Vertex Pharmaceuticals (VRTX) Competitors $454.64 -2.40 (-0.52%) Closing price 07/3/2025 03:51 PM EasternExtended Trading$454.64 0.00 (0.00%) As of 07/3/2025 04:53 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock VRTX vs. AMZN, AXSM, CRSP, GOOG, ISRG, MRNA, RGEN, ABBV, LLY, and PFEShould you be buying Vertex Pharmaceuticals stock or one of its competitors? The main competitors of Vertex Pharmaceuticals include Amazon.com (AMZN), Axsome Therapeutics (AXSM), CRISPR Therapeutics (CRSP), Alphabet (GOOG), Intuitive Surgical (ISRG), Moderna (MRNA), Repligen (RGEN), AbbVie (ABBV), Eli Lilly and Company (LLY), and Pfizer (PFE). Vertex Pharmaceuticals vs. Its Competitors Amazon.com Axsome Therapeutics CRISPR Therapeutics Alphabet Intuitive Surgical Moderna Repligen AbbVie Eli Lilly and Company Pfizer Vertex Pharmaceuticals (NASDAQ:VRTX) and Amazon.com (NASDAQ:AMZN) are related large-cap companies, but which is the better business? We will compare the two companies based on the strength of their dividends, risk, institutional ownership, profitability, valuation, earnings, media sentiment and analyst recommendations. Does the media favor VRTX or AMZN? In the previous week, Amazon.com had 226 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 261 mentions for Amazon.com and 35 mentions for Vertex Pharmaceuticals. Vertex Pharmaceuticals' average media sentiment score of 1.14 beat Amazon.com's score of 0.94 indicating that Vertex Pharmaceuticals is being referred to more favorably in the media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Vertex Pharmaceuticals 27 Very Positive mention(s) 1 Positive mention(s) 7 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Amazon.com 160 Very Positive mention(s) 38 Positive mention(s) 41 Neutral mention(s) 16 Negative mention(s) 2 Very Negative mention(s) Positive Is VRTX or AMZN more profitable? Amazon.com has a net margin of 10.14% compared to Vertex Pharmaceuticals' net margin of -8.91%. Amazon.com's return on equity of 24.14% beat Vertex Pharmaceuticals' return on equity.Company Net Margins Return on Equity Return on Assets Vertex Pharmaceuticals-8.91% -3.36% -2.42% Amazon.com 10.14%24.14%10.90% Do insiders and institutionals believe in VRTX or AMZN? 91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. Comparatively, 72.2% of Amazon.com shares are owned by institutional investors. 0.2% of Vertex Pharmaceuticals shares are owned by company insiders. Comparatively, 9.7% of Amazon.com shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term. Which has more risk and volatility, VRTX or AMZN? Vertex Pharmaceuticals has a beta of 0.41, meaning that its stock price is 59% less volatile than the S&P 500. Comparatively, Amazon.com has a beta of 1.33, meaning that its stock price is 33% more volatile than the S&P 500. Do analysts rate VRTX or AMZN? Vertex Pharmaceuticals presently has a consensus price target of $511.62, indicating a potential upside of 12.53%. Amazon.com has a consensus price target of $245.60, indicating a potential upside of 10.07%. Given Vertex Pharmaceuticals' higher probable upside, equities research analysts plainly believe Vertex Pharmaceuticals is more favorable than Amazon.com.