NASDAQ:DYAI Dyadic International Q2 2025 Earnings Report $0.80 -0.02 (-2.44%) Closing price 04:00 PM EasternExtended Trading$0.80 0.00 (-0.13%) As of 05:07 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. ProfileEarnings HistoryForecast Dyadic International EPS ResultsActual EPS-$0.06Consensus EPS -$0.06Beat/MissMet ExpectationsOne Year Ago EPSN/ADyadic International Revenue ResultsActual Revenue$0.97 millionExpected Revenue$0.60 millionBeat/MissBeat by +$367.00 thousandYoY Revenue GrowthN/ADyadic International Announcement DetailsQuarterQ2 2025Date8/13/2025TimeAfter Market ClosesConference Call DateWednesday, August 13, 2025Conference Call Time5:00PM ETConference Call ResourcesConference Call AudioConference Call TranscriptPress Release (8-K)Quarterly Report (10-Q)Earnings HistoryCompany ProfilePowered by Dyadic International Q2 2025 Earnings Call TranscriptProvided by QuartrAugust 13, 2025 ShareLink copied to clipboard.Key Takeaways Positive Sentiment: Dyadic completed a strategic rebrand to Dyadic Applied Biosolutions, marking its shift to a market-facing, revenue-driven biotech focused on sustainable, animal-free proteins for life sciences, food nutrition, and bioindustrial markets. Positive Sentiment: The company strengthened its balance sheet with a $5.3 million equity raise on August 1, providing funds to drive late-stage product development, scale-up efforts, and multiple upcoming commercial launches. Positive Sentiment: In life sciences, Dyadic is on track to launch recombinant human albumin in 2025—having already received $1 million in milestone fees and anticipating an additional $0.5 million—while advancing transferrin, FGFs, and RNase-free DNase-1 toward commercialization. Positive Sentiment: Second-quarter revenue nearly doubled to $967,000 year-over-year, and net loss narrowed to $1.79 million (versus $2.045 million), reflecting improved operational efficiency and milestone-driven income. Negative Sentiment: Dyadic remains unprofitable and its cash runway—down from $9.3 million to $7.3 million at quarter end—depends on timely product revenues and maintaining expenses at or below last year’s levels, risking liquidity if milestones slip. AI Generated. May Contain Errors.Conference Call Audio Live Call not available Earnings Conference CallDyadic International Q2 202500:00 / 00:00Speed:1x1.25x1.5x2xThere are 7 speakers on the call. Operator00:00:00Evening and welcome to Dyadic International's Q2 twenty twenty five Conference Call. Currently, participants are in listen only mode. Following management's prepared remarks, there will be a brief question and answer session. As a reminder, this conference call is being recorded today, 08/13/2025. I would now like to turn the call over to Ms. Operator00:00:20Ping Rawson, Dyadic's Chief Financial Officer. Please go ahead. Speaker 100:00:26Thank you. Good evening and welcome everyone to Diadic International's Q2 twenty twenty five conference call. I hope you have had an opportunity to review Diadic's press releases announcing financial results for the quarter ended 06/30/2025. You may access our release and Form 10 Q under the Investors section of the company's website at dyadic.com. On today's call, our President and Chief Operating Officer, Joe Hazleton, will give a review of our second quarter twenty twenty five business and corporate highlights and provide a commentary on the strategic direction of the business. Speaker 100:01:06I will follow with a review of our financial results in more detail. I'll be and we will be joined by our CEO, Mark Imofar for a brief question and answer session. At this time, I would like to inform you that certain commentary made in this conference call may be considered forward looking statements, which involve risks and uncertainties and other factors that could cause Dyadic's actual results, performance, scientific or otherwise, or achievements to be materially different from those expressed or implied by these forward looking statements. Dyadic expressly disclaims any duty to provide updates to its forward looking statements, whether because of new information, future events or otherwise. Participants are directed to the risk factors set forth in Dyadic's reports filed with the SEC. Speaker 100:02:00It is now my pleasure to pass the call to our President and COO, Joe Hazleton. Joe? Speaker 200:02:07Thanks, Ping, and thanks, everyone, for joining us today. Since I first joined the company in 2022, we've moved from being a platform focused organization with deep science but limited commercial traction to one with a clear execution driven strategy. Over the past three years, we've reshaped our leadership team, rebranded our platforms and realigned our priorities towards high growth non therapeutic markets where we can generate sustainable revenue more predictably and at scale. With our precision engineered fungal expression platforms, C1 and DAPIVIS, we can produce high yield animal free recombinant proteins at large scale and lower across life sciences, food nutrition and bioindustrial applications. This is no longer just a platform story, it's a product story. Speaker 200:02:55We are now at the commercial inflection point and Dyadic is built to compete and win in these markets. The second quarter of twenty twenty five underscored the company's commitment to the new strategy. We've completed our leadership and operational transformation from a technology focused R and D company to a market facing revenue driven biotechnology business. On August 1, we introduced our new name Dyadic Applied Biosolutions that reflects our sharpened mission of delivering applied biotechnology solutions to meet the growing global demand for non animal derived high value proteins and enzymes. Our proprietary platforms provide the foundation for our business. Speaker 200:03:34C1 was originally developed for large scale industrial enzyme production and over the years we've reengineered it into a highly versatile cGMP compatible protein production platform. To date it's demonstrated its ability to produce pharmaceutically relevant high value proteins at exceptional yields and low cost. It is fully scalable delivering the quality and consistency needed for applications in cell culture media, molecular diagnostics, and other life science markets. DAPIDIS has been purpose built for the food nutrition and industrial sectors. It has been optimized to produce functional proteins like alpha lactalbumin, human lactoferrin, and non animal dairy enzymes, as well as bioindustrial enzyme solutions. Speaker 200:04:18This optimization allows us to meet the specific performance and regulatory needs of these markets while maintaining competitive economics. Both platforms share advantages over traditional production systems. They enable faster development timelines, higher production yields, lower manufacturing costs, and completely animal free processes. Together they give us the ability to tailor protein production to multiple verticals efficiently, reliably and at commercial scale, helping us address the growing global demand for sustainable precision engineered proteins that power progress. We recently strengthened our balance sheet by completing a $5,300,000 equity raise on August 1. Speaker 200:04:59This provides the resources to fund late stage product development, scale up and multiple upcoming product launches. With this stronger financial foundation in place, we're now turning our attention to executing our strategic priorities across our core business segments of life sciences, food nutrition and bioindustrial. Our strategy focuses on high demand non therapeutic markets where our platforms enable rapid cost effective and scalable protein production supporting products that generate recurring revenue and long term value. In life sciences, we're advancing several high value programs to deliver scalable animal free solutions for cell culture media and molecular biology applications. These solutions support critical industries such as the biopharmaceutical manufacturing, cell and gene therapy, regenerative medicine, and cultivated meat production where highly consistent animal free components are essential to ensure safety, regulatory compliance, and reproducible performance. Speaker 200:05:58We're focused on commercializing albumin, transferrin and fibroblast growth factors or FGFs, three of the most important functional proteins in cell culture media. Albumin helps stabilize and transport nutrients, transferrin delivers irons for healthy cell growth, and growth factors trigger cell expansion. Producing these proteins at scale with consistent quality is essential but can be costly. Our protein production platforms address this by enabling high yield, low cost, animal free production, helping customers lower costs and reduce reliance on animal derived