As of the most recent reporting period, the following institutional investors, funds, and major shareholders have reported short positions of Vertex Pharmaceuticals: Arrowpoint Investment Partners Singapore Pte. Ltd., Wolverine Trading LLC, Squarepoint Ops LLC, Torno Capital LLC, Sig Brokerage LP, Point72 Asset Management L.P., Nomura Holdings Inc., Millennium Management LLC, LMR Partners LLP, Group One Trading LLC, Eisler Capital Management Ltd., Cresset Asset Management LLC, Cubist Systematic Strategies LLC, Citadel Advisors LLC, Cantor Fitzgerald L. P., Capstone Investment Advisors LLC, Bank of America Corp DE, BNP Paribas Financial Markets, Jane Street Group LLC, Lido Advisors LLC, Tudor Investment Corp ET AL, Boothbay Fund Management LLC, Parallax Volatility Advisers L.P., Two Sigma Securities LLC, Susquehanna International Group LLP, Hsbc Holdings PLC, Concourse Financial Group Securities Inc., PEAK6 LLC, Walleye Trading LLC, Walleye Capital LLC, Barclays PLC, Capital Fund Management S.A., Capula Management Ltd, JPMorgan Chase & Co., Simplex Trading LLC, Twin Tree Management LP, HighTower Advisors LLC, Allianz Asset Management GmbH, Wolverine Asset Management LLC, Valeo Financial Advisors LLC, IMC Chicago LLC, Fiduciary Family Office LLC, and JPMorgan Chase & Co.. These positions are disclosed in Form 13F filings with the Securities and Exchange Commission.