Prothena (PRTA) Competitors $6.52 +0.23 (+3.66%) Closing price 07/8/2025 04:00 PM EasternExtended Trading$6.43 -0.09 (-1.32%) As of 07/8/2025 06:37 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock PRTA vs. GPCR, CVAC, CALT, AUPH, BGM, NAGE, AMPH, DYN, ABCL, and PAHCShould you be buying Prothena stock or one of its competitors? The main competitors of Prothena include Structure Therapeutics (GPCR), CureVac (CVAC), Calliditas Therapeutics AB (publ) (CALT), Aurinia Pharmaceuticals (AUPH), BGM Group (BGM), Niagen Bioscience (NAGE), Amphastar Pharmaceuticals (AMPH), Dyne Therapeutics (DYN), AbCellera Biologics (ABCL), and Phibro Animal Health (PAHC). These companies are all part of the "pharmaceutical products" industry. Prothena vs. Its Competitors Structure Therapeutics CureVac Calliditas Therapeutics AB (publ) Aurinia Pharmaceuticals BGM Group Niagen Bioscience Amphastar Pharmaceuticals Dyne Therapeutics AbCellera Biologics Phibro Animal Health Prothena (NASDAQ:PRTA) and Structure Therapeutics (NASDAQ:GPCR) are both small-cap medical companies, but which is the better stock? We will compare the two businesses based on the strength of their earnings, analyst recommendations, media sentiment, dividends, valuation, risk, profitability and institutional ownership. Is PRTA or GPCR more profitable? Structure Therapeutics has a net margin of 0.00% compared to Prothena's net margin of -79.94%. Structure Therapeutics' return on equity of -16.35% beat Prothena's return on equity.Company Net Margins Return on Equity Return on Assets Prothena-79.94% -21.61% -19.32% Structure Therapeutics N/A -16.35%-15.71% Which has more risk & volatility, PRTA or GPCR? Prothena has a beta of 0.01, meaning that its stock price is 99% less volatile than the S&P 500. Comparatively, Structure Therapeutics has a beta of -1.87, meaning that its stock price is 287% less volatile than the S&P 500. Do analysts prefer PRTA or GPCR? Prothena currently has a consensus price target of $31.50, indicating a potential upside of 383.13%. Structure Therapeutics has a consensus price target of $76.17, indicating a potential upside of 306.44%. Given Prothena's higher probable upside, equities research analysts clearly believe Prothena is more favorable than Structure Therapeutics.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Prothena 1 Sell rating(s) 4 Hold rating(s) 4 Buy rating(s) 0 Strong Buy rating(s) 2.33Structure Therapeutics 0 Sell rating(s) 0 Hold rating(s) 7 Buy rating(s) 0 Strong Buy rating(s) 3.00 Does the media favor PRTA or GPCR? In the previous week, Structure Therapeutics had 2 more articles in the media than Prothena. MarketBeat recorded 3 mentions for Structure Therapeutics and 1 mentions for Prothena. Structure Therapeutics' average media sentiment score of 0.56 beat Prothena's score of -0.16 indicating that Structure Therapeutics is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Prothena 0 Very Positive mention(s) 1 Positive mention(s) 0 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Neutral Structure Therapeutics 1 Very Positive mention(s) 1 Positive mention(s) 1 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Do insiders & institutionals hold more shares of PRTA or GPCR? 97.1% of Prothena shares are held by institutional investors. Comparatively, 91.8% of Structure Therapeutics shares are held by institutional investors. 9.2% of Prothena shares are held by insiders. Comparatively, 9.4% of Structure Therapeutics shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term. Which has stronger earnings and valuation, PRTA or GPCR? Prothena has higher revenue and earnings than Structure Therapeutics. Structure Therapeutics is trading at a lower price-to-earnings ratio than Prothena, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioProthena$135.16M2.60-$122.31M-$2.08-3.13Structure TherapeuticsN/AN/A-$122.53M-$0.87-21.54 SummaryStructure Therapeutics beats Prothena on 9 of the 15 factors compared between the two stocks. Get Prothena News Delivered to You Automatically Sign up to receive the latest news and ratings for PRTA and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding PRTA and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart PRTA vs. The Competition Export to ExcelMetricProthenaMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$338.57M$2.88B$5.47B$8.95BDividend YieldN/A2.46%5.25%4.06%P/E Ratio-3.1320.8027.0020.10Price / Sales2.60286.98435.75120.29Price / CashN/A41.1936.8257.86Price / Book0.727.487.985.56Net Income-$122.31M-$55.04M$3.16B$248.40M7 Day Performance3.16%2.44%2.40%4.67%1 Month Performance24.19%1.90%2.19%6.64%1 Year Performance-68.36%4.35%33.82%21.31% Prothena Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)PRTAProthena3.0398 of 5 stars$6.52+3.7%$31.50+383.1%-67.7%$338.57M$135.16M-3.13130GPCRStructure Therapeutics2.6717 of 5 stars$20.74-1.6%$76.17+267.2%-49.7%$1.21BN/A-23.84136Positive NewsCVACCureVac4.4998 of 5 stars$5.43+0.9%$6.83+25.8%+73.2%$1.21B$579.18M5.90880CALTCalliditas Therapeutics AB (publ)N/A$40.00flatN/AN/A$1.19B$1.60B-21.62180AUPHAurinia Pharmaceuticals2.5572 of 5 stars$8.47-2.0%$11.50+35.8%+34.8%$1.17B$235.13M30.25300BGMBGM GroupN/A$10.59-11.5%N/AN/A$1.16B$25.10M0.00298News CoverageAnalyst DowngradeNAGENiagen Bioscience1.2984 of 5 stars$14.41+1.3%$19.50+35.3%N/A$1.12B$99.60M84.76120AMPHAmphastar Pharmaceuticals4.4152 of 5 stars$22.96-0.5%$32.33+40.8%-39.5%$1.09B$731.97M8.322,028DYNDyne Therapeutics3.6401 of 5 stars$9.52-0.5%$41.13+332.0%-75.0%$1.09BN/A-2.65100ABCLAbCellera Biologics2.5473 of 5 stars$3.43-5.0%$8.33+143.0%+41.5%$1.08B$28.83M-6.12500News CoverageAnalyst ForecastHigh Trading VolumePAHCPhibro Animal Health3.673 of 5 stars$25.54-0.5%$21.80-14.6%+71.9%$1.04B$1.02B32.741,940News CoverageAnalyst Upgrade Related Companies and Tools Related Companies Structure Therapeutics Competitors CureVac Competitors Calliditas Therapeutics AB (publ) Competitors Aurinia Pharmaceuticals Competitors BGM Group Competitors Niagen Bioscience Competitors Amphastar Pharmaceuticals Competitors Dyne Therapeutics Competitors AbCellera Biologics Competitors Phibro Animal Health Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:PRTA) was last updated on 7/9/2025 by MarketBeat.com Staff From Our PartnersA grave, grave error.I thought what happened 25 years ago was a once- in-a-lifetime event… but how wrong I was. 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