| 11/16/2024 | Geode Capital Management LLC | 56,597 | $905K | 0.0% | +68.7% | 0.050% | |
| 11/15/2024 | XTX Topco Ltd | 10,174 | $163K | 0.0% | -37.9% | 0.009% | |
| 11/15/2024 | Jane Street Group LLC | 177,260 | $2.83M | 0.0% | N/A | 0.156% | |
| 11/15/2024 | Wellington Management Group LLP | 100,613 | $1.61M | 0.0% | N/A | 0.089% | |
| 11/15/2024 | State Street Corp | 48,592 | $777K | 0.0% | N/A | 0.043% | |
| 11/15/2024 | RTW Investments LP | 50,000 | $800K | 0.0% | N/A | 0.044% | |
|
| 11/15/2024 | Point72 Asset Management L.P. | 2,715,663 | $43.42M | 0.1% | +54.1% | 2.397% | |
| 11/15/2024 | Janus Henderson Group PLC | 1,294,864 | $20.70M | 0.0% | N/A | 1.143% | |
| 11/15/2024 | HighVista Strategies LLC | 46,116 | $737K | 0.3% | N/A | 0.041% | |
| 11/15/2024 | Baker BROS. Advisors LP | 1,227,178 | $19.62M | 0.2% | +123.4% | 1.083% | |
| 11/14/2024 | PFM Health Sciences LP | 269,158 | $4.30M | 0.2% | -57.7% | 0.238% | |
| 11/14/2024 | Fred Alger Management LLC | 177,553 | $2.84M | 0.0% | +1,515.1% | 0.157% | |
| 11/14/2024 | Walleye Capital LLC | 11,721 | $187K | 0.0% | N/A | 0.010% | |
| 11/14/2024 | Suvretta Capital Management LLC | 70,000 | $1.12M | 0.0% | N/A | 0.062% | |
| 11/14/2024 | Ally Bridge Group NY LLC | 309,614 | $4.95M | 2.7% | N/A | 0.273% | |
| 11/13/2024 | FMR LLC | 2,916,494 | $46.64M | 0.0% | +4.6% | 2.574% | |
| 11/13/2024 | The Manufacturers Life Insurance Company | 264,969 | $4.24M | 0.0% | +88.1% | 0.234% | |
| 11/5/2024 | GSA Capital Partners LLP | 93,658 | $1.50M | 0.1% | +66.1% | 0.083% | |
| 11/1/2024 | Atria Investments Inc | 17,134 | $274K | 0.0% | +7.0% | 0.015% | |
| 10/25/2024 | China Universal Asset Management Co. Ltd. | 13,593 | $217K | 0.0% | +99.7% | 0.014% | |
| 10/23/2024 | Mirae Asset Global Investments Co. Ltd. | 2,556 | $40K | 0.0% | +47.7% | 0.003% | |
| 10/17/2024 | Harbour Capital Advisors LLC | 16,675 | $259K | 0.1% | N/A | 0.017% | |
| 10/7/2024 | GAMMA Investing LLC | 2,972 | $48K | 0.0% | +103.1% | 0.003% | |
| 9/16/2024 | Cubist Systematic Strategies LLC | 26,073 | $235K | 0.0% | -64.1% | 0.026% | |
| 8/20/2024 | Nantahala Capital Management LLC | 450,000 | $4.06M | 0.2% | N/A | 0.448% | |
| 8/19/2024 | Point72 Asset Management L.P. | 1,762,004 | $15.91M | 0.0% | -22.0% | 1.754% | |
| 8/16/2024 | Perceptive Advisors LLC | 3,933,307 | $35.52M | 0.8% | +27.6% | 3.914% | |
| 8/16/2024 | Quarry LP | 9,608 | $87K | 0.0% | +47.8% | 0.010% | |
| 8/16/2024 | Driehaus Capital Management LLC | 2,092,011 | $18.89M | 0.2% | +89.5% | 2.082% | |
| 8/15/2024 | The Manufacturers Life Insurance Company | 140,894 | $1.27M | 0.0% | +30.4% | 0.140% | |
| 8/15/2024 | Affinity Asset Advisors LLC | 1,135,702 | $10.26M | 1.2% | +36.7% | 1.130% | |
| 8/14/2024 | Fred Alger Management LLC | 10,993 | $99K | 0.0% | N/A | 0.011% | |
| 8/14/2024 | Sandia Investment Management LP | 10,000 | $90K | 0.1% | N/A | 0.010% | |
| 8/14/2024 | Cubist Systematic Strategies LLC | 26,073 | $235K | 0.0% | -64.1% | 0.026% | |
