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Karyopharm Therapeutics (KPTI) Institutional Ownership

Karyopharm Therapeutics logo
$6.30 +0.28 (+4.65%)
Closing price 08/22/2025 04:00 PM Eastern
Extended Trading
$6.38 +0.08 (+1.27%)
As of 08/22/2025 07:50 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.
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Institutional Ownership Changes (13F Filings) for Karyopharm Therapeutics (NASDAQ:KPTI)

Current
Institutional Ownership
Percentage
66.44%
Number of
Institutional Buyers
(last 12 months)
25
Total
Institutional Inflows
(last 12 months)
$58.82M
Number of
Institutional Sellers
(last 12 months)
20
Total
Institutional Outflows
(last 12 months)
$157.72M
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KPTI Institutional Buying and Selling by Quarter

Karyopharm Therapeutics Major Shareholders & Ownership History

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Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
8/15/2025 Bridgeway Capital Management LLC37,836$163K0.0%N/A0.436%
8/15/2025 Bank of America Corp DE168,534$726K0.0%+26.8%1.944%
8/13/2025 Baird Financial Group Inc.10,532$45K0.0%N/A0.122%
8/13/2025 Silverback Asset Management LLC70,000$302K0.0%+40.0%0.810%
8/12/2025 XTX Topco Ltd13,056$56K0.0%N/A0.151%
8/8/2025 Geode Capital Management LLC91,841$396K0.0%-7.8%1.063%
6/27/2025 Goldman Sachs Group Inc.85,410$319K0.0%-93.6%0.989%
5/19/2025 Jane Street Group LLC11,420$43K0.0%-98.5%0.132%
5/16/2025 Goldman Sachs Group Inc.85,410$319K0.0%-93.6%0.997%
5/16/2025 Adage Capital Partners GP L.L.C.421,322$1.58M0.0%-93.3%4.916%
5/15/2025 Birchview Capital LP27,985$105K0.1%-93.3%0.327%
5/15/2025 Palo Alto Investors LP324,032$1.21M0.2%-93.4%3.781%
5/14/2025 T. Rowe Price Investment Management Inc.139,646$523K0.0%N/A1.629%
5/13/2025 Altium Capital Management LLC49,333$185K0.4%-93.3%0.576%
5/5/2025 C WorldWide Group Holding A S100,000$374K0.0%-93.3%1.167%
4/29/2025 Bank of New York Mellon Corp11,086$41K0.0%-93.3%0.129%
2/17/2025 Velan Capital Investment Management LP40,000$27K0.0%N/A0.032%
2/17/2025 Two Sigma Advisers LP76,600$52K0.0%+145.5%0.061%
2/17/2025 Two Sigma Investments LP137,786$93K0.0%+60.3%0.109%
2/17/2025 Shay Capital LLC172,153$116K0.0%N/A0.136%
2/17/2025 Millennium Management LLC1,154,414$781K0.0%-8.0%0.915%
2/17/2025 Focus Partners Wealth45,818$31K0.0%N/A0.036%
2/17/2025 D. E. Shaw & Co. Inc.229,685$155K0.0%-78.1%0.182%
2/17/2025 Cubist Systematic Strategies LLC328,807$222K0.0%-33.7%0.261%
2/17/2025 Bank of America Corp DE161,708$109K0.0%-29.4%0.128%
2/17/2025 BNP Paribas Financial Markets1,313,893$889K0.0%-33.7%1.041%
2/14/2025 Jane Street Group LLC748,306$506K0.0%+265.5%0.593%
2/14/2025 Northern Trust Corp283,729$192K0.0%+23.5%0.225%
2/14/2025 Birchview Capital LP419,832$284K0.2%-10.6%0.333%
2/14/2025 Opti Capital Management LP125,000$85K0.0%N/A0.099%
2/14/2025 Adage Capital Partners GP L.L.C.6,319,842$4.27M0.0%+46.3%5.008%
2/14/2025 Price T Rowe Associates Inc. MD64,300$44K0.0%-52.3%0.051%
2/14/2025 Silverarc Capital Management LLC595,990$403K0.1%+6.7%0.472%
2/14/2025 Eversept Partners LP2,088,757$1.41M0.1%-62.4%1.655%
2/14/2025 TD Waterhouse Canada Inc.48,049$32K0.0%N/A0.038%
2/13/2025 Marshall Wace LLP2,401,413$1.63M0.0%+15.3%1.903%
2/13/2025 Renaissance Technologies LLC1,202,590$813K0.0%-3.1%0.953%
2/12/2025 Geode Capital Management LLC1,392,314$942K0.0%+2.7%1.103%
11/19/2024 Barclays PLC95,767$79K0.0%-89.0%0.076%
11/16/2024 Geode Capital Management LLC1,355,392$1.13M0.0%+3.3%1.082%
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11/15/2024 Barclays PLC95,767$79K0.0%-89.0%0.076%
11/15/2024 Jane Street Group LLC204,750$170K0.0%-86.8%0.163%
11/15/2024 State Street Corp409,510$340K0.0%-9.8%0.327%
