Laboratory Co. of America Q4 2023 Earnings Call Transcript

Presentation

[Operator]

Good day and welcome to the Laboratory Corporation of America Holdings Fourth Quarter and Full Year 2023 Earnings Conference Call. [Operator Instructions]

I would now like to hand the conference over to your speaker today, Christin O'Donnell, Vice President, Investor Relations. Please go ahead.

[Christin O'Donnell, Vice President of Investor Relations at Laboratory Co. of America]

Thank you, operator. Good morning and welcome to Labcorp's fourth quarter 2023 conference call. As detailed in today's press release, there will be a replay of this conference call available via telephone and Internet. With me today are Adam Schechter, Chairman and Chief Executive Officer; and Glenn Eisenberg, Executive Vice President and Chief Financial Officer.

This morning, in the Investor Relations section of our website at www.labcorp.com, we posted both our press release and an investor relations presentation with additional information on our business operations, which include a reconciliation of the non-GAAP financial measures to the most comparable GAAP financial measures, both of which are discussed during today's call. Additionally, we are making forward-looking statements. These forward-looking statements include, but are not limited to, statements with respect to the estimated 2024 guidance and the related assumptions; the recently completed spinoff of Fortrea Holdings, Inc.; the impact of various factors on the company's businesses; operating and financial results, cash flows and/or financial conditions, including the COVID-19 pandemic, and global economic and market conditions; future business strategies, expected savings, benefits, and synergies from the LaunchPad initiative and from other acquisitions; and other strategic transactions and partnerships and opportunities for future growth. Each of the forward-looking statements is subject to change based upon various factors, many of which are beyond our control. More information is included in our most recent Annual Report on Form 10-K and subsequent quarterly reports on Form 10-Q and in the company's other filings with the SEC. We have no obligation to provide any updates to these forward-looking statements, even if our expectations change.

Now, I'll turn the call over to Adam Schechter.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Thank you, Christin. Good morning, everyone. It's a pleasure to be with you today to discuss our fourth quarter 2023 results and our guidance for 2024. Labcorp delivered a strong finish to what was a transformational year for the company. Looking back, we executed well on our strategic priorities. We successfully integrated the lab operations of Ascension, one of the largest health systems in the United States. We completed the spin of Fortrea, our former clinical development and commercialization services business. We announced six new laboratory partnerships, reinforcing our position as a partner of choice for health systems and regional local laboratories. And we launched new innovative tests in our focused specialty areas across the business. As we begin 2024, we have momentum in both Diagnostic Laboratories and Biopharma laboratory services. We expect to drive continued growth by expanding our base business, finalizing and integrating acquisitions and partnerships, by advancing our position in science, technology, and innovation. We will continue to focus and lead in oncology, woman's health, autoimmune disease, and neurology.

Now, turning to the fourth quarter results. Labcorp performed well, driven by strong base business revenue growth in both Diagnostics and Biopharma. In the fourth quarter, revenue totaled $3 billion. Adjusted earnings per share was $3.30. And free cash flow from continuing operations, excluding spin-related items, was $422 million. Enterprise revenue increased 4% compared to fourth quarter of 2022, with Diagnostics growing 3%, led by base business growth of 8%; and Biopharma growing 7% due to strong performance in central laboratories, more than offsetting softness in Early Development Research Laboratories. Enterprise base business margin was flat compared to the prior year despite being constrained by the mix impact from recently closed hospital partnerships. Looking forward, in 2024, we expect strong enterprise revenue growth of 4.7% to 6.5%. We expect margin improvement across both Diagnostics and Biopharma, and we expect adjusted EPS of $14.30 to $15.40 and implied growth rate at the midpoint of 10%. We also expect free cash flow to grow in excess of earnings. In a moment, Glenn will provide more details on our results and our 2024 guidance.

Turning to our enterprise strategy. In the fourth quarter, we continue to see positive momentum from our health systems and regional local lab partnership strategy. Labcorp continues to demonstrate that we are a partner of choice with several new health systems and regional local laboratory relationships. This is primarily due to our leadership in science and technology, our dedication to patients, and our commitment to quality and efficiency. We announced a strategic partnership with Baystate Health in western Massachusetts to acquire its outreach laboratory business and select operating assets. We completed the acquisition of select assets from Legacy Health. Labcorp now manages Legacy's inpatient hospital laboratories serving patients throughout Oregon and Southwest Washington state, and we entered into an agreement to acquire ambulatory lab draw stations and a stat lab from Providence Medical Groups in California. Looking ahead, our M&A pipeline is robust, and we remain focused on integrating and expanding our health system and regional local laboratory partnerships. These partnerships are typically accretive in the first year, with margins expanding over time during integration, and they return their cost of capital within just a few years.

Turning now to our progress in science, technology, and innovation. In the fourth quarter, Ovia Health by Labcorp announced it will offer Fertility and Family Building benefit. This benefit is a first of its kind that will allow employers and health plans to offer customizable solutions to employees and members to support their family building needs. Labcorp announced the availability of an ATN Profile, the first blood-based test that combines three well-researched blood markers to identify and assess biological changes associated with Alzheimer's disease. Last month, we announced the launch of the new FDA cleared blood test for risk assessment and clinical management of severe preeclampsia.

Labcorp and Hawthorne Effect announced strategic collaboration to advance decentralized clinical trial capabilities for pharma, biotech, and medical device sponsors. The collaboration is expected to increase patient diversity and inclusion, to decrease site burden, and to accelerate enrollment in clinical study timelines. Finally, for our central laboratory customers, we introduced a new sample tracking application to provide enhanced near-real-time visibility of specimens within a central lab. This phase is the first of many that will be launched for Labcorp customers. The application allows users to view events in a central lab specimen sample journey for each assigned protocol and to customize how their data is structured.

Turning now to the year ahead, we are focused on advancing our growth drivers that outlined in our September 2023 Investor Day. We plan to continue to be a partner of choice for health systems and regional local laboratories. We will continue to develop, license, and ultimately scale specialty testing, including companion diagnostics. We will work to bring our specialty testing to other parts of the world, which increases our global reach by leveraging our scale. For example, we're enabling our central laboratories in China and Geneva to perform liquid biopsy tests for clinical trials, and we are well positioned for long-term success in cell and gene therapy and consumerism. We see tremendous opportunity for growth as we continue to focus on bringing new innovation, technology, and products to market.

