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Spyre Therapeutics (SYRE) Competitors

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$21.29 -1.12 (-5.00%)
Closing price 04:00 PM Eastern
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$21.32 +0.03 (+0.12%)
As of 07:33 PM Eastern
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SYRE vs. KRYS, SWTX, BHVN, RXRX, PTCT, OGN, RARE, ALVO, RNA, and ADMA

Should you be buying Spyre Therapeutics stock or one of its competitors? The main competitors of Spyre Therapeutics include Krystal Biotech (KRYS), SpringWorks Therapeutics (SWTX), Biohaven (BHVN), Recursion Pharmaceuticals (RXRX), PTC Therapeutics (PTCT), Organon & Co. (OGN), Ultragenyx Pharmaceutical (RARE), Alvotech (ALVO), Avidity Biosciences (RNA), and ADMA Biologics (ADMA). These companies are all part of the "pharmaceutical products" industry.

Spyre Therapeutics vs.

Spyre Therapeutics (NASDAQ:SYRE) and Krystal Biotech (NASDAQ:KRYS) are both medical companies, but which is the better stock? We will compare the two companies based on the strength of their community ranking, dividends, valuation, analyst recommendations, profitability, risk, media sentiment, earnings and institutional ownership.

Krystal Biotech has a net margin of 30.69% compared to Spyre Therapeutics' net margin of 0.00%. Krystal Biotech's return on equity of 11.41% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -210.01% -44.40%
Krystal Biotech 30.69%11.41%10.40%

80.4% of Spyre Therapeutics shares are owned by institutional investors. Comparatively, 86.3% of Krystal Biotech shares are owned by institutional investors. 6.2% of Spyre Therapeutics shares are owned by company insiders. Comparatively, 14.1% of Krystal Biotech shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Spyre Therapeutics has a beta of 2.85, indicating that its stock price is 185% more volatile than the S&P 500. Comparatively, Krystal Biotech has a beta of 0.84, indicating that its stock price is 16% less volatile than the S&P 500.

Krystal Biotech has higher revenue and earnings than Spyre Therapeutics. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre Therapeutics$890K1,230.27-$338.79M-$7.47-2.85
Krystal Biotech$290.52M18.60$10.93M$2.9962.83

In the previous week, Krystal Biotech had 25 more articles in the media than Spyre Therapeutics. MarketBeat recorded 32 mentions for Krystal Biotech and 7 mentions for Spyre Therapeutics. Krystal Biotech's average media sentiment score of 0.75 beat Spyre Therapeutics' score of 0.61 indicating that Krystal Biotech is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
1 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Krystal Biotech
9 Very Positive mention(s)
7 Positive mention(s)
10 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Krystal Biotech received 275 more outperform votes than Spyre Therapeutics when rated by MarketBeat users. However, 100.00% of users gave Spyre Therapeutics an outperform vote while only 67.51% of users gave Krystal Biotech an outperform vote.

CompanyUnderperformOutperform
Spyre TherapeuticsOutperform Votes
18
100.00%
Underperform Votes
No Votes
Krystal BiotechOutperform Votes
293
67.51%
Underperform Votes
141
32.49%

Spyre Therapeutics currently has a consensus price target of $54.83, suggesting a potential upside of 157.55%. Krystal Biotech has a consensus price target of $210.00, suggesting a potential upside of 11.79%. Given Spyre Therapeutics' stronger consensus rating and higher possible upside, equities analysts plainly believe Spyre Therapeutics is more favorable than Krystal Biotech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
0 Sell rating(s)
0 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
3.13
Krystal Biotech
0 Sell rating(s)
1 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
3.00

Summary

Krystal Biotech beats Spyre Therapeutics on 12 of the 18 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding {thisCompany.Symbol} and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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SYRE vs. The Competition

MetricSpyre TherapeuticsPharmaceutical IndustryMedical SectorNASDAQ Exchange
Market Cap$1.09B$7.04B$5.78B$8.98B
Dividend YieldN/A2.87%4.78%3.85%
P/E Ratio-2.856.1326.4618.82
Price / Sales1,230.27313.78457.6880.73
Price / CashN/A67.8344.0437.47
Price / Book-96.776.747.634.64
Net Income-$338.79M$138.11M$3.18B$245.69M
7 Day Performance-7.11%-2.02%-1.82%-2.63%
1 Month Performance-4.44%-1.54%0.22%-2.37%
1 Year Performance3.96%-3.14%17.49%13.65%

Spyre Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SYRE
Spyre Therapeutics
2.0845 of 5 stars
$21.29
-5.0%
$54.83
+157.6%
+2.1%$1.09B$890,000.00-2.85100Analyst Upgrade
News Coverage
KRYS
Krystal Biotech
4.4767 of 5 stars
$153.24
-1.6%
$206.67
+34.9%
+63.6%$4.41B$50.70M86.58210Earnings Report
Analyst Forecast
Analyst Revision
News Coverage
SWTX
SpringWorks Therapeutics
1.2527 of 5 stars
$57.43
-2.0%
$70.83
+23.3%
+22.8%$4.27B$5.45M-14.80230Earnings Report
Analyst Forecast
Insider Trade
News Coverage
BHVN
Biohaven
3.3776 of 5 stars
$41.45
-0.8%
$63.15
+52.4%
-15.8%$4.19BN/A-4.43239Short Interest ↓
RXRX
Recursion Pharmaceuticals
1.5231 of 5 stars
$10.53
+23.9%
$8.75
-16.9%
-17.8%$4.11B$64.60M-6.88400High Trading Volume
PTCT
PTC Therapeutics
3.6197 of 5 stars
$51.82
+4.3%
$58.85
+13.6%
+93.9%$4.00B$937.82M-8.721,410Analyst Forecast
News Coverage
OGN
Organon & Co.
4.8637 of 5 stars
$15.30
-6.3%
$20.80
+36.0%
-15.2%$3.94B$6.26B3.0310,000
RARE
Ultragenyx Pharmaceutical
4.6097 of 5 stars
$42.49
-2.4%
$92.43
+117.5%
-7.1%$3.92B$434.25M-6.571,276Analyst Forecast
ALVO
Alvotech
2.6284 of 5 stars
$12.99
+1.6%
$18.00
+38.6%
-26.7%$3.92B$391.87M-7.021,026News Coverage
RNA
Avidity Biosciences
1.613 of 5 stars
$32.31
-2.2%
$65.80
+103.7%
+132.7%$3.85B$9.56M-11.22190
ADMA
ADMA Biologics
3.5404 of 5 stars
$15.90
-1.1%
$21.25
+33.6%
+212.2%$3.76B$258.21M56.79530

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This page (NASDAQ:SYRE) was last updated on 2/21/2025 by MarketBeat.com Staff
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