Caribou Biosciences (CRBU) Stock Price, News & Analysis

Company Overview

Caribou Biosciences, Inc. is a clinical-stage biopharmaceutical company that leverages its proprietary CRISPR-Cas gene-editing platform to develop transformative cell therapies and in vivo treatments for a range of cancers and genetic diseases. The company’s core technology enables precise modification of cellular genomes, allowing the design of engineered T-cell and NK-cell therapies aimed at improving safety, efficacy and persistence in patients with hematologic and solid tumor malignancies. Alongside its oncology portfolio, Caribou is advancing in vivo editing programs targeting monogenic disorders, with initiatives in areas such as Duchenne muscular dystrophy and familial amyloidosis.

Established in 2011 and headquartered in Berkeley, California, Caribou Biosciences was co-founded by Nobel laureate Jennifer Doudna, one of the pioneers of CRISPR gene-editing technology. The company holds licenses to foundational CRISPR intellectual property from the University of California, enabling continuous innovation in genome engineering. Since completing its initial public offering in August 2021, Caribou has focused on progressing its clinical pipeline and expanding manufacturing capabilities to support its growing roster of investigational therapies.

Caribou’s leadership team combines deep expertise in molecular biology, clinical development and manufacturing scale-up, supported by an advisory board that includes leading figures in biotechnology and medicine. The company has established strategic collaborations with pharmaceutical and academic partners to advance its research programs and accelerate clinical translation. Caribou continues to conduct trials across multiple regions, aiming to bring its next-generation cell therapies and in vivo gene-editing treatments to patients worldwide.

Key Stats

• Today's Range: $1.81 to $1.90
• 50-Day Range: $1.25 to $2.48
• 52-Week Range: $0.66 to $3.00
• Volume: 475,819 shs
• Average Volume: 810,433 shs
• Market Capitalization: $174.13 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $6.67
• Consensus Rating: Buy

Caribou Biosciences Stock Analysis - MarketRank™

Caribou Biosciences scored higher than 43% of companies evaluated by MarketBeat, and ranked 698th out of 932 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.5 / 5
• Analyst Rating: Buy

Consensus Rating

Caribou Biosciences has received a consensus rating of Buy. The company's average rating score is 3.00, and is based on 3 buy ratings, no hold ratings, and no sell ratings.

Upside Potential

Caribou Biosciences has a consensus price target of $6.67, representing about 256.5% upside from its current price of $1.87.

Amount of Analyst Coverage

Caribou Biosciences has received no research coverage in the past 90 days.

Earnings and Valuation

• Score: 0.6 / 5
• Proj. Earnings Growth: Decreasing

Earnings Growth

Earnings for Caribou Biosciences are expected to decrease in the coming year, from ($1.64) to ($1.78) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Caribou Biosciences is -1.05, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Caribou Biosciences is -1.05, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Caribou Biosciences has a P/B Ratio of 0.67. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities.

Short Interest

• Score: 4.0 / 5
• Short Interest Level: Healthy

Percentage of Shares Shorted

4.75% of the float of Caribou Biosciences has been sold short.

Short Interest Ratio / Days to Cover

Caribou Biosciences has a short interest ratio ("days to cover") of 2.5, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Caribou Biosciences has recently decreased by 0.26%, indicating that investor sentiment is improving.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Caribou Biosciences does not currently pay a dividend.

Dividend Growth

Caribou Biosciences does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

4.75% of the float of Caribou Biosciences has been sold short.

Short Interest Ratio / Days to Cover

Caribou Biosciences has a short interest ratio ("days to cover") of 2.5, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Caribou Biosciences has recently decreased by 0.26%, indicating that investor sentiment is improving.

News and Social Media

• Score: 0.0 / 5
• News Sentiment: N/A

Search Interest

Only 2 people have searched for CRBU on MarketBeat in the last 30 days. This is a decrease of -80% compared to the previous 30 days.

MarketBeat Follows

Only 2 people have added Caribou Biosciences to their MarketBeat watchlist in the last 30 days. This is a decrease of 0% compared to the previous 30 days.

Company Ownership

• Score: 1.7 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Caribou Biosciences insiders have not sold or bought any company stock.

Percentage Held by Insiders

Only 8.28% of the stock of Caribou Biosciences is held by insiders.

Percentage Held by Institutions

77.51% of the stock of Caribou Biosciences is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

CRBU Stock Analysis - Frequently Asked Questions

How have CRBU shares performed this year?

Caribou Biosciences' stock was trading at $1.59 at the beginning of the year. Since then, CRBU shares have increased by 17.6% and is now trading at $1.87.

How were Caribou Biosciences' earnings last quarter?

Caribou Biosciences, Inc. (NASDAQ:CRBU) released its quarterly earnings data on Tuesday, August, 12th. The company reported ($0.35) EPS for the quarter, topping analysts' consensus estimates of ($0.40) by $0.05. The company earned $2.67 million during the quarter, compared to analyst estimates of $1.64 million. Caribou Biosciences had a negative trailing twelve-month return on equity of 62.35% and a negative net margin of 1,800.93%.

When did Caribou Biosciences IPO?

Caribou Biosciences (CRBU) raised $202 million in an IPO on Friday, July 23rd 2021. The company issued 13,500,000 shares at a price of $14.00-$16.00 per share.

Who are Caribou Biosciences' major shareholders?

Caribou Biosciences' top institutional shareholders include Geode Capital Management LLC (1.05%), Aberdeen Group plc (0.97%), Bank of America Corp DE (0.87%) and Pale Fire Capital SE (0.83%). Insiders that own company stock include Rachel E Haurwitz, Barbara G Mcclung, Ryan Fischesser, Syed Ali-Aamir Rizvi and Sriram Ryali.
View institutional ownership trends.

How do I buy shares of Caribou Biosciences?

Shares of CRBU stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Caribou Biosciences own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Caribou Biosciences investors own include Voyager Therapeutics (VYGR), American Water Works (AWK), The RMR Group (RMR), Waste Connections (WCN), AU Optronics (AUOTY), DiamondRock Hospitality (DRH) and iShares Micro-Cap ETF (IWC).

Company Calendar

• Last Earnings: 8/12/2025
• Today: 9/06/2025
• Next Earnings (Estimated): 11/05/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:CRBU
• CIK: 1619856
• Web: cariboubio.com
• Phone: 510-982-6030
• Fax: N/A
• Employees: 100
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Caribou Biosciences: $6.67
• High Price Target: $11.00
• Low Price Target: $3.00
• Potential Upside/Downside: +256.5%
• Consensus Rating: Buy
• Rating Score (0-4): 3.00
• Research Coverage: 3 Analysts

Profitability

• EPS (Trailing Twelve Months): ($1.78)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$149.10 million
• Net Margins: -1,800.93%
• Pretax Margin: -1,801.03%
• Return on Equity: -62.35%
• Return on Assets: -49.65%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 6.66
• Quick Ratio: 6.66

Sales & Book Value

• Annual Sales: $9.99 million
• Price / Sales: 17.43
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $2.79 per share
• Price / Book: 0.67

Miscellaneous

• Outstanding Shares: 93,120,000
• Free Float: 85,412,000
• Market Cap: $174.13 million
• Optionable: Optionable
• Beta: 2.54