In closing, 2023 was a strong and transformative year for Labcorp. We executed our strategy at exceptional scale and pace. I want to thank our more than 60,000 employees for their hard work and dedication to customers around the world. This enabled us to enter 2024 with considerable momentum that we intend to capitalize on to drive further value for our customers, our shareholders, and our employees as we pursue our mission to improve health and to improve lives.

With that, I'll turn the call over to Glenn.

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Thank you, Adam. Going to start my comments with a review of our fourth quarter results, followed by a discussion of our performance in each segment, and conclude with our 2024 full-year guidance. For reference, we've also included additional business information that can be found in our supplemental deck on our Investor Relations website. Revenue for the quarter was $3 billion, an increase of 3.5% compared to last year, primarily due to organic base business growth and the impact from acquisitions, partially offset by lower COVID testing. The base business grew 7.4% compared to the base business last year, while COVID testing revenue was down 73%. Organically, in constant currency, the base business grew 5.2%.

Operating loss for the quarter was $123 million due to an impairment charge of $334 million related to our Early Development Research Laboratories business as we've experienced soft biotech markets. In addition, we had $125 million of special charges related to acquisitions, COVID and the spin of Fortrea. Excluding these items and amortization, adjusted operating income in the quarter was $395 million, or 13% of revenue, compared to $413 million, or 14.1% last year. The decrease in adjusted operating income and margin was due to lower COVID testing. Base business margins were in line with last year as the benefit of demand and LaunchPad savings were offset by higher personnel and stranded costs and the mixed impact of recently completed hospital partnerships.

Our LaunchPad and stranded cost reduction initiatives delivered around $125 million of savings this year, consistent with our long-term target of $100 million to $125 million per year. The adjusted tax rate for the quarter was 19.5% compared to 25.4% last year. The lower adjusted tax rate was primarily due to the geographic mix of earnings and the benefit from increased R&D tax credits. We expect our adjusted tax rate for 2024 to be approximately 23%. Fully diluted EPS for the quarter was a loss of $1.95 due to the Early Development impairment charge. Adjusted EPS were $3.30 in the quarter, up 8% from last year. Operating cash flow from continuing operations was $580 million in the quarter compared to $607 million a year ago. The reduction in cash flow was due to lower COVID testing.

Capital expenditures totaled $165 million in the quarter. For the full year, capital expenditures were 3.7% of revenue, and we expect this to be approximately 3.5% in 2024. Free cash flow from continuing operations for the quarter was $414 million. The company invested $155 million in acquisitions and paid out $61 million in dividends. While we did not use any cash for share repurchases during the quarter, we completed the accelerated share repurchase program, which reduced our share count by approximately 1.1 million shares in the quarter. At the end of the year, we had $530 million of share repurchase authorization remaining.

For the full year, free cash flow from continuing operations, excluding spin-related cost, was $888 million. The company invested $672 million on acquisitions, paid out $254 million in dividends, repurchased $1 billion of stock, and paid down $300 million of maturing debt. We continue to have a robust pipeline of potential acquisition opportunities that will supplement our organic growth. In addition, we continue to believe that our share repurchase program is an important part of our capital allocation strategy. At year end, we had $537 million in cash with debt of 5.1 billion. Our leverage was 2.5 times gross debt to trailing 12 months adjusted EBITDA.

Now I'll review our segment performance beginning with Diagnostic Laboratories. Revenue for the quarter was $2.3 billion, an increase of 2.6% compared to last year, with organic growth of 0.8% and acquisitions contributing 1.8%. The base business grew organically by 5.7% compared to the base business last year, while COVID testing revenue was down 73%. Total volume increased 2.4% compared to last year as organic volume grew 0.3%, which was constrained by lower COVID testing, while acquisition volume contributed 2.1%. Base business volume grew 5.2% compared to the base business last year as organic volume increased 3.1% while acquisitions contributed 2.2%. Price/mix increased 0.2% versus last year due to an organic base business increase that was mostly offset by lower COVID testing. Base business organic price/mix was up 2.6% compared to the base business last year.

Diagnostics adjusted operating income for the quarter was $354 million, or 15.1% of revenue, compared to $387 million, or 16.9% last year. The decrease in adjusted operating income was due to a reduction in COVID testing. Base business operating income was up due to the benefit of higher organic demand, acquisitions, and LaunchPad savings, which were partially offset by higher personnel costs, including healthcare-related costs. The decrease in margin was due to the reduction in COVID testing and the mix impact from recently closed hospital partnerships, which we expect to improve over time.

Now I'll review our segment performance of Biopharma Laboratory Services. Revenue for the quarter was $695 million, an increase of 7.1% compared to last year due to an increase in organic revenue of 4% and foreign currency translation of 3.1%. The 7.1% revenue growth was driven by continued strength in Central Labs, which was up 12% while Early Development was down 2% due to higher-than-normal cancellations. Biopharma adjusted operating income for the quarter was $109 million, or 15.7% of revenue compared to $95 million, or 14.7% last year. Adjusted operating income and margin increased due to organic growth and LaunchPad savings, partially offset by higher personnel and stranded costs. We ended the quarter with a backlog of $8.2 billion, and we expect approximately $2.5 billion of this backlog to convert into revenue over the next 12 months. Book-to-bill for the quarter was 1.26, with the trailing 12 months at 1.04.

Now I'll discuss our 2024 full year guidance, which assumes foreign exchange rates effective as of December 31, 2023, for the full year. The Enterprise guidance also includes the impact from currently anticipated capital allocation, with free cash flow targeted for acquisitions, share repurchases, and dividends. We expect enterprise revenue to grow 4.7% to 6.5% compared to 2023. This includes the favorable impact from foreign currency translation of 60 basis points. We expect Diagnostics revenue to be up 3.2% to 4.8% compared to 2023. The impact from lower COVID testing of around $130 million is expected to be offset by the annualization of acquisitions that were completed in 2023. We expect Biopharma revenue to grow 5.5% to 7.5% compared to 2023. This guidance includes the positive impact from foreign currency translation of 220 basis points. We expect Central Labs and Early Development to both grow within this segment guidance range. We expect margins in Diagnostics and Biopharma to be up in 2024 versus 2023, driven by top line growth and LaunchPad savings.

