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Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
FOLD Amicus Therapeutics	$5.91 -5.3%	$6.06	$5.51 ▼ $12.65	$1.92B	0.51	3.23 million shs	2.98 million shs
HALO Halozyme Therapeutics	$56.60 -1.8%	$54.92	$42.01 ▼ $70.51	$7.10B	1.15	1.75 million shs	1.00 million shs
IONS Ionis Pharmaceuticals	$42.00 -1.3%	$36.72	$23.95 ▼ $52.34	$6.77B	0.23	1.62 million shs	1.80 million shs
RGEN Repligen	$118.10 -2.7%	$125.01	$102.97 ▼ $182.52	$6.82B	1.11	728,951 shs	611,917 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
FOLD Amicus Therapeutics	-5.29%	-4.98%	-1.99%	-11.79%	-44.40%
HALO Halozyme Therapeutics	-1.82%	+1.43%	+4.85%	-3.77%	+7.71%
IONS Ionis Pharmaceuticals	-1.29%	+1.60%	+18.01%	+48.15%	-11.71%
RGEN Repligen	-2.66%	-8.14%	-7.39%	-10.60%	-3.67%

Compare MarketRank™

Company	Overall Score	Analyst's Opinion	Short Interest Score	ESG Score	News and Social Media Sentiment	Company Ownership	Earnings & Valuation
FOLD Amicus Therapeutics	4.1007 of 5 stars	3.4	1.0	4.3	3.3	0.0	1.9
HALO Halozyme Therapeutics	4.9624 of 5 stars	3.1	4.0	4.4	2.8	2.5	4.4
IONS Ionis Pharmaceuticals	4.5191 of 5 stars	4.4	2.0	3.0	2.5	3.3	0.6
RGEN Repligen	4.6339 of 5 stars	4.3	1.0	4.5	2.3	1.7	1.9

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
FOLD Amicus Therapeutics	2.70	Moderate Buy	$16.22	174.49% Upside
HALO Halozyme Therapeutics	2.17	Hold	$62.50	10.42% Upside
IONS Ionis Pharmaceuticals	2.76	Moderate Buy	$57.13	36.03% Upside
RGEN Repligen	2.69	Moderate Buy	$170.75	44.58% Upside

Current Analyst Ratings Breakdown

Latest FOLD, RGEN, IONS, and HALO Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
7/10/2025	HALO Halozyme Therapeutics	The Goldman Sachs Group Subscribe to MarketBeat All Access for the recommendation accuracy rating	Initiated Coverage	Neutral	$55.00
7/8/2025	RGEN Repligen	Evercore ISI Subscribe to MarketBeat All Access for the recommendation accuracy rating	Lower Price Target	In-Line ➝ In-Line	$140.00 ➝ $130.00
7/1/2025	IONS Ionis Pharmaceuticals	Barclays Subscribe to MarketBeat All Access for the recommendation accuracy rating	Upgrade	Equal Weight ➝ Overweight	$51.00 ➝ $57.00
6/26/2025	IONS Ionis Pharmaceuticals	HC Wainwright Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$50.00
6/24/2025	RGEN Repligen	Barclays Subscribe to MarketBeat All Access for the recommendation accuracy rating	Initiated Coverage	Overweight	$150.00
6/12/2025	IONS Ionis Pharmaceuticals	JPMorgan Chase & Co. Subscribe to MarketBeat All Access for the recommendation accuracy rating	Boost Price Target	Neutral ➝ Neutral	$45.00 ➝ $48.00
5/29/2025	HALO Halozyme Therapeutics	HC Wainwright Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$72.00
5/20/2025	IONS Ionis Pharmaceuticals	HC Wainwright Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$50.00 ➝ $50.00
5/14/2025	HALO Halozyme Therapeutics	Morgan Stanley Subscribe to MarketBeat All Access for the recommendation accuracy rating	Downgrade	Overweight ➝ Equal Weight	$73.00 ➝ $62.00
5/13/2025	HALO Halozyme Therapeutics	Leerink Partnrs Subscribe to MarketBeat All Access for the recommendation accuracy rating	Downgrade	Hold ➝ Strong Sell
5/13/2025	HALO Halozyme Therapeutics	Leerink Partners Subscribe to MarketBeat All Access for the recommendation accuracy rating	Downgrade	Market Perform ➝ Underperform	$47.00

