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Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
ACIU AC Immune	$2.05 -1.0%	$2.12	$1.43 ▼ $3.98	$205.84M	1.65	154,114 shs	123,441 shs
AKBA Akebia Therapeutics	$3.13 +4.0%	$3.57	$1.24 ▼ $4.08	$829.90M	0.96	4.16 million shs	3.10 million shs
QURE uniQure	$16.26 +3.2%	$14.60	$4.45 ▼ $19.18	$892.14M	0.11	1.36 million shs	1.17 million shs
SANA Sana Biotechnology	$3.01 -10.7%	$3.68	$1.26 ▼ $7.30	$715.81M	1.9	5.92 million shs	8.69 million shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
ACIU AC Immune	-1.43%	-3.27%	-12.66%	+22.12%	-32.35%
AKBA Akebia Therapeutics	-2.59%	-3.53%	-16.16%	0.00%	+98.03%
QURE uniQure	-0.25%	+1.74%	+5.14%	+5.70%	+159.05%
SANA Sana Biotechnology	+4.66%	-2.88%	-30.94%	+48.46%	-41.70%

Compare MarketRank™

Company	Overall Score	Analyst's Opinion	Short Interest Score	ESG Score	News and Social Media Sentiment	Company Ownership	Earnings & Valuation
ACIU AC Immune	2.0492 of 5 stars	3.5	1.0	0.0	3.1	0.8	0.6
AKBA Akebia Therapeutics	3.8098 of 5 stars	3.5	2.0	4.0	2.1	0.8	0.6
QURE uniQure	2.4161 of 5 stars	3.5	1.0	0.0	2.6	2.5	0.6
SANA Sana Biotechnology	3.2019 of 5 stars	3.5	3.0	0.0	2.6	3.3	0.6

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
ACIU AC Immune	3.00	Buy	$12.00	485.37% Upside
AKBA Akebia Therapeutics	3.00	Buy	$6.75	115.65% Upside
QURE uniQure	3.00	Buy	$37.45	130.35% Upside
SANA Sana Biotechnology	3.00	Buy	$8.00	165.78% Upside

Current Analyst Ratings Breakdown

Latest ACIU, QURE, SANA, and AKBA Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
8/14/2025	QURE uniQure	Mizuho Subscribe to MarketBeat All Access for the recommendation accuracy rating	Upgrade	Neutral ➝ Outperform	$30.00
8/13/2025	AKBA Akebia Therapeutics	Zacks Research Subscribe to MarketBeat All Access for the recommendation accuracy rating	Downgrade	Strong-Buy ➝ Hold
7/30/2025	QURE uniQure	Cantor Fitzgerald Subscribe to MarketBeat All Access for the recommendation accuracy rating	Set Price Target		$47.00
7/29/2025	QURE uniQure	Chardan Capital Subscribe to MarketBeat All Access for the recommendation accuracy rating	Lower Price Target	Buy ➝ Buy	$38.00 ➝ $35.00
7/3/2025	SANA Sana Biotechnology	Morgan Stanley Subscribe to MarketBeat All Access for the recommendation accuracy rating	Initiated Coverage	Overweight	$12.00
6/24/2025	SANA Sana Biotechnology	JMP Securities Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Market Outperform ➝ Market Outperform	$5.00
6/4/2025	AKBA Akebia Therapeutics	HC Wainwright Subscribe to MarketBeat All Access for the recommendation accuracy rating	Initiated Coverage	Buy	$8.00
5/30/2025	QURE uniQure	Chardan Capital Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$38.00
5/29/2025	QURE uniQure	HC Wainwright Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$70.00

(Data available from 8/28/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
ACIU AC Immune	$28.92M	7.12	N/A	N/A	$0.90 per share	2.28
AKBA Akebia Therapeutics	$203.73M	4.07	N/A	N/A	$0.11 per share	28.45
QURE uniQure	$14.34M	62.23	N/A	N/A	($0.07) per share	-232.29
SANA Sana Biotechnology	N/A	N/A	N/A	N/A	$0.52 per share	N/A