components. In partnership with Proiant Health and Biologicals, we remain on track to launch recombinant human albumin in 2025. Speaker 200:06:40We've already received $1,000,000 in milestone payments and anticipate an additional $500,000 milestone in the third quarter related to productivity improvements along with future royalties from commercial sales. Our animal free recombinant transferrin has demonstrated performance equivalent to leading reference standards in cell proliferation testing with sampling to potential partners and validation underway for diagnostic and research use. Likewise, our recombinant FGS have shown comparable performance to market references in supporting animal muscle cell growth and we're actively sampling these products into cell culture, diagnostics and research markets. Beyond cell culture media, we're also targeting the global DNA and RNA molecular biology reagent market. This market is expected to see sustained growth as demand increases for cell and gene therapy, molecular diagnostics, and next generation sequencing. Speaker 200:07:34High purity, animal free enzymes are essential to these applications and supply chain reliability is critical for customers. Our lead product in this area is RNase free DNase-one, a key reagent used in biopharmaceutical manufacturing, gene therapy production, and molecular diagnostic workflows to remove DNA contamination without degrading RNA. We have successfully scaled up production at our European CDMO partner with validation completed and research grade manufacturing underway. Sampling is in progress and we're in active discussions with potential commercial partners. In food and nutrition, we're targeting a rapidly expanding global market for sustainable, functional, and animal free proteins, a high growth category as consumer preferences, regulatory shifts, and supply chain pressures push companies towards next generation ingredients. Speaker 200:08:26This includes specialized nutrition markets such as infant formula, medical nutrition, and wellness products where the demand for functional recombinant proteins with high purity and consistent quality is especially strong. Our recombinant alpha lactalbumin is a prime example. It's a key whey protein in human and bovine milk that provides both nutritional and functional benefits including essential amino acids and the ability to improve texture, solubility, and stability in formulations. Producing alpha lactalbumin without animals allows manufacturers to avoid dairy supply constraints, reduce their environmental footprint, and reach consumers seeking sustainable or allergen free alternatives. We've developed several production strains for alpha lactalbumin for both the food and research markets and are actively sampling with potential partners in the food nutrition segment and we're assessing manufacturing options for research use with initial revenues expected in 2026. Speaker 200:09:24Human lactoferrin is another high value protein in our portfolio Known for its antimicrobial, anti inflammatory, and immune supportive properties, it is used in premium nutrition products, dietary supplements, functional foods. We're currently exploring potential partnership opportunities in the precision fermentation segment for food and nutrition while we evaluate the potential for research use. Additionally, non animal dairy enzymes are vital to improving processing efficiency yield and product quality in dairy manufacturing. Producing these enzymes recombinantly with our platforms allows for better cost control, enhanced functionality, and a fully animal free supply chain, a growing requirement for both plant based and hybrid dairy products. In our partnership with enzymes we received a $250,000 milestone in the second quarter for productivity gains in this enzyme program with the first product launch targeted for late twenty twenty five and additional enzyme candidates progressing under the existing license. Speaker 200:10:23In the bioindustrial segment, we're helping companies address some of the largest and most persistent challenges in industrial biotechnology such as reducing feedstock costs, improving process yields, and replacing petrochemical or animal based inputs with sustainable bio based alternatives. Our Anthrozyme product developed in partnership with Farmbox Bio is a great example of how our technology delivers value in the bioindustrial segment. Anthrozyme is an enzyme cocktail that converts pre treated residues into fermentable sugars more efficiently, enabling lower cost biofuel production and other downstream uses. We've achieved high yields at lower cost, making large scale deployment more commercially viable. Following FermBox's delivery on its initial purchase order, we're actively sampling with additional prospective customers. Speaker 200:11:14We're engaged with companies in the biomass processing biofuels and other industrial markets both to expand the adoption of Enthrezyme and to advance our pulp and paper enzyme programs. We're developing tailored enzyme cocktails for pulp and paper applications to improve fiber processing efficiency, reduce chemical usage, and lower energy requirements as well for the biogas industry to increase methane yields from organic waste. We're actively engaged in sampling companies in these segments and anticipate seeing revenues from our bio industrial efforts in 2026. While our core focus is now on high value non therapeutic proteins with shorter paths to revenue, we continue to advance a select set of legacy vaccine and therapeutic R and D programs through fully funded partner led collaborations. These initiatives supported by world class organizations such as the Gates Foundation, CEPI and Foundation Biotechnicalo di Ciena extend the reach of our C1 platform into areas like monoclonal antibodies, virus like particles and other complex biologics. Speaker 200:12:18As part of our $3,000,000 grant from the Gates Foundation, we're developing low cost monoclonal antibodies for malaria and RSV, two diseases that continue to place a heavy burden on global health. We achieved key milestones in this program, triggering a $1,500,000 installment in the second quarter. TRUE CEPI and Foundation Biotechnicala de Siena were participating in a project valued at up to $2,400,000 aimed at advancing recombinant protein vaccine development. Similarly, the European Vaccines Hub, a €170,000,000 EU backed initiative, is evaluating our C1 technology for its potential to accelerate and lower the cost of vaccine and antibody production. We're also working with UVAX Bio under a CEPI award to develop a MERS vaccine candidate and to further assess C1's ability to enable rapid cost effective manufacturing. Speaker 200:13:14In each of these programs our role is clear: bring the speed, scale and cost efficiency of our protein production platforms to partners tackling some of the most pressing health challenges worldwide while we remain laser focused on delivering commercial products in the high value life sciences, food, and bioindustrial markets. As we move forward, Dyadic remains deeply committed to delivering sustainable value to our shareholders and partners with a growing pipeline, a strong network of collaborators, and platforms built for efficiency and scalability, we're well positioned to lead in the global production of non animal derived proteins and enzymes across our core business verticals, meeting the demands of today and shaping the solutions of tomorrow. With that, I'll now turn the call over to our Chief Financial Officer, Ping Rawson, who will walk us through our second quarter financial results. Ping? Speaker 100:14:05Thank you, Joe. I will now go over our key financial results for the quarter ended 06/30/2025 in more detail. You can find additional information in our earnings press release and Form 10 Q, which we filed earlier today. Total revenue for the quarter ended 06/30/2025 increased to $967,000 compared to $386,000 for the same period a year ago. The increase was driven by the $250,000 milestone revenue upon the achievement of commercially viable target yield related to the enzyme agreement and the grant revenue from the Gates Foundation and SAT program. Speaker 100:14:48Cost of research and development revenue and cost of grant revenue for the quarter ended 06/30/2025 increased to approximately $614,000 compared to $302,000 for the same period a year ago. The increase was related to the cost of grant revenue from the Gates Foundation and SAPI. Research and development expenses for the quarter increased to $629,000 compared to $516,000 for the same period a year ago. The increase was driven by a rise in the number of active internal research initiatives undertaken to expedite product development. G and A expenses for the quarter decreased to 1,000,004 