Spruce Biosciences (SPRB) Competitors $8.95 -0.06 (-0.67%) As of 08/18/2025 Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock SPRB vs. PMN, DARE, AYTU, GDTC, ASBP, CMMB, COCP, SYBX, MTEX, and PULMShould you be buying Spruce Biosciences stock or one of its competitors? The main competitors of Spruce Biosciences include Promis Neurosciences (PMN), Dare Bioscience (DARE), Aytu BioPharma (AYTU), CytoMed Therapeutics (GDTC), Aspire Biopharma (ASBP), Chemomab Therapeutics (CMMB), Cocrystal Pharma (COCP), Synlogic (SYBX), Mannatech (MTEX), and Pulmatrix (PULM). These companies are all part of the "pharmaceutical products" industry. Spruce Biosciences vs. Its Competitors Promis Neurosciences Dare Bioscience Aytu BioPharma CytoMed Therapeutics Aspire Biopharma Chemomab Therapeutics Cocrystal Pharma Synlogic Mannatech Pulmatrix Spruce Biosciences (NASDAQ:SPRB) and Promis Neurosciences (NASDAQ:PMN) are both small-cap medical companies, but which is the superior stock? We will contrast the two businesses based on the strength of their analyst recommendations, earnings, media sentiment, institutional ownership, risk, valuation, dividends and profitability. Which has more volatility and risk, SPRB or PMN? Spruce Biosciences has a beta of 2.43, meaning that its share price is 143% more volatile than the S&P 500. Comparatively, Promis Neurosciences has a beta of -0.04, meaning that its share price is 104% less volatile than the S&P 500. Do institutionals and insiders believe in SPRB or PMN? 91.7% of Spruce Biosciences shares are held by institutional investors. Comparatively, 50.1% of Promis Neurosciences shares are held by institutional investors. 6.9% of Spruce Biosciences shares are held by company insiders. Comparatively, 6.1% of Promis Neurosciences shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term. Is SPRB or PMN more profitable? Promis Neurosciences has a net margin of 0.00% compared to Spruce Biosciences' net margin of -555.23%. Spruce Biosciences' return on equity of -62.10% beat Promis Neurosciences' return on equity.Company Net Margins Return on Equity Return on Assets Spruce Biosciences-555.23% -62.10% -47.49% Promis Neurosciences N/A -266.69%-131.59% Which has preferable earnings and valuation, SPRB or PMN? Promis Neurosciences has lower revenue, but higher earnings than Spruce Biosciences. Promis Neurosciences is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioSpruce Biosciences$4.91M1.02-$47.92M-$99.25-0.09Promis NeurosciencesN/AN/A$2.78M-$0.21-2.69 Do analysts rate SPRB or PMN? Spruce Biosciences presently has a consensus target price of $131.25, suggesting a potential upside of 1,366.48%. Promis Neurosciences has a consensus target price of $4.33, suggesting a potential upside of 666.96%. Given Spruce Biosciences' higher probable upside, research analysts clearly believe Spruce Biosciences is more favorable than Promis Neurosciences.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Spruce Biosciences 0 Sell rating(s) 6 Hold rating(s) 0 Buy rating(s) 0 Strong Buy rating(s) 2.00Promis Neurosciences 0 Sell rating(s) 0 Hold rating(s) 3 Buy rating(s) 0 Strong Buy rating(s) 3.00 Does the media refer more to SPRB or PMN? In the previous week, Spruce Biosciences and Spruce Biosciences both had 4 articles in the media. Spruce Biosciences' average media sentiment score of -0.04 beat Promis Neurosciences' score of -0.50 indicating that Spruce Biosciences is