| 2/18/2025 | Frazier Life Sciences Management L.P. | 10,664,774 | $43.94M | 1.8% | +44.5% | 13.874% | |
| 2/17/2025 | VR Adviser LLC | 1,266,457 | $5.22M | 0.4% | -63.0% | 1.648% | |
| 2/17/2025 | Woodline Partners LP | 3,212,597 | $13.24M | 0.1% | +429.9% | 4.179% | |
| 2/17/2025 | Squarepoint Ops LLC | 14,059 | $58K | 0.0% | N/A | 0.018% | |
| 2/17/2025 | Two Sigma Advisers LP | 15,900 | $66K | 0.0% | N/A | 0.021% | |
| 2/17/2025 | Two Sigma Investments LP | 135,807 | $560K | 0.0% | N/A | 0.177% | |
| 2/17/2025 | Point72 Asset Management L.P. | 4,150,237 | $17.10M | 0.0% | N/A | 5.399% | |
| 2/17/2025 | ProShare Advisors LLC | 20,685 | $85K | 0.0% | +86.4% | 0.027% | |
| 2/17/2025 | MPM Bioimpact LLC | 3,094,896 | $12.75M | 1.8% | +101.2% | 4.026% | |
| 2/17/2025 | Millennium Management LLC | 180,419 | $743K | 0.0% | +774.9% | 0.235% | |
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| 2/17/2025 | Cubist Systematic Strategies LLC | 89,309 | $368K | 0.0% | N/A | 0.116% | |
| 2/17/2025 | Bridgeway Capital Management LLC | 177,481 | $731K | 0.0% | -4.3% | 0.231% | |
| 2/17/2025 | Cantor Fitzgerald L. P. | 20,000 | $82K | 0.0% | N/A | 0.026% | |
| 2/17/2025 | BNP Paribas Financial Markets | 7,686 | $32K | 0.0% | -35.6% | 0.010% | |
| 2/17/2025 | Ameriprise Financial Inc. | 96,784 | $399K | 0.0% | +187.0% | 0.126% | |
| 2/17/2025 | Algert Global LLC | 14,779 | $61K | 0.0% | -39.9% | 0.019% | |
| 2/17/2025 | Ally Bridge Group NY LLC | 781,489 | $3.22M | 2.7% | -40.9% | 1.017% | |
| 2/17/2025 | Acorn Capital Advisors LLC | 2,001,048 | $8.24M | 4.5% | N/A | 2.603% | |
| 2/17/2025 | Acuta Capital Partners LLC | 771,958 | $3.18M | 3.2% | +165.7% | 1.004% | |
| 2/14/2025 | Northern Trust Corp | 482,815 | $1.99M | 0.0% | +11.3% | 0.628% | |
| 2/14/2025 | Boothbay Fund Management LLC | 93,859 | $387K | 0.0% | N/A | 0.122% | |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 2,500,000 | $10.30M | 0.0% | N/A | 3.252% | |
| 2/14/2025 | Price T Rowe Associates Inc. MD | 25,166 | $104K | 0.0% | +32.1% | 0.033% | |
| 2/14/2025 | Silverarc Capital Management LLC | 734,234 | $3.03M | 0.7% | +52.1% | 0.955% | |
| 2/14/2025 | Vivo Capital LLC | 3,487,903 | $14.37M | 1.6% | +116.3% | 4.537% | |
| 2/14/2025 | MetLife Investment Management LLC | 38,785 | $160K | 0.0% | +104.9% | 0.050% | |
| 2/14/2025 | Dimensional Fund Advisors LP | 134,353 | $553K | 0.0% | +86.1% | 0.175% | |
| 2/13/2025 | Marshall Wace LLP | 42,921 | $177K | 0.0% | -47.1% | 0.056% | |
| 2/13/2025 | Jump Financial LLC | 21,589 | $89K | 0.0% | N/A | 0.028% | |
| 2/13/2025 | Walleye Capital LLC | 33,097 | $136K | 0.0% | N/A | 0.043% | |
| 2/13/2025 | XTX Topco Ltd | 67,201 | $277K | 0.0% | N/A | 0.087% | |
| 2/13/2025 | Barclays PLC | 156,267 | $643K | 0.0% | +64.1% | 0.203% | |
| 2/13/2025 | Summit Investment Advisors Inc. | 6,332 | $26K | 0.0% | +84.2% | 0.008% | |
| 2/13/2025 | Raymond James Financial Inc. | 12,000 | $49K | 0.0% | N/A | 0.016% | |
