing our confidence that we will become cash flow positive without additional funding. Before we dive into the details around our 2024 performance, I would like to take a moment here to thank all past and present Technova associates for putting us in position of strength as we lift to 2025 and beyond. Our associates' ability to execute on our strategy while reducing costs is a testament to the culture and commitment we have here at Technova. Now, I want to provide more color than in years past about our performance by product type and end market. Speaker 200:05:14Technova is a leading supplier of both research and clinical grade catalog and customer agents. Our catalog business supports research and discovery across the entire life science community by providing over 1,400 SKUs of commonly used reagents. These reagents are a cornerstone to basic molecular and cellular biology experiments, which is why about 3,000 customers use our products annually. In 2024, catalog reagents represented approximately 60% of our total revenue. While we grew low single digit in this segment in 2024, we exited the second half of the year with 7% growth compared to the second half of twenty twenty three, which we believe reflects an improvement in the general R and D funding environment and strong commercial and operational execution internally. Speaker 200:06:10The diversity of our end markets we serve and the lack of customer concentration with no direct catalog customer representing more than 4% of total catalog revenue in 2024 provides not only an entry point for our faster growing custom products, but also a stable and predictable foundation for us as we execute on our growth strategy. The remaining 40% of our revenue is generated from custom research or clinical grade reagents that are manufactured to a customer specification and other non product revenue related primarily to services and shipping. Our ability to quote, manufacture, QC and ship custom products in weeks instead of months is a critical differentiator for us in the market. Our largest end market for these custom products is biopharma, which includes sales to large pharma, small and mid sized biotech, including cell and gene therapies and CDMOs. We believe this segment reflects our exposure to the bioprocessing end market. Speaker 200:07:17Sales to these customers represented approximately 70% of custom revenue and 25% of our total revenue in 2024. The remaining custom revenue is from regions predominantly sold to the life science tools and diagnostics customers and other end markets such as academic institutions, animal health and agriculture. The performance of our custom biopharma business demonstrates the progress we have made in executing on our growth strategy. In 2024, this segment grew about 40% compared to 2023, attributable in part to the onboarding of a new therapeutic clinical customer. But excluding that new customer, our growth was still robust at approximately 25%. Speaker 200:08:08Of the 48 total clinical customers we served in 2024, '30 '9 were biopharma related and of those 23 were cell and gene therapy related. We often support many or all the therapies in a customer's pipeline. Based on our own analysis, we believe we now support at least 50 therapies in preclinical trials, 10 therapies in Phase one trials and three therapies in Phase two or later trials. As a reminder, based on our market research, we expect revenue per therapy to increase on average approximately 30 fold as a therapy moved from Phase one to commercialization. For the remainder of the revenue generated from customer agents, those associated with accounts outside of biopharma, twenty twenty four was a challenging year. Speaker 200:08:58First, we had a large single order from a diagnostics company in 2023 that made for a difficult year on year comparison. In addition, a few of our larger life science tools companies in the sequencing and spatial genomics segments ordered significantly less than in the prior year. Looking ahead, we believe many of these account specific headwinds will subside. Taking these product and market segments together, we still expect 2025 to be a recovery year and we are optimistic that the market will return to more historically typical rates of growth as we enter 2026. We expect to see mid single digit growth in our catalog business this year considering the market's recent stabilization and that we have little to no direct exposure to NIH or tariff related policies. Speaker 200:09:51We also believe customer agents in the Life Science Tools and Diagnostics segment will grow mid single digits. Given our recent conversations with these customers and a more favorable year on year comparison. Regarding the custom products we sell to biopharma accounts, while we exited 2024 with momentum, we believe uncertainty in the current macro environment has caused some of our customers to delay orders and others to reduce their annual budgets. We are nonetheless confident that we will achieve at least 15% growth in this segment. Therefore, we believe our guidance for revenue growth of 7% at the midpoint fairly reflects the current overall market environment and the specific end markets we serve. Speaker 200:10:36Lastly, we believe there is an opportunity over the next twelve to twenty