Our guidance range for adjusted EPS is $14.30 to $15.40, with implied growth rate at the midpoint of approximately 10%. While we do not guide to quarterly performance, it's worth noting that first quarter earnings will be below typical quarterly seasonality due to weather disruption in January that we expect will impact earnings by $0.10 to $0.15 in the quarter. Free cash flow is expected to be between $1 billion to $1.15 billion, with an implied growth rate at the midpoint of approximately 21%. In summary, we expect to drive continued profitable growth and strong free cash flow generation that will be used for acquisitions that supplement our organic growth while also returning capital to shareholders through our share repurchase program and dividends.

Operator, we will now take questions.

Questions and Answers

[Operator]

[Operator Instructions] Our first question comes from Jack Meehan with Nephron Research. Your line is open.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Morning, Jack.

[Jack Meehan, Analyst at Nephron Healthcare Investment Research]

Good morning. Hope you guys are doing well. I wanted to start with a question on capital allocation. So last year was obviously pretty active year for you guys. Integrating Ascension, doing the spin. Feels like you have a little bit more bandwidth and the cash flow has been strong. I was wondering if you thought there could be any larger deals available, either in the independent lab or health system space. I know it's tough to come up with something that's Ascension size, but what does the funnel look like?

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Yeah, hi, Jack. So if you look at the pipeline for M&A we have, it remains very strong. As you say, there's not deals the size of Ascension necessarily in health systems, but there's quite a few of health systems that, when you add them up, obviously become meaningful. In fact, if you look at our longer-term guidance, historically, we've said that we'd have 1% to 2% growth from inorganic means. We have now said we believe it's going to be 1.5% to 2.5%, reflecting that we believe that there is significant opportunity before us. We also mentioned partnerships with regional and local laboratories, and I think that there could be some additional partnerships in that area. But as I think about capital allocation in general, I'll first start off that we're committed to our dividend. We then look to do as many of these hospital local, regional laboratory deals as we can do because they're so sensible to do. They return the cost of capital very quickly, they're accretive in the first year, and we know how to do them really well. And then if there's something that is strategic to us in one of our strategic priorities, we would look to do those, albeit we're not looking at anything know massive size. But after that, we then look at our share buybacks, which we continue to believe is a good way to use our funds as well.

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Yeah, Jack, the only thing I'd also add to your comment earlier is that our guidance assumes that, again, we're going to generate between $1 billion to $1.15 billion of new free cash flow this coming year and that we'll redeploy that for capital allocation of M&A, buybacks, and dividends. But the balance sheet is also strong. We ended the year at 2.5 times gross debt to trailing 12 months adjusted EBITDA, and we have a targeted range of 2.5 to 3 times. So to your point, if there were attractive opportunities out there on the M&A front, obviously share repurchases as well, in addition to the free cash flow, we also have additional financial flexibility to pursue those opportunities.

[Jack Meehan, Analyst at Nephron Healthcare Investment Research]

Great. And can you talk about, on the Diagnostics side, what realized unit price was in the quarter? What your expectation is for next year? And the reason I ask is I get a lot of questions on the margins in the business, and it feels like we're in this elevated inflationary environment. Just what do you think -- do you see opportunities to use price more as a lever to offset that?

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Yeah. So, Jack, let me first talk about margins just in general. So if you look at 2023, the margins were basically flat versus prior year. If you look at some of the things that we had to overcome, they were pretty significant, like COVID work that was significantly less this year than the prior year. But in addition to that, the hospital deals that we've done, in particular in the fourth quarter, had an impact on our margins because although they're accretive in the first year, they're dilutive in the first couple of months as we do the integration, until we have the ability to reduce costs to the level that makes sense over time. So we saw some impact from that in the fourth quarter as well. I feel really good about our margin accretion as we go into 2024. And we've said that we expect the margins to increase, but we also expect them to increase in each of the businesses, not just Diagnostics, but also Biopharma.

Within Biopharma, we expect them to be increased not just in central laboratories but also in early development. So we continue to look for ways to reduce costs through our LaunchPad initiative. We're committed to reducing costs by $100 million to $125 million this year and each year for the next several years. In addition to that, our volume growth is helping us significantly. In particular, as we see growth in Biopharma, that's going to help us with our margins. Despite the fact that we still have COVID overhang in 2024 versus '23, that we're continuing to improve the margins in our hospital deals, we're expecting to see the margins being accretive and growing this year, which to me is just a good sense of the underlying growth, with particular focus on price. I would say price is net neutral when you look at overall price. There is some benefit to mix, and we continue to see mix helping us there.

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Yeah. Jack, the thing, too, as Adam said, when you think about the Diagnostics business and the benefit, frankly, of seeing PAMA at least deferred out one year, that we expect the margins within Diagnostics to be up in '24 all in. And that's even with the expectation that COVID testing is going to be down. Obviously, the underlying base business margin improvement would even be greater than that. And as Adam said, the nice thing is with the growth that we expect, it's demand driven. A lot of it is the volume side. Price/mix is still going to be favorable at a lesser extent than obviously the volume. But with unit prices being relatively flat, we have the opportunity again to still see favorable mix to help drive that improvement.

[Jack Meehan, Analyst at Nephron Healthcare Investment Research]

Great. Thank you.

[Operator]

One moment for our next question. Our next question comes from Kevin Caliendo with UBS. Your line is open.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Morning, Kevin.

[Kevin Caliendo, Analyst at UBS Investment Bank]

Good morning. Thanks for taking my question, guys. On Biopharma, just want to understand the expectations for margin there and how much of that is improvement in early development. I know you have an easy comp in 1Q versus actual improvement in margin and mix. But can you just talk about the dynamics of that and the cadence of that as we think about it over the course of the year?

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Yeah, I'll talk a little bit and I'll ask Glenn to provide some additional context. Our Biopharma Laboratory Service business remains a leader in both segments: we're a leader in central laboratory; we're also a leader in early development. Central laboratory performed very well in the fourth quarter, and we expect it's going to continue to perform well as we look at 5.5% to 7.5% growth in 2024 across the segment. But early development, we expect to continue to improve as we go through the year, and we also expect early development to grow about the same amount as the overall guidance that we're given for Biopharma. A lot of the early development growth we expect will be in the second half of the year as we continue to see improvement and ramp up. Our RFPs look good in both segments. The largest segment obviously, by far, is the central laboratories. The RFPs look good, our win rate looks good, big pharma is continuing to send us a lot of RFPs, I feel great. If you look at early development, the RFPs look good, the win rate looks good. What we've faced are some cancellations that are well above normal levels, and we expect as we go through 2024 that will normalize and get us back to the RFPs and the win rate being positive for us and therefore providing us with growth.

