Septerna (SEPN) Competitors $11.30 -0.10 (-0.88%) Closing price 07/3/2025 03:29 PM EasternExtended Trading$11.27 -0.03 (-0.26%) As of 07/3/2025 04:46 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOwnershipSEC FilingsTrendsBuy This Stock SEPN vs. HRMY, IRON, TARS, BEAM, CNTA, ARQT, ADPT, IMCR, SPRY, and EWTXShould you be buying Septerna stock or one of its competitors? The main competitors of Septerna include Harmony Biosciences (HRMY), Disc Medicine (IRON), Tarsus Pharmaceuticals (TARS), Beam Therapeutics (BEAM), Centessa Pharmaceuticals (CNTA), Arcutis Biotherapeutics (ARQT), Adaptive Biotechnologies (ADPT), Immunocore (IMCR), ARS Pharmaceuticals (SPRY), and Edgewise Therapeutics (EWTX). These companies are all part of the "pharmaceutical products" industry. Septerna vs. Its Competitors Harmony Biosciences Disc Medicine Tarsus Pharmaceuticals Beam Therapeutics Centessa Pharmaceuticals Arcutis Biotherapeutics Adaptive Biotechnologies Immunocore ARS Pharmaceuticals Edgewise Therapeutics Harmony Biosciences (NASDAQ:HRMY) and Septerna (NASDAQ:SEPN) are both small-cap medical companies, but which is the better investment? We will compare the two companies based on the strength of their earnings, institutional ownership, analyst recommendations, risk, valuation, media sentiment, dividends and profitability. Do insiders and institutionals believe in HRMY or SEPN? 86.2% of Harmony Biosciences shares are held by institutional investors. 23.6% of Harmony Biosciences shares are held by company insiders. Comparatively, 4.3% of Septerna shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term. Is HRMY or SEPN more profitable? Harmony Biosciences has a net margin of 20.53% compared to Septerna's net margin of 0.00%. Harmony Biosciences' return on equity of 24.32% beat Septerna's return on equity.Company Net Margins Return on Equity Return on Assets Harmony Biosciences20.53% 24.32% 15.92% Septerna N/A N/A N/A Which has better valuation and earnings, HRMY or SEPN? Harmony Biosciences has higher revenue and earnings than Septerna. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioHarmony Biosciences$714.73M2.58$145.49M$2.6212.25Septerna$1.08M466.23-$71.80MN/AN/A Does the media prefer HRMY or SEPN? In the previous week, Harmony Biosciences' average media sentiment score of 1.00 beat Septerna's score of 0.79 indicating that Harmony Biosciences is being referred to more favorably in the media. Company Overall Sentiment Harmony Biosciences Positive Septerna Positive Do analysts prefer HRMY or SEPN? Harmony Biosciences currently has a consensus target price of $53.63, indicating a potential upside of 67.11%. Septerna has a consensus target price of $26.75, indicating a potential upside of 136.73%. Given Septerna's higher possible upside, analysts plainly believe Septerna is more favorable than Harmony Biosciences.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Harmony Biosciences 0 Sell rating(s) 0 Hold rating(s) 7 Buy rating(s) 1 Strong Buy rating(s) 3.13Septerna 0 Sell rating(s) 1 Hold rating(s) 4 Buy rating(s) 0 Strong Buy rating(s) 2.80 SummaryHarmony Biosciences beats Septerna on 11 of the 13 factors compared between the two stocks. Get Septerna News Delivered to You Automatically Sign up to receive the latest news and ratings for SEPN and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding SEPN and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart SEPN vs. The Competition Export to ExcelMetricSepternaMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$506.63M$2.91B$5.53B$9.05BDividend YieldN/A2.44%5.24%4.03%P/E RatioN/A21.5627.5220.22Price / Sales466.23281.76421.02118.64Price / CashN/A42.7336.8958.07Price / Book1.197.518.045.67Net Income-$71.80M-$55.05M$3.18B$249.13M7 Day Performance7.52%4.61%2.90%3.28%1 Month Performance7.41%4.72%3.70%5.55%1 Year PerformanceN/A5.92%36.15%21.12% Septerna Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)SEPNSepterna1.6869 of 5 stars$11.30-0.9%$26.75+136.7%N/A$506.63M$1.08M0.00N/AHRMYHarmony Biosciences4.7975 of 5 stars$31.93+0.1%$53.63+67.9%+3.9%$1.83B$714.73M12.19200Positive NewsIRONDisc Medicine3.0639 of 5 stars$51.68+0.1%$96.70+87.1%+23.2%$1.79BN/A-13.1830Analyst ForecastTARSTarsus Pharmaceuticals2.2421 of 5 stars$40.60-0.1%$66.67+64.2%+42.0%$1.71B$182.95M-14.8750BEAMBeam Therapeutics2.7082 of 5 stars$16.71-0.3%$48.75+191.7%-14.7%$1.69B$63.52M-3.62510CNTACentessa Pharmaceuticals3.0445 of 5 stars$13.00+4.6%$27.89+114.5%+67.1%$1.66B$6.85M-7.18200ARQTArcutis Biotherapeutics2.0664 of 5 stars$14.40+4.2%$18.80+30.6%+42.9%$1.65B$212.82M-13.85150Positive NewsADPTAdaptive Biotechnologies3.3343 of 5 stars$10.56+1.7%$10.57+0.1%+253.3%$1.58B$178.96M-11.00790News CoverageGap UpIMCRImmunocore2.3758 of 5 stars$31.12-0.7%$58.89+89.2%-8.4%$1.56B$333.58M-72.37320SPRYARS Pharmaceuticals3.2498 of 5 stars$16.57+4.9%$31.00+87.1%+81.4%$1.55B$89.15M-103.5690Insider TradeEWTXEdgewise Therapeutics2.4951 of 5 stars$14.18-0.8%$39.78+180.5%-29.1%$1.50BN/A-9.1560News CoverageAnalyst RevisionGap Up Related Companies and Tools Related Companies HRMY Competitors IRON Competitors TARS Competitors BEAM Competitors CNTA Competitors ARQT Competitors ADPT Competitors IMCR Competitors SPRY Competitors EWTX Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:SEPN) was last updated on 7/5/2025 by MarketBeat.com Staff From Our PartnersTrump’s New Order Could Boost Social Security Benefits by 400%If you collect—or plan to collect—Social Security, you need to see this. 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