Syros Pharmaceuticals (SYRS) Short Interest Ratio & Short Volume $0.03 0.00 (-6.45%) As of 11:31 AM Eastern Add Compare Share Share Short Interest Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Syros Pharmaceuticals Short Interest DataSyros Pharmaceuticals (SYRS) has a short interest of 4.19 million shares, representing 17.70% of the float (the number of shares available for trading by the public). This marks a 345.93% increase in short interest from the previous month. The short interest ratio (days to cover) is 0.2, indicating that it would take 0.2 days of the average trading volume of 8.04 million shares to cover all short positions.Current Short Interest4,190,000 sharesPrevious Short Interest939,600 sharesChange Vs. Previous Month+345.93%Dollar Volume Sold Short$387,156.00Short Interest Ratio0.2 Days to CoverLast Record DateMarch 15, 2025Outstanding Shares26,832,000 sharesFloat Size23,670,000 sharesShort Percent of Float17.70%Today's Trading Volume415,474 sharesAverage Trading Volume8,043,257 sharesToday's Volume Vs. Average5% Short Selling Syros Pharmaceuticals? Sign up to receive the latest short interest report for Syros Pharmaceuticals and its competitors with MarketBeat's FREE newsletter. Email Address Skip Charts & View Short Interest HistoryShort Interest ChartDays to Cover ChartShort Percent of Float ChartSYRS Short Interest Over TimeSYRS Days to Cover Over TimeSYRS Percentage of Float Shorted Over Time Remove Ads Syros Pharmaceuticals Short Interest History Export to ExcelReport DateTotal Shares Sold ShortDollar Volume Sold ShortChange from Previous ReportPercentage of Float ShortedDays to CoverPrice on Report Date 3/15/20254,190,000 shares $387,156.00 +345.9%17.7%0.2 $0.09 2/28/2025939,600 shares $134,550.72 +2.9%4.0%0.1 $0.14 2/15/2025913,100 shares $168,923.50 +26.3%3.9%0.4 $0.19 1/31/2025723,200 shares $126,704.64 -47.2%4.2%0.1 $0.18 1/15/20251,370,000 shares $326,197.00 +24.6%7.9%0.1 $0.24 12/31/20241,100,000 shares $252,780.00 -29.9%6.3%0.1 $0.23 12/15/20241,570,000 shares $325,304.00 -29.6%9.0%0.2 $0.21 11/30/20242,230,000 shares $605,445.00 -53.3%12.8%0.3 $0.27 11/15/20244,770,000 shares $1.24 million +281.6%27.7%0.6 $0.26 10/31/20241,250,000 shares $3.15 million +31.2%6.4%2.8 $2.52 Get the Latest News and Ratings for SYRS and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Syros Pharmaceuticals and its competitors with MarketBeat's FREE daily newsletter. 10/15/2024952,600 shares $1.90 million -4.7%4.8%2.5 $1.99 9/30/2024999,900 shares $2.15 million -9.1%5.1%3.1 $2.15 9/15/20241,100,000 shares $2.15 million +14.9%5.6%3.6 $1.95 8/31/2024957,500 shares $1.57 million -22.8%4.8%4 $1.64 8/15/20241,240,000 shares $1.90 million -6.8%6.2%5.3 $1.53 7/31/20241,330,000 shares $7.98 million +4.7%6.7%12.9 $6.00 7/15/20241,270,000 shares $7.80 million -3.1%6.4%12.5 $6.14 6/30/20241,310,000 shares $6.76 million +4.0%6.6%9.8 $5.16 6/15/20241,260,000 shares $7.56 million -4.6%6.4%7.8 $6.00 5/31/20241,320,000 shares $6.73 million -13.2%6.6%8 $5.10 5/15/20241,520,000 shares $8.38 million +4.8%7.6%8 $5.51 4/30/20241,450,000 shares $7.83 million -22.0%7.8%7.4 $5.40 4/15/20241,860,000 shares $9.95 million +2.2%10.1%8.5 $5.35 3/31/20241,820,000 shares $9.74 million +4.6%9.9%8.4 $5.35 3/15/20241,740,000 shares $10.46 million +31.8%9.6%8.2 $6.01 2/29/20241,320,000 shares $9.58 million +29.4%7.3%4.1 $7.26 2/15/20241,020,000 shares $7.22 million +38.1%5.6%3.4 $7.08 1/31/2024738,800 shares $5.28 million +27.1%3.6%2.6 $7.14 1/15/2024581,200 shares $4.21 million +18.5%2.8%2.2 $7.24 12/31/2023490,600 shares $3.82 million -2.6%2.5%2.1 $7.79 12/15/2023503,500 shares $2.09 million +2.1%2.5%2.5 $4.16 11/30/2023493,400 shares $1.36 million +0.3%3.0%3.2 $2.75 11/15/2023491,800 shares $1.50 million -11.1%3.0%8.5 $3.04 10/31/2023553,100 shares $1.38 million -9.5%3.4%9.3 $2.49 10/15/2023611,200 shares $1.58 million -5.6%3.8%10.5 $2.59 9/30/2023647,300 shares $2.56 million +8.7%4.0%10.7 $3.95 9/15/2023595,500 shares $2.34 million -4.2%3.7%9.7 $3.93 8/31/2023621,800 shares $2.43 million -0.1%3.8%9.9 $3.90 8/15/2023622,600 shares $2.37 million -6.4%3.8%9.3 $3.81 7/31/2023665,000 shares $2.65 million +0.8%3.6%9 $3.98Trump’s betrayal exposed (Ad)Trump’s Final Reset Inside the shocking plot to re-engineer America’s financial system…and why you need to move your money now.Millions of Americans are about to be wiped out, while others could make a fortune… click here to ma 7/15/2023660,000 shares $2.21 million +2.9%3.6%8.5 $3.35 6/30/2023641,500 shares $2.02 million +1.9%3.5%8.2 $3.15 6/15/2023629,700 shares $2.04 million +0.6%3.5%7.7 $3.24 5/31/2023625,800 shares $2.41 million -0.7%4.0%6.2 $3.85 5/15/2023630,200 shares $2.37 million -4.9%4.0%5.8 $3.76 4/30/2023662,700 shares $2.11 million -6.2%4.4%6.3 $3.18 4/15/2023706,700 shares $1.91 million -2.4%4.7%5.5 $2.70 3/31/2023724,200 shares $1.93 million +11.5%4.8%5.5 $2.67 3/15/2023649,500 shares $2.01 million +21.6%4.3%4.9 $3.09 2/28/2023534,300 shares $2.01 million -5.9%3.6%4.4 $3.76 2/15/2023567,600 shares $2.35 million -7.7%3.8%4.8 $4.14 1/31/2023615,100 shares $3.14 million +5.2%3.8%4.9 $5.11 1/15/2023584,700 shares $2.79 million -39.4%3.7%5.4 $4.77 12/30/2022964,400 shares $3.46 million +1.9%6.0%8.3 $3.59 12/15/2022946,500 shares $3.43 million +13.2%5.9%7.6 $3.62 11/30/2022836,400 shares $3.31 million +1.6%5.2%3.3 $3.96 11/15/2022823,300 shares $3.30 million +21.8%5.1%3.4 $4.01 10/31/2022676,000 shares $3.39 million +11.1%3.4%2.9 $5.02 10/15/2022608,700 shares $3.51 million -13.7%3.1%2.6 $5.77 9/30/2022705,200 shares $4.54 million -9.1%8.9%3.2 $6.44 9/15/2022775,700 shares $5.66 million -79.9%12.6%3.6 $7.29 8/31/20223,850,000 shares $3.08 million +5.2%14.3%5.3 $0.80 8/15/20223,660,000 shares $3.70 million +78.5%13.6%4.5 $1.01 7/31/20222,050,000 shares $1.61 million No Change7.6%2.4 $0.79 7/15/20222,050,000 shares $1.92 million +31.4%7.6%2.4 $0.94 6/30/20221,560,000 shares $1.50 million -53.3%3.5%1.7 $0.96 6/15/20223,340,000 shares $3.57 million -4.8%7.5%3.3 $1.07 5/31/20223,510,000 shares $2.89 million -14.8%8.0%3.9 $0.82 5/15/20224,120,000 shares $3.70 million +9.6%9.4%5 $0.90 4/30/20223,760,000 shares $3.17 million +29.7%9.0%4.9 $0.84 4/15/20222,900,000 shares $2.63 million -9.4%7.0%3.9 $0.91 3/31/20223,200,000 shares $3.81 million -4.8%7.8%5.4 $1.19 3/15/20223,360,000 shares $3.73 million -18.8%8.2%7 $1.11 2/28/20224,140,000 shares $5.34 million +1.7%10.1%9.3 $1.29 2/15/20224,070,000 shares $6.47 million -4.7%9.9%9.4 $1.59 1/31/20224,270,000 shares $8.45 million +4.4%10.9%10 $1.98 1/15/20224,090,000 shares $11.00 million +19.6%10.5%11.6 $2.69 12/31/20213,420,000 shares $11.15 million No Change8.8%10.2 $3.26 12/15/20213,420,000 shares $11.97 million -7.6%8.8%9.4 $3.50 11/30/20213,700,000 shares $14.65 million +3.6%9.5%8.2 $3.96 11/15/20213,570,000 shares $15.21 million -7.0%9.2%7.6 $4.26 10/29/20213,840,000 shares $15.86 million -6.8%9.8%8.1 $4.13 10/15/20214,120,000 shares $18.66 million +1.7%10.5%8.1 $4.53 9/30/20214,050,000 shares $18.10 million -6.0%10.3%7 $4.47 9/15/20214,310,000 shares $22.58 million -2.9%11.0%6.5 $5.24 8/31/20214,440,000 shares $23.53 million No Change11.3%6 $5.30 8/13/20214,440,000 shares $20.34 million +2.1%11.3%3.6 $4.58 7/30/20214,350,000 shares $20.10 million +9.9%10.8%3.2 $4.62 7/15/20213,960,000 shares $18.14 million -17.2%9.4%2.9 $4.58 6/30/20214,780,000 shares $26.05 million -2.3%11.4%3.5 $5.45Trump’s betrayal exposed (Ad)Trump’s Final Reset Inside the shocking plot to re-engineer America’s financial system…and why you need to move your money now.Millions of Americans are about to be wiped out, while others could make a fortune… click here