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Stocks to Compare Sections All Sections Selected Performance Chart Price & Volume MarketRank Analyst Ratings Sales & Book Value Profitability & Earnings Dividends Debt Ownership Miscellaneous Headlines About Compare NASDAQ:AMLXNASDAQ:HRTXNASDAQ:NGNENASDAQ:OPTN On This Page Performance ChartPrice & VolumeMarketRank™Analyst RatingsSales & Book ValueProfitability & EarningsDividendsDebtOwnershipMiscellaneousHeadlinesAbout Comparison Ideas Stock Ideas Comparative Price Performance Over Time1 day7 days30 days90 days365 daysCompare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeAMLXAmylyx Pharmaceuticals$3.91+4.8%$3.53$1.58▼$7.27$268.02M-0.511.48 million shs1.34 million shsHRTXHeron Therapeutics$2.41+5.2%$1.82$1.04▼$3.93$367.12M1.551.88 million shs1.76 million shsNGNENeurogene$17.78+0.6%$18.04$14.42▼$74.49$264.12M1.01210,282 shs119,358 shsOPTNOptiNose$5.47+0.4%$5.86$4.82▼$31.50$55.03M-0.353,729 shs10,913 shsThe 10 Best AI Stocks to Own in 2025Wondering where to start (or end) with AI stocks? These 10 simple stocks can help investors build long-term wealth as artificial intelligence continues to grow into the future.Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceAMLXAmylyx Pharmaceuticals+4.83%+16.37%+4.55%-11.34%+13.66%HRTXHeron Therapeutics+5.24%+0.42%+45.18%+50.63%+2.12%NGNENeurogene+0.62%+5.14%-5.88%-20.39%-51.07%OPTNOptiNose+0.37%+0.55%-4.04%-25.32%-80.76%Remove AdsCompare MarketRank™CompanyOverall ScoreAnalyst's OpinionShort Interest ScoreDividend StrengthESG ScoreNews and Social Media SentimentCompany OwnershipEarnings & ValuationAMLXAmylyx Pharmaceuticals2.9056 of 5 stars3.41.00.00.03.03.31.3HRTXHeron Therapeutics3.8677 of 5 stars3.50.00.04.23.91.70.6NGNENeurogene2.2808 of 5 stars3.61.00.00.04.00.80.6OPTNOptiNose4.082 of 5 stars3.52.00.04.22.42.50.6Compare Analyst ForecastsCompanyConsensus Rating ScoreConsensus RatingConsensus Price Target% Upside from Current PriceAMLXAmylyx Pharmaceuticals 2.71Moderate Buy$7.3387.55% UpsideHRTXHeron Therapeutics 3.00Buy$5.67135.13% UpsideNGNENeurogene 3.13Buy$60.83242.14% UpsideOPTNOptiNose 3.00Buy$16.67204.69% UpsideCurrent Analyst Ratings BreakdownLatest OPTN, HRTX, AMLX, and NGNE Analyst RatingsDateCompanyBrokerageActionRatingPrice TargetDetails3/5/2025AMLXAmylyx PharmaceuticalsHC WainwrightSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingBuy ➝ Buy$12.00 ➝ $12.002/28/2025HRTXHeron TherapeuticsNeedham & Company LLCSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingBuy ➝ Buy$4.00 ➝ $4.001/16/2025OPTNOptiNoseLake Street CapitalSubscribe to MarketBeat All Access for the recommendation accuracy ratingLower Price TargetBuy ➝ Buy$45.00 ➝ $17.001/3/2025OPTNOptiNoseHC WainwrightSubscribe to MarketBeat All Access for the recommendation accuracy ratingBoost Price TargetBuy ➝ Buy$5.00 ➝ $18.00(Data available from 3/13/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)Compare Sales & Book ValueCompanyAnnual RevenuePrice/SalesCashflowPrice/CashBook ValuePrice/BookAMLXAmylyx Pharmaceuticals$87.37M3.07$0.71 per share5.51$6.42 per share0.61HRTXHeron Therapeutics$144.29M2.54N/AN/A($0.23) per share-10.48NGNENeurogene$925K285.54N/AN/A$14.51 per share1.23OPTNOptiNose$75.67M0.73N/AN/A($11.56) per share-0.47Compare Profitability & EarningsCompanyNet IncomeEPSTrailing P/E RatioForward P/E RatioP/E GrowthNet MarginsReturn on Equity (ROE)Return on Assets (ROA)Next Earnings DateAMLXAmylyx Pharmaceuticals$49.27M-$4.44N/AN/AN/AN/A-36.97%-29.61%5/8/2025 (Estimated)HRTXHeron Therapeutics-$110.56M-$0.09N/AN/AN/A-20.31%N/A-12.72%5/6/2025 (Estimated)NGNENeurogene-$36.32MN/A0.00N/AN/AN/A-32.81%-27.96%3/17/2025 (Estimated)OPTNOptiNose-$35.48M-$4.20N/AN/AN/A-41.16%N/A-27.42%3/20/2025 (Estimated)Latest OPTN, HRTX, AMLX, and NGNE EarningsDateQuarterCompanyConsensus EstimateReported EPSBeat/MissGap EPSRevenue EstimateActual RevenueDetails3/20/2025N/AOPTNOptiNose-$0.67N/AN/AN/A$21.02 