and $37,000 compared to $1,608,000 for the same period a year ago. Speaker 100:15:42The decrease reflected reductions in business development and investor relation expenses of $82,000 accounting and legal expenses of $41,000 insurance expenses of $28,000 and management incentives of $22,000 Loss from operations for the quarter decreased to $1,729,000 compared to $2,043,000 for the same period a year ago. Net loss for the quarter decreased to $1,794,000 or $06 per share compared to $2,045,000 or $07 per share for the same period a year ago. As of 06/30/2025, our cash, cash equivalents, restricted cash and cash equivalents and the carrying value of investment grade securities, including accrued interest were approximately $7,300,000 compared to $9,300,000 as of 12/31/2024. As Joe mentioned earlier, on 08/01/2025, the company closed its public offering of 6,052,000 shares of its common stock at a public offering price of $0.95 per share. The net proceeds from the offering were approximately $5,300,000 after deducting underwriting discounts and the commissions and estimated offering expenses. Speaker 100:17:14The company intends to use the net proceeds of the offering for working capital and the general corporate purposes, such as product development, sales and marketing. For the rest of 2025, we anticipate achieving our third and last milestone of 500,000 in revenue from Perlion along with additional income from BNS1 and other products, while maintaining our operating expenses at or below last year's level. We continue to strengthen our balance sheet to support our near term revenue growth, rebranding strategy and accelerate our commercialization opportunities for products and applications. With that, I will now ask the operator to begin our Q and A session. Each caller will be allowed one question and one follow-up question to provide all callers with an opportunity to participate. Speaker 100:18:12If time permits, the operator will allow additional questions from those who have already spoken. Mark Imofarb, our CEO, will join us and I will ask the operator to begin our Q and A session, after which Joe Hazleton will provide closing remarks. Operator? Operator00:18:31Thank you. We will now be conducting a question and answer session. Session. You may press 2 if you would like to remove your question from the queue. And our first question will come from John Vandermosten with Zacks. Speaker 300:19:07Great. Thank you and good evening everyone. First question is on cash burn rates. Now that we have some anticipated product revenues coming in, what is the updated cash burn expected for this year and also over the next twelve months or so? Speaker 100:19:27Hi, John. Good evening. Thank you for having you here. Like I mentioned in my script, I think we definitely expect additional revenue from our products and milestone payments. And we expect our operating expenses, G and A and R and D will remain the same level as last year, if not less. Speaker 100:19:47So, I think overall is really depends on the sale of the product for the third quarter and fourth quarter. I think at this point, we do not provide a specific cash burn guidance as we normally do. But I think, you know, you can at least expect this equivalent cash burn as last year or even less. Again, depending on revenue for the upcoming two quarters. I hope that answers your question. Speaker 300:20:17I think so. Yeah, I mean, it's probably uncertain on how those product revenues are going to come out. So I understand that. Second question is on the proteins. The leading proteins seem to be albumin transferrin and DNase one. Speaker 300:20:30And I think I understand albumin and ProLiant how that works, but can you tell me where that expands and the other two in terms of timeline and milestones of commercialization? Speaker 200:20:43Yeah, John, it's a great question. So DNase one is the more commercially ready one. We've completed scale up, as I mentioned on the call at our CDMO and now we're beginning to manufacture research grade product, which means we're also beginning to negotiate and work through OEM and supply agreements with potential customers in the market. So I think from a revenue standpoint, that's probably the first one. And then transferring, we've done some initial validation. Speaker 200:21:16It actually looks like we may have some better performance metrics as far as its ability to withstand temperature, in applications. So we're currently further evaluating that and also looking at potential scale up options to at least start producing, in addition to our sample quantities, producing small amounts of saleable quantities for the research market. So I think that would probably be second, but we're probably looking at late twenty twenty five and into 2026 because we do need to complete the commercial manufacturing process. Operator00:21:48And our next question comes from Dick Williams with Williams Resource Group. Speaker 400:21:54Hi, Joe. Terrific job. It's incredible the amount of opportunities that we seem to have on our table. But the one area maybe you can give me a little color on is the firm box deal with the ag waste and whatever else fits in that category. Could you give a color in terms of the market that is over there where they are currently using it, the customer they have that they're selling it to, and the opportunity to go to more customers over there? Speaker 400:22:26And then do we have any opportunities here in The US that you are looking at or have talked to thus far to determine if we can do something here? Speaker 200:22:38Hey, Dick. It's a great question. In terms of overall market potential, the bioindustrial enzymes for biofuels and biogas is a very large market. Majority of them are produced recombinantly today, and that's approximately about a $10,000,000,000 market. The first customer base or at least it seems the ones that are a little more aggressive are based in India as well as some Asia Pacific as well. Speaker 200:23:04So that's where the majority of the sampling and the majority of our efforts are kind of focused. As far as on this side of the pond, that is starting to increase but not to the same extent. The focus on biofuels in The US and the North America isn't quite as strong as it is overseas. But the interest is picking up and we're starting to evaluate potential manufacturing options here in The US because as we look at these enzyme cocktails that we're starting to produce, it's not just for biofuels and biogas. We're looking at the other applications that they can be used for such as pulp and paper, textiles, areas where the diag knows very well and has been in the past. Speaker 200:23:45So we're evaluating those opportunities so we move forward as well. Operator00:23:56Our next caller is Glenn Primack with LUSA Investment Group. Speaker 500:24:02Good afternoon, Mr. Hazleton and Ms. Rawson. I have a couple of questions. One on the planned uses of the capital raise. Speaker 500:24:16Do you have the back end systems in place already to execute on the new model and be able to measure progress in real time? Speaker 200:24:29In terms of the are you talking in terms of being able to process orders? Or Speaker 500:24:34Yeah. Like, the the MIS management information system. So, like, if you need to see how something's going, you can get it without scrambling around. Speaker 200:24:45I think at least from my standpoint initially, think we have the appropriate systems in place to handle the orders because we're doing it in bulk sale. So I don't anticipate need for a lot of additional resources in terms of infrastructure to support that. As far as the reporting, don't know, Ping, if you have any ideas on that. Speaker 100:25:07Yeah, I think it's pretty straightforward. Our product is very high value and very easy to ship around and we have been shipping similar products for research purposes. So, we definitely don't see the difference of what we are doing right now other than, you know, having more volume in the future. So, we are talking to potentially, you know, distribution center and those for logistic purposes. But again, I do not see that could be a potential issue as we are scaling up and making our growth and potentially two more products. Speaker 100:25:44For infrastructure, definitely as we grow more, we will look out additional resources and platform and outsource capacities to support a business. Speaker 500:25:57Okay. Thanks. And then my second question is there, as you head into '26, have you already put together a three year plan, or will you start that sometime in the fall? Speaker 200:26:12We're starting that in the fall. We've actually begun the process. But again, we have to evaluate some of the additional products that we have in the pipeline. We have to validate applications so we can