| 5/16/2024 | BVF Inc. IL | 522,238 | $1.17M | 0.0% | -1.8% | 7.937% | |
| 2/12/2024 | Monashee Investment Management LLC | 121,841 | $454K | 0.1% | -14.1% | 2.269% | |
| 11/15/2023 | Adage Capital Partners GP L.L.C. | 292,764 | $1.85M | 0.0% | -75.6% | 5.442% | |
| 11/14/2023 | Monashee Investment Management LLC | 141,841 | $896K | 0.4% | N/A | 2.636% | |
| 11/13/2023 | Acadian Asset Management LLC | 10,937 | $67K | 0.0% | -93.3% | 0.203% | |
| 11/13/2023 | Silverarc Capital Management LLC | 354,608 | $2.24M | 0.7% | N/A | 6.591% | |
| 11/3/2023 | Carlyle Group Inc. | 13,333 | $84K | 0.0% | -93.3% | 0.248% | |
| 8/7/2023 | Acadian Asset Management LLC | 164,085 | $78K | 0.0% | -30.0% | 0.291% | |
| 5/5/2023 | Carlyle Group Inc. | 200,000 | $75K | 0.0% | N/A | 0.355% | |
| 11/10/2022 | Kingsbury Capital Investment Advisors LLC | 298,638 | $224K | 0.3% | +732.5% | 0.530% | |
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| 8/9/2022 | Pictet Asset Management SA | 2,903,180 | $2.65M | 0.0% | -9.5% | 5.153% | |
| 8/9/2022 | Kingsbury Capital Investment Advisors LLC | 35,873 | $33K | 0.0% | +58.5% | 0.064% | |
| 5/17/2022 | Endurant Capital Management LP | 314,238 | $1.08M | 0.3% | +17.1% | 0.558% | |
| 5/16/2022 | Frazier Life Sciences Management L.P. | 1,374,047 | $4.74M | 0.4% | N/A | 2.440% | |
| 5/12/2022 | Connor Clark & Lunn Investment Management Ltd. | 20,560 | $71K | 0.0% | N/A | 0.037% | |
| 5/5/2022 | Russell Investments Group Ltd. | 458,138 | $1.58M | 0.0% | +61.6% | 0.814% | |
| 5/4/2022 | ClariVest Asset Management LLC | 158,900 | $548K | 0.0% | +20.7% | 0.282% | |
| 3/3/2022 | Walleye Capital LLC | 155,449 | $609K | 0.0% | N/A | 0.276% | |
| 2/15/2022 | Adage Capital Partners GP L.L.C. | 1,200,000 | $4.70M | 0.0% | +18.2% | 2.131% | |
| 2/14/2022 | ClariVest Asset Management LLC | 131,679 | $517K | 0.0% | +45.2% | 0.234% | |
| 2/14/2022 | GSA Capital Partners LLP | 145,329 | $570K | 0.1% | +274.3% | 0.258% | |
| 2/11/2022 | Ensign Peak Advisors Inc | 140,767 | $552K | 0.0% | +33.7% | 0.250% | |
| 2/10/2022 | Pictet Asset Management SA | 3,301,019 | $12.94M | 0.0% | -2.5% | 5.863% | |
| 2/10/2022 | Acadian Asset Management LLC | 18,889 | $74K | 0.0% | N/A | 0.034% | |
| 2/9/2022 | Dimensional Fund Advisors LP | 344,162 | $1.35M | 0.0% | +2.6% | 0.611% | |
| 2/8/2022 | ProShare Advisors LLC | 16,009 | $63K | 0.0% | N/A | 0.028% | |
| 2/8/2022 | Northern Trust Corp | 385,420 | $1.51M | 0.0% | -4.3% | 0.685% | |
| 2/7/2022 | SG Americas Securities LLC | 12,046 | $47K | 0.0% | -36.7% | 0.021% | |
| 1/21/2022 | Russell Investments Group Ltd. | 283,563 | $1.11M | 0.0% | +7.0% | 0.504% | |
| 11/16/2021 | Two Sigma Advisers LP | 382,029 | $2.56M | 0.0% | +19.4% | 0.680% | |
| 11/16/2021 | Two Sigma Investments LP | 308,964 | $2.07M | 0.0% | +175.4% | 0.550% | |
| 11/15/2021 | Man Group plc | 106,684 | $716K | 0.0% | +27.9% | 0.190% | |
| 11/15/2021 | California State Teachers Retirement System | 48,422 | $325K | 0.0% | -5.2% | 0.086% | |