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Vertex Pharmaceuticals 0 Sell rating(s) 14 Hold rating(s) 13 Buy rating(s) 1 Strong Buy rating(s) 2.54Amazon.com 0 Sell rating(s) 2 Hold rating(s) 45 Buy rating(s) 1 Strong Buy rating(s) 2.98 Which has preferable earnings and valuation, VRTX or AMZN? Amazon.com has higher revenue and earnings than Vertex Pharmaceuticals. Vertex Pharmaceuticals is trading at a lower price-to-earnings ratio than Amazon.com, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioVertex Pharmaceuticals$11.02B10.59-$535.60M-$3.92-115.98Amazon.com$637.96B3.71$59.25B$6.1436.34 SummaryAmazon.com beats Vertex Pharmaceuticals on 12 of the 16 factors compared between the two stocks. Get Vertex Pharmaceuticals News Delivered to You Automatically Sign up to receive the latest news and ratings for VRTX and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding VRTX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart VRTX vs. The Competition Export to ExcelMetricVertex PharmaceuticalsMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$118.03B$2.91B$5.55B$9.04BDividend YieldN/A2.44%5.22%4.00%P/E Ratio-115.9821.5627.6420.24Price / Sales10.59281.65418.75118.07Price / CashN/A42.7336.8958.10Price / Book7.137.518.035.67Net Income-$535.60M-$55.14M$3.18B$249.21M7 Day Performance3.02%4.61%2.93%3.28%1 Month Performance0.92%0.90%1.72%3.95%1 Year Performance-4.20%5.40%34.39%20.98% Vertex Pharmaceuticals Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)VRTXVertex Pharmaceuticals4.7255 of 5 stars$454.64-0.5%$511.62+12.5%-4.2%$118.03B$11.02B-115.986,100Positive NewsAMZNAmazon.com4.6153 of 5 stars$219.65-1.6%$245.81+11.9%+11.6%$2.33T$637.96B35.771,556,000Trending NewsAnalyst ForecastInsider TradeAXSMAxsome Therapeutics4.7394 of 5 stars$104.34+0.9%$172.33+65.2%+28.5%$5.14B$385.69M-18.08380Trending NewsAnalyst ForecastAnalyst RevisionCRSPCRISPR Therapeutics3.0112 of 5 stars$48.54+2.2%$71.75+47.8%-1.8%$4.19B$35M-10.74473GOOGAlphabet4.8621 of 5 stars$177.27-0.6%$206.38+16.4%-6.1%$2.15T$359.71B19.76190,200Trending NewsInsider TradeISRGIntuitive Surgical4.3278 of 5 stars$543.38+1.8%$588.95+8.4%+22.5%$194.76B$8.35B79.6715,638Positive NewsMRNAModerna4.3784 of 5 stars$27.63+1.7%$46.61+68.7%-74.2%$10.69B$3.24B-3.165,800Options VolumeRGENRepligen4.7707 of 5 stars$124.24+0.6%$172.83+39.1%+6.1%$6.98B$634.44M-276.091,778News CoverageABBVAbbVie4.9049 of 5 stars$185.52+1.8%$211.29+13.9%+13.3%$327.70B$56.33B78.9555,000Trending NewsAnalyst RevisionLLYEli Lilly and Company4.9877 of 5 stars$776.15+0.1%$1,011.61+30.3%-14.8%$735.59B$45.04B63.1547,000Trending NewsPFEPfizer4.977 of 5 stars$24.23+0.2%$29.17+20.4%-9.3%$137.76B$63.63B17.5681,000Trending News Related Companies and Tools Related Companies Amazon.com Alternatives Axsome Therapeutics Alternatives CRISPR Therapeutics Alternatives Alphabet Alternatives Intuitive Surgical Alternatives Moderna Alternatives Repligen Alternatives AbbVie Alternatives Eli Lilly and Company Alternatives Pfizer Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:VRTX) was last updated on 7/6/2025 by MarketBeat.com Staff From Our PartnersINVESTOR ALERT: Tiny “$3 AI Wonder Stock” on the Verge of Blasting OffRight now, we’re witnessing a monumental shift in the world.Traders Agency | SponsoredThe day and month stocks are most likely to crash nextGood News for Stocks 50-year Wall Street veteran, Marc Chaikin is stepping forward to share why history giv...Chaikin Analytics | Sponsored140% Yields From Stocks Like Tesla? 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