Can-Fite BioPharma Ltd. is a clinical-stage biopharmaceutical company headquartered in Petah Tikva, Israel, that focuses on the development of small molecule drugs for the treatment of inflammatory, oncology and liver diseases. Established in 1994, the company leverages its proprietary technology platform centered on modulating the adenosine receptor system to advance novel therapeutic candidates. Can-Fite’s research and development efforts are directed toward addressing significant unmet medical needs in autoimmune and cancer indications.
The company’s lead product candidates include piclidenoson (CF101) and namodenoson (CF102). Piclidenoson is being evaluated for the treatment of rheumatoid arthritis and psoriasis, with pivotal studies designed to demonstrate efficacy and safety in patients who have shown inadequate responses to existing therapies. Namodenoson is in clinical development for hepatocellular carcinoma and nonalcoholic steatohepatitis (NASH), conditions with limited treatment options and high unmet demand. Can-Fite’s pipeline also features earlier-stage programs aimed at expanding the application of its adenosine receptor technology across additional therapeutic areas.
Can-Fite conducts its clinical trials in multiple geographies, including North America, Europe and Israel, collaborating with leading research institutions and contract research organizations to ensure rigorous study design and execution. The company has entered into strategic partnerships and licensing agreements to facilitate development, regulatory filing and potential commercialization of its product candidates. These collaborations are intended to extend Can-Fite’s global reach and leverage external expertise to accelerate development timelines.
Under the leadership of Chief Executive Officer Pnina Fishman, Can-Fite has maintained a focused strategy on clinical advancement and regulatory engagement. The management team brings extensive experience in biopharmaceutical development, regulatory affairs and commercial strategy. Looking ahead, Can-Fite aims to complete late-stage trials for its lead candidates, pursue regulatory approvals, and explore additional indications for its adenosine receptor platform to deliver new treatment options for patients worldwide.
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