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
ACIU AC Immune	-$57.83M	-$0.58	N/A	N/A	N/A	-174.94%	-49.35%	-23.16%	11/4/2025 (Estimated)
AKBA Akebia Therapeutics	-$69.41M	-$0.17	N/A	N/A	N/A	-17.91%	N/A	-13.47%	11/6/2025 (Estimated)
QURE uniQure	-$239.56M	-$3.92	N/A	N/A	N/A	-1,387.98%	-1,010.74%	-33.27%	11/4/2025 (Estimated)
SANA Sana Biotechnology	-$266.76M	-$1.06	N/A	N/A	N/A	N/A	-91.96%	-43.07%	11/14/2025 (Estimated)

Latest ACIU, QURE, SANA, and AKBA Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
8/11/2025	Q2 2025	SANA Sana Biotechnology	-$0.20	-$0.16	+$0.04	-$0.39	N/A	N/A
8/5/2025	Q2 2025	ACIU AC Immune	-$0.20	-$0.25	-$0.05	-$0.25	$1.98 million	$1.65 million
7/29/2025	Q2 2025	QURE uniQure	-$0.89	-$0.69	+$0.20	-$0.69	$5.00 million	$5.26 million

Compare Dividends

Company	Annual Payout	Dividend Yield	3-Year Dividend Growth	Payout Ratio	Years of Consecutive Growth
ACIU AC Immune	N/A	N/A	N/A	N/A	N/A
AKBA Akebia Therapeutics	N/A	N/A	N/A	N/A	N/A
QURE uniQure	N/A	N/A	N/A	N/A	N/A
SANA Sana Biotechnology	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
ACIU AC Immune	N/A	1.33	1.33
AKBA Akebia Therapeutics	1.61	1.98	1.84
QURE uniQure	1.53	9.98	9.98
SANA Sana Biotechnology	N/A	2.47	2.47

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
ACIU AC Immune	51.36%
AKBA Akebia Therapeutics	33.92%
QURE uniQure	78.83%
SANA Sana Biotechnology	88.23%

Insider Ownership

Company	Insider Ownership
ACIU AC Immune	4.60%
AKBA Akebia Therapeutics	3.00%
QURE uniQure	4.79%
SANA Sana Biotechnology	30.10%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
ACIU AC Immune	140	100.41 million	95.79 million	Optionable
AKBA Akebia Therapeutics	430	265.15 million	257.19 million	Optionable
QURE uniQure	500	54.87 million	52.24 million	Optionable
SANA Sana Biotechnology	380	237.81 million	166.23 million	Optionable

ACIU, QURE, SANA, and AKBA Headlines

Recent News About These Companies

Sana Biotechnology to Present at September 2025 Investor Conferences

August 26 at 4:05 PM | globenewswire.com

Deutsche Bank AG Has $1.12 Million Stock Holdings in Sana Biotechnology, Inc. $SANA

August 26 at 3:19 AM | marketbeat.com

Citizens JMP Reiterates a Buy Rating on Sana Biotechnology (SANA) With a $5 PT

August 25 at 12:22 AM | msn.com

Biotech’s Big Bang: IPOs, Uplists, and the Short Squeeze Effect

August 21, 2025 | msn.com

Sana Biotechnology Announces Closing of Full Exercise of Underwriters’ Option to Purchase Additional Shares

August 21, 2025 | uk.finance.yahoo.com

Sana Biotechnology Announces Closing of Full Exercise of Underwriters’ Option to Purchase ...

