Wetteny Joseph
Chief Financial Officer at Zoetis
Thank you, Kristin, and good morning, everyone. We had a solid start to the year with growth driven by our livestock business and strong international market performance. Echoing Kristin's comments, our Q1 results are in-line with our expectations. As we indicated on our Q4 earnings call, we expected the first quarter to be below the low-end of our forecasted annual operational growth rate of 6% for 2023. In the first quarter, we generated revenue of $2 billion growing 1% on a reported basis and 4% on an operational basis. Adjusted net income of $607 million declined 3% on both a reported and an operational basis. Of the 4% operational revenue growth, 5% is from price with a 1% decline in volume. The volume decline is driven primarily by US Companion Animal distributor destocking in the quarter. Our livestock portfolio led the way in terms of species growth growing 12% operationally with companion animal revenues flat on an operational basis in the quarter. Livestock growth was broad based with double-digit operational growth across cattle, poultry, sheep and fish.
The growth in cattle was driven by additional supply of key products in the US. We saw growth in our poultry portfolio driven by higher sales of vaccines. Our sheep products benefited from favorable market conditions in Australia as well as our acquisition of Jurox in the fourth quarter of 2022. Finally, our fish portfolio continues to perform well with double-digit operational growth driven by strong vaccine performance in Norway. Sales of our Companion Animal products were flat operationally in the quarter with growth in our monoclonal antibody products Cytopoint, Librela and Solensia offsetting declines in Apoquel, parasiticides and anti-infectives. Our monoclonal bodies for osteoarthritis pain in dogs and cats, Librela and Solensia, posted $51 million in revenue globally in the quarter, with strong demand for both products. Additionally Solensia benefited from our US launch in the third quarter last year. As for Librela in the US, we still anticipate approval in the first half of this year with the launch later in the second-half. Simparica Trio posted global revenue of $151 million in the quarter, representing an operational decline of 7% versus the comparable 2022 period. This was primarily the result of US distributor destocking during the quarter as well as pre-price increase buying and promotional activity during the fourth quarter. This decline was partially offset by growth in our International markets from increased clinic penetration and launches in new markets. Our key dermatology portfolio declined 3% operationally with $290 million in global revenue. This decline is attributed to the impact of pre-price increased buy-ins in the US in Q4 and in Japan in the comparable period in 2022.
Cytopoint partially offset this decline with double-digit growth based on continuing to veterinary preference for injectables, which keep revenues in the clinic. Cytopoint better reflects underlying market demand due to our direct sales model on our dermatology portfolio and the lack of retail channel impacts. While we do believe conversion from Apoquel to Cytopoint maybe accelerating, our overall outlook for our key dermatology portfolio remains unchanged. Our Companion Animal Diagnostics portfolio declined 3% operationally. The declines in the US, partially offset by growth internationally.
Now moving on to revenue growth by segment for the quarter. US revenue was $1 billion in the quarter declining 1%, with Companion Animal Products declining 7% and livestock sales growing 15%. Companion Animal performance in the quarter is reflective of the expectations we set-in the prior quarter and is the result of distributor inventory and promotional impacts. As Kristin mentioned, demand for the veterinary market as demonstrated by distributor sales to clinics is healthy and growing. We continue to see robust sales outgrowth across our Companion Animal portfolio, including strong growth in parasiticides and our key dermatology products and our outlook for the full year remains unchanged. US vet practice trends are improving, where clinic visits up 2% in the quarter and clinic revenue growth of 11%. Average revenue per visit is up 9%. These trends are slightly better than we expected and largely reflect the normalization of the COVID impact on vet clinic visits. Total visits in the quarter remain above pre-pandemic levels and clinic revenues have grown on average of 10% annually over that period. Spend per visit remained elevated as the standard of care continues to increase.
Turning to product performance, the Companion Animal decline in the US was driven largely by a decrease in sales of our parasiticides portfolio as well as key dermatology products. Simparica Trio posted sales of $127 million in the quarter, declining 13%, driven by distributor destocking, partially offset by growth in-patient share where we continue to outpace the over the all flea, tick and heartworm market. Our outlook for Trio remains unchanged as we continue to see strong customer demand and continue conversion from topicals and collars.