(Data available from 7/16/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
FOLD Amicus Therapeutics	$528.29M	3.44	N/A	N/A	$0.65 per share	9.09
HALO Halozyme Therapeutics	$1.02B	6.87	$4.57 per share	12.39	$2.86 per share	19.79
IONS Ionis Pharmaceuticals	$705M	9.48	N/A	N/A	$3.73 per share	11.26
RGEN Repligen	$634.44M	10.46	$3.02 per share	39.05	$35.21 per share	3.35

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
FOLD Amicus Therapeutics	-$56.11M	-$0.09	N/A	13.74	N/A	-5.41%	4.67%	1.05%	8/14/2025 (Estimated)
HALO Halozyme Therapeutics	$444.09M	$3.76	15.05	9.10	0.39	44.76%	136.91%	26.05%	8/5/2025 (Estimated)
IONS Ionis Pharmaceuticals	-$453.90M	-$2.99	N/A	N/A	N/A	-63.65%	-91.85%	-15.77%	7/30/2025 (Estimated)
RGEN Repligen	-$25.51M	-$0.45	N/A	50.04	3.47	-3.93%	4.53%	3.17%	7/29/2025 (Estimated)

Latest FOLD, RGEN, IONS, and HALO Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
8/7/2025	Q2 2025	IONS Ionis Pharmaceuticals	$0.19	N/A	N/A	N/A	N/A	N/A
8/5/2025	Q2 2025	HALO Halozyme Therapeutics	$1.22	N/A	N/A	N/A	$282.66 million	N/A
7/29/2025	Q2 2025	RGEN Repligen	$0.40	N/A	N/A	N/A	$174.62 million	N/A
5/6/2025	Q1 2025	HALO Halozyme Therapeutics	$0.98	$1.11	+$0.13	$0.93	$231.21 million	$264.86 million
4/30/2025	Q1 2025	IONS Ionis Pharmaceuticals	-$1.07	-$0.93	+$0.14	-$0.93	$144.31 million	$132.00 million
4/29/2025	Q1 2025	RGEN Repligen	$0.35	$0.39	+$0.04	$0.10	$163.65 million	$169.17 million

Compare Dividends

Company	Annual Payout	Dividend Yield	3-Year Dividend Growth	Payout Ratio	Years of Consecutive Growth
FOLD Amicus Therapeutics	N/A	N/A	N/A	N/A	N/A
HALO Halozyme Therapeutics	N/A	N/A	N/A	N/A	N/A
IONS Ionis Pharmaceuticals	N/A	N/A	N/A	N/A	N/A
RGEN Repligen	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
FOLD Amicus Therapeutics	2.02	3.34	2.47
HALO Halozyme Therapeutics	3.13	8.39	7.30
IONS Ionis Pharmaceuticals	2.63	9.66	9.62
RGEN Repligen	0.27	6.79	5.79

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
FOLD Amicus Therapeutics	N/A
HALO Halozyme Therapeutics	97.79%
IONS Ionis Pharmaceuticals	93.86%
RGEN Repligen	97.64%

Insider Ownership

Company	Insider Ownership
FOLD Amicus Therapeutics	2.20%
HALO Halozyme Therapeutics	2.90%
IONS Ionis Pharmaceuticals	2.71%
RGEN Repligen	1.20%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
FOLD Amicus Therapeutics	480	307.93 million	301.16 million	Optionable
HALO Halozyme Therapeutics	390	123.22 million	119.65 million	Optionable
IONS Ionis Pharmaceuticals	1,069	159.16 million	154.85 million	Optionable
RGEN Repligen	1,778	56.18 million	55.51 million	Optionable

FOLD, RGEN, IONS, and HALO Headlines

Recent News About These Companies

Repligen Corporation (NASDAQ:RGEN) Shares Acquired by Rice Hall James & Associates LLC

July 15 at 5:45 AM | marketbeat.com

Repligen (NASDAQ:RGEN) Trading Down 5.4% - Here's Why

July 14 at 2:04 PM | marketbeat.com

TimesSquare Capital Management LLC Has $30.03 Million Stock Holdings in Repligen Corporation (NASDAQ:RGEN)

July 14 at 8:50 AM | marketbeat.com

Slow Capital Inc. Has $4.18 Million Stock Holdings in Repligen Corporation (NASDAQ:RGEN)