determine the appropriate forecast for these products and in the segments we're going to be able to launch versus what our potential partners can do. But that is on the docket. Operator00:26:35Our next question comes from Robert Hoffman with Princeton Opportunity Management. Speaker 600:26:41Thank you. As Mark will attest, I've been a patient and shareholder of Diane for a long time. And so my first question is pretty straightforward. Is there any conflict with DuPont in terms of now that you're doing more industrial type of activity? Yeah, Rob, it's Mark. Speaker 600:27:03I'm not quite sure what you mean by conflict, but we don't see Speaker 100:27:06any conflict. Speaker 600:27:07Didn't you guys have I thought it was that you basically sublicensed it back for medical stuff. Wasn't that the structure of the purchase line. No? I heard that wrong. Yeah. Speaker 600:27:23No, no, you're 100% correct. But we had a non compete that ended three, four years ago. And then we've and we're not using C1 for industrial products. We're using DAPA BIS, which we've recreated. So we don't see any conflicts. Speaker 600:27:40So there's no issue with DuPont coming back and saying, hey, we should get some percentage of your revenue? As far as we see, the answer is no. Okay. I was hoping that was the answer. And then just very quickly, post this recent deal, can you give us a fully diluted share count? Speaker 600:28:04Maybe it's in the queue, and I haven't opened that yet. But if you could give that, that would be great. Speaker 100:28:09So we issued 6,052,000 shares through the public offering. Speaker 600:28:17So it accounts like 36,000,000 plus shares. It's in the queue as well. Speaker 100:28:21Yes. It's also in the PROSA that you can see the dilution impact. Operator00:28:29And we'll go next to Louis Titterton, private investor. Speaker 600:28:35Hi there. Hey, Mark. It's been a long time since I've talked Speaker 200:28:38to you. Speaker 600:28:38How are you? Good, Lou. How are you doing? I'm doing great. I have a simple question that I I think I heard that that expenses were gonna stay the same or drop for the next year while revenues are gonna increase. Speaker 600:28:50Is there some point where we think we're gonna cross over and be actually profitable? Speaker 200:28:56Yes. The goal is that we're cash flow positive by the 2026, and then we start to see, you know, increased profitability in 2027 and beyond. Speaker 600:29:06That would be wonderful. Thank you very much. Appreciate it. Operator00:29:14Our next question comes from Tony Bowers with IntroACT. Speaker 600:29:20Hi, Joe. Hi, Mark. Hi, Peng. We've dealt with a lot of big clumsy organizations in the past that don't make decisions quickly. Which of your platforms has the least number of decision makers involved to see commercial realization? Speaker 200:29:38Tony, that's a great question. And to be honest, it's not really platform specific. It's more product specific. So to your point, when you're dealing with biopharmaceutical products that require human clinical trials, FDA or EMA regulatory review, that's a much higher burden. And obviously, that's our C1 platform. Speaker 200:30:00But for things like food and nutrition, bioindustrial, while there are some regulatory requirements that you do have to meet for, let's just say, food nutrition, whether that's a GRAS certification or the EU has their own methods of evaluating those, they're not nearly as stringent. And they can be done in parallel as you're scaling up your process. As you look at it, any of the products that we're currently focusing on for the research, diagnostic markets, food and nutrition, bioindustrial, those are a factor of reaching the scale and cost efficiency needed to support its commercialization in the market. And as you can see, like with albumin, in some cases that's a twelve month or less path to revenue. In some cases, could be a little longer. Speaker 200:30:47In some cases, it could be a little shorter. But it's really product specific and kind of segment specific. Speaker 600:30:55And which of the markets has the largest addressable market and kind of best competitive factors? Speaker 200:31:08That's another great question. I hate to say it this way, but it is kind of market specific. I think the highest addressable market is really that cell culture media market, and simply because it's growing at a very high rate and the need for non animal solutions is much greater. Because from a regulatory standpoint, they're looking for consistency, purity, and scalability. So those are things that are driving that market. Speaker 200:31:35Now the other markets like food nutrition and bioindustrial, those are from a dollar standpoint, they're a lot larger. So like non animal dairy products, that's upwards of a $50,000,000,000 market. And again, we're targeting very select segments of those markets. But overall, I think the life sciences area is one where the demand is greatest. I think our platforms offer the best advantages. Speaker 200:31:59And it offers us probably the quicker path to revenue. Operator00:32:04We'll take a follow-up question from Robert Hoffman with Princeton Opportunity Management. Speaker 600:32:11Yeah, just to clarify. So was cut off on the fully diluted. So it's approximately 36,000,000. Is that right? Yeah, exactly. Speaker 600:32:22By the way, the one thing, Robert, is we didn't issue any warrants to the new shareholders. So I saw that. That's inspector. I'm kind of a follow-up on the last person's question. And I'm not asking for it today, but it would be very helpful for us to have some sense of the addressable market. Speaker 600:32:44When you said the area is a $50,000,000,000 market, is that the end market? Or is that what the component that you might be selling into? And so it's just be great for us to kind of get a sense of what you think the total addressable market would be for, let's say, albumin. I know I pronounced that. Mispronounced that. Speaker 600:33:08But something like that. And then we can then say, oh, well, if they got 10, if they got 5%. Because in my history is one of those where you're either going to get no percent or you're going to get a decent percent. Maybe you'll get 1%. But in these markets, you will either be accepted or you won't. Speaker 600:33:28And if you're accepted, you should be able to have a decent market share. So in some future presentation, it might be helpful for you to help us quantify those things. Speaker 200:33:38Actually, Robert, it's a great point. And if you do happen to get to our website and pull up the most recent investor presentation, we do give total addressable markets for the life sciences, food nutrition, and bioindustrial segments for the areas that we're going into, like cell culture media. We think that's approximately a 5,000,000,000 to $6,000,000,000 market opportunity for recombinant products. The top three revenue products in that category are albumin transfer and growth factors. They account for probably three of that $6,000,000,000 market. Speaker 200:34:15And when you look at it in terms of, to your point, how do you capture share in that, ProLiant Health and Biologics, our partner for albumin, is the second largest producer of naturally derived bovine albumin in the world. Their customer base is global and accounts for a large percentage of the albumin utilization today. So for us, it's about making sure we have the right partners in the right segments, as well as products that can support commercialization. So you're 100% right, and hopefully, if you take a look at that presentation, it'll provide a little more granularity into the markets. Operator00:34:52And that does conclude today's question and answer session. I will now turn the call over to Dyadic's President and COO, Joe Hazleton. Speaker 400:35:01Thank Speaker 200:35:01you. Q2 twenty twenty five marked a pivotal step in our shift to a commercially focused enterprise. Through our rebranding to Dyadic Applied Biosolutions, leadership expansion, and disciplined capital strategy, we're better positioned to deliver high value animal free proteins and enzymes to growing life sciences, food nutrition, and bioindustrial markets. With commercial launches approaching, a robust pipeline, and strong partnerships validating our technology, we believe we're well placed to capture meaningful opportunities ahead. Thank you for your continued support, and we look forward to updating you on our progress. Operator00:35:39The conference has now concluded. Thank you for attending today's presentation. You may now disconnect your lines at this time.Read morePowered by Earnings DocumentsPress Release(8-K)Quarterly report(10-Q) Dyadic International Earnings HeadlinesDyadic International, Inc. 