Ilan Daskal
Executive Vice President & Chief Financial Officer at Bio-Rad Laboratories
Thank you, Andy. Now I would like to review the results of the third quarter. Net sales for the third quarter of 2022 were $680.8 million, which is an 8.9% decline on a reported basis versus $747 million in Q3 of 2021. The third quarter decline in revenue was mainly a result of lower COVID related sales this year as well as the receipt of the onetime $32 million settlement for bank royalties from 10 times in the year ago period. On a currency-neutral basis, revenue declined 4.1%. We estimate that COVID-related sales were $17 million in the quarter and continued to reflect an elevated level in demand, particularly in Asia as a result of the ongoing outbreaks in China. Year-over-year core revenue, which excludes COVID-related sales and the 10 times $32 million settlement in the third quarter of 2021 increased 6.1% on a currency neutral basis. On a geographic basis, we experienced currency-neutral year-over-year core revenue growth in Europe and Asia.
Core revenue in the Americas was largely flat as a result of the supply chain constraints that we have been experiencing in the past year. As Andy mentioned earlier, we continue to carry an elevated order backlog as a result of supply chain constraints and continued strong customer demand. We are now seeing higher production volumes and anticipate reductions of order backlog through the remainder of this year. Sales of the Life Science Group in the third quarter of 2022 were $317.9 million compared to $373.5 million in Q3 of 2021, which is a 14.9% decline on a reported basis and an 11% decline on a currency-neutral basis. Excluding last year's 10 times settlement, the Life Science Group sales declined 6.9% on a reported basis and a 2.3% decline on a currency-neutral basis.
Despite supply chain constraints, the underlying Life Science year-over-year currency-neutral core revenue growth was 9.4%. The year-over-year growth was primarily driven by Western loading, qPCR, process media and our antibody products. We continue to see a strong order backlog for ddPCR instruments as we continue to work through the supply chain challenges. I will highlight that ddPCR consumables continue to post strong double-digit growth. During the third quarter, we launched the QX600 ddPCR system as previously communicated. While not material to the third quarter results, the initial market reception for the QX600 has been encouraging, and we are seeing a strong order pipeline building. Process Media, which can fluctuate on a quarterly basis, continues to experience solid year-over-year growth, and we continue to expect strong double-digit growth for the franchise for the full year of 2022.
Excluding Process Media sales and last year's 10 times settlement, the underlying Life Science business declined 4.2% on a currency-neutral basis versus Q3 of 2021 due to lower COVID-related sales. When also excluding COVID-related sales, revenue growth was 9.6% on a currency-neutral basis. On a geographic basis, Life Science experienced currency neutral year-over-year core revenue growth in Europe and Asia and was relatively flat in the Americas. Sales of the Clinical Diagnostics Group in the third quarter were $361.9 million compared to $372.2 million in Q3 of 2021, which is a 2.8% decline on a reported basis and growth of 3% on a currency-neutral basis. Core Clinical Diagnostics year-over-year growth, which excludes COVID-related sales, increased 3.7% on a currency-neutral basis despite headwinds from sporadic lockdowns in China. The Diagnostics Group currency-neutral year-over-year increase was primarily driven by quality control, blood typing and infectious disease products.
And as I mentioned earlier, supply chain constraints had an impact on instrument placements. Despite the supply chain constraints impacting the instrument placements, we experienced increased consumables volume for diagnostics driven by strong recovery in routine testing markets. As such, we believe that we are positioned to benefit from the strong underlying market dynamics in the coming quarters. On a geographic basis, the Diagnostics Group year-over-year currency-neutral core revenue grew in the Americas and Asia and declined in Europe. The reported gross margin for the third quarter of 2022 was 54.9% on a GAAP basis and compares to 58.6% in Q3 of 2021. Recall that in the third quarter of 2021 included $32 million from a legal settlement that benefited gross margin in the year ago period.
The year-over-year gross margin decline was also impacted by significantly higher logistics and material costs, lower COVID sales as well as overall product mix. These headwinds were partially offset by a positive currency neutral due to the strong dollar and continued operational efficiencies achieved through the restructuring efforts. While we have implemented price increases to address inflationary costs, the realized price capture has only been a partial offset due to our instrument backlog situation. Amortization related to prior acquisitions recorded in cost of goods sold was $4.4 million as compared to $4.7 million in Q3 of 2021. SG&A expenses for Q3 of 2022 were $211 million or 31% of sales compared to $216.2 million or 28.9% in Q3 of 2021. The year-over-year SG&A expenses decreased mainly due to the stronger dollar and normalized employee-related benefits but was partially offset by higher discretionary spend. Total amortization expense related to acquisitions recorded in SG&A for the quarter was $1.8 million versus $2.4 million in Q3 of 2021.