| 8/14/2024 | First Light Asset Management LLC | 4,780,560 | $43.17M | 3.8% | +59.2% | 4.758% | |
| 8/14/2024 | Marshall Wace LLP | 224,948 | $2.03M | 0.0% | -2.9% | 0.224% | |
| 8/14/2024 | Farallon Capital Management LLC | 1,996,000 | $18.02M | 0.1% | +438.0% | 1.986% | |
| 8/12/2024 | XTX Topco Ltd | 16,385 | $148K | 0.0% | N/A | 0.016% | |
| 8/9/2024 | Renaissance Technologies LLC | 173,700 | $1.57M | 0.0% | -20.6% | 0.173% | |
| 8/8/2024 | American Century Companies Inc. | 935,151 | $8.44M | 0.0% | +1.3% | 0.931% | |
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| 8/3/2024 | TD Asset Management Inc | 321,168 | $2.90M | 0.0% | +40.5% | 0.320% | |
| 7/29/2024 | HighMark Wealth Management LLC | 93,000 | $840K | 0.5% | N/A | 0.093% | |
| 5/30/2024 | Lynx1 Capital Management LP | 17,400 | $197K | 0.1% | N/A | 0.017% | |
| 5/24/2024 | Farallon Capital Management LLC | 371,000 | $4.19M | 0.0% | N/A | 0.369% | |
| 5/17/2024 | Artal Group S.A. | 1,412,500 | $15.96M | 0.4% | +39.5% | 1.250% | |
| 5/15/2024 | First Light Asset Management LLC | 3,002,045 | $33.92M | 2.6% | N/A | 2.980% | |
| 5/15/2024 | Price T Rowe Associates Inc. MD | 2,958,079 | $33.43M | 0.0% | +16.5% | 2.936% | |
| 5/15/2024 | Affinity Asset Advisors LLC | 830,546 | $9.39M | 1.2% | +4.4% | 0.824% | |
| 5/14/2024 | EntryPoint Capital LLC | 9,636 | $109K | 0.1% | N/A | 0.010% | |
| 5/14/2024 | Platinum Investment Management Ltd. | 485,174 | $5.48M | 0.2% | +27.3% | 0.482% | |
| 5/10/2024 | Acadian Asset Management LLC | 29,409 | $330K | 0.0% | N/A | 0.029% | |
| 4/29/2024 | China Universal Asset Management Co. Ltd. | 10,817 | $122K | 0.0% | +69.2% | 0.011% | |
| 2/20/2024 | Quarry LP | 6,000 | $48K | 0.0% | N/A | 0.006% | |
| 2/15/2024 | Octagon Capital Advisors LP | 2,060,100 | $16.40M | 2.6% | +333.2% | 2.110% | |
| 2/15/2024 | BVF Inc. IL | 8,774,570 | $69.85M | 1.8% | -3.6% | 8.988% | |
| 2/14/2024 | Kynam Capital Management LP | 442,704 | $3.52M | 0.4% | -39.4% | 0.453% | |
| 2/14/2024 | Platinum Investment Management Ltd. | 381,083 | $3.03M | 0.1% | +12.9% | 0.390% | |
| 2/13/2024 | Affinity Asset Advisors LLC | 795,729 | $6.33M | 1.2% | -21.8% | 0.815% | |
| 2/9/2024 | Franklin Resources Inc. | 1,115,817 | $8.88M | 0.0% | +34.1% | 1.143% | |
| 2/9/2024 | Trexquant Investment LP | 14,354 | $114K | 0.0% | N/A | 0.015% | |
| 2/7/2024 | Jump Financial LLC | 14,300 | $114K | 0.0% | N/A | 0.015% | |
| 1/24/2024 | China Universal Asset Management Co. Ltd. | 6,394 | $51K | 0.0% | +371.2% | 0.007% | |
| 11/15/2023 | Kynam Capital Management LP | 730,472 | $4.73M | 0.8% | +0.2% | 0.768% | |
| 11/15/2023 | Acuta Capital Partners LLC | 323,349 | $2.09M | 1.4% | N/A | 0.340% | |
| 11/15/2023 | Adage Capital Partners GP L.L.C. | 2,830,500 | $18.31M | 0.0% | +25.8% | 2.974% | |
| 11/15/2023 | Affinity Asset Advisors LLC | 1,018,091 | $6.59M | 1.9% | +13.0% | 1.045% | |
| 11/13/2023 | Rathbones Group PLC | 31,300 | $203K | 0.0% | N/A | 0.032% | |