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Email Address About Dyadic InternationalDyadic International (NASDAQ:DYAI), Inc., a biotechnology platform company, develops, produces, and sells enzymes and other proteins in the United States and internationally. It utilizes C1-cell protein production platform based on an industrially proven microorganism (C1) for the development and production of biologic products including enzymes and other proteins for human and animal health. The company offers DYAI-100, SARS-CoV-2-RBD antigen vaccine candidate towards a first-in-human Phase 1 clinical trial to demonstrate the safety in humans of a protein produced using the C1 platform. It has also developed the Dapibus thermophilic, a filamentous fungal-based microbial protein production platform to enable the development and large-scale manufacture of cost-effective proteins, metabolites, and other biologic products for use in non-pharmaceutical applications, including food, nutrition, and wellness. The company has a research and development agreement with VTT Technical Research Centre of Finland, Ltd.; license agreement with South Africa's Rubic One Health; Joint Development Agreement with a Global Food Ingredient Company; and sub-license agreement with Abic Biological Laboratories Ltd., Alphazyme, LLC, and Abic Biological Laboratories Ltd. Dyadic International, Inc. was founded in 1979 and is headquartered in Jupiter, Florida.View Dyadic International ProfileRead more More Earnings Resources from MarketBeat Earnings Tools Today's Earnings Tomorrow's Earnings Next Week's Earnings Upcoming Earnings Calls Earnings Newsletter Earnings Call Transcripts Earnings Beats & Misses Corporate Guidance Earnings Screener Earnings By Country U.S. Earnings Reports Canadian Earnings Reports U.K. Earnings Reports Latest Articles Brinker Serves Up Earnings Beat, Sidesteps Cost PressuresWhy BigBear.ai Stock's Dip on Earnings Can Be an Opportunity CrowdStrike Faces Valuation Test Before Key Earnings ReportPost-Earnings, How Does D-Wave Stack Up Against Quantum Rivals?Why SoundHound AI's Earnings Show the Stock Can Move HigherAirbnb Beats Earnings, But the Growth Story Is Losing AltitudeDutch Bros Just Flipped the Script With a Massive Earnings Beat Upcoming Earnings Palo Alto Networks (8/18/2025)Home Depot (8/19/2025)Medtronic (8/19/2025)Analog Devices (8/20/2025)Synopsys (8/20/2025)Lowe's Companies (8/20/2025)TJX Companies (8/20/2025)Intuit (8/21/2025)Workday (8/21/2025)Alibaba Group (8/21/2025) Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. 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There are 7 speakers on the call. Operator00:00:00Evening and welcome to Dyadic International's Q2 twenty twenty five Conference Call. Currently, participants are in listen only mode. Following management's prepared remarks, there will be a brief question and answer session. As a reminder, this conference call is being recorded today, 08/13/2025. I would now like to turn the call over to Ms. Operator00:00:20Ping Rawson, Dyadic's Chief Financial Officer. Please go ahead. Speaker 100:00:26Thank you. Good evening and welcome everyone to Diadic International's Q2 twenty twenty five conference call. I hope you have had an opportunity to review Diadic's press releases announcing financial results for the quarter ended 06/30/2025. You may access our release and Form 10 Q under the Investors section of the company's website at dyadic.com. On today's call, our President and Chief Operating Officer, Joe Hazleton, will give a review of our second quarter twenty twenty five business and corporate highlights and provide a commentary on the strategic direction of the business. Speaker 100:01:06I will follow with a review of our financial results in more detail. I'll be and we will be joined by our CEO, Mark Imofar for a brief question and answer session. At this time, I would like to inform you that certain commentary made in this conference call may be considered forward looking statements, which involve risks and uncertainties and other factors that could cause Dyadic's actual results, performance, scientific or otherwise, or achievements to be materially different from those expressed or implied by these forward looking statements. Dyadic expressly disclaims any duty to provide updates to its forward looking statements, whether because of new information, future events or otherwise. Participants are directed to the risk factors set forth in Dyadic's reports filed with the SEC. Speaker 100:02:00It is now my pleasure to pass the call to our President and COO, Joe Hazleton. Joe? Speaker 200:02:07Thanks, Ping, and thanks, everyone, for joining us today. Since I first joined the company in 2022, we've moved from being a platform focused organization with deep science but limited commercial traction to one with a clear execution driven strategy. Over the past three years, we've reshaped our leadership team, rebranded our platforms and realigned our priorities towards high growth non therapeutic markets where we can generate sustainable revenue more predictably and at scale. With our precision engineered fungal expression platforms, C1 and DAPIVIS, we can produce high yield animal free recombinant proteins at large scale and lower across life sciences, food nutrition and bioindustrial applications. This is no longer just a platform story, it's a product story. Speaker 200:02:55We are now at the commercial inflection point and Dyadic is built to compete and win in these markets. The second quarter of twenty twenty five underscored the company's commitment to the new strategy. We've completed our leadership and operational transformation from a technology focused R and D company to a market facing revenue driven biotechnology business. On August 1, we introduced our new name Dyadic Applied Biosolutions that reflects our sharpened mission of delivering applied biotechnology solutions to meet the growing global demand for non animal derived high value proteins and enzymes. Our proprietary platforms provide the foundation for our business. Speaker 200:03:34C1 was originally developed for large scale industrial enzyme production and over the years we've reengineered it into a highly versatile cGMP compatible protein production platform. To date it's demonstrated its ability to produce pharmaceutically relevant high value proteins at exceptional yields and low cost. It is fully scalable delivering the quality and consistency needed for applications in cell culture media, molecular diagnostics, and other life science markets. DAPIDIS has been purpose built for the food nutrition and industrial sectors. It has been optimized to produce functional proteins like alpha lactalbumin, human lactoferrin, and non animal dairy enzymes, as well as bioindustrial enzyme solutions. Speaker 200:04:18This optimization allows us to meet the specific performance and regulatory needs of these markets while maintaining competitive economics. Both platforms share advantages over traditional production systems. They enable faster development timelines, higher production yields, lower manufacturing costs, and completely animal free processes. Together they give us the ability to tailor protein production to multiple verticals efficiently, reliably and at commercial scale, helping us address the growing global demand for sustainable precision engineered proteins that power progress. We recently strengthened our balance sheet by completing a $5,300,000 equity raise on August 1. Speaker 200:04:59This provides the resources to fund late stage product development, scale up and multiple upcoming product launches. With this stronger financial foundation in place, we're now turning our attention to executing our strategic priorities across our core business segments of life sciences, food nutrition and bioindustrial. Our strategy focuses on high demand non therapeutic markets where our platforms enable rapid cost effective and scalable protein production supporting products that generate recurring revenue and long term value. In life sciences, we're advancing several high value programs to deliver scalable animal free solutions for cell culture media and molecular biology applications. These solutions support critical industries such as the biopharmaceutical manufacturing, cell and gene therapy, regenerative medicine, and cultivated meat production where highly consistent animal free components are essential to ensure safety, regulatory compliance, and reproducible performance. Speaker 200:05:58We're focused on commercializing albumin, transferrin and fibroblast growth factors or FGFs, three of the most important functional proteins in cell culture media. Albumin helps stabilize and transport nutrients, transferrin delivers irons for healthy cell growth, and growth factors trigger cell expansion. Producing these proteins at scale with consistent quality is