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Yeah. Kevin, just would add that when you look at the cadence to your point, one we expect Biopharma margins to be up year over year. Given the softness that we experienced, especially in the first half of 2023, with the supply constraints that we experienced in the early development in particular, you would expect to see the stronger part of the margin improvement in the first half of the year versus the second, but margins that would still be up year over year, even as we go through each quarter of the year. And as Adam commented, we expect margin improvement driven across both of our businesses. So we have early development and central lab both looking at revenue growth within that guidance range of 5.5% to 7.5%. So on good top line growth, LaunchPad savings, we expect to see good margin improvement and to leverage that top line well.

[Kevin Caliendo, Analyst at UBS Investment Bank]

Great. If I can ask a quick follow up to that. Just the outlook for NHP pricing and your reliability of supply, what's happening in the marketplace there? We've heard pricing is coming under pressure a little bit. How do you anticipate that helps or hurts on the margin front? How should we think about that impact?

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Yeah. So, Kevin, right now supply is not an issue. We have as much supply as we need. I feel very good about, as we go through this year and into the future, we have multiple suppliers now. We've certainly seen some of the pricing come down in the market, which is a good thing for us, because NHP cost is largely a passthrough for us. We pass the benefit on to our clients. So you might see the revenue come down for us because the cost is coming down, but it shouldn't have any significant impact. In fact, it could help us a little bit when it comes to our margins.

[Kevin Caliendo, Analyst at UBS Investment Bank]

Great. Thank you so much, guys.

[Operator]

One moment for our next question. Our next question comes from Erin Wright with Morgan Stanley. Your line is open.

[Erin Wright, Analyst at Morgan Stanley & Co., LLC]

Great, thanks.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Good morning, Erin.

[Erin Wright, Analyst at Morgan Stanley & Co., LLC]

Hi. Good morning. So how would you characterize just general volume trends and utilization trends relative to pre-COVID. And just excluding COVID dynamics I know you also mentioned some of the weather impact in the first quarter. How big of an impact is that and how should we think about just volume dynamics as we head throughout the year in 2024? Thanks.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Sure, Erin. So first of all, I would say we came into 2024 with significant momentum. The Diagnostics base business grew 8% in the fourth quarter, Biopharma grew 7.1% in the fourth quarter. So I feel good about the guidance that we're providing for each of those businesses. So for Diagnostics, it's 3.2% to 4.8%, midpoint of 4% growth. Biopharma, it's 5.5% to 7.5%, midpoint of 6.5% growth. So very strong revenue growth. We are comfortable also saying that there'll be margin improvement in each of those businesses. That's despite the fact that there is going to be an impact in Diagnostics from weather, and we expect it to be $0.10 to $0.15 in the first quarter. And therefore, the first quarter will be the hardest quarter for us of 2024. But the numbers I just gave you and the ranges that I gave you, midpoints, we already know what the weather was in January, so it already contemplates what happened in January.

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Yeah. Erin, couple of comments, too, as well, that demand utilization is positive. And frankly, we're at the higher end right now when you look at it year over year. When with the guide of, call it, again, midpoint of around 4% for Diagnostics, organically next year, our normal historical call it two-thirds volume, one-third price/mix is probably a good indication, which still speaks to the fact that volume levels are up nicely. When you compare them to pre-pandemic levels, we're within the normal range, where historically we would say 1% to 2% from volume 1% on the price side, we're within that 1% to 2% growth rate now.

CAGR, organically compared to 2019, on the lower end, but well north of 1% growth. So we're at a normal level right now, a little bit higher expected than historical. And the weather impact that we saw in January, to give you the rounded numbers, probably impacted our revenue by around $25 million. And incrementally, the dropdown on that would be at around 60% margin, so call it around $15 million-ish of operating income, or that $0.10 to $0.15 range that we gave in our prepared remarks from an earnings per share standpoint.

[Erin Wright, Analyst at Morgan Stanley & Co., LLC]

Okay. Perfect. Thanks. And just your quick thoughts on the regulatory environment as it stands now, whether it's LDTs, PAMA, SALSA, do you think PAMA just continues to be pushed out at this point? What are your thoughts there? Thanks.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Yeah. So, Erin, we continue to support SALSA, and we continue to be optimistic that SALSA will get passed. We have support from both sides of the aisle and ACLA, our trade organization, is working really hard to get that legislation passed. If it doesn't get passed, then we'll try to see if there's a way to get another year's delay. In our guidance -- longer-term guidance, we assume that there will be an impact from PAMA. So therefore, we continue to say, if not this year, it'll be next year. If it's not next year, it will be the following year. Until the SALSA legislation is passed, then I'm not going to take a lot of comfort that it could be another year delay or so forth. We're going to really work hard to have that passed. With regard to LDTs, we do not support the FDA's what they're currently thinking about in terms of taking legislation that was created for the device industry and applying it to the diagnostic industry. We were very supportive of VALID and that was legislation that would give FDA oversight of laboratory developed tests. We think that's the right path to go. We'll continue to work with the trade organization to see if we can make progress there, but we think legislation that is fit for purpose for the diagnostic industry is the right path forward.

[Erin Wright, Analyst at Morgan Stanley & Co., LLC]

Great. Thank you.

[Operator]

One moment for our next question. Our next question comes from Stephanie Davis with Barclays. Your line is open.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Good morning, Stephanie.

