Rein Therapeutics, Inc. is a clinical-stage biotechnology company focused on the discovery and development of targeted therapies for patients with genetically defined cancers. The company’s core mission is to address unmet medical needs in oncology by designing small-molecule inhibitors that selectively target aberrant signaling pathways associated with tumor growth and progression. Founded in 2018, Rein Therapeutics leverages structure-based drug design and precision oncology approaches to advance its pipeline of investigational agents from lead identification through clinical evaluation.
The company’s lead product candidate, RNTX-1001, is an orally bioavailable, irreversible pan-ERBB kinase inhibitor engineered to inhibit multiple members of the ERBB family, including mutant forms of EGFR that often confer resistance to existing therapies. RNTX-1001 is being evaluated in Phase 1 clinical trials for its safety, tolerability and preliminary efficacy in patients with advanced solid tumors harboring ERBB mutations. In parallel, Rein Therapeutics is advancing preclinical programs targeting additional oncogenic drivers, aiming to expand its portfolio and address diverse molecular subtypes of cancer.
Rein Therapeutics is headquartered in Cambridge, Massachusetts, with research operations in the greater Boston area and strategic collaborations across North America and Europe. The company’s multidisciplinary R&D team integrates medicinal chemistry, structural biology and translational science to accelerate the bench-to-bedside development of its therapies. By forging partnerships with academic institutions, contract research organizations and industry collaborators, Rein Therapeutics seeks to optimize trial design and streamline patient access to its investigational agents.
Under the leadership of CEO Rishab Sehgal, Rein Therapeutics draws on deep expertise in oncology drug development and precision medicine. The management team and board of directors include veterans from established biopharmaceutical companies and renowned research institutions, bringing extensive experience in clinical operations, regulatory strategy and commercial planning. Together, they guide Rein Therapeutics’ efforts to deliver novel treatment options to cancer patients driven by specific genetic alterations.
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