Septerna (SEPN) Stock Forecast & Price Target $40.88 +0.12 (+0.29%) Closing price 04:00 PM EasternExtended Trading$40.60 -0.28 (-0.67%) As of 07:30 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Analyst Forecasts Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsInsider TradesNews and TrendsOptions ChainOwnershipSEC FilingsShort Interest Septerna - Analysts' Recommendations and Stock Price Forecast (2026) How MarketBeat Calculates Price Target and Consensus Rating Consensus Rating Moderate BuyBased on 11 Analyst RatingsSell1Hold1Buy9 Based on 11 Wall Street analysts who have issued ratings for Septerna in the last 12 months, the stock has a consensus rating of "Moderate Buy." Out of the 11 analysts, 1 has given a sell rating, 1 has given a hold rating, 8 have given a buy rating, and 1 has given a strong buy rating for SEPN. Consensus Price Target $52.4428.29% Upside According to the 11 analysts' twelve-month price targets for Septerna, the average price target is $52.44. The highest price target for SEPN is $62.00, while the lowest price target for SEPN is $43.00. The average price target represents a forecasted upside of 28.29% from the current price of $40.88. MarketBeat calculates consensus analyst ratings for stocks using the most recent rating from each Wall Street analyst that has rated a stock within the last twelve months. Each analyst's rating is normalized to a standardized rating score of 1 (sell), 2 (hold), 3 (buy) or 4 (strong buy). Analyst consensus ratings scores are calculated using the mean average of the number of normalized sell, hold, buy and strong buy ratings from Wall Street analysts. Each stock's consensus analyst rating is derived from its calculated consensus ratings score (0 to .5 = Strong Sell, .5 to 1 = Sell, 1 to 1.5 = Reduce, 1.5 to 2.5 = Hold, 2.5 to 3.0 = Moderate Buy, 3.0 to 3.5 = Buy, >3.5 = Strong Buy). MarketBeat's consensus price targets are a mean average of the most recent available price targets set by each analyst that has set a price target for the stock in the last twelve months. MarketBeat's consensus ratings and consensus price targets may differ from those calculated by other firms due to differences in methodology and available data. Get the Latest News and Ratings for SEPN and Related Stocks Enter your email address to receive the latest news and analysts' ratings for Septerna and its competitors. Sign Up View SMS TermsSMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. 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SEPN Analyst Ratings Over TimeTypeCurrent Forecast10/22/25 to 10/22/261 Month Ago9/22/25 to 9/22/263 Months Ago7/24/25 to 7/24/261 Year Ago10/22/24 to 10/22/25Strong Buy1 Strong Buy rating(s)1 Strong Buy rating(s)1 Strong Buy rating(s)0 Strong Buy rating(s)Buy8 Buy rating(s)8 Buy rating(s)8 Buy rating(s)4 Buy rating(s)Hold1 Hold rating(s)1 Hold rating(s)1 Hold rating(s)1 Hold rating(s)Sell1 Sell rating(s)1 Sell rating(s)1 Sell rating(s)1 Sell rating(s)Consensus Price Target$52.44$52.44$45.89$26.75Forecasted Upside28.29% Upside29.88% Upside38.64% Upside21.59% UpsideConsensus RatingModerate BuyModerate BuyModerate BuyModerate Buy SEPN Analyst Recommendations By MonthAnalyst Ratings Chart DescriptionThe chart below shows how a company's ratings by analysts have changed over time. Each bar represents the previous year of ratings for that month. Within each bar, the sell ratings are shown in red, the hold ratings are shown in yellow, the buy ratings are shown in green, and the strong buy ratings are shown in dark green.Skip Chart & View Analyst Rating History SEPN Price Targets by MonthAverage Share Price and Price Target by Month Chart DescriptionThe chart below shows how a company's share price and consensus price target have changed over time. The dark blue line represents the company's actual price. The lighter blue line represents the stock's consensus price target. The even lighter blue range in the background of the two lines represents the low price target and the high price target for each stock.Skip Chart and View Analyst Price Target HistorySkip Chart & View Price History Table Septerna Stock vs. The CompetitionTypeSepternaHealthcare CompaniesBroader MarketConsensus Rating Score 2.82 2.32 2.53Consensus RatingModerate BuyHoldModerate BuyPredicted Upside28.38% Upside1,333.79% Upside15.80% UpsideNews Sentiment RatingNeutral NewsSee Recent SEPN NewsNeutral NewsPositive News Recent Analyst Forecasts and Stock Ratings Most Recent from Each Brokerage All Show All Ratings Strong Buy Buy Hold Sell Rating Show All Upside > 100% Upside 50% - 100% Upside 20% - 50% Upside 10% - 20% Upside 0% - 10% Downside 0% - 10% Downside 10% - 20% Downside 20% - 50% Downside 50% - 100% Downside > 100% Upside/Downside All Actions Upgrades Downgrades Initiates Coverage Raises Target Lowers Target Reiterates Rating Action 10/22/2024 - 10/22/2026 Report Date Report Date From Report Date To 1M3M6MYTD1Y2Y3Y5Y More filters Fewer filters Done 0 