essential but can be costly. Our protein production platforms address this by enabling high yield, low cost, animal free production, helping customers lower costs and reduce reliance on animal derived components. In partnership with Proiant Health and Biologicals, we remain on track to launch recombinant human albumin in 2025. Speaker 200:06:40We've already received $1,000,000 in milestone payments and anticipate an additional $500,000 milestone in the third quarter related to productivity improvements along with future royalties from commercial sales. Our animal free recombinant transferrin has demonstrated performance equivalent to leading reference standards in cell proliferation testing with sampling to potential partners and validation underway for diagnostic and research use. Likewise, our recombinant FGS have shown comparable performance to market references in supporting animal muscle cell growth and we're actively sampling these products into cell culture, diagnostics and research markets. Beyond cell culture media, we're also targeting the global DNA and RNA molecular biology reagent market. This market is expected to see sustained growth as demand increases for cell and gene therapy, molecular diagnostics, and next generation sequencing. Speaker 200:07:34High purity, animal free enzymes are essential to these applications and supply chain reliability is critical for customers. Our lead product in this area is RNase free DNase-one, a key reagent used in biopharmaceutical manufacturing, gene therapy production, and molecular diagnostic workflows to remove DNA contamination without degrading RNA. We have successfully scaled up production at our European CDMO partner with validation completed and research grade manufacturing underway. Sampling is in progress and we're in active discussions with potential commercial partners. In food and nutrition, we're targeting a rapidly expanding global market for sustainable, functional, and animal free proteins, a high growth category as consumer preferences, regulatory shifts, and supply chain pressures push companies towards next generation ingredients. Speaker 200:08:26This includes specialized nutrition markets such as infant formula, medical nutrition, and wellness products where the demand for functional recombinant proteins with high purity and consistent quality is especially strong. Our recombinant alpha lactalbumin is a prime example. It's a key whey protein in human and bovine milk that provides both nutritional and functional benefits including essential amino acids and the ability to improve texture, solubility, and stability in formulations. Producing alpha lactalbumin without animals allows manufacturers to avoid dairy supply constraints, reduce their environmental footprint, and reach consumers seeking sustainable or allergen free alternatives. We've developed several production strains for alpha lactalbumin for both the food and research markets and are actively sampling with potential partners in the food nutrition segment and we're assessing manufacturing options for research use with initial revenues expected in 2026. Speaker 200:09:24Human lactoferrin is another high value protein in our portfolio Known for its antimicrobial, anti inflammatory, and immune supportive properties, it is used in premium nutrition products, dietary supplements, functional foods. We're currently exploring potential partnership opportunities in the precision fermentation segment for food and nutrition while we evaluate the potential for research use. Additionally, non animal dairy enzymes are vital to improving processing efficiency yield and product quality in dairy manufacturing. Producing these enzymes recombinantly with our platforms allows for better cost control, enhanced functionality, and a fully animal free supply chain, a growing requirement for both plant based and hybrid dairy products. In our partnership with enzymes we received a $250,000 milestone in the second quarter for productivity gains in this enzyme program with the first product launch targeted for late twenty twenty five and additional enzyme candidates progressing under the existing license. Speaker 200:10:23In the bioindustrial segment, we're helping companies address some of the largest and most persistent challenges in industrial biotechnology such as reducing feedstock costs, improving process yields, and replacing petrochemical or animal based inputs with sustainable bio based alternatives. Our Anthrozyme product developed in partnership with Farmbox Bio is a great example of how our technology delivers value in the bioindustrial segment. Anthrozyme is an enzyme cocktail that converts pre treated residues into fermentable sugars more efficiently, enabling lower cost biofuel production and other downstream uses. We've achieved high yields at lower cost, making large scale deployment more commercially viable. Following FermBox's delivery on its initial purchase order, we're actively sampling with additional prospective customers. Speaker 200:11:14We're engaged with companies in the biomass processing biofuels and other industrial markets both to expand the adoption of Enthrezyme and to advance our pulp and paper enzyme programs. We're developing tailored enzyme cocktails for pulp and paper applications to improve fiber processing efficiency, reduce chemical usage, and lower energy requirements as well for the biogas industry to increase methane yields from organic waste. We're actively engaged in sampling companies in these segments and anticipate seeing revenues from our bio industrial efforts in 2026. While our core focus is now on high value non therapeutic proteins with shorter paths to revenue, we continue to advance a select set of legacy vaccine and therapeutic R and D programs through fully funded partner led collaborations. These initiatives supported by world class organizations such as the Gates Foundation, CEPI and Foundation Biotechnicalo di Ciena extend the reach of our C1 platform into areas like monoclonal antibodies, virus like particles and other complex biologics. Speaker 200:12:18As part of our $3,000,000 grant from the Gates Foundation, we're developing low cost monoclonal antibodies for malaria and RSV, two diseases that continue to place a heavy burden on global health. We achieved key milestones in this program, triggering a $1,500,000 installment in the second quarter. TRUE CEPI and Foundation Biotechnicala de Siena were participating in a project valued at up to $2,400,000 aimed at advancing recombinant protein vaccine development. Similarly, the European Vaccines Hub, a €170,000,000 EU backed initiative, is evaluating our C1 technology for its potential to accelerate and lower the cost of vaccine and antibody production. We're also working with UVAX Bio under a CEPI award to develop a MERS vaccine candidate and to further assess C1's ability to enable rapid cost effective manufacturing. Speaker 200:13:14In each of these programs our role is clear: bring the speed, scale and cost efficiency of our protein production platforms to partners tackling some of the most pressing health challenges worldwide while we remain laser focused on delivering commercial products in the high value life sciences, food, and bioindustrial markets. As we move forward, Dyadic remains deeply committed to delivering sustainable value to our shareholders and partners with a growing pipeline, a strong network of collaborators, and platforms built for efficiency and scalability, we're well positioned to lead in the global production of non animal derived proteins and enzymes across our core business verticals, meeting the demands of today and shaping the solutions of tomorrow. With that, I'll now turn the call over to our Chief Financial Officer, Ping Rawson, who will walk us through our second quarter financial results. Ping? Speaker 100:14:05Thank you, Joe. I will now go over our key financial results for the quarter ended 06/30/2025 in more detail. You can find additional information in our earnings press release and Form 10 Q, which we filed earlier today. Total revenue for the quarter ended 06/30/2025 increased to $967,000 compared to $386,000 for the same period a year ago. The increase was driven by the $250,000 milestone revenue upon the achievement of commercially viable target yield related to the enzyme agreement and the grant revenue from the Gates Foundation and SAT program. Speaker 100:14:48Cost of research and development revenue and cost of grant revenue for the quarter ended 06/30/2025 increased to approximately $614,000 compared to $302,000 for the same period a year ago. The increase was related to the cost of grant revenue from the Gates Foundation and SAPI. Research and development expenses for the quarter increased to $629,000 compared to $516,000 for the same period