Scott M. Brinker
President and Chief Investment Officer at Healthpeak Properties
Okay. Thank you, Tom. I'll cover operating results then discuss acquisitions and development. Starting with life science results. Virtually, our entire footprint is in the three hot beds of biotech innovation, Boston, San Francisco and San Diego. Over the past four decades, these markets have developed an unmatched ecosystem of academics, capital and scientific talent, placing them at the heart of the biotech revolution that's just getting started. We've purposely chosen to concentrate our resources and build a strong position in these markets, which is driving strong performance. Year-to-date, we signed 2.2 million square feet of leases, which is two times our full year budget from the beginning of the year. The leasing success was broad-based across all three markets and included new developments, renewals and expansions.
In the third quarter, we signed 406,000 square feet of renewals at a 20% cash mark-to-market, that's in line with the current upside across our entire life science rent roll. And of course, the mark-to-market will vary from quarter-to-quarter and year-to-year. Same-store cash NOI growth for the quarter was 6.8%, bringing year-to-date growth to 7.7%. The results were driven by contractual escalators, leasing activity and mark-to-market on renewals. Looking forward, we have a leasing pipeline of nearly 600,000 square feet under signed letters of intent, including new developments, renewals and expansions with existing tenants. Our run rate, annual cash NOI for life science now exceeds $500 million. and is in the $600 million range, including development leases that have been signed but not yet commenced.
Moving to medical office. Leasing activity continues to outperform our expectations. We had 700,000 square feet of commencements in the quarter. Mark-to-market on renewals was 2.3% and retention was strong at 80% for the trailing 12 months, both in line with historical averages. We're seeing strong demand in Nashville, Seattle, Dallas and Denver, all markets where you've seen us grow in recent quarters. Thanks to our cash NOI growth this quarter was 2.9%, toward the high end of our historical range, driven by leasing activity, strong collections and part of the income. We're also benefiting from our green investments to reduce carbon footprint and operating cost. Hospital inpatient and outpatient volumes are strong and hospitals continue to invest in our affiliated properties, benefiting our unique on-campus portfolio.
Finishing with CCRCs. Our concentration in Florida is a long-term positive, but made for a more challenging third quarter as the state was hit hard by the Delta variant. This had a temporary impact on occupancy, especially in assisted living and skilled. Consistent with the national headlines, labor is a headwind. As a result, same-store cash NOI growth was negative 1.7% for the quarter, excluding CARES Act funding. Independent living represents 2/3 of the total unit count at our campuses and demand for those units is strong. The number of entry fee sales in 3Q was nearly back to 2019 levels, and entry free cash receipts in the quarter exceeded historical levels. We have strong pricing power in most of our markets, supported by the housing market. Moving to medical office acquisitions. In September, we acquired two on-campus MOBs in Dallas, affiliated with the Baylor Scott & White system for $60 million.
This was an off-market acquisition and expands our number one medical office market share in Dallas. In October, we acquired an MOB in Seattle for $43 million. The building expands our footprint on the campus of Swedish Medical Center to 600,000 square feet. We see potential to significantly densify the site over time, taking advantage of the land locked location next to one of Seattle's leading hospitals. Also in October, we acquired a 55,000 square foot MOB on the campus of an HA Hospital in New Orleans at $34 million. Once again, this acquisition was done off market. Turning to life science development. Lease up is exceeding our underwriting on both the rate and timing. Our active development pipeline is now 87% pre-leased, excluding Vantage phase one, which commenced yesterday. The final phase of the shore is now 100% pre-leased and the rate on the final lease was 32% higher than the initial lease we signed at the shore just three years ago.
Staying in South San Francisco with very strong leasing activity at our Nexus project nextdoor, we chose to commence development at Vantage. A picture can say a thousand words, so please take a look at the investment deck we published yesterday. On page seven, you'll see that the Vantage campus sits in the heart of South San Francisco, adjacent to our Nexus and Pointe Grand campuses. Phase one will include 343,000 square feet and deliver in the second half of 2023. Upon completion of all phases, the Vantage campus will include at least one million square feet of Class A lab and potentially far more subject to entitlements which are ongoing. Moving to San Diego, where we fully pre-leased our 540,000 square feet of active development. In the third quarter, we secured the next phase of our growth with a covered land play acquisition.
The site sits between our existing Sorrento Gateway and Sorrento Summit campuses, all of which have excellent visibility and accessibility from Interstate 805. Once the site is developed, we'll have 700,000 square feet across these three campuses. In Boston, our 101 Cambridge Park Drive project in Alewife delivered in 4Q 2022 is now 88% pre-leased. The average lease rate is $99 per foot or 27% above our underwriting. This project brings our footprint in the Alewife submarket of West Cambridge to 1.1 million square feet across 18 acres. And that brings us to the series of acquisitions we announced yesterday. In eight separate transactions totaling $625 million of initial investment, we assembled 36 acres of largely contiguous land in the AOA submarket West Cambridge. We now have a significant development opportunity on the East Coast to balance our enormous development pipeline in South San Francisco.
The blended Year one FFO yield is 4.2% with the potential for huge earnings and NAV upside in the future. Roughly 1/4 of the $625 million investment represents stabilized cash flowing acquisitions, the remainder are covered land plays, primarily single-store industrial and flex office that we intend to eventually replace with Class A lab buildings in phases over the next decade plus. We'll be working with the City of Cambridge on the development plan and have more to share in coming quarters. If you turn to page four of yesterday's investment deck, you'll see the assemblages within walking distance to our existing buildings in Alewife. Both sites have commuter access by train, car and bike. In particular, we're within walking distance to the Alewife train station and adjacent to Route two in the Minuteman bike path, all of which connect Cambridge, Downtown Boston and the Western suburbs.
These campus settings are a competitive advantage for leasing because we can provide world-class amenities, infrastructure and flexibility for tenants to grow without relocating. This is very, very different than owning a single lab building in an isolated location. I'll turn it to Pete.