[Stephanie Davis, Analyst at Barclays Bank]

Hey, guys. Good morning. Congrats on the quarter. Thanks for taking my question. I was hoping you could walk us through what's driving some of your Diagnostics market growth being so above market, especially on the EPS side, because I've historically attributed some of your above market growth to the Ascension deal. But I also thought about the lower margin profile. So I guess I'm a little surprised at this level of profitability bifurcation versus your largest peer.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Yeah. So what I would say, Stephanie, is number one, we have momentum in the Diagnostics business, and the momentum is coming from our base core business. We see it in both routine and esoteric testing. We have four therapeutic categories that we focus on that have higher growth in other specialty areas, and we're going to continue to focus in those areas: oncology, woman's health, autoimmune disease, and neurology. And I believe that those are going to help us continue to grow because those parts of the market should grow disproportionately as we continue to go into the future. At the same time, there's no doubt that the acceleration of the hospital and local laboratory partnerships has enabled us to grow faster than what we've grown in the past. And the good news is we have a strong pipeline of those as we go into the future. That's why we raised the longer-term guidance for inorganic growth to 1.5% to 2.5%. Historically, we would have said 1% to 2%. So I think all those things combined give us momentum when it comes to the Diagnostic volume.

[Stephanie Davis, Analyst at Barclays Bank]

Understood. Looking forward to it. And changing gears a little bit for the follow up. Could you dig a bit more into the Ovia announcement? How much of that was driven by inbounds from your existing employer clients versus the decision to expand into the market? And what does this mean in terms of investment lift [Phonetic] in employer-facing sales or platform tech investments and the like?

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Yeah. So if you look at what we've done with Ovia, we think it's a terrific way for us to have a digital capability in a very important core therapeutic area that we're focused on women's health. And it really is what they've offered, a first of its kind Fertility, Family Building benefit that we will be bringing to customers. The service offers care navigation and concierge services that helps individuals throughout their family-building journey. And we can offer it directly to patients if they like, we can offer it to employers. We have a very strong employer group, Labcorp Employer Services, and this is just one of many offerings that we're going to be bringing to the marketplace. But because women's health is so important and because we are so focused on it, this is just another avenue for us to help in the women's health arena.

[Stephanie Davis, Analyst at Barclays Bank]

Awesome. Thank you so much.

[Operator]

One moment for our next question. Our next question comes from Patrick Donnelly with Citi. Your line is open.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Morning, Patrick.

[Patrick Donnelly, Analyst at Citigroup Global Markets]

Hey, guys. Hey, good morning. Thanks for taking the question. Maybe on the Biopharma booking side, the book-to-bill picked up a little bit from last quarter. I know last quarter you guys were flagging maybe some elevated cancellations on the emerging biotech side. Can you just let us know what the environment looks like now? How you're feeling about that backdrop, again, just given a little bit of volatility there, and we've seen some biotech IPOs trickle out. How are you feeling about the backdrop and how should we think about bookings this year?

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Yeah, absolutely. And I'll start broadly about our Biopharma business and then I'll talk about the individual segments as well. So broadly, we had a good quarter of 1.26, which we said in third quarter, we expected the fourth quarter to be improved, and obviously it was improved. If you look at our trailing 12 months, it's about 1.04, and we believe that you want to be around 1.05 to 1.1. And the 1.1 is typically what we're targeting, and I feel confident we'll be able to get there as we go through this year. We dropped off a really strong quarter in the fourth quarter of 2022.

If I break apart the businesses, and we start with the much larger business, which is the Central Laboratory business, our RFPs are very strong. Our book-to-bill is very strong. Our win rate is very strong. We're not seeing as many cancellations as we're seeing in the other part of the business because it's focused more on larger pharma. Although there are some cancellations there; there always are, it's not nearly as large as what we're seeing in Early Development. In Early Development, I feel comfortable as we go through 2024 because RFPs coming into us are still very strong. Our win rate remains good. I feel good about where our win rate is. What's happened there is, there's been a lot of cancellations. So I think there's two reasons for that: one is I think with NHP pricing the way it was, some very small biotech companies that got in line just decided to say we're just not going to do it now and then I also think that there are other pressures with smaller biotech companies that they're going through financially. As I look at this year, I feel good about both businesses. And in Early Development, we're actually even seeing a larger amount of our business come from large and middle-sized pharma versus early pharma or early biotech. And I think as we make that transition to get more and more larger pharma in Early Development, we'll be able to even have a stronger book-to-bill moving forward. But net-net, I feel confident in both of those businesses, the ranges that we've provided, and where we are today with the book-to-bills.

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Yeah, Patrick, just one other thing to think through as well. Again, we had a strong fourth quarter, which obviously is very encouraging, but it was still driven more on the Central Lab side. So while the orders and the RFPs and our win rates for even Early Development are doing well, it's those cancellations that have impacted it. So as you think about the cadence, too, for next year, when you look at the Biopharma, expect to be a second half weighted year on the revenue growth. So both businesses again within that 5.5% to 7.5% growth. But because of those cancellations, we do expect to see Early Development growth rate be much stronger in the second half than the first, whereas on the Central Lab, given the continued strength of its backlog, we expect that normal cadence of improvement each quarter as we go.

[Patrick Donnelly, Analyst at Citigroup Global Markets]

Okay, that's helpful. And then just a couple of quick ones on the P&L for '24. Glenn, you talked a little bit about the Diagnostics margins. Can you talk about what the COVID headwind is? I'm just trying to figure out maybe the core expansion versus the COVID headwind, if you have that. And then just quickly the interest expense expectations for the year and how you're thinking about the debt load addressing that at all during '24. Thank you.

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Sure. Again, expect to see margins in both businesses are up, but specifically in Diagnostics, we do expect margins to be up in total Diagnostics, albeit slightly up because of the impact, to your point, of COVID still being a headwind and the underlying base business margins doing well. But overall, we would say that we're going to be down around $130 million due to COVID from a margin standpoint, call it, 20 to 30 basis points of headwind that we're going to get. That again will be more than offset by the growth of the business and our LaunchPad initiative.

When you look at the interest expense, you can effectively take the run rate or where we ended the fourth quarter and annualize that. And then we do have around $1 billion of debt that's due late in 2024, so around $600 million in September, another $400 million in December. So we'll look to refinance it. The absolute debt levels that we have at that $5 billion, $5.1 billion we expect to maintain. So we'll just refinance at obviously slightly higher rates than what will be maturing. So if you wanted to add 10% to the annualized number on top of that to reflect the refinancings at the end of the year, that'd be a decent ballpark to be in. And again, the debt load from where we stand will look for refinancing. We commented a little bit earlier that the leverage that we have as a company is still within our targeted range of the 2.5 to 3 times. But we're at the lower end. So obviously we could potentially use additional leverage, additional debt, as we see potential other opportunities to deploy capital above the $1 billion plus of free cash flow that we'll generate this year. Plus we're sitting on a little bit of excess cash.