a year ago. The increase was driven by a rise in the number of active internal research initiatives undertaken to expedite product development. G and A expenses for the quarter decreased to 1,000,004 and $37,000 compared to $1,608,000 for the same period a year ago. Speaker 100:15:42The decrease reflected reductions in business development and investor relation expenses of $82,000 accounting and legal expenses of $41,000 insurance expenses of $28,000 and management incentives of $22,000 Loss from operations for the quarter decreased to $1,729,000 compared to $2,043,000 for the same period a year ago. Net loss for the quarter decreased to $1,794,000 or $06 per share compared to $2,045,000 or $07 per share for the same period a year ago. As of 06/30/2025, our cash, cash equivalents, restricted cash and cash equivalents and the carrying value of investment grade securities, including accrued interest were approximately $7,300,000 compared to $9,300,000 as of 12/31/2024. As Joe mentioned earlier, on 08/01/2025, the company closed its public offering of 6,052,000 shares of its common stock at a public offering price of $0.95 per share. The net proceeds from the offering were approximately $5,300,000 after deducting underwriting discounts and the commissions and estimated offering expenses. Speaker 100:17:14The company intends to use the net proceeds of the offering for working capital and the general corporate purposes, such as product development, sales and marketing. For the rest of 2025, we anticipate achieving our third and last milestone of 500,000 in revenue from Perlion along with additional income from BNS1 and other products, while maintaining our operating expenses at or below last year's level. We continue to strengthen our balance sheet to support our near term revenue growth, rebranding strategy and accelerate our commercialization opportunities for products and applications. With that, I will now ask the operator to begin our Q and A session. Each caller will be allowed one question and one follow-up question to provide all callers with an opportunity to participate. Speaker 100:18:12If time permits, the operator will allow additional questions from those who have already spoken. Mark Imofarb, our CEO, will join us and I will ask the operator to begin our Q and A session, after which Joe Hazleton will provide closing remarks. Operator? Operator00:18:31Thank you. We will now be conducting a question and answer session. Session. You may press 2 if you would like to remove your question from the queue. And our first question will come from John Vandermosten with Zacks. Speaker 300:19:07Great. Thank you and good evening everyone. First question is on cash burn rates. Now that we have some anticipated product revenues coming in, what is the updated cash burn expected for this year and also over the next twelve months or so? Speaker 100:19:27Hi, John. Good evening. Thank you for having you here. Like I mentioned in my script, I think we definitely expect additional revenue from our products and milestone payments. And we expect our operating expenses, G and A and R and D will remain the same level as last year, if not less. Speaker 100:19:47So, I think overall is really depends on the sale of the product for the third quarter and fourth quarter. I think at this point, we do not provide a specific cash burn guidance as we normally do. But I think, you know, you can at least expect this equivalent cash burn as last year or even less. Again, depending on revenue for the upcoming two quarters. I hope that answers your question. Speaker 300:20:17I think so. Yeah, I mean, it's probably uncertain on how those product revenues are going to come out. So I understand that. Second question is on the proteins. The leading proteins seem to be albumin transferrin and DNase one. Speaker 300:20:30And I think I understand albumin and ProLiant how that works, but can you tell me where that expands and the other two in terms of timeline and milestones of commercialization? Speaker 200:20:43Yeah, John, it's a great question. So DNase one is the more commercially ready one. We've completed scale up, as I mentioned on the call at our CDMO and now we're beginning to manufacture research grade product, which means we're also beginning to negotiate and work through OEM and supply agreements with potential customers in the market. So I think from a revenue standpoint, that's probably the first one. And then transferring, we've done some initial validation. Speaker 200:21:16It actually looks like we may have some better performance metrics as far as its ability to withstand temperature, in applications. So we're currently further evaluating that and also looking at potential scale up options to at least start producing, in addition to our sample quantities, producing small amounts of saleable quantities for the research market. So I think that would probably be second, but we're probably looking at late twenty twenty five and into 2026 because we do need to complete the commercial manufacturing process. Operator00:21:48And our next question comes from Dick Williams with Williams Resource Group. Speaker 400:21:54Hi, Joe. Terrific job. It's incredible the amount of opportunities that we seem to have on our table. But the one area maybe you can give me a little color on is the firm box deal with the ag waste and whatever else fits in that category. Could you give a color in terms of the market that is over there where they are currently using it, the customer they have that they're selling it to, and the opportunity to go to more customers over there? Speaker 400:22:26And then do we have any opportunities here in The US that you are looking at or have talked to thus far to determine if we can do something here? Speaker 200:22:38Hey, Dick. It's a great question. In terms of overall market potential, the bioindustrial enzymes for biofuels and biogas is a very large market. Majority of them are produced recombinantly today, and that's approximately about a $10,000,000,000 market. The first customer base or at least it seems the ones that are a little more aggressive are based in India as well as some Asia Pacific as well. Speaker 200:23:04So that's where the majority of the sampling and the majority of our efforts are kind of focused. As far as on this side of the pond, that is starting to increase but not to the same extent. The focus on biofuels in The US and the North America isn't quite as strong as it is overseas. But the interest is picking up and we're starting to evaluate potential manufacturing options here in The US because as we look at these enzyme cocktails that we're starting to produce, it's not just for biofuels and biogas. We're looking at the other applications that they can be used for such as pulp and paper, textiles, areas where the diag knows very well and has been in the past. Speaker 200:23:45So we're evaluating those opportunities so we move forward as well. Operator00:23:56Our next caller is Glenn Primack with LUSA Investment Group. Speaker 500:24:02Good afternoon, Mr. Hazleton and Ms. Rawson. I have a couple of questions. One on the planned uses of the capital raise. Speaker 500:24:16Do you have the back end systems in place already to execute on the new model and be able to measure progress in real time? Speaker 200:24:29In terms of the are you talking in terms of being able to process orders? Or Speaker 500:24:34Yeah. Like, the the MIS management information system. So, like, if you need to see how something's going, you can get it without scrambling around. Speaker 200:24:45I think at least from my standpoint initially, think we have the appropriate systems in place to handle the orders because we're doing it in bulk sale. So I don't anticipate need for a lot of additional resources in terms of infrastructure to support that. As far as the reporting, don't know, Ping, if you have any ideas on that. Speaker 100:25:07Yeah, I think it's pretty straightforward. Our product is very high value and very easy to ship around and we have been shipping similar products for research purposes. So, we definitely don't see the difference of what we are doing right now other than, you know, having more volume in the future. So, we are talking to potentially, you know, distribution center and those for logistic purposes. But again, I do not see that could be a potential issue as we are scaling up and making our growth and potentially two more products. Speaker 100:25:44For infrastructure, definitely as we grow more, we will look out additional resources and platform and outsource capacities to support a business. Speaker 500:25:57Okay. Thanks. And then my second question is there, as you head into '26, have you already put together a three year plan, or will you start that sometime in the fall? Speaker 200:26:12We're starting