four months to expand our product portfolio through collaborations and acquisitions. While we have spent the past couple of years investing in infrastructure, systems and scalability, numerous other companies have focused on developing novel products and technologies. By working closely with these companies, we believe we can expand our product portfolio and geographic footprint. The combination of our operational and commercial scale with our collaborators' novel products and technologies creates a great opportunity to drive additional top line growth and margin expansion over the longer term. In summary, while we still expect 2025 to be a recovery year, we are confident in our strategy, ability to execute and capital runway. Speaker 200:11:26I will now hand the call over to Matt to talk through the financials. Speaker 300:11:32Thanks, Stephen. Good afternoon, everyone. I'm pleased with our financial performance in 2024. As Stephen mentioned, we finished the year with momentum, delivering 1718% year over year revenue growth in the third and fourth quarters respectively. And we significantly improved free cash outflow from $26,700,000 in the full year 2023 to $13,500,000 for the full year 2024. Speaker 300:12:00On to revenue, total revenue for the fourth quarter twenty twenty four was $9,300,000 an 18% increase from $7,900,000 for the fourth quarter twenty twenty three and thirty seven point seven million dollars for the full year 2024, a 3% increase from $36,700,000 for the full year 2023. When adjusted to exclude revenue from a single large clinical solutions order of $2,700,000 in 2023, total revenue growth was 11% in 2024. Lab Essentials products are targeted at the Research Use Only or RUL market and include both catalog and custom products. Lab essentials revenue was $6,800,000 in the fourth quarter twenty twenty four, a two percent increase from $6,700,000 in the fourth quarter twenty twenty three. Slight increase in Lab essentials revenue in fourth quarter twenty twenty four was attributable to an increased number of customers, partially offset by lower average revenue per customer. Speaker 300:13:07For the full year, Lab Essentials revenue was $28,900,000 in 2024, consistent with $28,800,000 in 2023, driven by an 8% increase in the number of customers to 3,045 that was somewhat offset by a 7% decrease in the average revenue per customer to $9,486 Clinical solutions products are made according to good manufacturing practices or GMP quality standards and are primarily used by our customers as components or inputs in the development and manufacture of diagnostic and therapeutic products. Clinical solutions revenue was $1,900,000 in the fourth quarter of twenty twenty four, a 110% increase from $900,000 in the fourth quarter of twenty twenty three. The increase in clinical solutions revenue in the fourth quarter of twenty twenty four was attributable to an increased number of customers, partially offset by lower average revenue per customer. For the full year, clinical solutions revenue was $7,100,000 in 2024, a 5% increase from $6,700,000 in 2023. Excluding revenue of $2,700,000 from a single large order in 2023, clinical solutions revenue was up 76% in 2024. Speaker 300:14:40We added clinical solutions customers in 2024, growing from 34 customers in 2023 to 48 that spend more than $5,000 annually. Average revenue per customer in 2024 decreased 25% to $148,000 We expect revenue per customer to increase over time as customers ramp up their purchase volumes when they move through clinical trial phases. However, this metric can be affected by the addition of newer clinical customers who typically order less. Just as a reminder, due to the larger average order size and clinical solutions compared to Lab Essentials, there can be more quarter to quarter revenue lumpiness in this category. Looking at the income statements, gross profit for the fourth quarter of twenty twenty four was $2,100,000 compared to $1,300,000 in the fourth quarter twenty twenty three and $7,200,000 for the full year 2024 compared to $10,300,000 for the full year 2023. Speaker 300:15:50Gross margin was 23% in the fourth quarter twenty twenty four, which is up from 17% in the fourth quarter twenty twenty three and nineteen point two percent for the full year 2024, which is down from 28.1% for the full year 2023. The increase in gross profit percentage for the fourth quarter twenty twenty four was primarily driven by higher clinical solutions revenue coupled with reduced headcount, partially offset by increased overhead costs. The decrease in gross profit percentage for the full year 2024 was primarily driven by the $2,800,000 non recurring non cash charge related to the disposal of expired inventory and write down of excess inventory created in the second half of twenty twenty two as discussed in the prior quarter. Excluding the impact of this charge, gross margin would have been 26.5% for the full year 2024. The decrease in gross profit in 2024 was also driven by increased overhead costs, largely depreciation expense following the completion of our new manufacturing facility in 2023, which were partially offset by reduced headcount. Speaker 300:17:15Operating expenses for the fourth quarter twenty twenty four were $7,800,000 compared to $12,200,000 for