Results Export DateBrokerageAnalystActionRatingPrice TargetReport Date Upside/DownsideDetails10/15/2026 Weiss Ratings3 of 5 stars Reiterated RatingSell (D-)8/19/2026 JPMorgan Chase & Co.3 of 5 starsTessa Romero5 of 5 starsBoost TargetOverweight$38.00 ➝ $48.00+9.05%8/13/2026 JonesTrading4 of 5 starsCatherine Novack5 of 5 starsBoost TargetBuy$43.00 ➝ $62.00+36.53%8/12/2026 Wells Fargo & CompanySubscribe to MarketBeat All Access to unlock brokerage rankingsDerek ArchilaSubscribe to MarketBeat All Access to unlock analyst rankingsBoost TargetOverweight$48.00 ➝ $50.00+4.69%8/12/2026 HC WainwrightSubscribe to MarketBeat All Access to unlock brokerage rankingsRaghuram SelvarajuSubscribe to MarketBeat All Access to unlock analyst rankingsBoost TargetBuy$40.00 ➝ $60.00+25.63%8/11/2026 Raymond James FinancialSubscribe to MarketBeat All Access to unlock brokerage rankingsMartin AusterSubscribe to MarketBeat All Access to unlock analyst rankingsReiterated RatingStrong-Buy$49.00+10.61%8/11/2026 Stifel NicolausSubscribe to MarketBeat All Access to unlock brokerage rankingsAlex ThompsonSubscribe to MarketBeat All Access to unlock analyst rankingsSet Target$49.00+10.52%8/11/2026 GuggenheimSubscribe to MarketBeat All Access to unlock brokerage rankingsSeamus FernandezSubscribe to MarketBeat All Access to unlock analyst rankingsBoost TargetBuy$45.00 ➝ $51.00+31.27%7/1/2026 Truist FinancialSubscribe to MarketBeat All Access to unlock brokerage rankingsSrikripa DevarakondaSubscribe to MarketBeat All Access to unlock analyst rankingsBoost TargetBuy$35.00 ➝ $43.00+28.40%3/10/2026 Cantor FitzgeraldSubscribe to MarketBeat All Access to unlock brokerage rankingsJosh SchimmerSubscribe to MarketBeat All Access to unlock analyst rankingsReiterated RatingOverweight$60.00+109.72% Get the Latest News and Ratings for SEPN and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Septerna and its competitors with MarketBeat's FREE daily newsletter. 2/24/2026 Zacks ResearchSubscribe to MarketBeat All Access to unlock brokerage rankings UpgradeStrong Sell ➝ Hold11/19/2024 TD CowenSubscribe to MarketBeat All Access to unlock brokerage rankingsYaron WerberSubscribe to MarketBeat All Access to unlock analyst rankingsInitiated CoverageBuyAnalyst ratings data on MarketBeat is provided by Benzinga and other data providers. This page was last refreshed on Thursday at 10:18 PM ET. SEPN Forecast - Frequently Asked Questions What is Septerna's forecast for 2026? According to the research reports of 11 Wall Street equities research analysts, the average twelve-month stock price forecast for Septerna is $52.44, with a high forecast of $62.00 and a low forecast of $43.00. Should I buy or sell Septerna stock right now? 11 Wall Street equities research analysts have issued "buy," "hold," and "sell" ratings for Septerna in the last year. There is currently 1 sell rating, 1 hold rating, 8 buy ratings and 1 strong buy rating for the stock. The consensus among Wall Street equities research analysts is that investors should "moderate buy" SEPN shares. Does Septerna's stock price have much upside? According to analysts, Septerna's stock has a predicted upside of 28.29% based on their 12-month stock forecasts. What analysts cover Septerna? Septerna has been rated by research analysts at Guggenheim, HC Wainwright, JonesTrading, JPMorgan Chase & Co., Raymond James Financial, Stifel Nicolaus, Weiss Ratings, and Wells Fargo & Company in the past 90 days. Do Wall Street analysts like Septerna more than its competitors? Analysts like Septerna more than other "healthcare" companies. The consensus rating for Septerna is Moderate Buy while the average consensus rating for "healthcare" companies is Hold. Learn more on how SEPN compares to other companies. Stock Forecasts and Research Tools Related Companies Praxis Precision Medicines Stock Forecast Alkermes Stock Forecast Iovance Biotherapeutics Stock Forecast GRAIL Stock Forecast Kiniksa Pharmaceuticals International Stock Forecast Ligand Pharmaceuticals Stock Forecast Rhythm Pharmaceuticals Stock Forecast Immunovant Stock Forecast Kodiak Sciences Stock Forecast CG Oncology Stock Forecast Today's Analyst Ratings U.S. Ratings U.K. Ratings Canadian Ratings All Upgrades All Downgrades All Initiations All Price Target Changes Top-Rated Stocks Top Rated Stocks Top-Rated Dividend Stocks Top-Rated Small-Cap Stocks Top-Rated Tech Stocks Most-Upgraded Stocks Most-Downgraded Stocks Lowest-Rated Stocks More Ratings Tools Stock Ratings by Issuer Top-Rated Analysts Top-Rated Brokerages Stock Ratings Screener Free Ratings Newsletter Brokerages With Septerna RecommendationsWeiss RatingsJPMorgan Chase & Co.JonesTradingHC WainwrightWells Fargo & CompanyGuggenheimRaymond James FinancialStifel NicolausTruist FinancialWall Street ZenCantor FitzgeraldZacks Research MarketBeat monitors more than a dozen sources for Septerna analyst ratings, with the most recent rating issued on 10/15/2026. 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