Key dermatology product sales were $184 million for the quarter, declining 5%. Apoquel sales were negatively impacted by high sales in Q4 ahead of our 2023 price increases and significant retail buy-in in Q1 2022. Cytopoint sales growth partially offset the Apoquel decline due largely to its injectable administration, which is preferred by clinics. The US Companion Animal decline was partially offset by growth in sales of Solensia, which launched in the third quarter. We continue to see solid clinic penetration growth in Solensia and effect to drive awareness a feline way through our DTC advertising campaigns. US livestock grew 15% in the quarter, primarily resulting from our cattle business where we have improved several supply outages, which impacted our revenues throughout 2022 and replenished our channel partner inventories. While we will continue to see benefit from improved supply the replenishment impact is largely isolated to this quarter. We also saw growth in Sinovac's due to expanded label claims. Our poultry business also contributed to growth driven by expanded sales of vaccines.
Moving onto our International segment where revenue grew 3% on a reported basis and 10% operationally in the quarter with Companion Animal and livestock revenue both growing 10%. Increased sales of Companion Animal products resulted from our monoclonal antibodies for alleviation of osteoarthritis pain, small animal parasiticides as well as the impact of our Jurox acquisition which was completed in the fourth quarter of last year. We continue to be encouraged by the performance of Librela and Solensia. Librela generated $34 million or 74% operational growth, driven by strong underlying demand and the removal of supply allocations that were in-place for the first half of 2022. Solensia delivered $9 million in the first quarter sales Internationally, driven by stronger demand. Simparica Trio was the top contributor to growth for our International small animal parasiticides with $24 million in revenue where in 47% operationally due to expanding market share in the flea, tick and heartworm space. Our International key dermatology portfolio was flat operationally in the quarter. We saw double digit operational growth across most of our major markets, driven by higher compliance and new patients. However, this growth was offset by large pre-priced buy ups of Apoquel in Japan in 1Q22.
Our International livestock segment also grew 10% operationally in the quarter with growth in four of our five core species. Growth was driven by our cattle portfolio which benefited from price increases in certain emerging markets. Our sheep business had an exceptional quarter with high demand in Australia due to favorable market conditions as well as the impact of our Jurox acquisition. Poultry also contributed to growth in the quarter with higher key account penetration in the Middle East and Eastern Europe as well as the benefit of price. And lastly, our fish portfolio continues to perform well, driven by growth in salmon vaccines in Norway. Swine was flat for the quarter with strong sales in China partially offset by intermittent supply constraints in some markets.
Now moving on to the rest of the P&L for the quarter. Adjusted gross margins of 70.8% declined 80 basis points on a reported basis compared to the prior year resulting from higher manufacturing costs and our favorable product mix. This was partially offset by favorable foreign exchange and price increases. Adjusted operating expenses increased 12% operationally with SG&A growth of 11% operationally, driven by headcount-related compensation costs as a result of our US small animal field force expansion, which largely began in Q2 of 2022 and higher T&E. R&D grew 19% on an operational basis, driven by higher project spend for our pipeline candidates. Advancing projects include disruptive novel innovation and lifecycle management. R&D remains our first priority in capital allocation.
Other income and deductions in the quarter are reflective of a favorable benefit associated with a settlement in the current period for prior period underpaid royalties related to sales of certain products. The adjusted effective tax rate for the quarter was 20.5%, an increase of 160 basis points driven by lower net discrete tax benefits in the quarter and less favorable jurisdictional mix of earnings, partially offset by higher benefit in the US related to foreign-derived intangible income. And finally, adjusted net income declined 3% operationally and adjusted diluted EPS declined 1% operationally for the quarter. Capital expenditures in the first quarter were $223 million. We are still anticipating a significant increase in capital expenditures for the full year 2023. We continue to make investments to support our future growth including manufacturing capacity for our monoclonal antibodies as well as for solid dosage.
In the quarter, we repurchased $283 million of Zoetis shares and grew our dividend over 15% versus 1Q22. Now moving on to guidance for the full year 2023, as we have mentioned, the first quarter has gone largely as we expected. We are therefore reaffirming our 2023 guidance provided during February's earnings call. Note that guidance reflects foreign exchange rates as of late April. Foreign exchange rates have been volatile over the quarter. We will continue to monitor the impact of this volatility going forward. For the year, we continue to expect revenue between $8.575 and $8.725 5 billion, representing a range of 6% to 8% operational growth. We also continue to expect adjusted net income to be in the range of $2.49 to $2.54 billion, representing operational growth of 7% to 9%. And finally, we expected this adjusted diluted EPS to be in the range of $5.34 to $5.44 and reported diluted EPS to be in the range of $5.003 to $5.014, both consistent with our February guidance.
Just to summarize before we go to Q&A, we remain confident in our ability to deliver on our full year guidance commitments and expect more normalized growth in subsequent quarters. We continue to see positive trends and solid fundamentals in the underlying demand and are confident that our innovative portfolio will continue to allow us to grow in-line with or faster than the market. Now, I'll hand things over to the operator to open the line for your questions. Operator?