that in the fall. We've actually begun the process. But again, we have to evaluate some of the additional products that we have in the pipeline. We have to validate applications so we can determine the appropriate forecast for these products and in the segments we're going to be able to launch versus what our potential partners can do. But that is on the docket. Operator00:26:35Our next question comes from Robert Hoffman with Princeton Opportunity Management. Speaker 600:26:41Thank you. As Mark will attest, I've been a patient and shareholder of Diane for a long time. And so my first question is pretty straightforward. Is there any conflict with DuPont in terms of now that you're doing more industrial type of activity? Yeah, Rob, it's Mark. Speaker 600:27:03I'm not quite sure what you mean by conflict, but we don't see Speaker 100:27:06any conflict. Speaker 600:27:07Didn't you guys have I thought it was that you basically sublicensed it back for medical stuff. Wasn't that the structure of the purchase line. No? I heard that wrong. Yeah. Speaker 600:27:23No, no, you're 100% correct. But we had a non compete that ended three, four years ago. And then we've and we're not using C1 for industrial products. We're using DAPA BIS, which we've recreated. So we don't see any conflicts. Speaker 600:27:40So there's no issue with DuPont coming back and saying, hey, we should get some percentage of your revenue? As far as we see, the answer is no. Okay. I was hoping that was the answer. And then just very quickly, post this recent deal, can you give us a fully diluted share count? Speaker 600:28:04Maybe it's in the queue, and I haven't opened that yet. But if you could give that, that would be great. Speaker 100:28:09So we issued 6,052,000 shares through the public offering. Speaker 600:28:17So it accounts like 36,000,000 plus shares. It's in the queue as well. Speaker 100:28:21Yes. It's also in the PROSA that you can see the dilution impact. Operator00:28:29And we'll go next to Louis Titterton, private investor. Speaker 600:28:35Hi there. Hey, Mark. It's been a long time since I've talked Speaker 200:28:38to you. Speaker 600:28:38How are you? Good, Lou. How are you doing? I'm doing great. I have a simple question that I I think I heard that that expenses were gonna stay the same or drop for the next year while revenues are gonna increase. Speaker 600:28:50Is there some point where we think we're gonna cross over and be actually profitable? Speaker 200:28:56Yes. The goal is that we're cash flow positive by the 2026, and then we start to see, you know, increased profitability in 2027 and beyond. Speaker 600:29:06That would be wonderful. Thank you very much. Appreciate it. Operator00:29:14Our next question comes from Tony Bowers with IntroACT. Speaker 600:29:20Hi, Joe. Hi, Mark. Hi, Peng. We've dealt with a lot of big clumsy organizations in the past that don't make decisions quickly. Which of your platforms has the least number of decision makers involved to see commercial realization? Speaker 200:29:38Tony, that's a great question. And to be honest, it's not really platform specific. It's more product specific. So to your point, when you're dealing with biopharmaceutical products that require human clinical trials, FDA or EMA regulatory review, that's a much higher burden. And obviously, that's our C1 platform. Speaker 200:30:00But for things like food and nutrition, bioindustrial, while there are some regulatory requirements that you do have to meet for, let's just say, food nutrition, whether that's a GRAS certification or the EU has their own methods of evaluating those, they're not nearly as stringent. And they can be done in parallel as you're scaling up your process. As you look at it, any of the products that we're currently focusing on for the research, diagnostic markets, food and nutrition, bioindustrial, those are a factor of reaching the scale and cost efficiency needed to support its commercialization in the market. And as you can see, like with albumin, in some cases that's a twelve month or less path to revenue. In some cases, could be a little longer. Speaker 200:30:47In some cases, it could be a little shorter. But it's really product specific and kind of segment specific. Speaker 600:30:55And which of the markets has the largest addressable market and kind of best competitive factors? Speaker 200:31:08That's another great question. I hate to say it this way, but it is kind of market specific. I think the highest addressable market is really that cell culture media market, and simply because it's growing at a very high rate and the need for non animal solutions is much greater. Because from a regulatory standpoint, they're looking for consistency, purity, and scalability. So those are things that are driving that market. Speaker 200:31:35Now the other markets like food nutrition and bioindustrial, those are from a dollar standpoint, they're a lot larger. So like non animal dairy products, that's upwards of a $50,000,000,000 market. And again, we're targeting very select segments of those markets. But overall, I think the life sciences area is one where the demand is greatest. I think our platforms offer the best advantages. Speaker 200:31:59And it offers us probably the quicker path to revenue. Operator00:32:04We'll take a follow-up question from Robert Hoffman with Princeton Opportunity Management. Speaker 600:32:11Yeah, just to clarify. So was cut off on the fully diluted. So it's approximately 36,000,000. Is that right? Yeah, exactly. Speaker 600:32:22By the way, the one thing, Robert, is we didn't issue any warrants to the new shareholders. So I saw that. That's inspector. I'm kind of a follow-up on the last person's question. And I'm not asking for it today, but it would be very helpful for us to have some sense of the addressable market. Speaker 600:32:44When you said the area is a $50,000,000,000 market, is that the end market? Or is that what the component that you might be selling into? And so it's just be great for us to kind of get a sense of what you think the total addressable market would be for, let's say, albumin. I know I pronounced that. Mispronounced that. Speaker 600:33:08But something like that. And then we can then say, oh, well, if they got 10, if they got 5%. Because in my history is one of those where you're either going to get no percent or you're going to get a decent percent. Maybe you'll get 1%. But in these markets, you will either be accepted or you won't. Speaker 600:33:28And if you're accepted, you should be able to have a decent market share. So in some future presentation, it might be helpful for you to help us quantify those things. Speaker 200:33:38Actually, Robert, it's a great point. And if you do happen to get to our website and pull up the most recent investor presentation, we do give total addressable markets for the life sciences, food nutrition, and bioindustrial segments for the areas that we're going into, like cell culture media. We think that's approximately a 5,000,000,000 to $6,000,000,000 market opportunity for recombinant products. The top three revenue products in that category are albumin transfer and growth factors. They account for probably three of that $6,000,000,000 market. Speaker 200:34:15And when you look at it in terms of, to your point, how do you capture share in that, ProLiant Health and Biologics, our partner for albumin, is the second largest producer of naturally derived bovine albumin in the world. Their customer base is global and accounts for a large percentage of the albumin utilization today. So for us, it's about making sure we have the right partners in the right segments, as well as products that can support commercialization. So you're 100% right, and hopefully, if you take a look at that presentation, it'll provide a little more granularity into the markets. Operator00:34:52And that does conclude today's question and answer session. I will now turn the call over to Dyadic's President and COO, Joe Hazleton. Speaker 400:35:01Thank Speaker 200:35:01you. Q2 twenty twenty five marked a pivotal step in our shift to a commercially focused enterprise. Through our rebranding to Dyadic Applied Biosolutions, leadership expansion, and disciplined capital strategy, we're better positioned to deliver high value animal free proteins and enzymes to growing life sciences, food nutrition, and bioindustrial markets. With commercial launches approaching, a robust pipeline, and strong partnerships validating our technology, we believe we're well placed to capture meaningful opportunities ahead. Thank you for your continued support, and we look forward to updating you on our progress. Operator00:35:39The conference has now concluded. Thank you for attending today's presentation. You may now disconnect your lines at this time.Read morePowered by