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Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
AMPH Amphastar Pharmaceuticals	$30.50 +2.8%	$24.10	$20.39 ▼ $53.96	$1.38B	0.76	642,582 shs	494,895 shs
AXSM Axsome Therapeutics	$118.51 +1.2%	$106.36	$75.56 ▼ $139.13	$5.85B	0.51	611,443 shs	727,981 shs
CRSP CRISPR Therapeutics	$54.32 +2.8%	$54.75	$30.04 ▼ $71.13	$4.80B	1.8	3.00 million shs	1.72 million shs
NUVL Nuvalent	$76.08 +3.3%	$78.55	$55.53 ▼ $113.51	$5.31B	1.3	509,960 shs	407,091 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
AMPH Amphastar Pharmaceuticals	+2.83%	+2.25%	+34.78%	+24.64%	-34.93%
AXSM Axsome Therapeutics	+1.17%	+8.52%	+11.42%	+12.79%	+34.81%
CRSP CRISPR Therapeutics	+2.84%	-9.06%	-20.28%	+47.37%	+8.66%
NUVL Nuvalent	+3.30%	+0.05%	-5.47%	+3.52%	-7.96%

Compare MarketRank™

Company	Overall Score	Analyst's Opinion	Short Interest Score	ESG Score	News and Social Media Sentiment	Company Ownership	Earnings & Valuation
AMPH Amphastar Pharmaceuticals	3.3432 of 5 stars	1.3	1.0	3.7	2.9	4.2	1.3
AXSM Axsome Therapeutics	4.7967 of 5 stars	4.5	1.0	4.5	3.6	4.2	0.6
CRSP CRISPR Therapeutics	3.809 of 5 stars	4.3	3.0	0.0	2.8	3.3	0.6
NUVL Nuvalent	3.2832 of 5 stars	4.5	1.0	0.0	2.8	3.3	0.0

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
AMPH Amphastar Pharmaceuticals	2.50	Moderate Buy	$31.50	3.28% Upside
AXSM Axsome Therapeutics	3.07	Buy	$178.00	50.20% Upside
CRSP CRISPR Therapeutics	2.50	Moderate Buy	$71.60	31.81% Upside
NUVL Nuvalent	3.08	Buy	$118.91	56.29% Upside

Current Analyst Ratings Breakdown

Latest AMPH, NUVL, AXSM, and CRSP Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
8/19/2025	NUVL Nuvalent	Piper Sandler Subscribe to MarketBeat All Access for the recommendation accuracy rating	Initiated Coverage	Overweight	$112.00
8/12/2025	AMPH Amphastar Pharmaceuticals	Needham & Company LLC Subscribe to MarketBeat All Access for the recommendation accuracy rating	Upgrade	Hold ➝ Buy	$36.00
8/8/2025	AMPH Amphastar Pharmaceuticals	Piper Sandler Subscribe to MarketBeat All Access for the recommendation accuracy rating	Lower Price Target	Neutral ➝ Neutral	$30.00 ➝ $25.00
8/7/2025	CRSP CRISPR Therapeutics	HC Wainwright Subscribe to MarketBeat All Access for the recommendation accuracy rating	Boost Price Target	Buy ➝ Buy	$65.00 ➝ $80.00
8/6/2025	CRSP CRISPR Therapeutics	Barclays Subscribe to MarketBeat All Access for the recommendation accuracy rating	Boost Price Target	Equal Weight ➝ Equal Weight	$42.00 ➝ $56.00
8/5/2025	AXSM Axsome Therapeutics	Bank of America Subscribe to MarketBeat All Access for the recommendation accuracy rating	Boost Price Target	Buy ➝ Buy	$173.00 ➝ $176.00
8/5/2025	AXSM Axsome Therapeutics	Royal Bank Of Canada Subscribe to MarketBeat All Access for the recommendation accuracy rating	Boost Price Target	Outperform ➝ Outperform	$184.00 ➝ $189.00
8/5/2025	CRSP CRISPR Therapeutics	Chardan Capital Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$82.00
8/5/2025	CRSP CRISPR Therapeutics	Royal Bank Of Canada Subscribe to MarketBeat All Access for the recommendation accuracy rating	Boost Price Target	Sector Perform ➝ Sector Perform	$38.00 ➝ $42.00
8/4/2025	AXSM Axsome Therapeutics	Needham & Company LLC Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$150.00
7/22/2025	CRSP CRISPR Therapeutics	Bank of America Subscribe to MarketBeat All Access for the recommendation accuracy rating	Lower Price Target	Buy ➝ Buy	$79.00 ➝ $78.00