August 21, 2025 | bakersfield.comB

Sana Biotechnology Announces Closing of Full Exercise of Underwriters' Option to Purchase Additional Shares

August 20, 2025 | tmcnet.com

Sana Biotechnology, Inc. Completes Sale of 3,358,208 Shares, Generating Approximately $86.3 Million in Gross Proceeds

August 20, 2025 | quiverquant.comQ

HC Wainwright Issues Optimistic Forecast for SANA Earnings

August 16, 2025 | marketbeat.com

Sana Biotechnology drops Washington plant build-out, pivots to CDMOs instead

August 14, 2025 | fiercepharma.comF

Sana Biotechnology Reports Non-Cash Impairment Losses

August 14, 2025 | theglobeandmail.com

Sana Biotech Bails on Factory in Old AT&T Call Center

August 12, 2025 | finance.yahoo.com

Sana Biotechnology (NASDAQ:SANA) Posts Earnings Results, Beats Estimates By $0.04 EPS

August 12, 2025 | marketbeat.com

Sana Biotechnology, Inc. (NASDAQ:SANA) Given Average Rating of "Buy" by Brokerages

August 12, 2025 | marketbeat.com

Sana: Q2 Earnings Snapshot

August 11, 2025 | sfgate.com

Sana suspends build-out of Bothell manufacturing facility

August 11, 2025 | bizjournals.com

Sana Biotechnology Reports Second Quarter 2025 Financial Results and Business Updates

August 11, 2025 | manilatimes.netM

Sana Biotechnology: Fundraising Triggers Major Sell-Off, I'm Still Intrigued

August 8, 2025 | seekingalpha.com

Sana Biotechnology (NASDAQ:SANA) Shares Gap Down - Here's What Happened

August 8, 2025 | marketbeat.com

Seattle biotech firm Sana Biotechnology raising $75 million through public offering

August 8, 2025 | bizjournals.com

Sana Biotechnology stock tumbles after pricing public offering

August 7, 2025 | investing.com

New MarketBeat Followers Over Time

Media Sentiment Over Time

ACIU, QURE, SANA, and AKBA Company Descriptions

AC Immune NASDAQ:ACIU

$2.05 -0.02 (-0.97%)

Closing price 04:00 PM Eastern

Extended Trading

$2.06 +0.01 (+0.49%)

As of 04:10 PM Eastern

AC Immune SA, a clinical stage biopharmaceutical company, discovers, designs, and develops medicines and diagnostic products for the prevention and treatment of neurodegenerative diseases associated with protein misfolding. Its SupraAntigen and Morphomer platforms are designed to generate vaccines, antibodies, and small molecules, which selectively interact with misfolded proteins that are common in a range of neurodegenerative diseases. The company is developing Crenezumab, a humanized, conformation-specific monoclonal antibody, which is in Phase II clinical studies trial for the treatment of Alzheimer's disease (AD). It is also developing ACI-24, an anti-Abeta vaccine candidate that is in Phase II clinical study for AD, as well as completed Phase Ib clinical study for Down syndrome; ACI-35, an anti-Tau vaccine candidate that is in Phase Ib/2a clinical study; and Tau- positron emission tomography (PET) imaging tracer, which is in Phase II clinical study. In addition, the company is researching and developing small molecule Tau aggregation inhibitors for AD and NeuroOrphan indications. Further, it has discovery and preclinical stage molecules targeting range of neurodegenerative diseases, which include diagnostics targeting TDP-43, alpha-synuclein, and NLRP3. AC Immune SA has license agreements and collaborations with Genentech, Inc.; Biogen International GmbH; Janssen Pharmaceuticals, Inc.; Life Molecular Imaging SA; Eli Lilly and Company; and WuXi Biologics. The company was incorporated in 2003 and is headquartered in Lausanne, Switzerland.