the fourth quarter twenty twenty three. Excluding the non recurring charges of 300,000 related to a loss contingency accrual and the non cash trading impairment charge of $2,200,000 in the fourth quarter twenty twenty three. Operating expenses were down $2,000,000 The decrease was was driven primarily by reduced headcount and spending in particular in professional fees. Operating expenses for 2024 were $33,400,000 compared to $45,900,000 in 2023. Excluding the non recurring charges of $1,400,000 for the full year 2024 and May for the full year 2023, Operating expenses decreased $8,100,000 The decrease was driven by reduced headcount and spending primarily on professional fees and insurance, partially offset by increased stock based compensation expense related to the stock option repricing as well as facility costs. Speaker 300:18:31At the end of fourth quarter twenty twenty four, we had 173 associates compared to two eleven a year prior. Net loss for the fourth quarter twenty twenty four was $5,700,000 or $0.11 per diluted share compared to a net loss of $10,700,000 or $0.26 per diluted share for the fourth quarter twenty twenty three. Net loss for the full year 2024 was $26,700,000 dollars or $0.57 per diluted share compared to a net loss of $36,800,000 or $1.16 per diluted share for the full year 2023. Adjusted EBITDA, a non GAAP measure was negative $3,200,000 for the fourth quarter of twenty twenty four compared to negative $6,000,000 for the fourth quarter of twenty twenty three. Adjusted EBITDA for the full year 2024 was negative $14,500,000 compared to negative $19,800,000 for the full year 2023. Speaker 300:19:43Excluding the $2,800,000 inventory charge, adjusted EBITDA would have been negative $11,700,000 in 2024. Cash flow and balance sheet highlights. Capital expenditures for the fourth quarter twenty twenty four were $600,000 compared to $300,000 for the fourth quarter twenty twenty three. Capital expenditures for the full year 2024 were $1,100,000 dollars compared to $7,900,000 for the full year 2023. Free cash flow, a non GAAP measure, which we define as cash provided by or used in operating activities, less purchases of property, plant and equipment was negative $1,500,000 for the fourth quarter twenty twenty four compared to negative $3,200,000 for the fourth quarter twenty twenty three. Speaker 300:20:40Free cash flow for the full year 2024 was negative $13,500,000 compared to $26,700,000 for the full year 2023. This decrease compared to prior periods for both the quarter and full year was due to lower cash used in operating activities and a decrease in capital expenditures. Note that for the financial periods in 2025, we are changing the definition of free cash flow to cash provided by or used in operating activities plus cash provided by or used in investing activities. This definition better aligns with our current reporting method for short term investments. Turning to the balance sheet as of 12/31/2024, we had $30,400,000 in cash, cash equivalents and short term investments and $12,100,000 in gross debt. Speaker 300:21:41For 2025 outlook, we are providing twenty twenty five total revenue guidance of $39,000,000 to $42,000,000 At the midpoint, this implies 7% revenue growth compared to 2024. While we saw a nice rebound in 2024 from our biopharma customers, we believe 2025 is another recovery year. There remains cautiousness across some of our customer base, which we believe is related to macroeconomic uncertainty, particularly as it relates to the rate of capital flowing into the sector. The low end of our range assumes these headwinds worsen and the high end assumes some easing. As we have indicated before, due to the high percentage of fixed costs associated with our operations, we estimate that each additional dollar of revenue drops through at a marginal cash rate of approximately 70% with some variability year to year. Speaker 300:22:41We expect to see gross margins in the high 20s percentage range in 2025 compared to a normalized mid 20s percentage range in 2024. The company posted operating expenses excluding non recurring charges below $8,000,000 for the third quarter in a row. That reflects steps we took during 2024 aimed at reducing operating expenses, which resulted in total cost savings of $8,100,000 excluding non recurring charges in 2024 compared to 2023. We believe that we are appropriately sized at operating expenses of approximately $8,000,000 per quarter, allowing us to moderately increase our investment in sales and marketing to position ourselves for the market recovery. At this spending level, we continue to expect to achieve adjusted EBITDA positive in the range of $50,000,000 to $55,000,000 in annualized revenue. Speaker 300:23:48The company saw a reduction in free cash outflow during the fourth quarter twenty twenty four, both sequentially and versus prior year. This is the lowest free cash outflow since first quarter twenty twenty one. Once again, the company is pleased to report that free cash outflow for the full year 2024 of $13,500,000 was significantly below our most recent guidance of less than $16,000,000 As we turn to 2025, the company expects free cash outflow to be less than $12,000,000 We are also pleased to announce the amendment and extension of our credit facility. First