July 14 at 7:10 AM | marketbeat.com

New York State Common Retirement Fund Grows Holdings in Repligen Corporation (NASDAQ:RGEN)

July 14 at 5:23 AM | marketbeat.com

Repligen Corporation (NASDAQ:RGEN) Shares Bought by Stephens Investment Management Group LLC

July 13 at 6:26 AM | marketbeat.com

Teacher Retirement System of Texas Increases Stake in Repligen Corporation (NASDAQ:RGEN)

July 11, 2025 | marketbeat.com

Banque Pictet & Cie SA Has $3.12 Million Stock Position in Repligen Corporation (NASDAQ:RGEN)

July 10, 2025 | marketbeat.com

Principal Financial Group Inc. Increases Position in Repligen Corporation (NASDAQ:RGEN)

July 9, 2025 | marketbeat.com

Repligen And 2 Other Stocks That May Be Trading Below Estimated Value

July 8, 2025 | finance.yahoo.com

Evercore ISI Cuts Repligen (NASDAQ:RGEN) Price Target to $130.00

July 8, 2025 | marketbeat.com

New York State Teachers Retirement System Has $6.49 Million Holdings in Repligen Corporation (NASDAQ:RGEN)

July 6, 2025 | marketbeat.com

Repligen Corporation (NASDAQ:RGEN) Receives Average Rating of "Moderate Buy" from Brokerages

July 6, 2025 | americanbankingnews.com

Repligen Corporation (NASDAQ:RGEN) Receives Consensus Rating of "Moderate Buy" from Analysts

July 6, 2025 | marketbeat.com

Repligen Corporation (NASDAQ:RGEN) Shares Sold by Impax Asset Management Group plc

July 5, 2025 | marketbeat.com

1 Healthcare Stock to Target This Week and 2 to Be Wary Of

July 3, 2025 | msn.com

WCM Investment Management LLC Has $13.74 Million Stock Position in Repligen Corporation (NASDAQ:RGEN)

July 3, 2025 | marketbeat.com

Mirae Asset Global Investments Co. Ltd. Has $3.98 Million Stake in Repligen Corporation (NASDAQ:RGEN)

July 2, 2025 | marketbeat.com

Allspring Global Investments Holdings LLC Purchases 16,421 Shares of Repligen Corporation (NASDAQ:RGEN)

June 30, 2025 | marketbeat.com

Wall Street Zen Downgrades Repligen (NASDAQ:RGEN) to Hold

June 29, 2025 | marketbeat.com

Artemis Investment Management LLP Grows Position in Repligen Corporation (NASDAQ:RGEN)

June 27, 2025 | marketbeat.com

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FOLD, RGEN, IONS, and HALO Company Descriptions

Amicus Therapeutics NASDAQ:FOLD

$5.91 -0.33 (-5.29%)

Closing price 07/15/2025 04:00 PM Eastern

Extended Trading

$5.96 +0.05 (+0.91%)

As of 07/15/2025 07:55 PM Eastern

Amicus Therapeutics, Inc., a biotechnology company, focuses on discovering, developing, and delivering medicines for rare diseases. Its commercial product and product candidates include Galafold, an oral precision medicine for the treatment of adults with a confirmed diagnosis of Fabry disease and an amenable galactosidase alpha gene variant; and Pombiliti + Opfolda, for the treatment of late onset. It has collaboration and license agreements with the University of Pennsylvania to research and develop parvovirus gene therapy products; and GlaxoSmithKline. Amicus Therapeutics, Inc. was incorporated in 2002 and is headquartered in Princeton, New Jersey.

Halozyme Therapeutics NASDAQ:HALO

$56.60 -1.05 (-1.82%)

Closing price 07/15/2025 04:00 PM Eastern

Extended Trading

$56.60 0.00 (0.00%)