[Patrick Donnelly, Analyst at Citigroup Global Markets]

Okay, great. Thanks a lot, Glenn.

[Operator]

One moment for our next question. Our next question comes from Brian Tanquilut with Jefferies. Your line is open.

[Brian Tanquilut, Analyst at Jefferies & Company, Inc.]

Hey, good morning, guys.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Good morning.

[Brian Tanquilut, Analyst at Jefferies & Company, Inc.]

So I guess my question, Glenn, as I think about the P&L lines, you go to cost of sales and G&A and factor in labor and obviously LaunchPad, seeing that it outpaced -- both those lines outpaced revenue growth in Q4, how are we thinking about -- I hear about margin improvement this year. So just curious how you're thinking about the labor environment and how that factors into driving margin improvement in terms of actual dollars and the growth in those P&L lines.

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Yeah. Brian, we normally view, well, one, obviously, it continues to be a tight labor market, but a market that's improved. From an attrition standpoint, we continue to see improvement, but as a company, we're still higher than we were pre-pandemic, and that varies across the segments because actually our Biopharma is back to where we've been, and we still see some additional pressure within the Diagnostic side, but again, improving. Our general premise is that the labor market, inflation for labor is around 3%. You can say 3% to 4%, but within that range. We've always commented that our LaunchPad initiative was really in place to help offset that inflationary pressure. For us, a 3% give or take increase in our labor, call it merit in particular, would be a little bit over $100 million. And again, we target that $100 million to $125 million a year. So again, we think things are leveling off, if you will, and that part of the margin improvement will be the LaunchPad initiative to help offset those inflationary costs.

[Brian Tanquilut, Analyst at Jefferies & Company, Inc.]

Understand? Just housekeeping. Maybe I just missed this, but share buybacks, how much share buyback activity is baked into the guidance?

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

So what we do guide to is that the free cash flow generation that we have will be used for share repo, M&A, and dividends. So it'll be across the board would be our expectation. We don't comment about how much is in each of the components, if you will, because it may vary based upon the acquisition opportunities that we see, but it'll be blended across. And again, we commented as well that we have some additional balance sheet strength if we wanted to use that for additional M&A or buybacks. But the guidance that we gave and the earnings guidance, if you will, is reflected with all three of those capital allocation opportunities.

[Brian Tanquilut, Analyst at Jefferies & Company, Inc.]

All right, got it. Thank you.

[Operator]

One moment for our next question. Our next question comes from Pito Chickering with Deutsche bank. Your line is open.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Morning, Pito.

[Pito Chickering, Analyst at Deutsche Bank Aktiengesellschaft]

Yeah, good morning, guys. Thanks for taking the questions. Back on the '24 guidance for Diagnostic business, can you try to help quantify the margin improvements next year? Any details on split between SG&A and gross margins, and how much is coming from acquisitions improving versus just pure organic improvements?

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Yeah, I'll give some context and I'll ask Glenn to add on. So if you look at the Diagnostic business, I'd say, the first thing is if you look at fourth quarter, you saw a very strong revenue growth, about 8%. If you look at margin versus prior year, it was down slightly, about 30 basis points. What drove that primarily was that there were some minor things like increased healthcare costs and so forth, but it was driven primarily by the hospital deals that we did that, although they're accretive in the first year, in the first several months, they're typically dilutive. And we did several of those deals at the end of last year.

As we come into this year, we're confident in the margin accretion for several reasons. One is obviously PAMA has been delayed. So that would have been a real headwind that we're not facing this year. We pushed that off into 2025. If you look at our volume increases, that's going to help us. The volume is going to be strong. If you look at the hospital deals, we said Ascension would continue to give us some margin improvement over the next several years. Each of the hospital deals get a bit better as they go year over year, so we'll get some improvement from the hospital deals continuing to improve. We're also going to be looking to reduce costs across the enterprise, but a significant amount, because of size is in Diagnostics of $100 million to $125 million. And when you look at all those things together, we're expecting inflation to be about 3%, which is more in a typical rate than it's been in prior years, and that's for inflation of people costs and so forth, should be around 3%, 3.5%. You put all this together, and that's why we're confident that even though we have a headwind from COVID that's fairly significant, about $130 million, we'll still be able to get some margin improvement in the Diagnostics business.

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Yeah. No, I think that's right, Pito, that when you look this year as COVID becomes less of an impact, still an impact, it's being offset by the acquisitions that we did late in the year. Really, it's the hospital partnerships. And to your point, the margin is constrained a little bit when we do the in-hospital lab management agreements. But a typical M&A for us that would include hospital labs management tend to be more weighted to, frankly, the acquisition component Ascension, as we've talked about, we called out, one, because of its sheer size, but also was disproportionately tied to the in hospital lab. So less of an impact, a little bit of a headwind, but less of an impact. So it's really top line growth, cost controls, LaunchPad business process improvement initiatives is really what's going to help drive the margins across both of our businesses.

[Pito Chickering, Analyst at Deutsche Bank Aktiengesellschaft]

Okay, great. And then back for fourth quarter on the early-stage cancellations. Is it clear as to why you saw that spike? Was that just a single customer or was that a swath of customers and why you think that should normalize in 2024? Thanks so much.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Sure. It wasn't specific to fourth quarter, although there was an increase in the fourth quarter. We saw it throughout last year, and we think there were several reasons. One, when there was an NHP supply issue, people were getting in line to run their NHP trials well in advance of what they typically would. By the time it was their turn, they would look and say, you know what, we're not going to do that trial. Either they reprioritize the pipeline, they decided the NHP costs were higher than what they had budgeted for, they decided just not to move forward at that time.

The second thing is the funding in smaller biotech has been more difficult, so they're choosing their trials very carefully and the compounds that they move forward. But as we go forward, we're seeing the RFPs look good as well as our win rates look good. So the cancellations, we believe are going to normalize. We're also starting to see a shift in our business a bit more towards mid-size and larger pharma as some of the smaller biotechs have had those cancellations. They have less cancellations typically than the smaller ones. So that's why we think we're going to see improvement as we go through this year.