to ma 6/15/20214,890,000 shares $28.07 million -14.4%11.7%3.6 $5.74 5/28/20215,710,000 shares $36.83 million -6.6%13.7%4.6 $6.45 5/14/20216,110,000 shares $31.10 million +15.7%14.6%6.8 $5.09 4/30/20215,280,000 shares $32.95 million +7.8%12.5%7.4 $6.24 4/15/20214,900,000 shares $32.49 million -9.4%11.6%6.9 $6.63 3/31/20215,410,000 shares $39.20 million +10.9%12.8%7.1 $7.25 3/15/20214,880,000 shares $43.82 million +21.1%11.6%6.2 $8.98 2/26/20214,030,000 shares $35.79 million +10.7%9.6%5 $8.88 2/12/20213,640,000 shares $42.77 million -4.0%8.7%4.9 $11.75 1/29/20213,790,000 shares $40.36 million +7.7%N/A5.4 $10.65 1/15/20213,520,000 shares $48.68 million No ChangeN/A4.9 $13.83 12/31/20203,520,000 shares $41.78 million -22.8%8.8%5.6 $11.87 12/15/20204,560,000 shares $53.12 million +2.0%14.0%7.8 $11.65 11/30/20204,470,000 shares $36.43 million -3.7%11.3%8.8 $8.15 11/15/20204,640,000 shares $40.74 million -20.6%11.7%10 $8.78 10/30/20205,840,000 shares $40.18 million +4.1%14.7%12 $6.88 10/15/20205,610,000 shares $50.01 million +15.7%14.2%13.5 $8.92 9/30/20204,850,000 shares $42.87 million +31.1%12.2%13 $8.84 9/15/20203,700,000 shares $38.48 million +2.2%9.3%9.9 $10.40 8/31/20203,620,000 shares $47.97 million +31.2%9.1%9.9 $13.25 8/14/20202,760,000 shares $32.87 million -4.8%7.0%7.9 $11.91 7/31/20202,900,000 shares $27.52 million -1.4%8.2%9 $9.49 7/15/20202,940,000 shares $33.49 million -7.8%8.4%8.2 $11.39 6/30/20203,190,000 shares $34.01 million +13.9%9.1%8.5 $10.66 6/15/20202,800,000 shares $25.82 million -1.8%8.0%7.9 $9.22 5/29/20202,850,000 shares $27.90 million +2.5%8.2%9 $9.79 5/15/20202,780,000 shares $26.22 million +2.6%8.0%8.5 $9.43 4/30/20202,710,000 shares $22.93 million -4.2%7.9%9.6 $8.46 4/15/20202,830,000 shares $24.65 million +19.4%8.8%11.4 $8.71 3/31/20202,370,000 shares $19.22 million -5.3%7.4%9.3 $8.11 SYRS Short Interest - Frequently Asked Questions What is Syros Pharmaceuticals' current short interest? Short interest is the volume of Syros Pharmaceuticals shares that have been sold short but have not yet been closed out or covered. As of March 15th, investors have sold 4,190,000 shares of SYRS short. 17.70% of Syros Pharmaceuticals' shares are currently sold short. Learn More on Syros Pharmaceuticals' current short interest. Which institutional investors are shorting Syros Pharmaceuticals? As of the most recent reporting period, the following institutional investors, funds, and major shareholders have reported short positions of Syros Pharmaceuticals: Torno Capital LLC, Citadel Advisors LLC, Concourse Financial Group Securities Inc., Affinity Asset Advisors LLC, and FNY Investment Advisers LLC. These positions are disclosed in Form 13F filings with the Securities and Exchange Commission. What is a good short interest percentage for Syros Pharmaceuticals? Companies that have a short interest as a percentage of float below 10% indicates positive investor sentiment and few short sellers. Stocks with a short interest percentage above 10% is considered high, suggesting some investors are pessimistic about the stock. Companies with a short interest percentage of 20% or more indicates widespread negative sentiment. 17.70% of Syros Pharmaceuticals' floating shares are currently sold short. Is Syros Pharmaceuticals' short interest increasing or decreasing? Syros Pharmaceuticals saw a increase in short interest in March. As of March 15th, there was short interest totaling 4,190,000 shares, an increase of 345.9% from the previous total of 939,600 shares. Changes in short volume can be used to identify positive and negative investor sentiment. Investors that short sell a stock are betting that its price will decline in the future. An increase in short sale volume suggests bearish (negative) sentiment among investors. A decrease on short sale volume suggests