(Data available from 8/23/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
AMPH Amphastar Pharmaceuticals	$731.97M	1.94	$5.14 per share	5.93	$16.29 per share	1.87
AXSM Axsome Therapeutics	$385.69M	15.33	N/A	N/A	$1.46 per share	81.17
CRSP CRISPR Therapeutics	$37.31M	132.42	N/A	N/A	$18.81 per share	2.89
NUVL Nuvalent	N/A	N/A	N/A	N/A	$13.03 per share	N/A

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
AMPH Amphastar Pharmaceuticals	$159.52M	$2.67	11.42	9.27	N/A	18.64%	20.76%	9.68%	11/5/2025 (Estimated)
AXSM Axsome Therapeutics	-$287.22M	-$5.07	N/A	42.02	N/A	-49.88%	-283.22%	-33.06%	11/11/2025 (Estimated)
CRSP CRISPR Therapeutics	-$366.25M	-$5.43	N/A	N/A	N/A	-1,229.43%	-20.05%	-17.09%	11/4/2025 (Estimated)
NUVL Nuvalent	-$260.76M	-$4.90	N/A	N/A	N/A	N/A	-32.58%	-30.14%	11/11/2025 (Estimated)

Latest AMPH, NUVL, AXSM, and CRSP Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
8/7/2025	Q2 2025	NUVL Nuvalent	-$1.27	-$1.31	-$0.04	-$1.39	N/A	N/A
8/4/2025	Q2 2025	AXSM Axsome Therapeutics	-$1.00	-$0.92	+$0.08	-$0.97	$140.02 million	$150.04 million
8/4/2025	Q2 2025	CRSP CRISPR Therapeutics	-$1.47	-$1.29	+$0.18	-$2.40	$6.44 million	$0.89 million

Compare Dividends

Company	Annual Payout	Dividend Yield	3-Year Dividend Growth	Payout Ratio	Years of Consecutive Growth
AMPH Amphastar Pharmaceuticals	N/A	N/A	N/A	N/A	N/A
AXSM Axsome Therapeutics	N/A	N/A	N/A	N/A	N/A
CRSP CRISPR Therapeutics	N/A	N/A	N/A	N/A	N/A
NUVL Nuvalent	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
AMPH Amphastar Pharmaceuticals	0.80	3.29	2.21
AXSM Axsome Therapeutics	1.66	1.57	1.51
CRSP CRISPR Therapeutics	N/A	16.61	16.61
NUVL Nuvalent	N/A	13.57	13.57

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
AMPH Amphastar Pharmaceuticals	65.09%
AXSM Axsome Therapeutics	81.49%
CRSP CRISPR Therapeutics	69.20%
NUVL Nuvalent	97.26%

Insider Ownership

Company	Insider Ownership
AMPH Amphastar Pharmaceuticals	27.50%
AXSM Axsome Therapeutics	22.30%
CRSP CRISPR Therapeutics	4.30%
NUVL Nuvalent	10.20%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
AMPH Amphastar Pharmaceuticals	2,028	46.49 million	33.71 million	Optionable
AXSM Axsome Therapeutics	380	49.90 million	38.77 million	Optionable
CRSP CRISPR Therapeutics	460	90.95 million	87.04 million	Optionable
NUVL Nuvalent	40	72.11 million	64.75 million	Optionable

AMPH, NUVL, AXSM, and CRSP Headlines

Recent News About These Companies

Nuvalent, Inc. $NUVL Shares Purchased by Russell Investments Group Ltd.

