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Stocks to Compare Sections All Sections Selected Performance Chart Price & Volume MarketRank Analyst Ratings Sales & Book Value Profitability & Earnings Dividends Debt Ownership Miscellaneous Headlines About Compare NASDAQ:ANNXNASDAQ:AUPHNASDAQ:SNDXNASDAQ:SYRE On This Page Performance ChartPrice & VolumeMarketRank™Analyst RatingsSales & Book ValueProfitability & EarningsDividendsDebtOwnershipMiscellaneousHeadlinesAbout Comparison Ideas Stock Ideas Comparative Price Performance Over Time1 day7 days30 days90 days365 daysCompare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeANNXAnnexon$2.60+2.8%$3.49$2.30▼$8.40$285.25M1.141.78 million shs820,743 shsAUPHAurinia Pharmaceuticals$8.16+0.6%$8.01$4.71▼$10.67$1.12B1.261.52 million shs887,610 shsSNDXSyndax Pharmaceuticals$12.95-1.1%$14.27$12.06▼$25.07$1.11B0.922.26 million shs767,111 shsSYRESpyre Therapeutics$18.04+0.1%$21.54$17.24▼$47.97$1.09B2.98552,802 shs416,114 shs(Almost) Everything You Need To Know About The EV MarketLooking to profit from the electric vehicle mega-trend? Enter your email address and we'll send you our list of which EV stocks show the most long-term potential.Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceANNXAnnexon-4.89%-5.60%-18.65%-43.02%-56.15%AUPHAurinia Pharmaceuticals-0.49%-0.98%+6.57%-13.45%+54.48%SNDXSyndax Pharmaceuticals-0.15%-8.33%-12.72%-5.96%-44.87%SYRESpyre Therapeutics-4.50%-12.05%-18.60%-25.25%-59.49%Remove AdsCompare MarketRank™CompanyOverall ScoreAnalyst's OpinionShort Interest ScoreDividend StrengthESG ScoreNews and Social Media SentimentCompany OwnershipEarnings & ValuationANNXAnnexon2.094 of 5 stars3.51.00.00.02.61.70.6AUPHAurinia Pharmaceuticals2.7692 of 5 stars3.51.00.00.03.40.81.9SNDXSyndax Pharmaceuticals3.7959 of 5 stars3.53.00.04.42.60.80.0SYRESpyre Therapeutics2.0885 of 5 stars3.60.00.00.03.41.70.6Compare Analyst ForecastsCompanyConsensus Rating ScoreConsensus RatingConsensus Price Target% Upside from Current PriceANNXAnnexon 3.00Buy$15.80507.69% UpsideAUPHAurinia Pharmaceuticals 3.00Buy$11.5040.93% UpsideSNDXSyndax Pharmaceuticals 2.90Moderate Buy$36.00177.99% UpsideSYRESpyre Therapeutics 3.13Buy$54.83203.95% UpsideCurrent Analyst Ratings BreakdownLatest ANNX, SYRE, AUPH, and SNDX Analyst RatingsDateCompanyBrokerageActionRatingPrice TargetDetails3/4/2025ANNXAnnexonNeedham & Company LLCSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingBuy ➝ Buy$16.00 ➝ $16.003/4/2025SNDXSyndax PharmaceuticalsJPMorgan Chase & Co.Subscribe to MarketBeat All Access for the recommendation accuracy ratingBoost Price TargetOverweight ➝ Overweight$35.00 ➝ $39.003/4/2025SNDXSyndax PharmaceuticalsCitigroupSubscribe to MarketBeat All Access for the recommendation accuracy ratingLower Price TargetBuy ➝ Buy$45.00 ➝ $42.003/4/2025SNDXSyndax PharmaceuticalsHC WainwrightSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingBuy ➝ Buy$51.00 ➝ $51.002/18/2025SYRESpyre TherapeuticsThe Goldman Sachs GroupSubscribe to MarketBeat All Access for the recommendation accuracy ratingUpgradeStrong-Buy1/13/2025SYRESpyre TherapeuticsWedbushSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingOutperform$65.001/8/2025SNDXSyndax PharmaceuticalsScotiabankSubscribe to MarketBeat All Access for the recommendation accuracy ratingLower Price TargetSector Perform ➝ Sector Perform$18.00 ➝ $16.0012/17/2024ANNXAnnexonHC WainwrightSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingBuy ➝ Buy$30.00 ➝ $30.00(Data available from 3/14/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)Compare Sales & Book ValueCompanyAnnual RevenuePrice/SalesCashflowPrice/CashBook ValuePrice/BookANNXAnnexonN/AN/AN/AN/A$3.20 per shareN/AAUPHAurinia Pharmaceuticals$235.13M4.77N/AN/A$2.63 per share3.10SNDXSyndax Pharmaceuticals$23.68M47.04N/AN/A$6.53 