Research and Development expense in the third quarter was $69.9 million or 10.3% of sales compared to $64.5 million or 8.6% of sales in Q3 of 2021. The year-over-year R&D expenses increased mainly due to project spend. Q3 operating income was $92.8 million or 13.6% of sales compared to $156.8 million or 21% in Q3 of 2021. Looking below the operating line, the change in fair market value of equity securities holdings which are substantially related to Bio-Rad's ownership of Sartorius AG shares, negatively impacted the reported results by $289 million. During the quarter, interest and other income resulted in net other expense of $13 million compared to net other expense of $3.2 million last year. Q3 of 2022 included about $8 million of interest and foreign currency expense and $5 million of expense related to an investment impairment. The effective tax rate for the third quarter of 2022 was 21.5% compared to 21.8% for the same period in 2021.
The effective tax rate reported in Q3 of 2022 was primarily affected by the unrealized loss in equity securities and the tax rate reported in Q3 of 2021 was primarily affected by an unrealized gain in equity securities. Reported net loss for the third quarter was $164.2 million and the diluted loss per share was $5.52 compared to $3,928 billion of net income and $129.96 per share in Q3 of 2021. This decrease from last year is largely related to changes in the valuation of the Sartorius Holdings. Moving on to the non-GAAP results. Looking at the results on a non-GAAP basis. We have excluded certain artypical and unique items that impacted both the gross and operating margins as well as other income. These items are detailed in the reconciliation table in the press release. Looking at the non-GAAP results for the third quarter.
In cost of goods sold, we have excluded $4.4 million of amortization of purchased intangibles and $1.3 million of restructuring costs. These exclusions moved the gross margin for the third quarter of 2022 to a non-GAAP gross margin of 55.7% versus 57.9% in Q3 of 2021. Non-GAAP SG&A in the third quarter of 2022 was 30% versus 29.6% in Q3 of 2021. In SG&A, on a non-GAAP basis, we have excluded restructuring expense of $2.8 million and in vitro diagnostic registration fee in Europe for previously approved products of $2.2 million, amortization of purchased intangibles of $1.8 million and a small legal related benefit. Non-GAAP R&D expense in the third quarter of 2022 was 10.2% versus 9% in Q3 of 2021. In R&D, on a non-GAAP basis, we have excluded $500,000 of restructuring costs. The cumulative sum of these non-GAAP adjustments result in moving the quarterly operating margin from 13.6% on a GAAP basis to 15.5% on a non-GAAP basis.
This non-GAAP operating margin compares to a non-GAAP operating margin of 19.4% in Q3 of 2021. We have also excluded certain items below the operating line, which are the decreasing value of Sartorius equity securities and loan receivable holdings of $289 million and a $6.6 million loss associated with venture investments. The non-GAAP effective tax rate for the third quarter of 2022 was 21.6% compared to 18% for the same period in 2021. The higher rate in 2022 was driven by geographical mix of earnings as well as a decrease in compensation-related tax deductions. And finally, non-GAAP net income for the third quarter of 2022 was $77.9 million or $2.60 diluted earnings per share compared to $112.2 million and $3.71 per share in Q3 of 2021.
Moving on to the balance sheet. Total cash and short-term investments at the end of Q3 were $1.856 billion compared to $1.973 billion at the end of Q2 of 2022. Inventory at the end of Q3 reached $685.9 million from $657.1 million in the prior quarter. The increase was the result of the ongoing supply chain constraints. For the third quarter of 2022, net cash generated from operating activities was $7.5 million, which compares to $230.4 million in Q3 of 2021. These lower quarterly operating cash flow mainly reflects the changes in the operating results and in working capital. During the third quarter, we completed the acquisition of Curiosity Diagnostics for a total consideration of up to $170 million, consisting of approximately $100 million in cash and up to $70 million in future milestones. During the third quarter, we did not purchase any shares of our stock.
The adjusted EBITDA for the third quarter of 2022 was $132.3 million or 19.4% of sales. The adjusted EBITDA in Q3 of 2021 was $165.1 million or 23.1% of sales. Net capital expenditures for the third quarter of 2022 were $24.1 million, and depreciation and amortization was $32.7 million. Moving on to the non-GAAP guidance. Taking into account the strong customer demand, we maintain the full year currency-neutral revenue growth outlook to be at the high end of our guidance range of 1% to 2%. Based on the stronger-than-anticipated COVID sales contribution year-to-date, we now assume full year COVID-related sales of about $105 million. Core revenue growth, which excludes COVID-related sales and the prior year legal settlement for bank royalties is now expected to be about 8%.
We anticipate full year core growth for the Life Science group to be about 15% and the Diagnostics group to be approximately 3%. As a result of the ongoing supply chain constraints, we now anticipate a full year gross margin projection to be about 57% versus our prior guidance of 57.5%. Operating income margin guidance remains at about 19% as we manage our operating expense plan for the remainder of this year. We now project an adjusted EBITDA at the low end of our prior guidance range of 24% and 24.3%. We continue to execute on our overall capital allocation model, which includes [13] acquisitions such as Curiosity, and we will continue to be opportunistic with share buybacks.
I'll now turn over the call to Norman to make a few comments regarding our capital allocation strategy. Norman?