millionN/A3/17/2025N/ANGNENeurogene-$1.10N/AN/AN/AN/AN/A3/4/2025Q4 2024AMLXAmylyx Pharmaceuticals-$0.49-$0.55-$0.06-$0.55N/A($0.67) million2/27/2025Q4 2024HRTXHeron Therapeutics-$0.03$0.02+$0.05$0.02$37.37 million$40.78 millionCompare DividendsCompanyAnnual PayoutDividend Yield3-Year Dividend GrowthPayout RatioYears of Consecutive GrowthAMLXAmylyx Pharmaceuticals$1.0225.98%N/AN/A N/AHRTXHeron TherapeuticsN/AN/AN/AN/AN/ANGNENeurogeneN/AN/AN/AN/AN/AOPTNOptiNoseN/AN/AN/AN/AN/ACompare DebtCompanyDebt-to-Equity RatioCurrent RatioQuick RatioAMLXAmylyx PharmaceuticalsN/A4.554.55HRTXHeron TherapeuticsN/A2.281.74NGNENeurogeneN/A9.099.09OPTNOptiNoseN/A0.790.72Compare OwnershipInstitutional OwnershipCompanyInstitutional OwnershipAMLXAmylyx Pharmaceuticals95.84%HRTXHeron Therapeutics80.01%NGNENeurogene52.37%OPTNOptiNose85.60%Insider OwnershipCompanyInsider OwnershipAMLXAmylyx Pharmaceuticals11.70%HRTXHeron Therapeutics5.76%NGNENeurogene9.92%OPTNOptiNose2.30%Compare Miscellaneous StatsCompanyEmployeesShares OutstandingFree FloatOptionableAMLXAmylyx Pharmaceuticals20068.55 million60.53 millionOptionableHRTXHeron Therapeutics300152.33 million143.33 millionOptionableNGNENeurogene9014.86 million13.38 millionOptionableOPTNOptiNose19010.06 million9.83 millionNot OptionableOPTN, HRTX, AMLX, and NGNE HeadlinesRecent News About These CompaniesOptinose Announces Reporting Date for Fourth Quarter and Full Year 2024 Financial ResultsMarch 11 at 9:05 PM | markets.businessinsider.comOptiNose, Inc. (NASDAQ:OPTN) CEO Sells $33,729.04 in StockMarch 5, 2025 | marketbeat.comOptiNose, Inc. (NASDAQ:OPTN) CEO Ramy A. Mahmoud Sells 6,376 SharesMarch 5, 2025 | insidertrades.comOptiNose trading resumesMarch 4, 2025 | markets.businessinsider.comOptiNose (OPTN) Projected to Post Quarterly Earnings on ThursdayFebruary 27, 2025 | marketbeat.comShort Interest in OptiNose, Inc. (NASDAQ:OPTN) Grows By 16.2%February 17, 2025 | marketbeat.com(OPTN) Technical Pivots with Risk ControlsFebruary 13, 2025 | news.stocktradersdaily.com(OPTN) Pivots Trading Plans and Risk ControlsFebruary 2, 2025 | news.stocktradersdaily.comWhen (OPTN) Moves Investors should ListenJanuary 22, 2025 | news.stocktradersdaily.comOptinose Reports $22.4 Million in Preliminary Q4 Revenue for XHANCEJanuary 18, 2025 | msn.comOptinose, Inc.: Optinose Announces Preliminary Unaudited Fourth Quarter 2024 XHANCE Net Revenue of $22.4 MillionJanuary 16, 2025 | finanznachrichten.deOptinose price target adjusted for stock split at Lake StreetJanuary 16, 2025 | markets.businessinsider.comLake Street Remains a Buy on Optinose (OPTN)January 16, 2025 | markets.businessinsider.comOptinose Reports Q4 XHANCE Net Product Revenue; Sees Continued Growth In Year AheadJanuary 15, 2025 | markets.businessinsider.comOptinose Announces Preliminary Unaudited Fourth Quarter 2024 XHANCE Net Revenue of $22.4 MillionJanuary 15, 2025 | globenewswire.comOptinose price target adjusted for stock split at H.C. WainwrightJanuary 3, 2025 | msn.comOptiNose trading halted, volatility trading pauseJanuary 1, 2025 | markets.businessinsider.comOptiNose trading halted, news pendingDecember 31, 2024 | markets.businessinsider.comOptinose, Inc.: Optinose Announces 1-for-15 Reverse Stock SplitDecember 28, 2024 | finanznachrichten.deOptinose Sets 1-for-15 Reverse Stock SplitDecember 26, 2024 | markets.businessinsider.comOptinose Announces 1-for-15 Reverse Stock SplitDecember 26, 2024 | globenewswire.comNew MarketBeat Followers Over TimeMedia Sentiment Over TimeOPTN, HRTX, AMLX, and NGNE Company DescriptionsAmylyx Pharmaceuticals NASDAQ:AMLX$3.91 +0.18 (+4.83%) Closing price 03/12/2025 04:00 PM EasternExtended Trading$3.84 -0.08 (-1.92%) As of 03/12/2025 06:26 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Amylyx Pharmaceuticals, Inc., a commercial-stage biotechnology company, engages in the discovery and development of treatment for amyotrophic lateral