| 2/13/2025 | Renaissance Technologies LLC | 100,400 | $414K | 0.0% | +42.0% | 0.131% | |
| 2/13/2025 | Invesco Ltd. | 23,621 | $97K | 0.0% | +21.2% | 0.031% | |
| 2/13/2025 | Wells Fargo & Company MN | 33,050 | $136K | 0.0% | +40.7% | 0.043% | |
| 2/12/2025 | Landscape Capital Management L.L.C. | 52,085 | $215K | 0.0% | -87.7% | 0.068% | |
| 2/12/2025 | Geode Capital Management LLC | 1,299,322 | $5.35M | 0.0% | +2.8% | 1.690% | |
| 2/12/2025 | JPMorgan Chase & Co. | 221,664 | $913K | 0.0% | +120.5% | 0.288% | |
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| 2/11/2025 | American Century Companies Inc. | 78,143 | $322K | 0.0% | +44.7% | 0.102% | |
| 2/11/2025 | Rosalind Advisors Inc. | 1,062,500 | $4.38M | 2.2% | +41.7% | 1.382% | |
| 2/10/2025 | Tejara Capital Ltd | 153,739 | $633K | 0.4% | -36.4% | 0.200% | |
| 2/6/2025 | Raymond James Financial Inc. | 12,000 | $49K | 0.0% | N/A | 0.016% | |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 173,063 | $713K | 0.0% | +14.7% | 0.225% | |
| 2/4/2025 | Bank of New York Mellon Corp | 140,219 | $578K | 0.0% | +2.1% | 0.182% | |
| 1/24/2025 | China Universal Asset Management Co. Ltd. | 16,298 | $67K | 0.0% | N/A | 0.021% | |
| 1/17/2025 | SG Americas Securities LLC | 26,792 | $110K | 0.0% | +14.5% | 0.035% | |
| 12/26/2024 | JPMorgan Chase & Co. | 100,517 | $336K | 0.0% | +220.6% | 0.131% | |
| 11/19/2024 | Barclays PLC | 95,232 | $319K | 0.0% | +180.8% | 0.124% | |
| 11/16/2024 | Geode Capital Management LLC | 1,264,166 | $4.22M | 0.0% | +10.2% | 1.645% | |
| 11/15/2024 | Barclays PLC | 95,232 | $319K | 0.0% | +180.8% | 0.124% | |
| 11/15/2024 | Jane Street Group LLC | 32,929 | $110K | 0.0% | -50.4% | 0.043% | |
| 11/15/2024 | State Street Corp | 952,912 | $3.18M | 0.0% | +5.9% | 1.240% | |
| 11/15/2024 | Checkpoint Capital L.P. | 250,000 | $835K | 0.4% | -50.0% | 0.325% | |
| 11/14/2024 | Fred Alger Management LLC | 76,544 | $256K | 0.0% | N/A | 0.100% | |
| 11/14/2024 | Ally Bridge Group NY LLC | 1,322,800 | $4.42M | 2.4% | -10.3% | 1.721% | |
| 11/14/2024 | Acuta Capital Partners LLC | 290,500 | $970K | 0.8% | +11.7% | 0.378% | |
| 11/13/2024 | BNP Paribas Financial Markets | 11,930 | $40K | 0.0% | +130.9% | 0.016% | |
| 11/9/2024 | Landscape Capital Management L.L.C. | 424,725 | $1.42M | 0.1% | -29.8% | 0.585% | |
| 11/9/2024 | Intech Investment Management LLC | 18,914 | $63K | 0.0% | N/A | 0.026% | |
| 11/7/2024 | MAI Capital Management | 1,327,285 | $4.43M | 0.0% | +0.7% | 1.828% | |
| 11/6/2024 | Oppenheimer & Co. Inc. | 81,947 | $274K | 0.0% | +34.7% | 0.113% | |
| 11/5/2024 | GSA Capital Partners LLP | 122,447 | $409K | 0.0% | N/A | 0.169% | |
| 10/30/2024 | Rosalind Advisors Inc. | 750,000 | $2.51M | 1.6% | -46.1% | 1.033% | |
| 10/3/2024 | SG Americas Securities LLC | 23,405 | $78K | 0.0% | N/A | 0.033% | |
| 8/15/2024 | The Manufacturers Life Insurance Company | 24,524 | $73K | 0.0% | +87.6% | 0.035% | |