per share1.98SYRESpyre Therapeutics$890K1,221.39N/AN/A($0.22) per share-82.00Compare Profitability & EarningsCompanyNet IncomeEPSTrailing P/E RatioForward P/E RatioP/E GrowthNet MarginsReturn on Equity (ROE)Return on Assets (ROA)Next Earnings DateANNXAnnexon-$134.24M-$1.02N/AN/AN/AN/A-38.99%-33.90%3/25/2025 (Estimated)AUPHAurinia Pharmaceuticals-$78.02M$0.05N/A14.57N/A-10.23%-4.41%-3.07%5/1/2025 (Estimated)SNDXSyndax Pharmaceuticals-$209.36M-$3.73N/AN/AN/AN/A-64.34%-57.72%5/6/2025 (Estimated)SYRESpyre Therapeutics-$338.79M-$4.23N/AN/AN/AN/A-210.01%-44.40%5/8/2025 (Estimated)Latest ANNX, SYRE, AUPH, and SNDX EarningsDateQuarterCompanyConsensus EstimateReported EPSBeat/MissGap EPSRevenue EstimateActual RevenueDetails3/25/2025N/AANNXAnnexon-$0.28N/AN/AN/AN/AN/A3/3/2025Q4 2024ANNXAnnexon-$0.28-$0.33-$0.05-$0.33N/AN/A3/3/2025Q4 2024SNDXSyndax Pharmaceuticals-$0.31-$1.10-$0.79-$1.10$86.32 million$7.68 million2/27/2025Q4 2024SYRESpyre Therapeutics-$0.89-$0.81+$0.08-$0.81$2.10 millionN/ACompare DividendsCompanyAnnual PayoutDividend Yield3-Year Dividend GrowthPayout RatioYears of Consecutive GrowthANNXAnnexonN/AN/AN/AN/AN/AAUPHAurinia PharmaceuticalsN/AN/AN/AN/AN/ASNDXSyndax PharmaceuticalsN/AN/AN/AN/AN/ASYRESpyre TherapeuticsN/AN/AN/AN/AN/ACompare DebtCompanyDebt-to-Equity RatioCurrent RatioQuick RatioANNXAnnexonN/A17.1717.18AUPHAurinia Pharmaceuticals0.175.605.11SNDXSyndax PharmaceuticalsN/A6.996.99SYRESpyre TherapeuticsN/A7.327.32Compare OwnershipInstitutional OwnershipCompanyInstitutional OwnershipANNXAnnexonN/AAUPHAurinia Pharmaceuticals36.83%SNDXSyndax PharmaceuticalsN/ASYRESpyre Therapeutics80.39%Insider OwnershipCompanyInsider OwnershipANNXAnnexon12.67%AUPHAurinia Pharmaceuticals4.30%SNDXSyndax Pharmaceuticals4.10%SYRESpyre Therapeutics6.20%Compare Miscellaneous StatsCompanyEmployeesShares OutstandingFree FloatOptionableANNXAnnexon60109.71 million93.09 millionOptionableAUPHAurinia Pharmaceuticals300137.34 million137.02 millionOptionableSNDXSyndax Pharmaceuticals11086.02 million81.86 millionOptionableSYRESpyre Therapeutics10060.26 million48.24 millionOptionableANNX, SYRE, AUPH, and SNDX HeadlinesRecent News About These CompaniesSpyre Therapeutics, Inc. (NASDAQ:SYRE) Given Consensus Recommendation of "Buy" by BrokeragesMarch 14 at 2:23 AM | marketbeat.comSpyre Therapeutics (NASDAQ:SYRE) Shares Gap Up - Should You Buy?March 12 at 11:08 AM | marketbeat.comCandriam S.C.A. Has $5.76 Million Stake in Spyre Therapeutics, Inc. (NASDAQ:SYRE)March 9, 2025 | marketbeat.comSpyre Therapeutics Announces Grants of Inducement AwardsMarch 7, 2025 | prnewswire.comSpyre Therapeutics (NASDAQ:SYRE) Reaches New 1-Year Low - Here's WhyMarch 5, 2025 | marketbeat.comSpyre Therapeutics (NASDAQ:SYRE) Stock Price Down 6.4% - Here's What HappenedMarch 4, 2025 | marketbeat.comJonesTrading Sticks to Its Hold Rating for Spyre Therapeutics (SYRE)March 3, 2025 | markets.businessinsider.comWedbush Reaffirms Their Buy Rating on Spyre Therapeutics (SYRE)March 1, 2025 | markets.businessinsider.comSpyre Therapeutics (NASDAQ:SYRE) Shares Up 6.6% After Earnings BeatMarch 1, 2025 | marketbeat.comSpyre Therapeutics Faces Compliance Hurdles After Transition from Smaller Reporting Company StatusMarch 1, 2025 | tipranks.comSpyre Therapeutics (NASDAQ:SYRE) Posts Earnings Results, Beats Expectations By $0.08 EPSFebruary 28, 2025 | marketbeat.comSpyre Therapeutics, Inc.: Spyre Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results and Provides Corporate UpdateFebruary 28, 2025 | finanznachrichten.deSpyre Therapeutics files $500M mixed securities shelfFebruary 28, 2025 | markets.businessinsider.comTD Cowen Keeps Their Buy Rating on Spyre Therapeutics (SYRE)February 28, 2025 | markets.businessinsider.comSpyre Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results and Provides Corporate