Akebia Therapeutics NASDAQ:AKBA

$3.13 +0.12 (+3.99%)

Closing price 04:00 PM Eastern

Extended Trading

$3.12 -0.01 (-0.32%)

As of 04:56 PM Eastern

Akebia Therapeutics, Inc., a biopharmaceutical company, focuses on the development and commercialization of therapeutics for patients with kidney diseases. The company's lead product investigational product candidate is Vafseo (vadadustat), an oral hypoxia-inducible factor prolyl hydroxylase, which is in Phase III development for the treatment of anemia due to chronic kidney disease (CKD) in dialysis-dependent and non-dialysis dependent patients. It offers Auryxia, a ferric citrate that is used to control the serum phosphorus levels in adult patients with DD-CKD on dialysis; and the treatment of iron deficiency anemia in adult patients with CKD not on dialysis. The company's product pipeline includes AKB-9090, a drug targeting critical-care indications; and AKB-10108, a drug targeting conditions related to premature birth. It has collaboration agreements with Mitsubishi Tanabe Pharma Corporation for the development and commercialization of vadadustat in Japan and other Asian countries, as well as research and license agreement with Janssen Pharmaceutica NV for the development and commercialization of hypoxia-inducible factor prolyl hydroxylase targeted compounds worldwide. Akebia Therapeutics, Inc. was incorporated in 2007 and is headquartered in Cambridge, Massachusetts.

uniQure NASDAQ:QURE

$16.26 +0.51 (+3.24%)

Closing price 04:00 PM Eastern

Extended Trading

$16.58 +0.32 (+1.96%)

As of 05:21 PM Eastern

uniQure N.V. develops treatments for patients suffering from rare and other devastating diseases. It offers HEMGENIX that has completed Phase III HOPE-B pivotal trial for the treatment of hemophilia B. The company also develops AMT-130, a gene therapy that is in Phase I/II clinical study for the treatment of Huntington's disease. In addition, it is developing AMT-162, which is in preclinical trial for the treatment of superoxide dismutase 1- amyotrophic lateral sclerosis; AMT-260 that is in preclinical trial to treat temporal lobe epilepsy; AMT-191, which is in preclinical trial for the treatment of fabry disease; AMT-161 that is in preclinical trial to treat amyotrophic lateral sclerosis caused by mutations; AMT-240, which is in preclinical trial to for the treatment of autosomal dominant Alzheimer's disease; and AMT-210 that is in preclinical trial to treat Parkinson's disease. The company was founded in 1998 and is headquartered in Amsterdam, the Netherlands.

Sana Biotechnology NASDAQ:SANA

$3.01 -0.36 (-10.68%)

Closing price 04:00 PM Eastern

Extended Trading

$3.04 +0.03 (+0.83%)

As of 05:43 PM Eastern

Sana Biotechnology, Inc., a biotechnology company, focuses on utilizing engineered cells as medicines. It develops ex vivo and in vivo cell engineering platforms for various therapeutic areas with unmet treatment needs, including oncology, diabetes, central nervous system disorders, B-cell-mediated autoimmune, and others. The company's product candidates include SC291 that is used as allogeneic cell therapies for hematologic malignancies; ARDENT for a potential treatment for non-Hodgkin's lymphoma, and chronic lymphoblastic leukemia; GLEAM, to treat multiple autoimmune disorders that involve production of autoimmune antibodies, including lupus nephritis, extrarenal lupus, antineutrophil cytoplasmic antibody -associated vasculitis, and others. It is developing SC262 to treat patients with relapsed and/or refractory B-cell malignancies; SC255 for multiple myeloma treatment; SC379, a therapy for patients with certain central nervous system disorders healthy allogeneic glial progenitor cells; SC451, a product candidate to treat diabetes, with an initial focus on type 1 diabetes mellitus; and UP421 that reduces long-term exogenous insulin dependence. The company has an option and license agreement with Beam Therapeutics Inc. for use of Beam's proprietary CRISPR Cas12b nuclease editing technology to research, develop, and commercialize engineered cell therapy products; and a license agreement with Harvard College to access certain intellectual property for the development of hypoimmune-modified cells. The company was formerly known as FD Therapeutics, Inc. and changed its name to Sana Biotechnology, Inc. in September 2018. Sana Biotechnology, Inc. was incorporated in 2018 and is headquartered in Seattle, Washington.

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Comparative Price Performance Over Time