being referred to more favorably in the media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Spruce Biosciences 0 Very Positive mention(s) 1 Positive mention(s) 2 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Neutral Promis Neurosciences 0 Very Positive mention(s) 0 Positive mention(s) 2 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Negative SummarySpruce Biosciences beats Promis Neurosciences on 8 of the 13 factors compared between the two stocks. Get Spruce Biosciences News Delivered to You Automatically Sign up to receive the latest news and ratings for SPRB and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding SPRB and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart SPRB vs. The Competition Export to ExcelMetricSpruce BiosciencesPharmaceutical IndustryMedical SectorNASDAQ ExchangeMarket Cap$5.03M$806.51M$5.75B$9.64BDividend YieldN/A4.84%3.91%4.09%P/E Ratio-9.521.1530.7825.12Price / Sales1.0225.87458.48157.26Price / CashN/A19.5625.2228.45Price / Book4.766.609.365.94Net Income-$47.92M-$4.93M$3.26B$265.56M7 Day Performance-2.19%-0.17%1.83%0.95%1 Month Performance8.48%-0.30%3.69%2.47%1 Year Performance-74.61%20.91%28.88%20.24% Spruce Biosciences Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)SPRBSpruce Biosciences2.0843 of 5 stars$8.95-0.7%$131.25+1,366.5%-73.4%$5.03M$4.91M-9.5220News CoverageShort Interest ↑PMNPromis Neurosciences3.0139 of 5 stars$0.62flat$4.33+602.3%-50.6%$20.17MN/A-2.945Earnings ReportGap DownDAREDare Bioscience2.4829 of 5 stars$2.11-4.1%$12.00+468.7%-40.9%$19.87M-$17.70K-0.9930Earnings ReportAnalyst UpgradeAYTUAytu BioPharma3.6323 of 5 stars$2.20-0.5%$10.00+354.5%-16.7%$19.84M$81.66M-3.06160Gap DownGDTCCytoMed Therapeutics2.2959 of 5 stars$1.78-1.4%$5.00+181.7%+6.8%$19.69M$69.50K0.00N/ANews CoveragePositive NewsShort Interest ↓ASBPAspire BiopharmaN/A$0.59+64.3%N/AN/A$17.78MN/A0.00N/ANews CoverageEarnings ReportGap DownHigh Trading VolumeCMMBChemomab Therapeutics3.3057 of 5 stars$0.94+1.1%$8.50+804.3%-15.3%$17.54MN/A-1.5920Earnings ReportUpcoming EarningsShort Interest ↓COCPCocrystal Pharma3.0408 of 5 stars$1.56-8.0%$6.00+284.6%-14.3%$17.39MN/A-1.2610News CoveragePositive NewsEarnings ReportShort Interest ↓SYBXSynlogic0.6152 of 5 stars$1.44-3.0%N/A-0.3%$17.32MN/A-0.5780Negative NewsShort Interest ↑MTEXMannatech0.4377 of 5 stars$8.53-6.3%N/A+14.1%$17.30M$112.98M-4.18250Earnings ReportShort Interest ↑Gap UpPULMPulmatrix1.1932 of 5 stars$4.71flatN/A+132.0%$17.19M$369K-2.1720Positive NewsShort Interest ↓ Related Companies and Tools Related Companies Promis Neurosciences Competitors Dare Bioscience Competitors Aytu BioPharma Competitors CytoMed Therapeutics Competitors Aspire Biopharma Competitors Chemomab Therapeutics Competitors Cocrystal Pharma Competitors Synlogic Competitors Mannatech Competitors Pulmatrix Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:SPRB) was last updated on 8/19/2025 by MarketBeat.com Staff From Our PartnersTrump’s national nightmare is herePorter Stansberry and Jeff Brown say a new U.S. national emergency is already underway — and it could trigger ...Porter & Company | SponsoredThis is my Christian duty“This land I will give to you…” — a 4,000-year-old line from Genesis may hold the key to unlocking a $150 tril...Paradigm Press | SponsoredAlex’s “Next Magnificent Seven” stocksThe original “Magnificent Seven” turned $7K into $1.18 million. 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