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Spruce Biosciences (SPRB) Competitors

Spruce Biosciences logo
$8.95 -0.06 (-0.67%)
As of 08/18/2025

SPRB vs. PMN, DARE, AYTU, GDTC, ASBP, CMMB, COCP, SYBX, MTEX, and PULM

Should you be buying Spruce Biosciences stock or one of its competitors? The main competitors of Spruce Biosciences include Promis Neurosciences (PMN), Dare Bioscience (DARE), Aytu BioPharma (AYTU), CytoMed Therapeutics (GDTC), Aspire Biopharma (ASBP), Chemomab Therapeutics (CMMB), Cocrystal Pharma (COCP), Synlogic (SYBX), Mannatech (MTEX), and Pulmatrix (PULM). These companies are all part of the "pharmaceutical products" industry.

Spruce Biosciences vs. Its Competitors

Spruce Biosciences (NASDAQ:SPRB) and Promis Neurosciences (NASDAQ:PMN) are both small-cap medical companies, but which is the superior stock? We will contrast the two businesses based on the strength of their analyst recommendations, earnings, media sentiment, institutional ownership, risk, valuation, dividends and profitability.

Spruce Biosciences has a beta of 2.43, meaning that its share price is 143% more volatile than the S&P 500. Comparatively, Promis Neurosciences has a beta of -0.04, meaning that its share price is 104% less volatile than the S&P 500.

91.7% of Spruce Biosciences shares are held by institutional investors. Comparatively, 50.1% of Promis Neurosciences shares are held by institutional investors. 6.9% of Spruce Biosciences shares are held by company insiders. Comparatively, 6.1% of Promis Neurosciences shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

Promis Neurosciences has a net margin of 0.00% compared to Spruce Biosciences' net margin of -555.23%. Spruce Biosciences' return on equity of -62.10% beat Promis Neurosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Spruce Biosciences-555.23% -62.10% -47.49%
Promis Neurosciences N/A -266.69%-131.59%

Promis Neurosciences has lower revenue, but higher earnings than Spruce Biosciences. Promis Neurosciences is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spruce Biosciences$4.91M1.02-$47.92M-$99.25-0.09
Promis NeurosciencesN/AN/A$2.78M-$0.21-2.69

Spruce Biosciences presently has a consensus target price of $131.25, suggesting a potential upside of 1,366.48%. Promis Neurosciences has a consensus target price of $4.33, suggesting a potential upside of 666.96%. Given Spruce Biosciences' higher probable upside, research analysts clearly believe Spruce Biosciences is more favorable than Promis Neurosciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spruce Biosciences
0 Sell rating(s)
6 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
2.00
Promis Neurosciences
0 Sell rating(s)
0 Hold rating(s)
3 Buy rating(s)
0 Strong Buy rating(s)
3.00

In the previous week, Spruce Biosciences and Spruce Biosciences both had 4 articles in the media. Spruce Biosciences' average media sentiment score of -0.04 beat Promis Neurosciences' score of -0.50 indicating that Spruce Biosciences is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spruce Biosciences
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Promis Neurosciences
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Negative

Summary

Spruce Biosciences beats Promis Neurosciences on 8 of the 13 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SPRB and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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SPRB vs. The Competition

MetricSpruce BiosciencesPharmaceutical IndustryMedical SectorNASDAQ Exchange
Market Cap$5.03M$806.51M$5.75B$9.64B
Dividend YieldN/A4.84%3.91%4.09%
P/E Ratio-9.521.1530.7825.12
Price / Sales1.0225.87458.48157.26
Price / CashN/A19.5625.2228.45
Price / Book4.766.609.365.94
Net Income-$47.92M-$4.93M$3.26B$265.56M
7 Day Performance-2.19%-0.17%1.83%0.95%
1 Month Performance8.48%-0.30%3.69%2.47%
1 Year Performance-74.61%20.91%28.88%20.24%

Spruce Biosciences Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SPRB
Spruce Biosciences
2.0843 of 5 stars
$8.95
-0.7%
$131.25
+1,366.5%
-73.4%$5.03M$4.91M-9.5220News Coverage
Short Interest ↑
PMN
Promis Neurosciences
3.0139 of 5 stars
$0.62
flat
$4.33
+602.3%
-50.6%$20.17MN/A-2.945Earnings Report
Gap Down
DARE
Dare Bioscience
2.4829 of 5 stars
$2.11
-4.1%
$12.00
+468.7%
-40.9%$19.87M-$17.70K-0.9930Earnings Report
Analyst Upgrade
AYTU
Aytu BioPharma
3.6323 of 5 stars
$2.20
-0.5%
$10.00
+354.5%
-16.7%$19.84M$81.66M-3.06160Gap Down
GDTC
CytoMed Therapeutics
2.2959 of 5 stars
$1.78
-1.4%
$5.00
+181.7%
+6.8%$19.69M$69.50K0.00N/ANews Coverage
Positive News
Short Interest ↓
ASBP
Aspire Biopharma
N/A$0.59
+64.3%
N/AN/A$17.78MN/A0.00N/ANews Coverage
Earnings Report
Gap Down
High Trading Volume
CMMB
Chemomab Therapeutics
3.3057 of 5 stars
$0.94
+1.1%
$8.50
+804.3%
-15.3%$17.54MN/A-1.5920Earnings Report
Upcoming Earnings
Short Interest ↓
COCP
Cocrystal Pharma
3.0408 of 5 stars
$1.56
-8.0%
$6.00
+284.6%
-14.3%$17.39MN/A-1.2610News Coverage
Positive News
Earnings Report
Short Interest ↓
SYBX
Synlogic
0.6152 of 5 stars
$1.44
-3.0%
N/A-0.3%$17.32MN/A-0.5780Negative News
Short Interest ↑
MTEX
Mannatech
0.4377 of 5 stars
$8.53
-6.3%
N/A+14.1%$17.30M$112.98M-4.18250Earnings Report
Short Interest ↑
Gap Up
PULM
Pulmatrix
1.1932 of 5 stars
$4.71
flat
N/A+132.0%$17.19M$369K-2.1720Positive News
Short Interest ↓

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This page (NASDAQ:SPRB) was last updated on 8/19/2025 by MarketBeat.com Staff
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