and foremost, we have reset the maturity date of the credit facility to March 2030 with no scheduled repayment of principal for the next three years. However, we are increasing the principal amount on our term loan to $13,200,000 representing a 1,100,000 increase rather than paying cash at closing for the exit fee owed to our lender. Speaker 300:24:55Through covenant changes, we have effectively increased our liquidity by $4,000,000 giving us additional cash runway. In conclusion, we're excited about the future and the company's competitive positioning in the market with attractive fundamentals and believe there is significant margin expansion potential when top line growth accelerates. With that, I'll turn the call back to Stephen. Thanks, Matt. Speaker 200:25:21Overall, we were pleased with our fourth quarter and full year 2024 performance and the progress we made against our strategic priorities. We believe the long term outlook for our end markets remains positive and we are committed to executing on our strategy to help our customers accelerate the introduction of novel therapies, diagnostics and other products that improve human health. We will now take your questions. Our first Operator00:26:04question comes from Matt LaRue of William Blair. Please go ahead, Matt. Speaker 400:26:12Hey guys and congrats on the nice progress. Stephen, I wanted to focus on the comments you made around sort of softening into the beginning of the year in order to perhaps some conservative customer budgets, delayed purchases. Is that something that February relative to January you saw the softening, moving to the first part? And then was this really regardless of customer designation, meaning large biopharma or small biotech or has change behavior mostly been within those kind of cash burn biotechs? Speaker 200:26:48Yes. Thanks, Matt. So I would say, yes, it's a little bit more recent that we're continuing to see this. It is a the phenomenon we've seen for the last couple of years where some customers are very excited. In December, we've talked about left with a lot of momentum. Speaker 200:27:08January still felt pretty good, but then you started to hear about, well, maybe we'll order that in Q2 instead of Q1 type of conversations. That said, of course, we still believe in that 15% growth I mentioned in biopharma in the script here. So, there's still some companies out there that are very positive. I think there's still some others are trying to figure out in this environment what that's going to mean for them in terms of their capital runway. So it's not all bad, but it is definitely picking up a little bit more in this to late January, February timeframe. Speaker 200:27:45We are seeing it more in the smaller companies, I would say. I think large pharma, we're still seeing pretty good pieces in the catalog business. It continues to do fairly well. Now we have very little academic exposure there as you know, but it's really more and maybe some life science tools and small, mid sized biotech that are kind of more in a tougher situation with regard to capital raise. Speaker 400:28:14Okay. Thanks. And then you give some numbers around on the clinical side where your own customers are out with respect to preclinical Phase I and Phase II and beyond. I understand the progression of that is in large part dependent on your customer's clinical success. But I was curious maybe if you could help us with what is the composition of your new customer pipeline look like? Speaker 400:28:36Is it all on the preclinical side or are you having opportunities to win business in the clinical stages as well? Speaker 200:28:46Yes. Obviously, as you get further down that pipeline, it's much harder to convert business. We have been successful moving a Phase two or later customer therapy over to us and then expanding within that pipeline to get the remaining therapies that they're working on, particularly on the downstream processing, which covers preclinical all the way through Phase two. So it can be done at the twelve to eighteen month process and it requires work on both sides to make that happen. Most of our new customers are coming in either preclinical or Phase one. Speaker 200:29:22And so that is where we typically attract them and we continue to see that go up despite them rationalizing some pipelines over the last couple of years and some difficult macro environments. But I think we are able to convert these customers given the platform. Speaker 400:29:41Okay. And then just last one would be for Matt. Obviously, you had the large clinical solutions order in 2023 that you were copping in 2024. Just as we're thinking about 2025, any kind of large one time ish kind of things to be aware of from 2024? Speaker 300:30:00No, I wouldn't highlight anything in particular in 2024. I'd just say generally with the business of our scale and then we are going to have times when there's lumpiness in the revenue and clinical solutions and even in lab essentials where we have some of our custom orders and larger customers there. But no, I think really with that one in particular was so large that it warranted calling out and of course it was disclosed in our filings, but I don't see anything so large like that to call out, but there will at times be some lumpiness. Speaker 