bullish (positive) sentiment. What is Syros Pharmaceuticals' float size? Syros Pharmaceuticals currently has issued a total of 26,832,000 shares. Some of Syros Pharmaceuticals' outstanding shares are available for trading, while others are subject to various restrictions. The public float, also referred to as floating shares or "the float", are shares that publicly owned, unrestricted and available to trade on the open market. Syros Pharmaceuticals currently has a public float of 23,670,000 shares. How does Syros Pharmaceuticals' short interest compare to its competitors? 17.70% of Syros Pharmaceuticals' shares are currently sold short. Here is how the short interest of companies in the industry of "pharmaceutical products" compare to Syros Pharmaceuticals: Turnstone Biologics Corp. (2.60%), Brainstorm Cell Therapeutics Inc. (2.77%), Relmada Therapeutics, Inc. (6.02%), TherapeuticsMD, Inc. (1.51%), ABVC BioPharma, Inc. (2.86%), Apollomics, Inc. (0.34%), Onconetix, Inc. (7.86%), Hoth Therapeutics, Inc. (2.17%), Ainos, Inc. (11.98%), Addex Therapeutics Ltd (0.13%), Which stocks are the most shorted right now? As of the most recent reporting period, the following stocks had the largest short interest positions: Invesco QQQ ($26.28 billion), iShares 20+ Year Treasury Bond ETF ($9.53 billion), MicroStrategy Incorporated ($8.50 billion), Apollo Global Management, Inc. ($4.86 billion), Super Micro Computer, Inc. ($4.85 billion), Charter Communications, Inc. ($4.28 billion), Capital One Financial Co. ($4.08 billion), AppLovin Co. ($3.82 billion), Canadian Natural Resources Limited ($3.78 billion), and Schlumberger Limited ($2.87 billion). View all of the most shorted stocks. What does it mean to sell short Syros Pharmaceuticals stock? Short selling SYRS is an investing strategy that aims to generate trading profit from Syros Pharmaceuticals as its price is falling. SYRS shares are trading down $0.00 today. To short a stock, an investor borrows shares, sells them and buys the shares back on the public market later to return it to the lender. Short sellers are betting that a stock will decline in price. If the stock does drop after selling, the short seller buys it back at a lower price and returns it to the lender. The difference between the sell price and the buy price is the trader's profit. How does a short squeeze work against Syros Pharmaceuticals? A short squeeze for Syros Pharmaceuticals occurs when it has a large amount of short interest and its stock appreciates in price. This forces short sellers to cover their short interest positions by buying actual shares of SYRS, which in turn drives the price of the stock up even further. How often is Syros Pharmaceuticals' short interest reported? Short interest is typically published by a stock exchange once per month. However, NASDAQ publishes a report for U.S. stocks, including SYRS, twice per month. The most recent reporting period available is March, 15 2025. More Short Interest Resources from MarketBeat Related Companies TSBX Short Interest Data BCLI Short Interest Data RLMD Short Interest Data TXMD Short Interest Data ABVC Short Interest Data APLM Short Interest Data ONCO Short Interest Data HOTH Short Interest Data AIMD Short Interest Data ADXN Short Interest Data Short Interest Tools Stocks to Short Largest Short Interest Positions Short Interest Increases Short Interest Decreases Short Interest Reporting Dates This page (NASDAQ:SYRS) was last updated on 3/27/2025 by MarketBeat.com Staff From Our PartnersA market crash is coming—here’s whenThe stock market cycle I've used to identify the most likely day of the next market crash is the exact same in...Chaikin Analytics | SponsoredYour Wealth is Under AttackPlease don't wait—this is your moment to take action. 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