August 22 at 3:56 AM | marketbeat.com

Nuvalent (NASDAQ:NUVL) CEO Sells $2,036,340.00 in Stock

August 21 at 6:02 PM | marketbeat.com

Nuvalent (NASDAQ:NUVL) Now Covered by Piper Sandler

August 21 at 8:10 AM | marketbeat.com

Insider Selling: Nuvalent (NASDAQ:NUVL) CEO Sells 27,000 Shares of Stock

August 20 at 5:26 AM | insidertrades.com

Piper Sandler Initiates Coverage on Nuvalent (NASDAQ:NUVL)

August 20 at 2:17 AM | americanbankingnews.com

Piper Sandler Initiates Coverage of Nuvalent (NUVL) with Overweight Recommendation

August 19, 2025 | msn.com

Nuvalent initiated with an Overweight at Piper Sandler

August 19, 2025 | msn.com

Vanguard Group Inc. Decreases Holdings in Nuvalent, Inc. $NUVL

August 19, 2025 | marketbeat.com

Lord Abbett & CO. LLC Sells 112,621 Shares of Nuvalent, Inc. (NASDAQ:NUVL)

August 18, 2025 | marketbeat.com

Citigroup Inc. Purchases 112,519 Shares of Nuvalent, Inc. (NASDAQ:NUVL)

August 15, 2025 | marketbeat.com

Nuvalent to Present Pivotal Data from ARROS-1 Clinical Trial of Zidesamtinib for TKI Pre-treated Patients with Advanced ROS1-positive NSCLC at WCLC 2025 Presidential Symposium

August 13, 2025 | prnewswire.com

Wedbush Forecasts Nuvalent's Q3 Earnings (NASDAQ:NUVL)

August 11, 2025 | marketbeat.com

Insider Selling: Nuvalent, Inc. (NASDAQ:NUVL) Insider Sells 5,500 Shares of Stock

August 10, 2025 | marketbeat.com

Nuvalent, Inc. (NASDAQ:NUVL) Insider Henry E. Pelish Sells 5,500 Shares

August 9, 2025 | insidertrades.com

Nuvalent Highlights Pipeline and Business Achievements, Reiterates Key Anticipated Milestones, and Reports Second Quarter 2025 Financial Results

August 7, 2025 | prnewswire.com

Nuvalent (NUVL) Projected to Post Earnings on Thursday

August 7, 2025 | marketbeat.com

XTX Topco Ltd Acquires New Stake in Nuvalent, Inc. (NASDAQ:NUVL)

August 5, 2025 | marketbeat.com

Jefferies Financial Group Inc. Acquires 23,795 Shares of Nuvalent, Inc. (NASDAQ:NUVL)

August 4, 2025 | marketbeat.com

Nuvalent, Inc. (NASDAQ:NUVL) Given Average Recommendation of "Buy" by Brokerages

August 4, 2025 | marketbeat.com

TD Asset Management Inc Purchases 23,412 Shares of Nuvalent, Inc. (NASDAQ:NUVL)

August 3, 2025 | marketbeat.com

Nuvalent (NUVL) Gets a Buy from Goldman Sachs

July 30, 2025 | theglobeandmail.com

New MarketBeat Followers Over Time

Media Sentiment Over Time

AMPH, NUVL, AXSM, and CRSP Company Descriptions

Amphastar Pharmaceuticals NASDAQ:AMPH

$30.50 +0.84 (+2.83%)

Closing price 08/22/2025 04:00 PM Eastern

Extended Trading

$30.40 -0.11 (-0.34%)

As of 08/22/2025 07:06 PM Eastern

Amphastar Pharmaceuticals, Inc., a bio-pharmaceutical company, develops, manufactures, markets, and sells generic and proprietary injectable, inhalation, and intranasal products in the United States, China, and France. It offers BAQSIMI, a nasal spray for the treatment of severe hypoglycemia; Primatene Mist, an over-the-counter epinephrine inhalation product for the temporary relief of mild symptoms of intermittent asthma; Enoxaparin, to prevent and treat deep vein thrombosis; REXTOVY and Naloxone for opioid overdose; Glucagon for injection emergency kit; and Cortrosyn, for use as a diagnostic agent in the screening of patients with adrenocortical insufficiency. The company provides Amphadase, an injection to absorb and disperse other injected drugs; Epinephrine injection for allergic reactions; Lidocaine jelly, an anesthetic product for urological procedures; Lidocaine topical solution for various procedures; Phytonadione injection, a vitamin K1 injection for newborn babies; emergency syringe products; morphine injection for use with patient-controlled analgesia pumps; and Lorazepam injection for surgery and medical procedures. In addition, it offers Neostigmine methylsulfate injection to treat myasthenia gravis and to reverse the effects of muscle relaxants; Isoproterenol hydrochloride injection for mild or transient episodes of heart block; Ganirelix Acetate injection for the inhibition of premature luteinizing hormone surges; Vasopressin to increase blood pressure; and Regadenoson, a stress agent for radionuclide myocardial perfusion imaging. Further, the company distributes recombinant human insulin APIs and porcine insulin API. Additionally, it develops generic product candidates, such as injectable, inhalation, and analytical technologies; biosimial product candidates; and intranasal epinephrine for the treatment of allergic reactions. The company was founded in 1996 and is headquartered in Rancho Cucamonga, California.

