Tango Therapeutics (TNGX) Stock Price, News & Analysis

Company Overview

Tango Therapeutics is a clinical-stage biotechnology company dedicated to developing precision medicines that exploit genetic vulnerabilities in cancer cells. Leveraging a proprietary synthetic lethality platform, the company identifies and targets tumor-specific dependencies in DNA damage response and related pathways. By focusing on tumor cell collateral sensitivities, Tango aims to bring differentiated small-molecule therapies to patients with genetic alterations that confer increased susceptibility to targeted inhibition.

The company’s lead pipeline comprises several early-stage programs, including inhibitors designed to selectively disable DNA repair proteins in tumor cells while sparing normal tissues. Tango has entered strategic collaborations with major pharmaceutical partners to advance these programs, most notably a multi-asset agreement with GSK to discover and develop DNA damage response inhibitors and a partnership with Merck focused on novel synthetic lethal targets in oncology. These alliances provide access to additional computational tools, screening libraries and global development expertise.

Founded in 2019 as a spin-out from Dana-Farber Cancer Institute and Harvard Medical School, Tango Therapeutics is headquartered in Cambridge, Massachusetts, near one of the world’s leading biopharma clusters. The management team combines scientific founders with broad drug development experience, enabling the company to rapidly translate genetic insights into translational programs. Tango has assembled an advisory board of academic and industry experts to guide target selection and clinical strategy.

With its concentrated focus on synthetic lethality, Tango Therapeutics seeks to address unmet needs in solid tumors and hematologic cancers driven by specific genetic lesions. The company is advancing its pipeline through IND-enabling studies and early clinical trials, aiming to validate its approach of pairing genomic profiling with highly selective therapies. Tango’s platform is designed to uncover novel treatment modalities that could extend the benefits of precision oncology to patient populations beyond those served by current standard-of-care agents.

Key Stats

• Today's Range: $6.78 to $7.40
• 50-Day Range: $5.01 to $7.22
• 52-Week Range: $1.03 to $11.92
• Volume: 3.92 million shs
• Average Volume: 1.73 million shs
• Market Capitalization: $772.14 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $10.50
• Consensus Rating: Buy

Tango Therapeutics Stock Analysis - MarketRank™

Tango Therapeutics scored higher than 46% of companies evaluated by MarketBeat, and ranked 703rd out of 933 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.5 / 5
• Analyst Rating: Buy

Consensus Rating

Tango Therapeutics has received a consensus rating of Buy. The company's average rating score is 3.00, and is based on 5 buy ratings, no hold ratings, and no sell ratings.

Amount of Analyst Coverage

Tango Therapeutics has only been the subject of 2 research reports in the past 90 days.

Earnings and Valuation

• Score: 0.0 / 5
• Proj. Earnings Growth: Decreasing

Earnings Growth

Earnings for Tango Therapeutics are expected to decrease in the coming year, from ($1.19) to ($1.38) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Tango Therapeutics is -5.22, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Tango Therapeutics is -5.22, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Tango Therapeutics has a P/B Ratio of 3.73. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.

Short Interest

• Score: 1.0 / 5
• Short Interest Level: Bearish

Percentage of Shares Shorted

40.11% of the float of Tango Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Tango Therapeutics has a short interest ratio ("days to cover") of 9.6.

Change versus previous month

Short interest in Tango Therapeutics has recently increased by 11.92%, indicating that investor sentiment is decreasing significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Tango Therapeutics does not currently pay a dividend.

Dividend Growth

Tango Therapeutics does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

40.11% of the float of Tango Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Tango Therapeutics has a short interest ratio ("days to cover") of 9.6.

Change versus previous month

Short interest in Tango Therapeutics has recently increased by 11.92%, indicating that investor sentiment is decreasing significantly.

News and Social Media

• Score: 3.1 / 5
• News Sentiment: 1.52

News Sentiment

Tango Therapeutics has a news sentiment score of 1.52. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a higher news sentiment than the 0.71 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 4 news articles for Tango Therapeutics this week, compared to 3 articles on an average week.

Search Interest

Only 4 people have searched for TNGX on MarketBeat in the last 30 days. This is a decrease of -78% compared to the previous 30 days.

Company Ownership

• Score: 2.5 / 5
• Insider Trading: Selling Shares

Insider Buying vs. Insider Selling

In the past three months, Tango Therapeutics insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $9,826,358.00 in company stock.

Percentage Held by Insiders

Only 7.50% of the stock of Tango Therapeutics is held by insiders.

Percentage Held by Institutions

78.99% of the stock of Tango Therapeutics is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

TNGX Stock Analysis - Frequently Asked Questions

How have TNGX shares performed this year?

Tango Therapeutics' stock was trading at $3.09 on January 1st, 2025. Since then, TNGX shares have increased by 124.6% and is now trading at $6.94.

How were Tango Therapeutics' earnings last quarter?

Tango Therapeutics, Inc. (NASDAQ:TNGX) posted its quarterly earnings results on Tuesday, August, 5th. The company reported ($0.35) EPS for the quarter, meeting the consensus estimate of ($0.35). The firm had revenue of $3.18 million for the quarter, compared to analysts' expectations of $6.41 million. Tango Therapeutics had a negative trailing twelve-month return on equity of 79.72% and a negative net margin of 599.11%.

Who are Tango Therapeutics' major shareholders?

Top institutional shareholders of Tango Therapeutics include Adage Capital Partners GP L.L.C. (5.31%), Nantahala Capital Management LLC (3.09%), Balyasny Asset Management L.P. (2.92%) and Geode Capital Management LLC (1.63%). Insiders that own company stock include Rock Ventures Iv LP Third, Boxer Capital, Llc, Boxer Capital Management, Llc, Barbara Weber, Mva Investors, Llc, Adam Crystal, Daniella Beckman, Douglas Barry and Mace Rothenberg.
View institutional ownership trends.

How do I buy shares of Tango Therapeutics?

Shares of TNGX stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Tango Therapeutics own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Tango Therapeutics investors own include NVIDIA (NVDA), Meta Platforms (META), Advanced Micro Devices (AMD), Broadcom (AVGO), Palo Alto Networks (PANW), Adobe (ADBE) and ServiceNow (NOW).

Company Calendar

• Last Earnings: 8/05/2025
• Today: 9/05/2025
• Next Earnings (Estimated): 11/05/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:TNGX
• CIK: 1819133
• Web: www.tangotx.com
• Phone: 857-320-4900
• Fax: N/A
• Employees: 90
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Tango Therapeutics: $10.50
• High Price Target: $13.00
• Low Price Target: $8.00
• Potential Upside/Downside: +53.7%
• Consensus Rating: Buy
• Rating Score (0-4): 3.00
• Research Coverage: 5 Analysts

Profitability

• EPS (Trailing Twelve Months): ($1.33)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$130.30 million
• Net Margins: -599.11%
• Pretax Margin: -598.40%
• Return on Equity: -79.72%
• Return on Assets: -49.30%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 4.75
• Quick Ratio: 4.75

Sales & Book Value

• Annual Sales: $42.07 million
• Price / Sales: 18.06
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $1.86 per share
• Price / Book: 3.67

Miscellaneous

• Outstanding Shares: 111,260,000
• Free Float: 102,916,000
• Market Cap: $759.91 million
• Optionable: Optionable
• Beta: 1.64