11/15/2024 Point72 Asia Singapore Pte. Ltd.82,446$68K0.0%-50.1%0.066%
11/13/2024 BNP Paribas Financial Markets1,982,354$1.65M0.0%-12.8%1.582%
11/13/2024 FMR LLC369,723$307K0.0%+26.1%0.295%
11/5/2024 GSA Capital Partners LLP1,775,700$1.47M0.1%+80.6%1.424%
10/10/2024 Exchange Traded Concepts LLC218,791$182K0.0%+34.9%0.176%
9/16/2024 Point72 DIFC Ltd35,939$31K0.0%N/A0.029%
9/16/2024 Cubist Systematic Strategies LLC568,975$494K0.0%N/A0.456%
9/16/2024 Point72 Asia Singapore Pte. Ltd.165,318$143K0.0%N/A0.133%
8/15/2024 AQR Capital Management LLC748,020$649K0.0%+494.5%0.600%
8/15/2024 Point72 Asia Singapore Pte. Ltd.165,318$143K0.0%N/A0.133%
8/14/2024 Cubist Systematic Strategies LLC568,975$494K0.0%N/A0.457%
8/14/2024 Point72 DIFC Ltd35,939$31K0.0%N/A0.029%
8/14/2024 Marshall Wace LLP2,580,863$2.25M0.0%-0.6%2.071%
8/12/2024 XTX Topco Ltd140,576$122K0.0%-42.1%0.113%
8/9/2024 Renaissance Technologies LLC756,227$656K0.0%-16.6%0.607%
8/6/2024 Acadian Asset Management LLC194,168$167K0.0%N/A0.156%
8/6/2024 Los Angeles Capital Management LLC354,020$307K0.0%-8.6%0.284%
7/26/2024 Bank of New York Mellon Corp166,315$144K0.0%-65.9%0.133%
5/17/2024 Ikarian Capital LLC409,355$618K0.1%+2.3%0.348%
5/10/2024 Vanguard Group Inc.8,338,401$12.59M0.0%-4.3%7.160%
5/3/2024 GSA Capital Partners LLP1,299,151$1.96M0.2%-44.4%1.115%
4/24/2024 Simplicity Wealth LLC44,011$66K0.0%N/A0.038%
2/15/2024 Birchview Capital LP469,832$406K0.3%-17.8%0.410%
2/12/2024 Monashee Investment Management LLC132,435$115K0.0%N/A0.116%
2/8/2024 Panagora Asset Management Inc.227,445$197K0.0%N/A0.199%
2/7/2024 BNP Paribas Financial Markets1,769,184$1.53M0.0%+6.5%1.545%
2/6/2024 Los Angeles Capital Management LLC391,540$339K0.0%N/A0.342%
1/29/2024Simplicity Solutions LLC37,938$33K0.0%N/A0.033%
1/25/2024 Bleakley Financial Group LLC37,938$33K0.0%N/A0.033%
1/12/2024 SG Americas Securities LLC73,430$64K0.0%+295.0%0.064%
1/5/2024 Exchange Traded Concepts LLC115,864$100K0.0%+34.0%0.101%
11/15/2023 Tejara Capital Ltd1,077,388$1.44M0.8%-5.8%0.941%
11/15/2023 GSA Capital Partners LLP568,298$762K0.1%N/A0.496%
11/14/2023 Avidity Partners Management LP8,298,570$11.12M0.4%-0.9%7.246%
11/13/2023 Silverarc Capital Management LLC561,955$753K0.2%+8.3%0.491%
11/13/2023 Tejara Capital Ltd1,077,388$1.44M1.1%-5.8%0.941%
11/8/2023Wade G W & Inc.45,140$60K0.0%N/A0.039%
11/7/2023 Quantbot Technologies LP21,699$29K0.0%-60.1%0.019%
11/7/2023 Barclays PLC1,152,298$1.54M0.0%+4.2%1.008%
10/18/2023 Exchange Traded Concepts LLC86,484$116K0.0%+30.2%0.076%
8/15/2023 Silverarc Capital Management LLC518,985$929K0.3%-66.3%0.454%
8/14/2023 Prelude Capital Management LLC15,933$29K0.0%-62.4%0.014%
8/14/2023 Graham Capital Management L.P.62,414$112K0.0%N/A0.055%
8/11/2023 Rubric Capital Management LP919,196$1.65M0.1%-79.3%0.804%
8/11/2023 Tejara Capital Ltd1,143,991$2.05M1.0%+128.1%1.000%
8/11/2023 Platinum Investment Management Ltd.500,000$895K0.0%N/A0.437%
8/11/2023 ExodusPoint Capital Management LP2,382,451$4.27M0.0%N/A2.083%
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8/9/2023 BNP Paribas Arbitrage SNC461,096$825K0.0%+24.8%0.403%
8/8/2023AlphaCentric Advisors LLC810,000$1.45M0.8%+237.5%0.708%
8/8/2023 Candriam S.C.A.1,435,694$2.57M0.0%-6.5%1.255%
8/7/2023 Principal Financial Group Inc.32,838$59K0.0%-32.8%0.029%
8/7/2023 Acadian Asset Management LLC98,946$177K0.0%N/A0.087%
8/4/2023 American International Group Inc.54,514$98K0.0%+45.1%0.048%
7/26/2023Simplicity Solutions LLC15,966$29K0.0%N/A0.014%
7/20/2023 Exchange Traded Concepts LLC66,422$119K0.0%N/A0.058%
7/19/2023 Kennedy Investment Group35,000$63K0.0%+75.0%0.031%
7/10/2023 SG Americas Securities LLC14,868$27K0.0%-58.5%0.013%
(Data available from 1/1/2016 forward)