UpdateFebruary 27, 2025 | prnewswire.comSpyre Therapeutics (SYRE) Projected to Post Earnings on ThursdayFebruary 27, 2025 | marketbeat.comSpyre Therapeutics (NASDAQ:SYRE) Hits New 1-Year Low - Should You Sell?February 25, 2025 | marketbeat.comSpyre Therapeutics to Participate in Upcoming March Investor ConferencesFebruary 25, 2025 | prnewswire.comSpyre Therapeutics (NASDAQ:SYRE) Trading Down 6.7% - Here's WhyFebruary 22, 2025 | marketbeat.comSpyre Therapeutics (NASDAQ:SYRE) Upgraded to "Strong-Buy" at The Goldman Sachs GroupFebruary 21, 2025 | marketbeat.comSpyre Therapeutics Announces Poster Presentation at the 20th Congress of the European Crohn's and Colitis OrganisationFebruary 19, 2025 | prnewswire.comNew MarketBeat Followers Over TimeMedia Sentiment Over TimeANNX, SYRE, AUPH, and SNDX Company DescriptionsAnnexon NASDAQ:ANNX$2.60 +0.07 (+2.77%) Closing price 04:00 PM EasternExtended Trading$2.65 +0.05 (+1.92%) As of 06:35 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Annexon, Inc., a clinical-stage biopharmaceutical company, discovers and develops medicines for treating inflammatory-related diseases. Its lead candidate is ANX005, an investigational full-length monoclonal antibody, which is in Phase 3 clinical trial for the treatment of patients with guillain-barré syndrome; completed Phase II clinical trial for treating Huntington's disease; and in Phase II clinical trial for the treatment of amyotrophic lateral sclerosis. The company is also developing ANX007, an antigen-binding fragment (Fab) that is in Phase 3 program for the treatment of patients with geographic atrophy; and ANX1502, a novel oral small molecule inhibitor, which is in Phase 1 clinical trials for autoimmune indications. In addition, it develops ANX009, a C1q-blocking Fab that is in Phase I clinical trial for treating patients with lupus nephritis. The company was incorporated in 2011 and is headquartered in Brisbane, California.Aurinia Pharmaceuticals NASDAQ:AUPH$8.16 +0.05 (+0.62%) Closing price 04:00 PM EasternExtended Trading$8.28 +0.13 (+1.53%) As of 07:03 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Aurinia Pharmaceuticals Inc., a commercial-stage biopharmaceutical company, focuses on developing and commercializing therapies to treat various diseases with unmet medical need in the United States. It offers LUPKYNIS for the treatment of adult patients with active lupus nephritis. It has a collaboration and license agreement with Otsuka Pharmaceutical Co., Ltd. The company was incorporated in 1993 and is headquartered in Edmonton, Canada.Syndax Pharmaceuticals NASDAQ:SNDX$12.95 -0.15 (-1.15%) Closing price 04:00 PM EasternExtended Trading$13.27 +0.32 (+2.48%) As of 07:48 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Syndax Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, develops therapies for the treatment of cancer. Its lead product candidates are revumenib, a potent, selective, small molecule inhibitor of the menin-MLL binding interaction for the treatment of KMT2A rearranged, acute leukemias, and solid tumor; and SNDX-6352 or axatilimab, a monoclonal antibody that blocks the colony stimulating factor 1, or CSF-1 receptor for the treatment of patients with chronic graft versus host disease (cGVHD) and idiopathic pulmonary fibrosis (IPF). The company is also developing Entinostat. It has an agreement with Eddingpharm International Company Limited for licensing, development, and commercialization of Entinostat. Syndax Pharmaceuticals, Inc. was incorporated in 2005 and is headquartered in Waltham, Massachusetts.Spyre Therapeutics NASDAQ:SYRE$18.04 +0.01 (+0.06%) Closing price 04:00 PM EasternExtended Trading$18.04 0.00 (-0.03%) As of 04:23 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts. 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