As of 07/15/2025 07:58 PM Eastern

Halozyme Therapeutics, Inc., a biopharma technology platform company, researches, develops, and commercializes proprietary enzymes and devices in the United States, Switzerland, Belgium, Japan, and internationally. The company's products are based on the patented recombinant human hyaluronidase enzyme (rHuPH20) that enables delivery of injectable biologics, such as monoclonal antibodies and other therapeutic molecules, as well as small molecules and fluids. It offers Hylenex recombinant, a formulation of rHuPH20 to facilitate subcutaneous (SC) fluid administration for achieving hydration to enhance the dispersion and absorption of other injected drugs in SC urography and to enhance resorption of radiopaque agents; rilpivirine, cabotegravir, and N6LS BNAB for the treatment of HIV; ocrelizumab for multiple sclerosis; XYOSTED, an injection for SC administration of testosterone replacement therapy; and ATRS-1902, a proprietary drug device combination product. The company also provides Herceptin (trastuzumab), Herceptin Hylecta, and Phesgo to treat breast cancer; Mabthera SC for the treatment of chronic lymphocytic leukemia; HYQVIA to treat primary immunodeficiency disorders; and DARZALEX for patients with amyloidosis, smoldering myeloma, and multiple myeloma. In addition, it offers Epinephrine Injection to treat allergic reactions; nivolumab+relatlimab and ANTI-TIM3 for the treatment of solid tumors; ARGX-117 for multifocal motor neuropathy; atezolizumab; nivolumab; afgartigimod; teriparatide injections; and OTREXUP, a SC methotrexate injection for adults with severe active rheumatoid arthritis and severe recalcitrant psoriasis, as well as children with active polyarticular juvenile idiopathic arthritis. Further, the company provides ATRS-1902 for adrenal crisis rescue; ARGX-113; and ARGX-117 to treat severe autoimmune diseases in multifocal motor neuropathy. Halozyme Therapeutics, Inc. was founded in 1998 and is headquartered in San Diego, California.

Ionis Pharmaceuticals NASDAQ:IONS

$42.00 -0.55 (-1.29%)

Closing price 07/15/2025 04:00 PM Eastern

Extended Trading

$41.99 -0.01 (-0.02%)

As of 07/15/2025 06:10 PM Eastern

Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an antisense injection for the treatment of polyneuropathy caused by hereditary transthyretin amyloidosis in adults; and WAYLIVRA, an antisense medicine for treatment for familial chylomicronemia syndrome (FCS) and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of ATTR; Olezarsen for patients with FCS and severe hypertriglyceridemia (SHTG); Donidalorsen for patients with hereditary angioedema; ION363 for patients with amyotrophic lateral sclerosis; Tofersen to inhibit the production of superoxide dismutase 1; Pelacarsen for patients with established cardiovascular disease and elevated lipoprotein(a); and Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus. In addition, the company develops IONIS-FB-LRx to inhibit the production of complement factor B and the alternative complement pathway; and ION224 to reduce the production of diacylglycerol acyltransferase 2. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with Metagenomi, Inc, AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis, Roche, Swedish Orphan Biovitrum AB, and PTC Therapeutics. The company was incorporated in 1989 and is based in Carlsbad, California.

Repligen NASDAQ:RGEN

$118.10 -3.23 (-2.66%)

Closing price 07/15/2025 04:00 PM Eastern

Extended Trading

$118.11 +0.01 (+0.01%)

As of 07/15/2025 04:48 PM Eastern

Repligen Corporation develops and commercializes bioprocessing technologies and systems for use in biological drug manufacturing process in North America, Europe, the Asia Pacific, and internationally. It offers Protein A ligands that are the binding components of Protein A affinity chromatography resins; and cell culture growth factor products. The company's chromatography products include OPUS pre-packed chromatography columns, which are used in the purification of biologics; and OPUS smaller-scale columns that are used in the high throughput process development screening, viral clearance validation studies, and scale down validation of chromatography processes. It also offers ELISA test kits; and chromatography resins under the CaptivA brand. In addition, the company provides filtration products, such as XCell Alternating Tangential Flow systems that are filtration devices used in upstream perfusion and cell culture processing; TangenX flat sheet cassettes, which are used in downstream biologic drug concentration, buffer exchange, and formulation processes; KrosFlo tangential flow filtration and tangential flow depth filtration systems; Spectra/Por laboratory and process dialysis products, and ProConnex TFDF flow paths. Further, it provides process analytics products, such as slope spectroscopy systems under the SoloVPE, FlowVPE, and FlowVPX brands. The company sells its products to life sciences, biopharmaceutical, and diagnostics companies; laboratory researchers; and contract manufacturing organizations. Repligen Corporation has collaboration agreements with Navigo Proteins GmbH to develop multiple affinity ligands. The company was incorporated in 1981 and is headquartered in Waltham, Massachusetts.

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Comparative Price Performance Over Time