200:30:35Yes, I think it's fair to say that in 2024 as a whole, we didn't have any single customer represent more than 4% of our total revenue. But to Matt's point, around $1,000,000 can shift a quarter and that obviously has a big impact. Speaker 400:30:52Okay, fair enough. Thanks a lot guys. Speaker 300:30:55Thanks Matt. Operator00:30:57Thank you. Our next question comes from Matthew Parisi of KeyBanc Capital Markets. Please go ahead, Matthew. Speaker 500:31:06Hi, yes. This is Matt Parisi on for Paul Knight at KeyBanc. I believe you mentioned on the call, but I was sure if you could just say it again, provide a number or the updated number of cell and gene therapy customers. And then if you could provide any insight to how many of the newly approved cell and gene therapies you are involved with or any the total commercial cell and gene therapies you are involved with? Speaker 200:31:32Yes. So we said on the call that now 27% of our total revenue is made up of cell and gene therapy related companies. And that includes obviously their discovery work revenue as well as their sort of clinical trial of work. So catalog, custom and our clinical solutions products. We also had 23 clinical customers in that category. Speaker 200:32:01We now support it will be updated in the slide deck as well, but you'll see that over 100 total cell and gene therapy customers. As of this point in time, we are not supporting any commercialized cell and gene therapies. If you remember, we really started down this pathway in 2021 and those have not migrated through, but that is obviously the strategy here is to get these customers in and go down that pipeline. Speaker 500:32:26Thank you. And then one other one would be, if you could just more around the modeling, if you could provide some detail on the phasing for revenues in 2025 and if we should expect the usual seasonal phasing throughout the year? Speaker 300:32:40Yes, I'll make this comment about 2025. I do expect the first quarter to be the lowest quarter of the year, probably similar to the year ago quarter, maybe a little bit below that. And that's in part due to some of the reasons that Stephen was just talking about. There's I mean, some always some lumpiness in there, but also the current market environment, but we're confident in the full year guidance. So I would expect to see from Q1 at the low point, moving up to Q2 and then into Q3 and then per our usual seasonality might expect a little bit less in Q4 just because of the fewer business days, which impacts the catalog part of our business in particular. Speaker 300:33:27So Q1 the lowest kind of progressing up to Q3 and maybe a little less than Q4, all getting us in that 39% to 42% range. Speaker 500:33:38Sounds great. Thank you so much. Thank you. Operator00:33:41Thank you. Our next question comes from Mark Massaro of Deutsche Bank. Please go ahead, Mark. Speaker 600:33:51Hey, guys. Thanks for taking the questions. Maybe a two parter. I understand that the revenue per customer declines as newer customers come on board. New customers typically order less than more mature customers. Speaker 600:34:08Can you give us a sense for how long it typically takes a new clinical customer to reach a similar level of a more mature customer? And then the second part of that, has there been any changes to any of the pricing of the reagents? I assume it's been flat to slightly up, but I just wanted to check on that. Speaker 200:34:31Sure, Mark. So on the revenue ramp, I'll just give you from a sales cycle perspective, right? We typically engage with the customer, present to them our capabilities, and then there's a process of where they come visit the facility, and then a quick little validation piece. And I'd say quick, but quick for us could be a couple months of work, to get them to validate that we can manufacture the product the way that they're looking for us to make. And then we're then very much dependent on their trial timelines, right. Speaker 200:35:00So what we've seen is, you know, some customers come in pretty early, they're spending the tens of thousands of dollars and then it takes about a year to year and a half to really get it ramped it up to the hundreds of thousands of dollars to give you that kind of perspective. And of course, every customer varies a little bit, but that kind of gives you an idea. On the pricing side, yes, we do annual price increases and it's based our portfolio, how unique each product is in the space and the market pricing. And so we go through that process and we've implemented new pricing for our entire catalog product as well as new algorithms for our custom pricing and we did that at the beginning of the year. Speaker 600:35:46Okay. And any chance that you could try to quantify what the price increases were? Were they consistent with general levels of inflation? Or is there any additional color you could provide? Speaker 200:36:00Yes, sure, Mark. About mid single digit increase on average overall. Speaker 600:36:05Yes. Okay. That makes sense. And then I think I heard you talk about your 2025 guidance, bakes in, if I heard correctly, mid single digit growth among, I think, some of your diagnostics customers. Did I hear that correctly? Speaker 600:36:21And is it safe to say that that might be the fastest growing