Agenus (AGEN) Competitors $4.38 -0.17 (-3.74%) Closing price 09/19/2025 04:00 PM EasternExtended Trading$4.38 0.00 (0.00%) As of 09/19/2025 06:57 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock AGEN vs. XOMA, EBS, LXRX, VNDA, CBIO, CDXS, IRWD, ACHV, SGMO, and FBIOShould you be buying Agenus stock or one of its competitors? The main competitors of Agenus include XOMA Royalty (XOMA), Emergent Biosolutions (EBS), Lexicon Pharmaceuticals (LXRX), Vanda Pharmaceuticals (VNDA), Crescent Biopharma (CBIO), Codexis (CDXS), Ironwood Pharmaceuticals (IRWD), Achieve Life Sciences (ACHV), Sangamo Therapeutics (SGMO), and Fortress Biotech (FBIO). These companies are all part of the "biotechnology" industry. Agenus vs. Its Competitors XOMA Royalty Emergent Biosolutions Lexicon Pharmaceuticals Vanda Pharmaceuticals Crescent Biopharma Codexis Ironwood Pharmaceuticals Achieve Life Sciences Sangamo Therapeutics Fortress Biotech XOMA Royalty (NASDAQ:XOMA) and Agenus (NASDAQ:AGEN) are both small-cap medical companies, but which is the superior business? We will contrast the two businesses based on the strength of their profitability, risk, earnings, dividends, valuation, analyst recommendations, institutional ownership and media sentiment. Does the media favor XOMA or AGEN? In the previous week, XOMA Royalty had 6 more articles in the media than Agenus. MarketBeat recorded 6 mentions for XOMA Royalty and 0 mentions for Agenus. XOMA Royalty's average media sentiment score of 0.61 beat Agenus' score of 0.00 indicating that XOMA Royalty is being referred to more favorably in the media. Company Overall Sentiment XOMA Royalty Positive Agenus Neutral Is XOMA or AGEN more profitable? XOMA Royalty has a net margin of -27.57% compared to Agenus' net margin of -167.52%. XOMA Royalty's return on equity of 2.63% beat Agenus' return on equity.Company Net Margins Return on Equity Return on Assets XOMA Royalty-27.57% 2.63% 0.97% Agenus -167.52%N/A -81.04% Which has more risk and volatility, XOMA or AGEN? XOMA Royalty has a beta of 0.99, meaning that its stock price is 1% less volatile than the S&P 500. Comparatively, Agenus has a beta of 1.44, meaning that its stock price is 44% more volatile than the S&P 500. Do analysts prefer XOMA or AGEN? XOMA Royalty presently has a consensus target price of $69.50, indicating a potential upside of 89.37%. Agenus has a consensus target price of $14.50, indicating a potential upside of 231.05%. Given Agenus' higher possible upside, analysts clearly believe Agenus is more favorable than XOMA Royalty.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score XOMA Royalty 0 Sell rating(s) 0 Hold rating(s) 2 Buy rating(s) 1 Strong Buy rating(s) 3.33Agenus 0 Sell rating(s) 2 Hold rating(s) 2 Buy rating(s) 0 Strong Buy rating(s) 2.50 Do insiders & institutionals hold more shares of XOMA or AGEN? 95.9% of XOMA Royalty shares are held by institutional investors. Comparatively, 61.5% of Agenus shares are held by institutional investors. 9.1% of XOMA Royalty shares are held by company insiders. Comparatively, 5.5% of Agenus shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth. Which has stronger valuation and earnings, XOMA or AGEN? XOMA Royalty has higher earnings, but lower revenue than Agenus. XOMA Royalty is trading at a lower price-to-earnings ratio than Agenus, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioXOMA Royalty$28.49M15.57-$13.82M-$1.55-23.68Agenus$103.46M1.35-$227.21M-$7.15-0.61 SummaryXOMA Royalty beats Agenus on 12 of the 16 factors compared between the two stocks. Get Agenus News Delivered to You Automatically Sign up to receive the latest news and ratings for AGEN and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding AGEN and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart AGEN vs. The Competition Export to ExcelMetricAgenusMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$144.98M$3.15B$5.80B$10.40BDividend YieldN/A2.37%5.63%4.60%P/E Ratio-0.6121.0580.5826.78Price / Sales1.35448.41534.22123.54Price / CashN/A46.6037.9961.55Price / Book-0.349.6615.776.40Net Income-$227.21M-$53.22M$3.30B$271.80M7 Day Performance-2.23%3.11%5.36%3.48%1 Month Performance-2.88%7.56%8.10%9.90%1 Year Performance-25.00%11.15%81.36%28.44% Agenus Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)AGENAgenus3.7799 of 5 stars$4.38-3.7%$14.50+231.1%-26.9%$144.98M$103.46M-0.61440XOMAXOMA Royalty4.162 of 5 stars$37.86+1.2%$69.50+83.6%+22.9%$457.73M$28.49M-24.4310EBSEmergent Biosolutions4.6916 of 5 stars$7.98-2.0%$13.50+69.2%+17.7%$425.74M$812.50M3.262,420LXRXLexicon Pharmaceuticals2.3116 of 5 stars$1.12-2.6%$3.23+187.9%-29.6%$407.01M$58.43M-3.39140VNDAVanda Pharmaceuticals4.1389 of 5 stars$4.38-2.9%$16.50+276.7%-3.4%$258.81M$203.47M-3.88290Positive NewsCBIOCrescent Biopharma4.0996 of 5 stars$12.22-2.2%$25.60+109.5%N/A$238.90M$10K-0.3550Gap UpCDXSCodexis2.8665 of 5 stars$2.44+0.4%$11.00+350.8%-23.7%$220.26M$59.35M-2.94250IRWDIronwood Pharmaceuticals4.2858 of 5 stars$1.28-2.3%$4.94+285.9%-68.7%$207.91M$351.41M-25.59220Positive NewsACHVAchieve Life Sciences2.496 of 5 stars$3.04-1.3%$14.67+382.5%-37.8%$155.34MN/A-2.0820Short Interest ↑SGMOSangamo Therapeutics2.9395 of 5 stars$0.50-0.9%$4.50+799.5%-39.3%$150.95M$57.80M-1.73480Positive NewsFBIOFortress Biotech2.7042 of 5 stars$3.55-8.7%$16.50+364.8%+99.5%$105.63M$59.30M-3.38170News CoveragePositive NewsAnalyst UpgradeHigh Trading Volume Related Companies and Tools Related Companies XOMA Royalty Alternatives Emergent Biosolutions Alternatives Lexicon Pharmaceuticals Alternatives Vanda Pharmaceuticals Alternatives Crescent Biopharma Alternatives Codexis Alternatives Ironwood Pharmaceuticals Alternatives Achieve Life Sciences Alternatives Sangamo Therapeutics Alternatives Fortress Biotech Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:AGEN) was last updated on 9/20/2025 by MarketBeat.com Staff From Our PartnersNvidia CEO Makes First Ever Tesla AnnouncementWhile headlines focus on Tesla’s car sales, tech analyst Jeff Brown says the real story is Tesla’s role in a $...Brownstone Research | SponsoredStunning new initiative unfolding in the White House?what I just learned about what’s unfolding in the White House is truly stunning… And you need to see it for...Paradigm Press | SponsoredIRS Wants Another Check on Sept 15th—What If You Could Keep It Instead?On September 15th, the IRS collects another round of quarterly tax payments—targeting self-employed profession...American Alternative | SponsoredAn $8 trillion-dollar discovery 17,000 ft underwater A strange rock pulled from the ocean floor may hold the key to a $16 trillion resource boom. 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