Prothena (PRTA) Competitors $8.77 +0.21 (+2.45%) Closing price 08/22/2025 04:00 PM EasternExtended Trading$8.76 -0.01 (-0.17%) As of 08/22/2025 07:44 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock PRTA vs. DYN, APGE, TWST, TVTX, BHVN, IMCR, CDTX, AUPH, WVE, and JANXShould you be buying Prothena stock or one of its competitors? The main competitors of Prothena include Dyne Therapeutics (DYN), Apogee Therapeutics (APGE), Twist Bioscience (TWST), Travere Therapeutics (TVTX), Biohaven (BHVN), Immunocore (IMCR), Cidara Therapeutics (CDTX), Aurinia Pharmaceuticals (AUPH), WAVE Life Sciences (WVE), and Janux Therapeutics (JANX). These companies are all part of the "pharmaceutical products" industry. Prothena vs. Its Competitors Dyne Therapeutics Apogee Therapeutics Twist Bioscience Travere Therapeutics Biohaven Immunocore Cidara Therapeutics Aurinia Pharmaceuticals WAVE Life Sciences Janux Therapeutics Prothena (NASDAQ:PRTA) and Dyne Therapeutics (NASDAQ:DYN) are both small-cap medical companies, but which is the superior business? We will compare the two companies based on the strength of their media sentiment, valuation, dividends, institutional ownership, analyst recommendations, risk, profitability and earnings. Do institutionals and insiders believe in PRTA or DYN? 97.1% of Prothena shares are held by institutional investors. Comparatively, 96.7% of Dyne Therapeutics shares are held by institutional investors. 9.2% of Prothena shares are held by company insiders. Comparatively, 14.1% of Dyne Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term. Does the media refer more to PRTA or DYN? In the previous week, Dyne Therapeutics had 4 more articles in the media than Prothena. MarketBeat recorded 5 mentions for Dyne Therapeutics and 1 mentions for Prothena. Dyne Therapeutics' average media sentiment score of 0.90 beat Prothena's score of 0.56 indicating that Dyne Therapeutics is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Prothena 0 Very Positive mention(s) 0 Positive mention(s) 1 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Dyne Therapeutics 3 Very Positive mention(s) 0 Positive mention(s) 2 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Which has better valuation & earnings, PRTA or DYN? Prothena has higher revenue and earnings than Dyne Therapeutics. Dyne Therapeutics is trading at a lower price-to-earnings ratio than Prothena, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioProthena$10.34M45.65-$122.31M-$5.64-1.55Dyne TherapeuticsN/AN/A-$317.42M-$3.86-3.26 Do analysts rate PRTA or DYN? Prothena presently has a consensus price target of $30.25, indicating a potential upside of 244.93%. Dyne Therapeutics has a consensus price target of $33.80, indicating a potential upside of 168.68%. Given Prothena's higher probable upside, research analysts clearly believe Prothena is more favorable than Dyne Therapeutics.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Prothena 1 Sell rating(s) 4 Hold rating(s) 4 Buy rating(s) 0 Strong Buy rating(s) 2.33Dyne Therapeutics 0 Sell rating(s) 2 Hold rating(s) 12 Buy rating(s) 2 Strong Buy rating(s) 3.00 Which has more volatility and risk, PRTA or DYN? Prothena has a beta of -0.03, indicating that its share price is 103% less volatile than the S&P 500. Comparatively, Dyne Therapeutics has a beta of 1.08, indicating that its share price is 8% more volatile than the S&P 500. Is PRTA or DYN more profitable? Dyne Therapeutics has a net margin of 0.00% compared to Prothena's net margin of -2,929.30%. Prothena's return on equity of -62.17% beat Dyne Therapeutics' return on equity.Company Net Margins Return on Equity Return on Assets Prothena-2,929.30% -62.17% -54.43% Dyne Therapeutics N/A -64.12%-56.75% SummaryDyne Therapeutics beats Prothena on 9 of the 16 factors compared between the two stocks. Get Prothena News Delivered to You Automatically Sign up to receive the latest news and ratings for PRTA and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding PRTA and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart PRTA vs. The Competition Export to ExcelMetricProthenaMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$472.09M$3.11B$5.81B$9.76BDividend YieldN/A2.23%4.39%4.06%P/E Ratio-1.5521.0031.3626.05Price / Sales45.65209.44387.8788.42Price / CashN/A44.5038.0259.36Price / Book1.458.129.536.60Net Income-$122.31M-$54.72M$3.26B$265.65M7 Day Performance6.30%2.62%2.14%2.00%1 Month Performance30.90%3.25%3.22%0.46%1 Year Performance-59.60%10.82%30.18%18.88% Prothena Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)PRTAProthena3.294 of 5 stars$8.77+2.5%$30.25+244.9%-59.6%$472.09M$10.34M-1.55130DYNDyne Therapeutics3.4201 of 5 stars$12.33-0.4%$33.80+174.1%-73.0%$1.76BN/A-3.19100APGEApogee Therapeutics3.5567 of 5 stars$36.90-1.0%$99.00+168.3%-20.9%$1.72BN/A-8.9391TWSTTwist Bioscience4.1567 of 5 stars$28.02-0.4%$49.40+76.3%-34.5%$1.70B$312.97M-19.32990Positive NewsTVTXTravere Therapeutics2.4123 of 5 stars$18.77-0.3%$32.21+71.6%+99.6%$1.68B$233.18M-9.20460News CoveragePositive NewsAnalyst DowngradeBHVNBiohaven3.823 of 5 stars$16.02+2.0%$53.75+235.5%-62.6%$1.66BN/A-2.09239Trending NewsAnalyst ForecastOptions VolumeGap UpIMCRImmunocore1.7738 of 5 stars$32.31-1.7%$58.00+79.5%-7.9%$1.66B$310.20M-80.78320Positive NewsCDTXCidara Therapeutics3.5423 of 5 stars$63.24-3.0%$64.14+1.4%+411.3%$1.65B$1.27M-5.6890AUPHAurinia Pharmaceuticals2.525 of 5 stars$12.22-0.4%$12.00-1.8%+81.5%$1.62B$260.11M28.42300Positive NewsWVEWAVE Life Sciences4.7597 of 5 stars$9.74-0.2%$20.27+108.1%+76.8%$1.55B$108.30M-10.82240Positive NewsJANXJanux Therapeutics2.1448 of 5 stars$25.53+1.7%$91.89+259.9%-47.1%$1.51B$10.59M-14.1830News Coverage Related Companies and Tools Related Companies Dyne Therapeutics Competitors Apogee Therapeutics Competitors Twist Bioscience Competitors Travere Therapeutics Competitors Biohaven Competitors Immunocore Competitors Cidara Therapeutics Competitors Aurinia Pharmaceuticals Competitors WAVE Life Sciences Competitors Janux Therapeutics Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:PRTA) was last updated on 8/24/2025 by MarketBeat.com Staff From Our PartnersGENIUS Act: Cancel Your Money?A new law called the GENIUS Act could quietly trigger the most radical shift in American finance in decades. 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