KPTI Institutional Ownership - Frequently Asked Questions

Who are the largest shareholders of KPTI shares?

During the previous two years, 54 institutional investors and hedge funds held shares of Karyopharm Therapeutics. The most heavily invested institutionals were Vanguard Group Inc. ($12.59M), Avidity Partners Management LP ($11.12M), Marshall Wace LLP ($1.63M), Adage Capital Partners GP L.L.C. ($1.58M), GSA Capital Partners LLP ($1.47M), Tejara Capital Ltd ($1.44M), and Eversept Partners LP ($1.41M).Learn more on Karyopharm Therapeutics' institutional investors.

What percentage of Karyopharm Therapeutics' stock is owned by institutional investors?

66.44% of Karyopharm Therapeutics' stock is owned by institutional investors. Learn more on KPTI's institutional investor holdings.

Which institutional investors have been buying Karyopharm Therapeutics' stock?

Of the 38 institutional investors that purchased Karyopharm Therapeutics' stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: Adage Capital Partners GP L.L.C. ($2M), GSA Capital Partners LLP ($1.36M), Cubist Systematic Strategies LLC ($1.14M), AQR Capital Management LLC ($622.19K), Jane Street Group LLC ($543.56K), Los Angeles Capital Management LLC ($391.54K), and Point72 Asia Singapore Pte. Ltd. ($330.64K).

How much institutional buying is happening at Karyopharm Therapeutics?

Institutional investors have bought a total of 5,515,716 shares in the last 24 months. This purchase volume represents approximately $58.82M in transactions.

Which of Karyopharm Therapeutics' major shareholders have been selling company stock?

Of the 20 institutional investors that sold Karyopharm Therapeutics' stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Adage Capital Partners GP L.L.C. ($5.90M), Palo Alto Investors LP ($4.58M), Eversept Partners LP ($3.46M), Goldman Sachs Group Inc. ($2.50M), Jane Street Group LLC ($2.08M), Barclays PLC ($1.56M), and C WorldWide Group Holding A S ($1.40M).

How much institutional selling is happening at Karyopharm Therapeutics?

Institutional investors have sold a total of 25,123,918 shares in the last 24 months. This volume of shares sold represents approximately $157.72M in transactions.


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This page (NASDAQ:KPTI) was last updated on 8/23/2025 by MarketBeat.com Staff
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