| 11/15/2021 | Kingdon Capital Management L.L.C. | 1,021,317 | $6.85M | 0.8% | +1.0% | 1.819% | |
| 11/15/2021 | Dimensional Fund Advisors LP | 335,427 | $2.25M | 0.0% | -5.9% | 0.597% | |
| 11/15/2021 | Ensign Peak Advisors Inc | 105,288 | $706K | 0.0% | N/A | 0.188% | |
| 11/12/2021 | Renaissance Technologies LLC | 210,569 | $1.41M | 0.0% | N/A | 0.375% | |
| 11/12/2021 | Hsbc Holdings PLC | 11,549 | $78K | 0.0% | N/A | 0.021% | |
| 11/12/2021 | Element Capital Management LLC | 26,434 | $177K | 0.1% | N/A | 0.047% | |
| 11/12/2021 | The Manufacturers Life Insurance Company | 15,235 | $102K | 0.0% | -34.6% | 0.027% | |
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| 11/12/2021 | Geode Capital Management LLC | 656,908 | $4.41M | 0.0% | -4.2% | 1.170% | |
| 11/12/2021 | Bellevue Group AG | 10,878,003 | $72.99M | 0.7% | +13.0% | 19.376% | |
| 11/10/2021 | Goldman Sachs Group Inc. | 85,026 | $571K | 0.0% | +63.9% | 0.151% | |
| 11/10/2021 | Panagora Asset Management Inc. | 195,619 | $1.31M | 0.0% | -2.5% | 0.348% | |
| 11/10/2021 | IndexIQ Advisors LLC | 35,626 | $239K | 0.0% | +11.1% | 0.063% | |
| 11/10/2021 | Citigroup Inc. | 4,765 | $32K | 0.0% | +100.4% | 0.008% | |
| 11/9/2021 | BlackRock Inc. | 2,622,580 | $17.60M | 0.0% | -1.2% | 4.671% | |
| 11/8/2021 | Russell Investments Group Ltd. | 265,010 | $1.78M | 0.0% | -5.4% | 0.472% | |
| 11/5/2021 | Advisor Group Holdings Inc. | 4,349 | $29K | 0.0% | +764.6% | 0.008% | |
| 11/2/2021 | New York State Common Retirement Fund | 19,067 | $128K | 0.0% | -40.1% | 0.034% | |
| 11/1/2021 | SG Americas Securities LLC | 19,043 | $128K | 0.0% | N/A | 0.034% | |
| 8/27/2021 | Endurant Capital Management LP | 748,013 | $5.85M | 1.6% | +5.4% | 1.332% | |
| 8/17/2021 | Weiss Multi Strategy Advisers LLC | 56,783 | $444K | 0.0% | +14.1% | 0.101% | |
| 8/17/2021 | Woodline Partners LP | 585,472 | $4.58M | 0.1% | -48.9% | 1.044% | |
| 8/17/2021 | Millennium Management LLC | 136,907 | $1.07M | 0.0% | -80.9% | 0.244% | |
| 8/17/2021 | Man Group plc | 83,418 | $652K | 0.0% | -6.0% | 0.149% | |
| 8/17/2021 | Price T Rowe Associates Inc. MD | 1,243,761 | $9.73M | 0.0% | +47.0% | 2.217% | |
| 8/17/2021 | BVF Inc. IL | 2,856,599 | $22.34M | 0.8% | -0.3% | 5.092% | |
| 8/17/2021 | Caxton Corp | 2,137,991 | $16.72M | 11.5% | +0.7% | 3.811% | |
| 8/16/2021 | UBS Asset Management Americas Inc. | 28,122 | $220K | 0.0% | +151.1% | 0.050% | |
| 8/16/2021 | California State Teachers Retirement System | 51,081 | $399K | 0.0% | +27.5% | 0.091% | |
| 8/16/2021 | Credit Suisse AG | 20,806 | $163K | 0.0% | +29.4% | 0.037% | |
| 8/16/2021 | Charles Schwab Investment Management Inc. | 270,586 | $2.12M | 0.0% | +10.7% | 0.482% | |
| 8/16/2021 | State Street Corp | 607,398 | $4.75M | 0.0% | +33.5% | 1.083% | |
| 8/16/2021 | Kingdon Capital Management L.L.C. | 1,011,495 | $7.91M | 0.9% | +5.2% | 1.803% | |