Axsome Therapeutics NASDAQ:AXSM

$118.51 +1.37 (+1.17%)

Closing price 08/22/2025 04:00 PM Eastern

Extended Trading

$118.47 -0.04 (-0.03%)

As of 08/22/2025 07:55 PM Eastern

Axsome Therapeutics, Inc., a biopharmaceutical company, engages in the development of novel therapies for central nervous system (CNS) disorders in the United States. The company's commercial product portfolio includes Auvelity (dextromethorphan-bupropion), a N-methyl-D-aspartate receptor antagonist with multimodal activity indicated for the treatment of major depressive disorder; and Sunosi (solriamfetol), a medication indicated to the treatment of excessive daytime sleepiness in patients with narcolepsy or obstructive sleep apnea. It is also developing AXS-05, which is in Phase III clinical trial to treat Alzheimer's disease agitation, as well as that has completed phase II clinical trial for the treatment of smoking cessation; AXS-07, an investigational medicine that has completed Phase III trials for the acute treatment of migraine; AXS-12, an investigational medicine, which is in Phase III trial to treat narcolepsy; AXS-14, a selective and potent norepinephrine reuptake inhibitor that has completed Phase III trial for the treatment of fibromyalgia and other conditions; and solriamfetol, a dual-acting dopamine and norepinephrine reuptake inhibitor, which has completed a Phase 2 trial for treating attention-deficit/hyperactivity disorder, and is in phase 2 major depressive, binge eating, and shift work disorder. Axsome Therapeutics, Inc. has a research collaboration agreement with Duke University for evaluating AXS-05 in smoking cessation. The company was incorporated in 2012 and is based in New York, New York.

CRISPR Therapeutics NASDAQ:CRSP

$54.32 +1.50 (+2.84%)

Closing price 08/22/2025 04:00 PM Eastern

Extended Trading

$54.58 +0.26 (+0.47%)

As of 08/22/2025 07:59 PM Eastern

CRISPR Therapeutics is a gene-editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene-editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic collaborations with companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Cambridge, Massachusetts, and business offices in San Francisco, California and London, United Kingdom. For more information, please visit www.crisprtx.com.

Nuvalent NASDAQ:NUVL

$76.08 +2.43 (+3.30%)

Closing price 08/22/2025 04:00 PM Eastern

Extended Trading

$76.08 0.00 (0.00%)

As of 08/22/2025 05:25 PM Eastern

Nuvalent, Inc., a clinical stage biopharmaceutical company, engages in the development of therapies for patients with cancer. Its lead product candidates are NVL-520, a novel ROS1-selective inhibitor to address the clinical challenges of emergent treatment resistance, central nervous system (CNS)-related adverse events, and brain metastases that may limit the use of ROS1 tyrosine kinase inhibitors (TKIs) for patients with ROS proto-oncogene 1 (ROS1)-positive non-small cell lung cancer (NSCLC) which is under the phase 2 portion of the ARROS-1 Phase 1/2 clinical trial; NVL-655, a brain-penetrant ALK-selective inhibitor, to address the clinical challenges of emergent treatment resistance, CNS-related adverse events, and brain metastases that might limit the use of first-, second-, and third-generation ALK inhibitors that is under the phase 2 portion of the ALKOVE-1 Phase 1/2 clinical trial; and NVL-330, a brain-penetrant human epidermal growth factor receptor 2 (HER2)-selective inhibitor designed to treat tumors driven by HER2ex20, brain metastases, and avoiding treatment-limiting adverse events including due to off-target inhibition of wild-type EGFR, which is expected to initiate phase 1 trial. The company was incorporated in 2017 and is headquartered in Cambridge, Massachusetts.

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Comparative Price Performance Over Time