OPKO Health (OPK) Competitors $1.41 +0.03 (+2.17%) Closing price 08/22/2025 04:00 PM EasternExtended Trading$1.40 -0.01 (-1.06%) As of 08/22/2025 07:55 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock OPK vs. LGND, FOLD, BCRX, CLDX, NVAX, INVA, DVAX, MNKD, GERN, and ZBIOShould you be buying OPKO Health stock or one of its competitors? The main competitors of OPKO Health include Ligand Pharmaceuticals (LGND), Amicus Therapeutics (FOLD), BioCryst Pharmaceuticals (BCRX), Celldex Therapeutics (CLDX), Novavax (NVAX), Innoviva (INVA), Dynavax Technologies (DVAX), MannKind (MNKD), Geron (GERN), and Zenas BioPharma (ZBIO). These companies are all part of the "biotechnology" industry. OPKO Health vs. Its Competitors Ligand Pharmaceuticals Amicus Therapeutics BioCryst Pharmaceuticals Celldex Therapeutics Novavax Innoviva Dynavax Technologies MannKind Geron Zenas BioPharma OPKO Health (NASDAQ:OPK) and Ligand Pharmaceuticals (NASDAQ:LGND) are both medical companies, but which is the better business? We will contrast the two companies based on the strength of their valuation, risk, dividends, analyst recommendations, profitability, institutional ownership, media sentiment and earnings. Which has better valuation & earnings, OPK or LGND? Ligand Pharmaceuticals has lower revenue, but higher earnings than OPKO Health. Ligand Pharmaceuticals is trading at a lower price-to-earnings ratio than OPKO Health, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioOPKO Health$713.10M1.57-$53.22M-$0.25-5.64Ligand Pharmaceuticals$167.13M18.66-$4.03M-$4.00-39.77 Do analysts prefer OPK or LGND? OPKO Health currently has a consensus target price of $2.75, indicating a potential upside of 95.04%. Ligand Pharmaceuticals has a consensus target price of $157.00, indicating a potential downside of 1.31%. Given OPKO Health's higher possible upside, analysts clearly believe OPKO Health is more favorable than Ligand Pharmaceuticals.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score OPKO Health 0 Sell rating(s) 2 Hold rating(s) 3 Buy rating(s) 1 Strong Buy rating(s) 2.83Ligand Pharmaceuticals 0 Sell rating(s) 0 Hold rating(s) 6 Buy rating(s) 0 Strong Buy rating(s) 3.00 Is OPK or LGND more profitable? OPKO Health has a net margin of -26.68% compared to Ligand Pharmaceuticals' net margin of -40.44%. Ligand Pharmaceuticals' return on equity of -9.21% beat OPKO Health's return on equity.Company Net Margins Return on Equity Return on Assets OPKO Health-26.68% -13.17% -8.28% Ligand Pharmaceuticals -40.44%-9.21%-8.09% Does the media prefer OPK or LGND? In the previous week, Ligand Pharmaceuticals had 8 more articles in the media than OPKO Health. MarketBeat recorded 10 mentions for Ligand Pharmaceuticals and 2 mentions for OPKO Health. OPKO Health's average media sentiment score of 1.68 beat Ligand Pharmaceuticals' score of 1.32 indicating that OPKO Health is being referred to more favorably in the media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment OPKO Health 2 Very Positive mention(s) 0 Positive mention(s) 0 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Very Positive Ligand Pharmaceuticals 7 Very Positive mention(s) 1 Positive mention(s) 2 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Which has more risk and volatility, OPK or LGND? OPKO Health has a beta of 1.19, suggesting that its stock price is 19% more volatile than the S&P 500. Comparatively, Ligand Pharmaceuticals has a beta of 0.85, suggesting that its stock price is 15% less volatile than the S&P 500. Do insiders and institutionals have more ownership in OPK or LGND? 64.6% of OPKO Health shares are held by institutional investors. Comparatively, 91.3% of Ligand Pharmaceuticals shares are held by institutional investors. 49.7% of OPKO Health shares are held by insiders. Comparatively, 7.0% of Ligand Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term. SummaryOPKO Health beats Ligand Pharmaceuticals on 9 of the 17 factors compared between the two stocks. Get OPKO Health News Delivered to You Automatically Sign up to receive the latest news and ratings for OPK and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding OPK and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart OPK vs. The Competition Export to ExcelMetricOPKO HealthMED INSTRUMENTS IndustryMedical SectorNASDAQ ExchangeMarket Cap$1.12B$7.12B$5.83B$9.78BDividend YieldN/A1.28%4.40%4.05%P/E Ratio-5.6427.4531.3026.05Price / Sales1.5775.20454.60117.80Price / Cash20.5021.9338.0259.36Price / Book0.876.889.536.60Net Income-$53.22M$176.42M$3.26B$265.65M7 Day Performance2.92%1.45%2.14%2.01%1 Month Performance-1.40%-2.71%2.81%-0.33%1 Year Performance-12.42%9.40%30.70%19.04% OPKO Health Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)OPKOPKO Health4.4548 of 5 stars$1.41+2.2%$2.75+95.0%-12.4%$1.12B$713.10M-5.642,997Positive NewsLGNDLigand Pharmaceuticals4.1212 of 5 stars$153.26+1.4%$157.00+2.4%+53.5%$3.00B$187.58M-38.3280Positive NewsShort Interest ↓FOLDAmicus Therapeutics4.3506 of 5 stars$7.41+0.1%$16.22+118.9%-35.0%$2.28B$571.16M-61.74480News CoveragePositive NewsBCRXBioCryst Pharmaceuticals4.1969 of 5 stars$8.38+0.1%$16.70+99.3%+7.9%$1.76B$450.71M-46.55530Positive NewsCLDXCelldex Therapeutics1.611 of 5 stars$24.48-4.0%$51.75+111.4%-36.3%$1.63B$7.02M-8.13150News CoverageAnalyst ForecastNVAXNovavax4.6262 of 5 stars$9.71+1.4%$15.86+63.3%-34.4%$1.58B$1.08B4.261,990News CoverageAnalyst ForecastINVAInnoviva4.5196 of 5 stars$20.78-0.7%$42.75+105.7%+8.2%$1.31B$358.71M67.03100News CoverageDVAXDynavax Technologies4.5211 of 5 stars$10.76-0.3%$24.33+126.1%-6.9%$1.26B$277.25M-23.39350News CoverageAnalyst ForecastMNKDMannKind3.1818 of 5 stars$3.81+2.1%$9.71+155.0%-22.9%$1.17B$285.50M34.64400GERNGeron3.1375 of 5 stars$1.44-0.7%$4.19+190.8%-67.4%$918.74M$164.45M-11.08229Gap UpZBIOZenas BioPharma1.4764 of 5 stars$17.28+2.7%$36.67+112.2%N/A$727.66M$5M-4.87N/A Related Companies and Tools Related Companies LGND Competitors FOLD Competitors BCRX Competitors CLDX Competitors NVAX Competitors INVA Competitors DVAX Competitors MNKD Competitors GERN Competitors ZBIO Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:OPK) was last updated on 8/23/2025 by MarketBeat.com Staff From Our PartnersBONUS GUIDE - Ben Stein Prepares For the Next Financial CrisisWith inflation high, debt soaring, and global tensions rising, a financial storm may be brewing. Economist ...Goldco Precious Metals | SponsoredGENIUS Act: Cancel Your Money?A new law called the GENIUS Act could quietly trigger the most radical shift in American finance in decades. B...Priority Gold | SponsoredAlex’s “Next Magnificent Seven” stocksThe original “Magnificent Seven” turned $7K into $1.18 million. Now, Alex Green has identified AI’s Next Ma...The Oxford Club | SponsoredThe $7 company helping Nvidia build the world’s first trillion-dollar robot …Michael Robinson has been at the forefront of the technology market for over 40 years. Spotting some profit...Weiss Ratings | SponsoredElon’s Secret Social Security BombshellTo All Americans Born Before April 16th, 1963: Did Trump Just Give The Green Light To Radically RE-DO Social S...Banyan Hill Publishing | SponsoredINVESTOR ALERT: Tiny “$3 AI Wonder Stock” on the Verge of Blasting OffRight now, we’re witnessing a monumental shift in the world.Traders Agency | SponsoredTrump set to Boost Social Security Checks by 400%?If you're collecting or planning to collect social security... You should see this presentation about Presi...InvestorPlace | SponsoredOut of 18,347 Cryptocurrencies... This is the ONLY OneThe Single Most Undervalued DeFi Protocol You've Never Heard Of If there's one cryptocurrency you should b...Crypto 101 Media | Sponsored Adding Choose a watchlist: Watchlist Adding You have already added ten stocks to your watchlist. Upgrade to MarketBeat All Access to add more stocks to your watchlist. Adding OPKO Health, Inc. Please log in to your account or sign up in order to add this asset to your watchlist. Share OPKO Health With A Colleague Link copied to clipboard. Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. Real-time analyst ratings, insider transactions, earnings data, and more. Our daily ratings and market update email newsletter. Sign in to your free account to enjoy all that MarketBeat has to offer. Sign In Create Account Your Email Address: Email Address Required Your Password: Password Required Log In or Sign in with Facebook Sign in with Google Forgot your password? Your Email Address: Please enter your email address. Please enter a valid email address Choose a Password: Please enter your password. Your password must be at least 8 characters long and contain at least 1 number, 1 letter, and 1 special character. Create My Account (Free) or Sign in with Facebook Sign in with Google By creating a free account, you agree to our terms of service. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.