| 8/16/2021 | Nuveen Asset Management LLC | 192,293 | $1.50M | 0.0% | +60.5% | 0.343% | |
| 8/16/2021 | Federated Hermes Inc. | 9,088 | $71K | 0.0% | +186.7% | 0.016% | |
| 8/16/2021 | Goldman Sachs Group Inc. | 51,880 | $406K | 0.0% | +38.1% | 0.092% | |
| 8/13/2021 | Northern Trust Corp | 427,124 | $3.34M | 0.0% | +16.2% | 0.761% | |
| 8/13/2021 | AXA S.A. | 20,500 | $160K | 0.0% | -76.9% | 0.037% | |
| 8/13/2021 | Geode Capital Management LLC | 686,047 | $5.36M | 0.0% | +21.5% | 1.223% | |
| 8/13/2021 | Vanguard Group Inc. | 2,692,980 | $21.06M | 0.0% | +4.6% | 4.801% | |
| 8/13/2021 | FMR LLC | 138,927 | $1.09M | 0.0% | -77.7% | 0.248% | |
| 8/12/2021 | Trexquant Investment LP | 17,299 | $135K | 0.0% | N/A | 0.031% | |
| 8/12/2021 | Dimensional Fund Advisors LP | 356,395 | $2.79M | 0.0% | +23.7% | 0.635% | |
| 8/12/2021 | JPMorgan Chase & Co. | 318,256 | $2.49M | 0.0% | -3.6% | 0.567% | |
| 8/12/2021 | The Manufacturers Life Insurance Company | 23,308 | $182K | 0.0% | +35.9% | 0.042% | |
| 8/12/2021 | Bellevue Group AG | 9,628,621 | $75.30M | 0.7% | +18.2% | 17.165% | |
| 8/11/2021 | BlackRock Inc. | 2,653,904 | $20.76M | 0.0% | -13.3% | 4.731% | |
| 8/11/2021 | Deutsche Bank AG | 32,145 | $251K | 0.0% | +17.3% | 0.057% | |
| 8/11/2021 | Panagora Asset Management Inc. | 200,694 | $1.57M | 0.0% | +15.1% | 0.358% | |
| 8/10/2021 | Virtus ETF Advisers LLC | 25,049 | $196K | 0.1% | -14.3% | 0.045% | |
| 8/9/2021 | ClariVest Asset Management LLC | 91,336 | $714K | 0.0% | +130.4% | 0.163% | |
| 8/6/2021 | Swiss National Bank | 74,000 | $579K | 0.0% | -3.5% | 0.132% | |
| 8/5/2021 | Rhumbline Advisers | 31,168 | $244K | 0.0% | +9.0% | 0.056% | |
| 8/5/2021 | GSA Capital Partners LLP | 38,595 | $302K | 0.0% | N/A | 0.069% | |
| 8/4/2021 | IndexIQ Advisors LLC | 32,057 | $251K | 0.0% | -7.3% | 0.057% | |
| 8/4/2021 | Russell Investments Group Ltd. | 280,184 | $2.19M | 0.0% | +546.4% | 0.499% | |
| 8/2/2021 | New York State Common Retirement Fund | 31,814 | $249K | 0.0% | +72.9% | 0.057% | |
| 7/30/2021 | Alliancebernstein L.P. | 39,200 | $307K | 0.0% | +17.4% | 0.070% | |
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| 5/19/2021 | Bamco Inc. NY | 45,000 | $568K | 0.0% | N/A | 0.080% | |
| 5/19/2021 | Squarepoint Ops LLC | 28,474 | $359K | 0.0% | -67.5% | 0.051% | |
| 5/18/2021 | BVF Inc. IL | 2,864,299 | $36.15M | 1.4% | +33.3% | 5.107% | |
| 5/18/2021 | Millennium Management LLC | 716,004 | $9.04M | 0.0% | +60.4% | 1.277% | |
| 5/18/2021 | D. E. Shaw & Co. Inc. | 13,855 | $175K | 0.0% | -54.0% | 0.025% | |
| 5/18/2021 | State of Wisconsin Investment Board | 35,600 | $449K | 0.0% | -11.4% | 0.063% | |
| 5/18/2021 | Cubist Systematic Strategies LLC | 11,784 | $149K | 0.0% | N/A | 0.021% | |
| 5/18/2021 | IHT Wealth Management LLC | 26,500 | $334K | 0.0% | +8.2% | 0.047% | |
| 5/18/2021 | Man Group plc | 88,727 | $1.12M | 0.0% | -12.3% | 0.158% | |
| 5/17/2021 | Endurant Capital Management LP | 709,360 | $8.95M | 2.3% | +4.1% | 1.265% | |