segment relative to perhaps the cell and gene therapy customers that may be under more pressure from a capital markets perspective? It would just be helpful to get a sense of also how you're thinking about the sequencing and spatial space? Speaker 200:36:43Yes, absolutely. So let me break it down for you. On the catalog side, which represents 60% of our business, we believe mid single digit. We exited the year as you're going to say with 7% growth in the back half of twenty twenty four. We're thinking this year it will be in the mid single digits there. Speaker 200:37:02Life science tools diagnostics, difficult year on year comparison, some challenges just with a few accounts. We think we're kind of over that now, but I do believe it will still be mid single digits to some of these companies are still struggling to ramp up a bit. And then the fastest growing segment is the biopharma, the custom biopharma, which we think represents the bioprocessing segment. And yes, we're seeing some headwinds, but remember, we grew 40% last year. And so we believe this is more of a 15% growth in 2024, given the current macro environment, right? Speaker 200:37:36And so the bookends of our guide is things get worse versus things get better. Speaker 600:37:43Yes, that makes sense. And then maybe one more, should we you might have mentioned it, should we assume flat headcount and flat commercial organization? Speaker 300:37:55I would say generally so, Mark. As I mentioned, we're going to we are going to tweak up the commercial investment a little bit this year and it won't be headcount driven. There may be a couple of headcount here and there. But by and large, as we've communicated in the past, we believe the infrastructure we have in the company, including our operating expenses and the headcount associated with that is generally where we needed to be right now as a company. So we're not looking to grow there. Speaker 300:38:26It's more just one off type of thing. So I would say, yes, generally flat, although not precisely there could be a couple here and there. Speaker 600:38:36All right, great. Thank you for taking my questions. Speaker 300:38:38Thanks, Mark. Operator00:38:40Thank you. Our next question comes from Matt Hewitt of Craig Hallum. Please go ahead, Matt. Speaker 700:38:49Good afternoon and thanks for taking the questions. Maybe first up, I was hoping we could dig in a little bit more on the market commentary. As you listen to earnings calls over the past few weeks, the bioprocessing sector in particular, commentary has been pretty healthy saying that in 2026, everyone expects the market to kind of get back to where it has been historically. It sounds like you're kind of calling for a similar, but maybe things have changed here over the past few weeks. Am I hearing that correctly? Speaker 200:39:23I think we'll put it this way, right? We're basically saying that we'll grow in the 15% range in that bioprocessing segment, which I think is probably similar to some of the peers. I still don't think we're back to what was historically normal rates of growth in that space. And if that happens, we think we could grow more like we did in 2024, right? We grew 40%. Speaker 200:39:46We were coming into the end of the year feeling pretty good about where we sat with those customers and then we did see some footage. So it is more recent, Matt, that we're starting to see things, some of these orders that we would have expected in Q1 get pushed to Q2, that sort of thing. So yes, does that help? Speaker 700:40:07Yes, it does. Thank you. And then maybe a little bit of an off question versus your comments earlier that you're really not impacted by NIH funding and tariffs and whatnot, but there has been some discussion about implementing like a 25% tariff on drugs that are imported to The U. S. How would that impact your business? Speaker 700:40:30I think you're largely a domestic provider, but is there a chance that you could potentially see some double dipping where maybe your customers that were manufacturing OUS say, you know what, we need to shift this production to The U. S. And therefore, the products that we've been ordering before, we now have to actually order a second round of those. Is that possible or am I thinking too far afield on that? Speaker 200:40:56It's certainly possible. First, I would say, yes, on the NIH side, 4% of our sales are related to academic institutions, of course, which are not all funded by the NIH. So pretty limited exposure there. Around 95% of our sales are domestic. And we manufacture everything here in The United States. Speaker 200:41:16So we're relatively insulated from that perspective. Now if we believe things are being brought more onshore here, we some of those 48 customers, clinical customer support are CDMOs. And if they get more busy, then we will likely get more busy and that could be an opportunity for additional growth. So I think it's possible there. I haven't really thought about the double dipping piece. Speaker 200:41:42I guess we'd have to wait and see. Speaker 700:41:45Got it. All right. Thank you very much. Operator00:41:50Thank you. And that is all the time we have for Q and A today. This concludes today's conference call. Thank you for participating. You may now disconnect.Read morePowered by