[Pito Chickering, Analyst at Deutsche Bank Aktiengesellschaft]

All right, great. Thanks so much.

[Operator]

One moment for our next question. Our next question comes from Elizabeth Anderson with Evercore ISI. Your line is open.

[Elizabeth Anderson, Analyst at Evercore ISI International]

Hi, guys.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Morning, Elizabeth.

[Elizabeth Anderson, Analyst at Evercore ISI International]

Hi. Good morning. Thanks for the question. So I just wanted to follow up on that last question. So the shift towards mid-to-larger pharma in Early Development, is that really solely a function of this cancellation dynamic that you're seeing over the shorter term? Because I thought from maybe one of your prior comments, it seems like that was also maybe more of a strategic shift moving up market there. So any additional color there would be helpful. And then secondarily, on the cost improvements in BLS, I understand what you're saying about the continued revenue improvement there. Are there any other cost improvements as we move further away from the spin, or should we think about those cost opportunities as largely you've already done them, and this is really just like an organic opportunity? Thank you.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Yeah, sure. As I think about the Early Development business, I've been saying for quite some time that we would like to see a shift towards more mid-to-larger size. And I want to be clear, it's still more in the smaller biotech than it is to the mid-to-larger size. It's been something that we've been working on for multiple years now, and we're seeing some progress, but also a part of it is that cancellations are occurring more often in the smaller biotech companies. So we were purposely moving in that direction. There is a reason that we're able to move a little bit faster, but we still have work to do there. But over time, I would like to see that mix move more towards mid-sized to larger pharma.

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Yeah. Elizabeth, also on the cost side for BLS, it's not only the growth, but there are cost opportunities in the post-spin environment. We still have stranded costs that affect our Biopharma business that we're continuing to take out. And obviously that's getting wrapped in our overall LaunchPad initiative. As we talk to the $100 million to $125 million of savings each year. We did take out meaningful amount of costs that were stranded. We had talked about having a $25 million run rate of cost savings in the fourth quarter, which we achieved, so we'll get the benefit of that going forward. But there's still opportunities to consolidate. We still have a little bit of excess capacity within our Early Development side of the business, so we're managing that cost and the capacity, leaving ample room, though, because of the expectation that we're going to start to see good growth in that business as well. But it's not only obviously top line growth, but still opportunities to take some costs out.

[Elizabeth Anderson, Analyst at Evercore ISI International]

Got it. And maybe just one quick follow up. Anything you can comment on the expected 2024 tax rate?

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Yeah. So we've guided that we think a 23% adjusted tax rate is reasonable for the company. And what's interesting, if you think about Labcorp today post spin, we actually have a higher percentage of our earnings now that are generated in lower tax rate jurisdictions than we did when we had the clinical business. In addition, we have a higher percentage of R&D, so a higher percentage of R&D benefit than we did when we had clinical. So overall, while we've historically have trended and seen our tax rate decline year to year over the last few years, the profile of the company gives us confidence that the 23% rate now is a sustainable rate, plus or minus, going forward.

[Elizabeth Anderson, Analyst at Evercore ISI International]

Great. Thank you very much.

[Operator]

One moment for our next question. Next question comes from Eric Coldwell with Baird. Your line is open.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Good morning, Eric.

[Eric Coldwell, Analyst at Robert W. Baird & Co., Inc.]

Good morning, guys. Of course, all of my self-proclaimed good questions have just been asked in the last couple of minutes here, but I'm going to dive into that last one on R&D tax credit. Can you tell us what specifically might have happened in the fourth quarter to drive what appears to be some additional upside and thoughts on legal or regulatory changes, in addition to Glenn's comments here about the geographic mix and the higher proportion of revenue associated with businesses that now would get an R&D tax credit. I'm just curious know how much of a sustainable impact this might be for favorable long term tax rate.

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Yeah. So Eric, when you think about the focus of the company, one of the key areas of target is in oncology. And obviously with PGDx, OmniSeq, other areas that we've acquired as well are more R&D driven than historically Labcorp was. So each year we continue to make more investments, more opportunities, and with that increased investment come the tax deductibility of that. Obviously there's still some pending tax laws that are out there right now. We're having to amortize that benefit over a number of years. So from a cash standpoint, we're pre-funding it, so hopefully that will change and we'll get more. There's obviously the impact of potentially global minimum taxes that really don't affect us that much, given as we look at where, again, geographically we generate our earnings, really not going to have any meaningful impact. So from a sustainability standpoint, we think that 23%, plus or minus, rate is a reasonable rate to go forward. But obviously, the more we grow, the more we grow internationally gives us an opportunity to structurally change that maybe a little bit more favorably as well.

[Eric Coldwell, Analyst at Robert W. Baird & Co., Inc.]

And Glenn, maybe education on my behalf, but are you seeing R&D tax credits on the CRO side as well, the BLS segment? Or is it mostly or entirely associated with your internal investments in advanced diagnostics and LDTs, things of that sort?

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Yeah. It's across the board. We have investments that span the entire company. I think the increase that we've been seeing that has been driving the more favorable amount, has been driven more on the Diagnostic side. But frankly, our oncology spans the enterprise. So everything that we work on and where we work on and who's working on it, again, we would say is across the enterprise, but more weighted to Diagnostics.

[Eric Coldwell, Analyst at Robert W. Baird & Co., Inc.]

Great. And if I could get one more in here. The stranded cost commentary, could you just remind us what you're sharing in terms of what those total costs were, how they phase out, and what happens at the end of 2024 when Fortrea thinks they're going to be completing their biggest TSA transitions, particularly on the IT side, what is the impact to Labcorp over the next handful of quarters and into '25 as you face these stranded costs, but they start to come out, and then what happens at the end of the TSAs? Thank you very much.

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

No, sure, Eric. So, from a stranded cost, we commented that we had around $45 million of stranded costs and that our initial target was to take out that $25 million at a run rate this year, which, again, we've achieved. So there's more to come. So in the fourth quarter, call it around a $6 million headwind that we had due to stranded costs that obviously impact margins. As we go forward with the TSA support, so what we're doing to support Fortrea, IT, and other areas. That's effectively a passthrough, right? We're providing the service, they're paying us for that service. Once they're fully sustainable on their own, and the TSAs would go away, our costs go away because, frankly, most of the costs are contract labor related on the IT side. So when the job's done, those costs are gone overall, but we continue to tackle the other stranded costs as well. So when you look at it, the goal was to have all the TSAs completed within two years. I can tell you Fortrea and Labcorp are both very motivated and incentivized to see that transition happen as soon as possible. The good news is that both are focused on it. We're making good progress. Fortrea is making very good progress, and we would expect to hopefully see those TSAs expire earlier than what we had planned, or at least what we had planned for. But again, the cost will go with that.