| 11/3/2023 | Platinum Investment Management Ltd. | 337,544 | $2.18M | 0.1% | +96.7% | 0.347% | |
| 10/27/2023 | TD Asset Management Inc | 186,310 | $1.21M | 0.0% | +127.1% | 0.191% | |
| 8/21/2023 | Affinity Asset Advisors LLC | 900,723 | $5.58M | 1.9% | +31.7% | 0.947% | |
| 8/11/2023 | Platinum Investment Management Ltd. | 171,625 | $1.06M | 0.0% | N/A | 0.180% | |
| 8/3/2023 | Tanager Wealth Management LLP | 696,096 | $4.31M | 0.9% | -5.6% | 0.728% | |
| 5/16/2023 | BVF Inc. IL | 9,423,215 | $36.28M | 1.3% | +36.7% | 9.961% | |
| 5/15/2023 | Affinity Asset Advisors LLC | 684,127 | $2.63M | 0.9% | +48.6% | 0.723% | |
| 5/15/2023 | EcoR1 Capital LLC | 5,618,779 | $21.63M | 0.7% | +7.4% | 5.939% | |
| 5/15/2023 | Sio Capital Management LLC | 347,869 | $1.34M | 0.7% | N/A | 0.368% | |
| 4/18/2023 | Tanager Wealth Management LLP | 737,059 | $2.84M | 0.7% | -60.8% | 0.779% | |
| 2/14/2023 | EcoR1 Capital LLC | 5,232,279 | $16.22M | 0.5% | +61.7% | 5.531% | |
| 1/27/2023 | Tanager Wealth Management LLP | 1,878,383 | $5.82M | 1.6% | N/A | 1.986% | |
| 11/15/2022 | Kynam Capital Management LP | 731,521 | $2.94M | 0.6% | -3.5% | 0.775% | |
| 11/15/2022 | EcoR1 Capital LLC | 3,236,352 | $13.01M | 0.4% | +1,007.1% | 3.431% | |
| 11/15/2022 | Ensign Peak Advisors Inc | 248,228 | $998K | 0.0% | +101.7% | 0.263% | |
| 11/14/2022 | Cormorant Asset Management LP | 1,972,728 | $7.93M | 0.6% | -32.6% | 2.091% | |
| 11/14/2022 | Point72 Asset Management L.P. | 117,800 | $474K | 0.0% | -11.8% | 0.125% | |
| 8/16/2022 | Woodline Partners LP | 1,314,652 | $6.40M | 0.1% | +48.9% | 1.398% | |
| 8/12/2022 | Ensign Peak Advisors Inc | 123,071 | $599K | 0.0% | -61.1% | 0.131% | |
| 8/12/2022 | Franklin Resources Inc. | 832,932 | $4.06M | 0.0% | +35.0% | 0.886% | |
| 8/11/2022 | Alps Advisors Inc. | 55,785 | $272K | 0.0% | N/A | 0.059% | |
| 8/4/2022 | TD Asset Management Inc. | 82,055 | $400K | 0.0% | +146.8% | 0.087% | |
| 7/26/2022 | Mirae Asset Global Investments Co. Ltd. | 57,342 | $703K | 0.0% | N/A | 0.061% | |
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| 5/13/2022 | Kynam Capital Management LP | 669,100 | $6.00M | 1.9% | +179.9% | 0.712% | |
| 5/4/2022 | OUP Management Co. LLC | 2,937,615 | $26.35M | 20.1% | +25.4% | 3.124% | |
| 2/19/2022 | Woodline Partners LP | 801,136 | $9.02M | 0.1% | -9.3% | 0.891% | |
| 2/15/2022 | Samsara BioCapital LLC | 1,459,693 | $16.44M | 3.2% | -5.1% | 1.624% | |
| 2/14/2022 | Virtus ETF Advisers LLC | 14,798 | $167K | 0.1% | N/A | 0.016% | |
| 2/14/2022 | Boxer Capital LLC | 1,251,137 | $14.09M | 0.5% | -6.2% | 1.392% | |
| 2/14/2022 | Point72 Asset Management L.P. | 1,097,908 | $12.36M | 0.0% | +263.3% | 1.221% | |
| 2/14/2022 | Deep Track Capital LP | 400,000 | $4.50M | 0.3% | N/A | 0.445% | |
| 2/14/2022 | Affinity Asset Advisors LLC | 419,144 | $4.72M | 1.7% | +106.3% | 0.466% | |
| 2/11/2022 | Ensign Peak Advisors Inc | 343,292 | $3.87M | 0.0% | +19.9% | 0.382% | |
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