sclerosis (ALS) and neurodegenerative diseases. The company's products include RELYVRIO, a dual UPR-Bax apoptosis inhibitor composed of sodium phenylbutyrate and taurursodiol for the treatment of ALS in adults in the United States and marketed as ALBRIOZA for the treatment of ALS in Canada. It is also developing AMX0114 for other neurodegenerative diseases. Amylyx Pharmaceuticals, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.Heron Therapeutics NASDAQ:HRTX$2.41 +0.12 (+5.24%) Closing price 03/12/2025 04:00 PM EasternExtended Trading$2.39 -0.02 (-0.83%) As of 03/12/2025 05:47 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Heron Therapeutics, Inc., a commercial-stage biotechnology company, focuses on enhancing the lives of patients by developing and commercializing therapeutic that enhances medical care. The company's product candidates utilize its proprietary Biochronomer, a drug delivery technology, which delivers therapeutic levels of a range of short-acting pharmacological agents over a period from days to weeks with a single administration. It offers SUSTOL (granisetron), an extended-release injection for the prevention of acute and delayed nausea and vomiting associated with moderately emetogenic chemotherapy, or anthracycline and cyclophosphamide combination chemotherapy regimens; and CINVANTI, an intravenous formulation of aprepitant, a substance P/neurokinin-1 receptor antagonist for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic cancer chemotherapy, as well as nausea and vomiting associated with moderately emetogenic cancer chemotherapy. The company is also developing ZYNRELEF, a dual-acting local anesthetic that delivers a fixed-dose combination of the local anesthetic bupivacaine and a low dose of the nonsteroidal anti-inflammatory drug meloxicam; and APONVIE, an intravenous formulation of a substance P/neurokinin-1 receptor antagonist indicated for the prevention of postoperative nausea and vomiting in adults. The company was formerly known as A.P. Pharma, Inc. and changed its name to Heron Therapeutics, Inc. in January 2014. Heron Therapeutics, Inc. was founded in 1983 and is headquartered in San Diego, California.Neurogene NASDAQ:NGNE$17.78 +0.11 (+0.62%) Closing price 03/12/2025 04:00 PM EasternExtended Trading$17.80 +0.02 (+0.11%) As of 03/12/2025 04:58 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Neurogene Inc., a biotechnology company, develops genetic medicines for rare neurological diseases. The company's product candidates include NGN-401 which is packaged in an adeno-associated virus 9 that is in Phase 1/2 clinical trial for the treatment of Rett syndrome; and NGN-101, a conventional gene therapy candidate that is in Phase 1/2 clinical trial to treat CLN5 Batten disease. It has a license agreement with The University of North Carolina, the University of Edinburgh, Virovek, Inc., and Sigma-Aldrich Co. LLC. The company is headquartered in New York, New York.OptiNose NASDAQ:OPTN$5.47 +0.02 (+0.37%) Closing price 03/12/2025 04:00 PM EasternExtended Trading$5.47 0.00 (0.00%) As of 03/12/2025 04:05 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.OptiNose, Inc., a specialty pharmaceutical company, focuses on the development and commercialization of products for patients treated by ear, nose, throat, and allergy specialists in the United States. The company offers XHANCE, a therapeutic product utilizing its proprietary exhalation delivery system (EDS) that delivers a topically acting corticosteroid for the treatment of chronic rhinosinusitis with nasal polyps, as well as is in Phase IIIb clinical trial for treatment of chronic sinusitis; and Onzetra Xsail, a powder EDS device. It has a license agreement with Currax Pharmaceuticals LLC for the commercialization of Onzetra Xsail. The company was founded in 2000 and is headquartered in Yardley, Pennsylvania. 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