| 8/14/2024 | Logos Global Management LP | 2,800,000 | $8.34M | 0.7% | +27.3% | 3.975% | |
| 8/14/2024 | Ally Bridge Group NY LLC | 1,474,926 | $4.40M | 2.6% | N/A | 2.094% | |
| 8/13/2024 | Rubric Capital Management LP | 5,026,931 | $14.98M | 0.4% | -9.7% | 7.137% | |
| 8/12/2024 | Hsbc Holdings PLC | 19,612 | $61K | 0.0% | N/A | 0.028% | |
| 8/9/2024 | Renaissance Technologies LLC | 51,900 | $155K | 0.0% | -55.6% | 0.074% | |
| 8/9/2024 | Dimensional Fund Advisors LP | 72,210 | $215K | 0.0% | +217.6% | 0.103% | |
| 8/8/2024 | American Century Companies Inc. | 54,108 | $161K | 0.0% | +17.1% | 0.077% | |
| 8/1/2024 | Rhumbline Advisers | 75,218 | $224K | 0.0% | +44.8% | 0.107% | |
| 7/26/2024 | Bank of New York Mellon Corp | 178,511 | $532K | 0.0% | +38.8% | 0.253% | |
| 7/12/2024 | Rosalind Advisors Inc. | 1,391,577 | $4.15M | 3.0% | +50.3% | 1.976% | |
| 5/29/2024 | Opaleye Management Inc. | 2,645,000 | $9.13M | 2.0% | +4.3% | 3.756% | |
| 5/15/2024 | Price T Rowe Associates Inc. MD | 13,561 | $47K | 0.0% | N/A | 0.019% | |
| 5/14/2024 | Propel Bio Management LLC | 260,000 | $897K | 0.5% | N/A | 0.369% | |
| 5/10/2024 | Vanguard Group Inc. | 2,303,648 | $7.95M | 0.0% | +2.7% | 3.271% | |
| 5/7/2024 | Oppenheimer & Co. Inc. | 60,415 | $208K | 0.0% | N/A | 0.086% | |
| 5/7/2024 | SG Americas Securities LLC | 14,592 | $50K | 0.0% | -85.1% | 0.021% | |
| 5/1/2024 | BNP Paribas Financial Markets | 20,577 | $71K | 0.0% | -84.4% | 0.030% | |
| 4/25/2024 | Rosalind Advisors Inc. | 926,016 | $3.20M | 3.0% | -50.3% | 1.343% | |
| 2/15/2024 | Opaleye Management Inc. | 2,535,000 | $3.40M | 0.9% | +48.6% | 3.970% | |
| 2/15/2024 | Frazier Life Sciences Management L.P. | 7,381,090 | $9.89M | 0.5% | +7.3% | 11.559% | |
| 2/5/2024 | WealthTrust Axiom LLC | 63,500 | $85K | 0.0% | -32.1% | 0.099% | |
| 1/12/2024 | SG Americas Securities LLC | 98,253 | $132K | 0.0% | +401.4% | 0.154% | |
| 1/4/2024 | Trust Co. of Toledo NA OH | 36,502 | $49K | 0.0% | -68.8% | 0.057% | |
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| 11/13/2023 | Silverarc Capital Management LLC | 927,415 | $2.02M | 0.6% | +4.7% | 1.452% | |
| 10/20/2023 | Trust Co. of Toledo NA OH | 117,145 | $255K | 0.1% | -6.2% | 0.183% | |
| 10/13/2023 | SG Americas Securities LLC | 19,597 | $43K | 0.0% | N/A | 0.031% | |
| 9/21/2023 | Barclays PLC | 14,052 | $34K | 0.0% | N/A | 0.022% | |
| 8/11/2023 | VR Adviser LLC | 3,422,397 | $8.18M | 1.3% | +12.2% | 5.697% | |
| 8/11/2023 | Tejara Capital Ltd | 180,227 | $431K | 0.2% | -5.3% | 0.300% | |
| 8/4/2023 | American International Group Inc. | 20,037 | $48K | 0.0% | N/A | 0.033% | |
| 8/3/2023 | Innovis Asset Management LLC | 43,232 | $103K | 0.0% | -50.5% | 0.072% | |
| 8/2/2023 | MAI Capital Management | 1,534,652 | $3.67M | 0.1% | -4.1% | 2.555% | |
| 7/10/2023 | Trust Co. of Toledo NA OH | 124,857 | $298K | 0.1% | +50.4% | 0.208% | |