[Eric Coldwell, Analyst at Robert W. Baird & Co., Inc.]

That's very helpful. Thank you, again.

[Operator]

One moment for our next question. Our next question comes from Lisa Gill with JPMorgan. Your line is open.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Morning, Lisa.

[Lisa Gill, Analyst at J.P. Morgan Securities]

Good morning. Thanks for taking my question. I first wanted to start with the guidance range. Glenn, can you help us understand, it's a pretty wide range, what's in the low end of the range and what gets you to the upper end of the range would be my first question. And then secondly, just want to understand managed care contracting and pricing for 2024. You talked about volume and pricing mix, but just curious, do you have many contracts that are up for renewal? Is there anything that's different when we think about contracting with managed care entities?

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Yeah. So I'll take the second one first, which is we feel confident in our contracts that we had put a few in place last year, but this year there's no major expiration. So we feel good about where we are and there's not much risk in the guidance range as we go through this year into next. But with regard to the ranges and certain things that go to the upper end of the bottom [Phonetic]. I'll start with the revenue range. Obviously, the Diagnostic volume looks great, and we're expecting that to continue. The weather is a bit of what's taking us a little bit back to the midpoint. So the weather is $0.10 to $0.15 impact, but the volume continues to be very, very strong. The rate in which we integrate the hospital deals will help us, and we have very good track record of doing that. But the good news is there's not as much volatility this year as there's been in years in the past with COVID. So I feel good about the range. And in fact, the EPS range, we've narrowed it versus what that range would have been last year, the year before that, because there is less volatility. And then I'd say in the Biopharma services business, I would say the strength we have and momentum is great. The thing that we're watching carefully are vendor cancellations, in particular in the Early Development, start to come back to more normal.

[Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer at Laboratory Co. of America]

Yeah, and Lisa, I think on Adam's comment that when you look at the profile of Labcorp, now that we've spun the clinical development business, it has taken out some of the volatility and variability, if you will. So the guidance ranges really, across the businesses and the enterprise are actually a little bit tighter than what we normally do. Obviously, we're just starting out the year. The midpoint, obviously, of our guidance is our best expectation that we have realizing, obviously, higher demand would promote more on the upper end or softer demand down below. But needless to say, as we go through the year, we'll continue to tighten the ranges with less time left in the year.

[Lisa Gill, Analyst at J.P. Morgan Securities]

Sounds great. Thank you so much.

[Operator]

[Operator Instructions] One moment for our next question. Our next question comes from Derik de Bruin with Bank of America. Your line is open.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Morning, Derik.

[John Kim, Analyst at BofA Securities]

Hey, good morning. This is John Kim on for Derik. I think a lot of the key questions I had have been answered, but I wanted to ask about the esoteric versus routine testing. You've laid out or you've reaffirmed your focus on the four therapeutic areas. And it seems like the esoteric had a pretty good growth in the fourth quarter. But going forward, can we continue to expect that high-single-digit, low-double-digit growth in esoteric and then the rest of it would be made up in routine?

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Yeah. So if you look at the esoteric testing volume, we continue to have a significant focus on the four therapeutic areas that we talked about. And we did in fact see in the fourth quarter and the full year that esoteric testing volume grew slightly faster than the routine. But it's [Indecipherable] note that both of them grew strongly. And we expect them to continue to both grow strongly. But we would expect esoteric to grow at a slightly higher rate in both volume, and the volume obviously is at higher dollars, so maybe a little bit faster in the dollars.

[John Kim, Analyst at BofA Securities]

Got you. And then in terms of pricing, you mentioned that you're expecting mostly flat pricing in 2024. There are no major contract renewals coming up and PAMA has obviously been pushed out. But if I look at the margins between Biopharma and Diagnostics, Biopharma had a pretty strong margin compared to the Diagnostics in the fourth quarter. And you mentioned that there's going to be a slight expansion in Diagnostics. What's going to be the dynamic between the two for the full year 2024? Is the fourth quarter a good jumping off point for the Biopharma margins?

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Yeah. No, I wouldn't use any one quarter for the margins. We expect the margins to actually improve across the business, across both Diagnostics and Biopharma. Diagnostics in the fourth quarter was impacted, to some degree, by the hospital integrations that we're doing, that there were several new ones, and although they're accretive in the first year, they were dilutive in the first couple of months. We expect that to improve as we go into next year. As we go into next year, there's still a COVID overhang in the Diagnostic business, probably about $130 million or so. But even with that, we expect to get some slight margin improvement in that business and overcome that.

[John Kim, Analyst at BofA Securities]

Appreciate it. Thank you.

[Adam H. Schechter, Chairman, President and Chief Executive Officer at Laboratory Co. of America]

Okay, so in closing, I know we're at the end of the hour, I just want to thank everybody for joining us today. I want to thank our team here at Labcorp for their focus and dedication and everything that they do to serve the patients that we all are trying to do the best we can to improve health and to improve lives. And we look forward to sharing more with you as we go through the year. Thank you.

[Operator]

[Operator Closing Remarks]

Participants

Corporate Executives

• Christin O'Donnell, Vice President of Investor Relations
• Adam H. Schechter, Chairman, President and Chief Executive Officer
• Glenn A. Eisenberg, Executive Vice President and Chief Financial Officer

Analysts

• Jack Meehan, Nephron Healthcare Investment Research
• Kevin Caliendo, UBS Investment Bank
• Erin Wright, Morgan Stanley & Co., LLC
• Stephanie Davis, Barclays Bank
• Patrick Donnelly, Citigroup Global Markets
• Brian Tanquilut, Jefferies & Company, Inc.
• Pito Chickering, Deutsche Bank Aktiengesellschaft
• Elizabeth Anderson, Evercore ISI International
• Eric Coldwell, Robert W. Baird & Co., Inc.
• Lisa Gill, J.P. Morgan Securities
• John Kim, BofA Securities